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The map label for this gene is argH

Identifier: 150399951

GI number: 150399951

Start: 1231315

End: 1232760

Strand: Reverse

Name: argH

Synonym: Mevan_1208

Alternate gene names: 150399951

Gene position: 1232760-1231315 (Counterclockwise)

Preceding gene: 150399952

Following gene: 150399946

Centisome position: 71.67

GC content: 33.2

Gene sequence:

>1446_bases
ATGAATATTTTAAGACGTGGAAGACTTGGAAGTAGCGTTAAAGAAGACGTGATGAAATTTACAACTAGCCTTGAATTTGA
TAAAGAAATCTTTCAAAGCGATATTTTATGTGATATTGCACATACAACAATGCTTATGGAGCAAAAAATTGTTTCCATAG
AGTTTGGTGAAAAAGTAATTGAAGAACTTAAAAAAATAGCTAAAGTAGGAATGGATAGCTTAAATTTAGACCCTTCTCTT
GACGATATTCATATGGTAATTGAAAGTGAACTGATAAAAAAATTAGGTGAAGACGTTGCTGGAAGAATGCATACTGGAAG
AAGTAGAAATGATGAAGTTGCAACAGATTTAAGACTTTCTTTAAGAAAAAAAGTTCTTGAAATAGTAAAACTCTTAATAG
ACATGGAAGAAAATATGCTCTCCCTTGCAAAAGAACATAGCGAAACTATAACTGTTGGATATACCCATTTGCAGCAGGCA
CAGCCTGTTACCTTTGGACATCAAATTTTAAGCCACGTTTCAGCAGTTGAAAGAGATATTTCAAGATTTTTTGATGCATA
TAACAGGATTAACATCTCCCCGTTAGGTTGCGGTGCAATGGCCACAACAGGATTTAATATCGATAGAAAAAGAACTATGG
AACTTTTAGGATTTTACGAATTAATCGAAAATTCAATGGATGGAGTATCTTCAAGAGACTTTATTGTAGAAACAATGGCA
AATATTTCAATGCTTGGAACAAACCTCTCAAAAATCTGTGAAGAACTCATTTTATTCTCTACTGCAGAATTTAAGACCGT
TGAAATTGCAGATGAATACACGTCCACGTCTTCGATAATGCCCCAAAAGAAAAATCCGGATGTAGCAGAAATTGCCCGTG
CAAAGCTCTCAACACTAAATGGCAATCTTATAACTGTTTTAACAATTATGAAAGCCCTTCCAAATACATATAATCGAGAT
TTGCAAGAAATATCGCCACATCTTTGGAAAAGCACCTATACCATAATAGACTGTATTAAAATGATTGATGGAATGGTTTC
AACTATTAAAGTAAATAAAGAAAGAATGAAAGAAAATGCAGAAAAAAATTATGCTACCGCAACAGAACTTGCAGATACCC
TTGTAAGGGAATGTAATATTGCATTTAGAATGGCTCATGGGATCGTTGGGGAACTTGTAAGGACTTCGATTGAAGAAAAA
GTTGAAATTAAAGATATAATTTTAGATGTCTTTAAGGCCAATGGGCTTCATTTATCAAAGGAAAAAATAGACTCTGCACT
AGACCCTTATGAAAACGTAAAATTAAGAGATGTAATTGGGGGTCCAGCTCCAAAAGAAGTAGAAAGAGCAGTTTTATCAT
TTAAAAACAAAATGGAGTTACATTCAAAAAATTTAAACGATAAAATGCGTTCAATTGAAGCAGTTGAGGAAAATTTGCTA
AATTGA

Upstream 100 bases:

>100_bases
TAACGTAGTGCTTGAACGGTGCATGATGTCTGAATATCAAAAATTTTTATAGTTTGGATGTCTAATCTTAAAGTAAAAAG
TCCGTTTAGGTGAATAAAAC

Downstream 100 bases:

>100_bases
ATACCTGTTATTTTTAAAATATACTTTTTAATATTAAAACGTTTCAAATATTTTTTTGACGACCATTGTTGCATAACTTC
CTTTATTAAGTGTAAATTTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNILRRGRLGSSVKEDVMKFTTSLEFDKEIFQSDILCDIAHTTMLMEQKIVSIEFGEKVIEELKKIAKVGMDSLNLDPSL
DDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIVKLLIDMEENMLSLAKEHSETITVGYTHLQQA
QPVTFGHQILSHVSAVERDISRFFDAYNRINISPLGCGAMATTGFNIDRKRTMELLGFYELIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELILFSTAEFKTVEIADEYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLITVLTIMKALPNTYNRD
LQEISPHLWKSTYTIIDCIKMIDGMVSTIKVNKERMKENAEKNYATATELADTLVRECNIAFRMAHGIVGELVRTSIEEK
VEIKDIILDVFKANGLHLSKEKIDSALDPYENVKLRDVIGGPAPKEVERAVLSFKNKMELHSKNLNDKMRSIEAVEENLL
N

Sequences:

>Translated_481_residues
MNILRRGRLGSSVKEDVMKFTTSLEFDKEIFQSDILCDIAHTTMLMEQKIVSIEFGEKVIEELKKIAKVGMDSLNLDPSL
DDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIVKLLIDMEENMLSLAKEHSETITVGYTHLQQA
QPVTFGHQILSHVSAVERDISRFFDAYNRINISPLGCGAMATTGFNIDRKRTMELLGFYELIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELILFSTAEFKTVEIADEYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLITVLTIMKALPNTYNRD
LQEISPHLWKSTYTIIDCIKMIDGMVSTIKVNKERMKENAEKNYATATELADTLVRECNIAFRMAHGIVGELVRTSIEEK
VEIKDIILDVFKANGLHLSKEKIDSALDPYENVKLRDVIGGPAPKEVERAVLSFKNKMELHSKNLNDKMRSIEAVEENLL
N
>Mature_481_residues
MNILRRGRLGSSVKEDVMKFTTSLEFDKEIFQSDILCDIAHTTMLMEQKIVSIEFGEKVIEELKKIAKVGMDSLNLDPSL
DDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIVKLLIDMEENMLSLAKEHSETITVGYTHLQQA
QPVTFGHQILSHVSAVERDISRFFDAYNRINISPLGCGAMATTGFNIDRKRTMELLGFYELIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELILFSTAEFKTVEIADEYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLITVLTIMKALPNTYNRD
LQEISPHLWKSTYTIIDCIKMIDGMVSTIKVNKERMKENAEKNYATATELADTLVRECNIAFRMAHGIVGELVRTSIEEK
VEIKDIILDVFKANGLHLSKEKIDSALDPYENVKLRDVIGGPAPKEVERAVLSFKNKMELHSKNLNDKMRSIEAVEENLL
N

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=449, Percent_Identity=33.4075723830735, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI68303542, Length=449, Percent_Identity=33.4075723830735, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI68303547, Length=449, Percent_Identity=31.1804008908686, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI68303549, Length=449, Percent_Identity=30.9576837416481, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=36.1233480176211, Blast_Score=294, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6321806, Length=466, Percent_Identity=34.7639484978541, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=34.5372460496614, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=34.5372460496614, Blast_Score=252, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_METVS (A6URI4)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323718.1
- ProteinModelPortal:   A6URI4
- SMR:   A6URI4
- STRING:   A6URI4
- GeneID:   5325684
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1208
- eggNOG:   arNOG04975
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 54254; Mature: 54254

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILRRGRLGSSVKEDVMKFTTSLEFDKEIFQSDILCDIAHTTMLMEQKIVSIEFGEKVI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELKKIAKVGMDSLNLDPSLDDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRLS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LRKKVLEIVKLLIDMEENMLSLAKEHSETITVGYTHLQQAQPVTFGHQILSHVSAVERDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRFFDAYNRINISPLGCGAMATTGFNIDRKRTMELLGFYELIENSMDGVSSRDFIVETMA
HHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NISMLGTNLSKICEELILFSTAEFKTVEIADEYTSTSSIMPQKKNPDVAEIARAKLSTLN
HHHHHCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCHHCCCCCCCCCCHHHHHHHHHHHCC
GNLITVLTIMKALPNTYNRDLQEISPHLWKSTYTIIDCIKMIDGMVSTIKVNKERMKENA
CCHHHHHHHHHHCCCHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EKNYATATELADTLVRECNIAFRMAHGIVGELVRTSIEEKVEIKDIILDVFKANGLHLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECH
EKIDSALDPYENVKLRDVIGGPAPKEVERAVLSFKNKMELHSKNLNDKMRSIEAVEENLL
HHHHHHCCCHHCCEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
N
C
>Mature Secondary Structure
MNILRRGRLGSSVKEDVMKFTTSLEFDKEIFQSDILCDIAHTTMLMEQKIVSIEFGEKVI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELKKIAKVGMDSLNLDPSLDDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRLS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LRKKVLEIVKLLIDMEENMLSLAKEHSETITVGYTHLQQAQPVTFGHQILSHVSAVERDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRFFDAYNRINISPLGCGAMATTGFNIDRKRTMELLGFYELIENSMDGVSSRDFIVETMA
HHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NISMLGTNLSKICEELILFSTAEFKTVEIADEYTSTSSIMPQKKNPDVAEIARAKLSTLN
HHHHHCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCHHCCCCCCCCCCHHHHHHHHHHHCC
GNLITVLTIMKALPNTYNRDLQEISPHLWKSTYTIIDCIKMIDGMVSTIKVNKERMKENA
CCHHHHHHHHHHCCCHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EKNYATATELADTLVRECNIAFRMAHGIVGELVRTSIEEKVEIKDIILDVFKANGLHLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECH
EKIDSALDPYENVKLRDVIGGPAPKEVERAVLSFKNKMELHSKNLNDKMRSIEAVEENLL
HHHHHHCCCHHCCEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA