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The map label for this gene is hisC

Identifier: 150399283

GI number: 150399283

Start: 583848

End: 584963

Strand: Reverse

Name: hisC

Synonym: Mevan_0531

Alternate gene names: 150399283

Gene position: 584963-583848 (Counterclockwise)

Preceding gene: 150399284

Following gene: 150399282

Centisome position: 34.01

GC content: 31.99

Gene sequence:

>1116_bases
ATGACAATAGATGATATAATAAGGCCAATAGTAAAGGAATTTAAAGCTTACGTTCCAGGAAAATCAAAAGAGGAAATTGC
AAGAAATTATGGCATTTCGATTGAAAAAATTATAAAGCTTGGTTCAAATGAAAATCCCTGGGGTTGTTCACCAAAAATCA
AAGAAGCACTTCTTTTGGAACTTTCAAAACTGCACCAGTACCCGGAACCTTTGAATTCCGAATTACTGGGGGAAATAAGT
AGTTTTATAGGCGTTCCTTGTGAAAATATAATAATTGGCGGGGATGGTGCAGACGAAGTAATTGACAATATAATGCGGAT
TTTAATTGATGAAGGGGATGAAGTAATTATTCCAATTCCAACATTTACACAATACGCAATTTCTGCAAAAATCCACGGTG
CAAAAATAAAGTGGGCAAAATTTGACAAGGAAAAAGACTTTAAACTTGATGTTGAAAGTGTATTGAATAATATAACTGAA
AAAACAAAAGCAATATTTTTATGCACCCCAAATAATCCAACGGGAAACGTAATTTCTAATGAAGACATTAAAAAAATTAT
CGAAAGTACAGATGCACTTATAATGATTGATCATGCTTACATTGAATATTCGAAAAAAGAGTACGATTTAACACAATGGG
CACTTAAATACGATAATGTACTTGTTCTTAGGACTTTTTCAAAAGTATTTGGCCTTGCAGGGCAAAGAATCGGATATGGC
GTTACAAATAAAAAAATTGTAGATTACATGATGAGAATAAAGCCGATATTTAGTTTAACTAGGGCTTCCCAAGTATCTGC
AATCACTGCTTTAAAAGATAAGGAATTTTTTAATGGATGTAAGATAAACGGGATTAGAAGTATAACTCAACTACATGATG
GATTAAAAAAATTCAAGCAATTAAAGGTTTACCCAACGGAAACAAATTATTTGCTTGTTGAAATAAAAAATGGAATGAAT
TCAAAAGAATTCTGTGAAATACTACTTAAAAAAGGCGTTATTGTACGGGACTGTTACTCTTTTGAAGGGCTTGAACCTTA
CTATTTCAGGGTTTCTATTGGCACTTTTGAGGAAAACGAAAGATTTTTAGAGATAATGTCTGAAATCATTGAATAA

Upstream 100 bases:

>100_bases
CTGCTGATGAATTAATATTCAAGCGTGCAAAAGAACTTTACGGTGCTGAAAAATTAAATTCAGAAGAATTACTATAACAA
AATTGTTTTCTGGTGTTTTT

Downstream 100 bases:

>100_bases
TATTCTAAAACCTTAAAAACATTCTAAATTATTTTAATTTAAACTTTTATTTTAAAATTATTTTTAATATTTTTCAGTAA
CTATATATGTTCGATTTTTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTIDDIIRPIVKEFKAYVPGKSKEEIARNYGISIEKIIKLGSNENPWGCSPKIKEALLLELSKLHQYPEPLNSELLGEIS
SFIGVPCENIIIGGDGADEVIDNIMRILIDEGDEVIIPIPTFTQYAISAKIHGAKIKWAKFDKEKDFKLDVESVLNNITE
KTKAIFLCTPNNPTGNVISNEDIKKIIESTDALIMIDHAYIEYSKKEYDLTQWALKYDNVLVLRTFSKVFGLAGQRIGYG
VTNKKIVDYMMRIKPIFSLTRASQVSAITALKDKEFFNGCKINGIRSITQLHDGLKKFKQLKVYPTETNYLLVEIKNGMN
SKEFCEILLKKGVIVRDCYSFEGLEPYYFRVSIGTFEENERFLEIMSEIIE

Sequences:

>Translated_371_residues
MTIDDIIRPIVKEFKAYVPGKSKEEIARNYGISIEKIIKLGSNENPWGCSPKIKEALLLELSKLHQYPEPLNSELLGEIS
SFIGVPCENIIIGGDGADEVIDNIMRILIDEGDEVIIPIPTFTQYAISAKIHGAKIKWAKFDKEKDFKLDVESVLNNITE
KTKAIFLCTPNNPTGNVISNEDIKKIIESTDALIMIDHAYIEYSKKEYDLTQWALKYDNVLVLRTFSKVFGLAGQRIGYG
VTNKKIVDYMMRIKPIFSLTRASQVSAITALKDKEFFNGCKINGIRSITQLHDGLKKFKQLKVYPTETNYLLVEIKNGMN
SKEFCEILLKKGVIVRDCYSFEGLEPYYFRVSIGTFEENERFLEIMSEIIE
>Mature_370_residues
TIDDIIRPIVKEFKAYVPGKSKEEIARNYGISIEKIIKLGSNENPWGCSPKIKEALLLELSKLHQYPEPLNSELLGEISS
FIGVPCENIIIGGDGADEVIDNIMRILIDEGDEVIIPIPTFTQYAISAKIHGAKIKWAKFDKEKDFKLDVESVLNNITEK
TKAIFLCTPNNPTGNVISNEDIKKIIESTDALIMIDHAYIEYSKKEYDLTQWALKYDNVLVLRTFSKVFGLAGQRIGYGV
TNKKIVDYMMRIKPIFSLTRASQVSAITALKDKEFFNGCKINGIRSITQLHDGLKKFKQLKVYPTETNYLLVEIKNGMNS
KEFCEILLKKGVIVRDCYSFEGLEPYYFRVSIGTFEENERFLEIMSEIIE

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI95147551, Length=299, Percent_Identity=22.4080267558528, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI169881279, Length=299, Percent_Identity=22.4080267558528, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI56713254, Length=251, Percent_Identity=25.0996015936255, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI56713256, Length=219, Percent_Identity=25.1141552511416, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788332, Length=375, Percent_Identity=25.3333333333333, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788722, Length=251, Percent_Identity=27.0916334661355, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788627, Length=215, Percent_Identity=26.5116279069767, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=368, Percent_Identity=27.445652173913, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METVS (A6UPL6)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323050.1
- ProteinModelPortal:   A6UPL6
- SMR:   A6UPL6
- STRING:   A6UPL6
- GeneID:   5325886
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0531
- eggNOG:   arNOG04897
- HOGENOM:   HBG646350
- OMA:   ASNENAF
- ProtClustDB:   PRK00950
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42224; Mature: 42092

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDDIIRPIVKEFKAYVPGKSKEEIARNYGISIEKIIKLGSNENPWGCSPKIKEALLLE
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHH
LSKLHQYPEPLNSELLGEISSFIGVPCENIIIGGDGADEVIDNIMRILIDEGDEVIIPIP
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECC
TFTQYAISAKIHGAKIKWAKFDKEKDFKLDVESVLNNITEKTKAIFLCTPNNPTGNVISN
CCHHHEEEEEECCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
EDIKKIIESTDALIMIDHAYIEYSKKEYDLTQWALKYDNVLVLRTFSKVFGLAGQRIGYG
HHHHHHHHCCCCEEEEEHHHHHHCCCHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCCCC
VTNKKIVDYMMRIKPIFSLTRASQVSAITALKDKEFFNGCKINGIRSITQLHDGLKKFKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LKVYPTETNYLLVEIKNGMNSKEFCEILLKKGVIVRDCYSFEGLEPYYFRVSIGTFEENE
EEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCH
RFLEIMSEIIE
HHHHHHHHHHC
>Mature Secondary Structure 
TIDDIIRPIVKEFKAYVPGKSKEEIARNYGISIEKIIKLGSNENPWGCSPKIKEALLLE
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHH
LSKLHQYPEPLNSELLGEISSFIGVPCENIIIGGDGADEVIDNIMRILIDEGDEVIIPIP
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECC
TFTQYAISAKIHGAKIKWAKFDKEKDFKLDVESVLNNITEKTKAIFLCTPNNPTGNVISN
CCHHHEEEEEECCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
EDIKKIIESTDALIMIDHAYIEYSKKEYDLTQWALKYDNVLVLRTFSKVFGLAGQRIGYG
HHHHHHHHCCCCEEEEEHHHHHHCCCHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCCCC
VTNKKIVDYMMRIKPIFSLTRASQVSAITALKDKEFFNGCKINGIRSITQLHDGLKKFKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LKVYPTETNYLLVEIKNGMNSKEFCEILLKKGVIVRDCYSFEGLEPYYFRVSIGTFEENE
EEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCH
RFLEIMSEIIE
HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA