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The map label for this gene is dxs [C]

Identifier: 150399190

GI number: 150399190

Start: 490131

End: 491069

Strand: Reverse

Name: dxs [C]

Synonym: Mevan_0438

Alternate gene names: 150399190

Gene position: 491069-490131 (Counterclockwise)

Preceding gene: 150399191

Following gene: 150399189

Centisome position: 28.55

GC content: 33.87

Gene sequence:

>939_bases
ATGATAGGTACAAAAAAAGGAATGAGGGATGCATACGGTGAAATTTTGGCCGAACTTGGTGCATCTAATGAAAATATTGT
AGTTTTAGATGCGGATTTATCAGGCTCAACAAAAACGAGTATTTTTGCAAAAAAATTTCCAAAAAGGTTTTTTAATGCAG
GAATTGCAGAACAAAACATGATTGGAATGGCAGCAGGTTTATCAAGGACTGGAAAAATTGTTTTCGCATCAACTTTTGCA
ATGTTTGCAACCGGAAGGGCATGGGAACAGATTAGAAATTCAATTGCTTACCCTAATTTAAATGTTAAAATATGTGCAAC
CCATGCTGGAATTACGGTTGGTGAAGATGGGGCATCTCACGAAATGACGGAAGACATTGCAATAATTCGTGCAATTCCAA
ACATGGTTGTAATTTCTCCATCAGACTATTTTGAAACAAAAAGTGCAATAAAATGGGCAGTTAGTTATAACGGGCCAGTC
TATGTTAGAATGCCGAGAGGAAACACGGAAGTTATTTTTGAAAACGAAGAAGAAGCTAAGTTTGAATTTAAAAAAGCAAA
AACATTAAAAGAAGGAACTAACTTAACAATTATTGCAACAGGGGAGCTTGTTTCAGAAGCACTCAATGCAAGCAAAATAT
TAAGCGAAAACAACGTTTCAGCAGAAGTAATTGCAATTTCAACAATCAAGCCAATCGATAGAGAAGCAATTAGAAATTCA
AAAAATTTTATTGTTTCAGTAGAGGACCACAGTATAATAGGGGGCCTTGGTAGTGCAATTTCGGAAGTAATATCTGAAGA
AGGATTAAACAAAAAGTTATTTAGAATTGGGATAAACGATGAATTTGGAAAATCTGGAAAAGCAGAAGAACTTTTAAAAT
ACTATAAACTTGATTCAGAATCAATTGCAAAATCAATTCTTTCTAAAATTAATCCATAA

Upstream 100 bases:

>100_bases
AGATTATAACTAATTTCACAATATTTATTTACTTTATTTACTTTATTTACATTTCTTACACTATTACTTAATAAATTTAA
ACTTTTAACGGTGACGCTTA

Downstream 100 bases:

>100_bases
TATTTTTATTTGCATTTTTCATATAATGATATTGCCATAATCTTAATTATATTTTAATTAATTATTTTAAAGGTAGCGTT
ATGAAAAAAATTGGAATTTT

Product: transketolase central region

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MIGTKKGMRDAYGEILAELGASNENIVVLDADLSGSTKTSIFAKKFPKRFFNAGIAEQNMIGMAAGLSRTGKIVFASTFA
MFATGRAWEQIRNSIAYPNLNVKICATHAGITVGEDGASHEMTEDIAIIRAIPNMVVISPSDYFETKSAIKWAVSYNGPV
YVRMPRGNTEVIFENEEEAKFEFKKAKTLKEGTNLTIIATGELVSEALNASKILSENNVSAEVIAISTIKPIDREAIRNS
KNFIVSVEDHSIIGGLGSAISEVISEEGLNKKLFRIGINDEFGKSGKAEELLKYYKLDSESIAKSILSKINP

Sequences:

>Translated_312_residues
MIGTKKGMRDAYGEILAELGASNENIVVLDADLSGSTKTSIFAKKFPKRFFNAGIAEQNMIGMAAGLSRTGKIVFASTFA
MFATGRAWEQIRNSIAYPNLNVKICATHAGITVGEDGASHEMTEDIAIIRAIPNMVVISPSDYFETKSAIKWAVSYNGPV
YVRMPRGNTEVIFENEEEAKFEFKKAKTLKEGTNLTIIATGELVSEALNASKILSENNVSAEVIAISTIKPIDREAIRNS
KNFIVSVEDHSIIGGLGSAISEVISEEGLNKKLFRIGINDEFGKSGKAEELLKYYKLDSESIAKSILSKINP
>Mature_312_residues
MIGTKKGMRDAYGEILAELGASNENIVVLDADLSGSTKTSIFAKKFPKRFFNAGIAEQNMIGMAAGLSRTGKIVFASTFA
MFATGRAWEQIRNSIAYPNLNVKICATHAGITVGEDGASHEMTEDIAIIRAIPNMVVISPSDYFETKSAIKWAVSYNGPV
YVRMPRGNTEVIFENEEEAKFEFKKAKTLKEGTNLTIIATGELVSEALNASKILSENNVSAEVIAISTIKPIDREAIRNS
KNFIVSVEDHSIIGGLGSAISEVISEEGLNKKLFRIGINDEFGKSGKAEELLKYYKLDSESIAKSILSKINP

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=313, Percent_Identity=37.0607028753994, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI4507521, Length=313, Percent_Identity=37.0607028753994, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI225637463, Length=309, Percent_Identity=38.1877022653722, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI225637459, Length=309, Percent_Identity=38.1877022653722, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI225637461, Length=309, Percent_Identity=38.1877022653722, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI133778974, Length=313, Percent_Identity=34.5047923322684, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI291084858, Length=272, Percent_Identity=27.5735294117647, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI156564403, Length=277, Percent_Identity=27.7978339350181, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786622, Length=299, Percent_Identity=30.4347826086957, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI48994911, Length=240, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788808, Length=325, Percent_Identity=24.9230769230769, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539652, Length=318, Percent_Identity=33.6477987421384, Blast_Score=161, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319593, Length=275, Percent_Identity=29.0909090909091, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6325331, Length=263, Percent_Identity=30.0380228136882, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551847, Length=277, Percent_Identity=36.8231046931408, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45550715, Length=277, Percent_Identity=36.8231046931408, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24645119, Length=277, Percent_Identity=36.8231046931408, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24666278, Length=314, Percent_Identity=33.1210191082803, Blast_Score=158, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33914; Mature: 33914

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGTKKGMRDAYGEILAELGASNENIVVLDADLSGSTKTSIFAKKFPKRFFNAGIAEQNM
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
IGMAAGLSRTGKIVFASTFAMFATGRAWEQIRNSIAYPNLNVKICATHAGITVGEDGASH
HHHHHCCCCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCEEECCCCCCC
EMTEDIAIIRAIPNMVVISPSDYFETKSAIKWAVSYNGPVYVRMPRGNTEVIFENEEEAK
HHHHHHHHHHHCCCEEEECCCHHHHCHHHEEEEEECCCEEEEEECCCCEEEEEECCHHHH
FEFKKAKTLKEGTNLTIIATGELVSEALNASKILSENNVSAEVIAISTIKPIDREAIRNS
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHCCC
KNFIVSVEDHSIIGGLGSAISEVISEEGLNKKLFRIGINDEFGKSGKAEELLKYYKLDSE
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHH
SIAKSILSKINP
HHHHHHHHHCCC
>Mature Secondary Structure
MIGTKKGMRDAYGEILAELGASNENIVVLDADLSGSTKTSIFAKKFPKRFFNAGIAEQNM
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
IGMAAGLSRTGKIVFASTFAMFATGRAWEQIRNSIAYPNLNVKICATHAGITVGEDGASH
HHHHHCCCCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCEEECCCCCCC
EMTEDIAIIRAIPNMVVISPSDYFETKSAIKWAVSYNGPVYVRMPRGNTEVIFENEEEAK
HHHHHHHHHHHCCCEEEECCCHHHHCHHHEEEEEECCCEEEEEECCCCEEEEEECCHHHH
FEFKKAKTLKEGTNLTIIATGELVSEALNASKILSENNVSAEVIAISTIKPIDREAIRNS
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHCCC
KNFIVSVEDHSIIGGLGSAISEVISEEGLNKKLFRIGINDEFGKSGKAEELLKYYKLDSE
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHH
SIAKSILSKINP
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]