BacMap

Definition	Methanococcus vannielii SB chromosome, complete genome.
Accession	NC_009634
Length	1,720,048

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The map label for this gene is psmA [H]

Identifier: 150400006

GI number: 150400006

Start: 1291094

End: 1291873

Strand: Reverse

Name: psmA [H]

Synonym: Mevan_1264

Alternate gene names: 150400006

Gene position: 1291873-1291094 (Counterclockwise)

Preceding gene: 150400008

Following gene: 150400005

Centisome position: 75.11

GC content: 37.05

Gene sequence:

>780_bases
ATGCAACAAATGGTTCCAGCATCAGGATACGATAGGGCAATAACCATATTCAGCCCAGAAGGACGACTTTACCAGGTAGA
ATATGCACGAGAAGCCGTAAGGCGAGGAACTACTGCGGTAGGCATTAAATGTAAAGACGGTGTTGTTTTAGCCGTTGACA
GAAGAATTACAAGTAAATTAATTGATGTTTCATCAATTGAAAAGATATTTCAAATTGACGACCATATTGTAGCTGCTACA
TCAGGTCTGGTTGCTGATGCAAGAGTTTTAATTGATAGGGCAAGGGTTGAAGCTCAAGTAAATAGAATATCATATGGCGA
AGCGATTACTGTCGAAGCACTTGCAAAAAAAATCTGCGATATTAAACAAGCGTATACTCACCACGGAGGTGCAAGGCCTT
TTGGTTTGGCACTTTTGATAACCGGAATTGATAGACACAGTGCAAGGCTCTTTGAAACTGACCCTAGTGGAGCTTTAATT
GAATACAAAGCTACTGCAATCGGTTCAGGACGGCCTGTTGCAATGGAAATTCTTGAAGAAAAATACGACGAAAATATGAG
CGTTAGTGAAGGTATGGAACTTGCAATTTACGCTTTAAGTAAAACTACTGAAGAATTAAAGCCTGAAAATATAGACATGG
CAATTGTAAAAGATACCGGAAAATTGGTCGAAAAAATAACTGTTTTTGAAATTGAAAAAATTGTAAAAAAAGTATATGAT
AAAATAAAAGTAGAAAACGAAGAGGCTGAAAAAAAGAAGGCTACTGAAAATATAGAATAG

Upstream 100 bases:

>100_bases
ATAAAAAGGATAGATATATATAAAAATTCATTAAAAAGTAGTAATTATATCCGTTGATTTTTAATTTAAAATTAATAATT
TAAACAGAGGAGGAAATTAC

Downstream 100 bases:

>100_bases
AAATAATCTCCTCAAATTATGCTAATTTTGTAATAAAATCTTATATTCGTGTTTTGTTTAATGCGTGGAAAGGTATATAA
ATAAAAGAGGGGATACATAT

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MQQMVPASGYDRAITIFSPEGRLYQVEYAREAVRRGTTAVGIKCKDGVVLAVDRRITSKLIDVSSIEKIFQIDDHIVAAT
SGLVADARVLIDRARVEAQVNRISYGEAITVEALAKKICDIKQAYTHHGGARPFGLALLITGIDRHSARLFETDPSGALI
EYKATAIGSGRPVAMEILEEKYDENMSVSEGMELAIYALSKTTEELKPENIDMAIVKDTGKLVEKITVFEIEKIVKKVYD
KIKVENEEAEKKKATENIE

Sequences:

>Translated_259_residues
MQQMVPASGYDRAITIFSPEGRLYQVEYAREAVRRGTTAVGIKCKDGVVLAVDRRITSKLIDVSSIEKIFQIDDHIVAAT
SGLVADARVLIDRARVEAQVNRISYGEAITVEALAKKICDIKQAYTHHGGARPFGLALLITGIDRHSARLFETDPSGALI
EYKATAIGSGRPVAMEILEEKYDENMSVSEGMELAIYALSKTTEELKPENIDMAIVKDTGKLVEKITVFEIEKIVKKVYD
KIKVENEEAEKKKATENIE
>Mature_259_residues
MQQMVPASGYDRAITIFSPEGRLYQVEYAREAVRRGTTAVGIKCKDGVVLAVDRRITSKLIDVSSIEKIFQIDDHIVAAT
SGLVADARVLIDRARVEAQVNRISYGEAITVEALAKKICDIKQAYTHHGGARPFGLALLITGIDRHSARLFETDPSGALI
EYKATAIGSGRPVAMEILEEKYDENMSVSEGMELAIYALSKTTEELKPENIDMAIVKDTGKLVEKITVFEIEKIVKKVYD
KIKVENEEAEKKKATENIE

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI23110942, Length=237, Percent_Identity=43.0379746835443, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI68303563, Length=219, Percent_Identity=46.1187214611872, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI68303561, Length=225, Percent_Identity=44.8888888888889, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI4506189, Length=229, Percent_Identity=43.6681222707424, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI156713442, Length=223, Percent_Identity=42.6008968609865, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI4506185, Length=223, Percent_Identity=42.6008968609865, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI4506181, Length=213, Percent_Identity=39.4366197183099, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI23110944, Length=215, Percent_Identity=37.2093023255814, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI68303565, Length=219, Percent_Identity=40.1826484018265, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI4506183, Length=169, Percent_Identity=41.4201183431953, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI23110939, Length=168, Percent_Identity=41.6666666666667, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI23110935, Length=226, Percent_Identity=34.070796460177, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4506179, Length=230, Percent_Identity=33.4782608695652, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI156713444, Length=156, Percent_Identity=37.8205128205128, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=38.5321100917431, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4506191, Length=207, Percent_Identity=26.5700483091787, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI73747875, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4758970, Length=176, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508491, Length=235, Percent_Identity=43.4042553191489, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17508493, Length=217, Percent_Identity=41.0138248847926, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25143215, Length=231, Percent_Identity=41.1255411255411, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17562790, Length=214, Percent_Identity=38.3177570093458, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17562788, Length=241, Percent_Identity=33.195020746888, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17562792, Length=217, Percent_Identity=34.5622119815668, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71998965, Length=206, Percent_Identity=32.0388349514563, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321574, Length=224, Percent_Identity=42.4107142857143, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324535, Length=237, Percent_Identity=41.3502109704641, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321692, Length=210, Percent_Identity=43.8095238095238, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324938, Length=212, Percent_Identity=38.6792452830189, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323547, Length=213, Percent_Identity=36.6197183098592, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6323974, Length=238, Percent_Identity=33.6134453781513, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321427, Length=161, Percent_Identity=38.5093167701863, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136420, Length=248, Percent_Identity=41.9354838709677, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17933602, Length=219, Percent_Identity=43.37899543379, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24654391, Length=240, Percent_Identity=40.8333333333333, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24654389, Length=240, Percent_Identity=40.8333333333333, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21356137, Length=236, Percent_Identity=40.2542372881356, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651571, Length=230, Percent_Identity=40.8695652173913, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19922898, Length=254, Percent_Identity=35.4330708661417, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17737927, Length=212, Percent_Identity=36.7924528301887, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281360341, Length=238, Percent_Identity=35.2941176470588, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586406, Length=238, Percent_Identity=35.2941176470588, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586400, Length=238, Percent_Identity=35.2941176470588, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586402, Length=238, Percent_Identity=35.2941176470588, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24652204, Length=220, Percent_Identity=36.3636363636364, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17737405, Length=181, Percent_Identity=38.121546961326, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19921232, Length=236, Percent_Identity=36.4406779661017, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24584895, Length=214, Percent_Identity=30.8411214953271, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130281, Length=173, Percent_Identity=28.9017341040462, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639979, Length=206, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355573, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652553, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 28660; Mature: 28660

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQMVPASGYDRAITIFSPEGRLYQVEYAREAVRRGTTAVGIKCKDGVVLAVDRRITSKL
CCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEECCCEEEEECHHHHHHH
IDVSSIEKIFQIDDHIVAATSGLVADARVLIDRARVEAQVNRISYGEAITVEALAKKICD
HCHHHHHHHHHHCCHHEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IKQAYTHHGGARPFGLALLITGIDRHSARLFETDPSGALIEYKATAIGSGRPVAMEILEE
HHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
KYDENMSVSEGMELAIYALSKTTEELKPENIDMAIVKDTGKLVEKITVFEIEKIVKKVYD
HHCCCCCHHCCCEEEEEEEHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
KIKVENEEAEKKKATENIE
HHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQQMVPASGYDRAITIFSPEGRLYQVEYAREAVRRGTTAVGIKCKDGVVLAVDRRITSKL
CCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEECCCEEEEECHHHHHHH
IDVSSIEKIFQIDDHIVAATSGLVADARVLIDRARVEAQVNRISYGEAITVEALAKKICD
HCHHHHHHHHHHCCHHEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IKQAYTHHGGARPFGLALLITGIDRHSARLFETDPSGALIEYKATAIGSGRPVAMEILEE
HHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
KYDENMSVSEGMELAIYALSKTTEELKPENIDMAIVKDTGKLVEKITVFEIEKIVKKVYD
HHCCCCCHHCCCEEEEEEEHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
KIKVENEEAEKKKATENIE
HHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA