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The map label for this gene is pyrC [H]

Identifier: 150399090

GI number: 150399090

Start: 384001

End: 385263

Strand: Reverse

Name: pyrC [H]

Synonym: Mevan_0336

Alternate gene names: 150399090

Gene position: 385263-384001 (Counterclockwise)

Preceding gene: 150399091

Following gene: 150399089

Centisome position: 22.4

GC content: 30.17

Gene sequence:

>1263_bases
ATGGTGCTTTTGAAAAACTGTAAAATAGTATCTGAAAATTCAATAAACGAAGCAGATATTTTAATTGAAGACAGGATAAT
CCAGAAAATTGGAAAAAACATTGAATATTCTGGAGAAAAGATAGATTTAACTGGAAAATATGTATTTCCTGGAATAATTG
ATTCACACGTTCACTTTCGATGGGGAAATTCTGAAAAGGAGGATTTTGTTTCAGGAAGTGAGGCTGCAATTTTTGGAGGA
GTAGTTTTTGCAATAGATATGCCAAACAATAATCCGCCTGTTACAACAAAAGAAATTTTTTATAAAAAAATGAATGAAGG
AAATGAAAAAAGTAAGGTAAACTTGTATTTTTCCTACGGAGTTACTGAAAATAATTACTTAGAAACAATTTCTGATGCAA
AATTTTACAAAATTTTCACGGTAAAGTCTGTTGGCGACTTATTTATATCGGATTACTCTAAATTAAGAGAAATATTAGAC
CAAAATAAAATTTTTGCAGTTCATGCAGAACATAAGGATGTAATTTTAAAAAATTCCGAGACTTATAACTTAGATAGCTT
TGAAAACCACTGTAAAATTAGAAGTAGGGAAAGTGAAATTGAAGCAGTCAGGGAGATTTTGGACGCACTTAAAGAAGTTG
ATAAAAATAGTAGAAATACTCCCCACGTTCATTTTTGCCACATATCTGTTAAAGAAGCGCTTGAATTGATAAAAAATGCC
AAAAAAATGTTTAAAAACGTTAAAATAAGTGTTGAAGTGTCCCCCCACCATTTATTTTTAAACTCTGAAATGGCAGGAAA
TTTAAAAGGTTCTGGAAAATTCAATCCCCCACTAAGGACAAAAGAAGATAATTTGGCGCTTTTAAATGGAATAATTGAGG
GAACTGTCGATATTGTTTCTACTGATCATGCACCACACAAAGACTGCGAAAAATTAAATCCTGTGGAAAACTGCCCTTCA
GGGATTTCAGGAATTGAAACACTTGTGCCGTTAATTATGAACTTGGTTCACGATAAAAAAATTTCAATTTTTGATGTTTA
CCGAGTTTTATCAAAAAATCCATCGGAAATATTTAAAATAAACAATAAAATCGAGATTGGAAATTTTGCAAATATGTCTA
TTATTGATTTAGATAAAAAAATGACCATATCTGGAAAAAATTTTAAATCAAAGTCAAAAATAACTCCTTTTGAAAATTGG
GAAGTTATGGGAGTTCCCGTTTACACAATAGTCAATGGAAATATTATCCAAACAAATATTTAA

Upstream 100 bases:

>100_bases
AATATGCATTTTAAATCAGAAATTCCAAAAGATATTAAAAATTTAGTTGAAAGGCTTAGGAAATGAAAAGTAAGCTAGAA
AAATAATTTTGGTGTAAAAA

Downstream 100 bases:

>100_bases
ATATAATTAAACGTAAATATAAGTTATTTATGGAGGGATAAAATGAGTTCAATGTTAAAGCCAGTACTTATTGGCGGTAT
TGTTTGTGGTATTCTTGCAG

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MVLLKNCKIVSENSINEADILIEDRIIQKIGKNIEYSGEKIDLTGKYVFPGIIDSHVHFRWGNSEKEDFVSGSEAAIFGG
VVFAIDMPNNNPPVTTKEIFYKKMNEGNEKSKVNLYFSYGVTENNYLETISDAKFYKIFTVKSVGDLFISDYSKLREILD
QNKIFAVHAEHKDVILKNSETYNLDSFENHCKIRSRESEIEAVREILDALKEVDKNSRNTPHVHFCHISVKEALELIKNA
KKMFKNVKISVEVSPHHLFLNSEMAGNLKGSGKFNPPLRTKEDNLALLNGIIEGTVDIVSTDHAPHKDCEKLNPVENCPS
GISGIETLVPLIMNLVHDKKISIFDVYRVLSKNPSEIFKINNKIEIGNFANMSIIDLDKKMTISGKNFKSKSKITPFENW
EVMGVPVYTIVNGNIIQTNI

Sequences:

>Translated_420_residues
MVLLKNCKIVSENSINEADILIEDRIIQKIGKNIEYSGEKIDLTGKYVFPGIIDSHVHFRWGNSEKEDFVSGSEAAIFGG
VVFAIDMPNNNPPVTTKEIFYKKMNEGNEKSKVNLYFSYGVTENNYLETISDAKFYKIFTVKSVGDLFISDYSKLREILD
QNKIFAVHAEHKDVILKNSETYNLDSFENHCKIRSRESEIEAVREILDALKEVDKNSRNTPHVHFCHISVKEALELIKNA
KKMFKNVKISVEVSPHHLFLNSEMAGNLKGSGKFNPPLRTKEDNLALLNGIIEGTVDIVSTDHAPHKDCEKLNPVENCPS
GISGIETLVPLIMNLVHDKKISIFDVYRVLSKNPSEIFKINNKIEIGNFANMSIIDLDKKMTISGKNFKSKSKITPFENW
EVMGVPVYTIVNGNIIQTNI
>Mature_420_residues
MVLLKNCKIVSENSINEADILIEDRIIQKIGKNIEYSGEKIDLTGKYVFPGIIDSHVHFRWGNSEKEDFVSGSEAAIFGG
VVFAIDMPNNNPPVTTKEIFYKKMNEGNEKSKVNLYFSYGVTENNYLETISDAKFYKIFTVKSVGDLFISDYSKLREILD
QNKIFAVHAEHKDVILKNSETYNLDSFENHCKIRSRESEIEAVREILDALKEVDKNSRNTPHVHFCHISVKEALELIKNA
KKMFKNVKISVEVSPHHLFLNSEMAGNLKGSGKFNPPLRTKEDNLALLNGIIEGTVDIVSTDHAPHKDCEKLNPVENCPS
GISGIETLVPLIMNLVHDKKISIFDVYRVLSKNPSEIFKINNKIEIGNFANMSIIDLDKKMTISGKNFKSKSKITPFENW
EVMGVPVYTIVNGNIIQTNI

Specific function: Unknown

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=372, Percent_Identity=28.494623655914, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4503379, Length=448, Percent_Identity=25, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4503051, Length=452, Percent_Identity=25, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI62422571, Length=452, Percent_Identity=25, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4503377, Length=449, Percent_Identity=25.8351893095768, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503375, Length=452, Percent_Identity=24.3362831858407, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI19923821, Length=451, Percent_Identity=25.0554323725055, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI190194363, Length=445, Percent_Identity=22.4719101123595, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI87082175, Length=449, Percent_Identity=25.6124721603563, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786722, Length=438, Percent_Identity=22.1461187214612, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=376, Percent_Identity=28.4574468085106, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17539558, Length=465, Percent_Identity=23.8709677419355, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.1306532663317, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24642586, Length=372, Percent_Identity=31.1827956989247, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221377917, Length=456, Percent_Identity=24.780701754386, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137462, Length=455, Percent_Identity=25.4945054945055, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24644287, Length=307, Percent_Identity=25.0814332247557, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644289, Length=274, Percent_Identity=25.5474452554745, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47502; Mature: 47502

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLKNCKIVSENSINEADILIEDRIIQKIGKNIEYSGEKIDLTGKYVFPGIIDSHVHFR
CEEEECCEEEECCCCCHHHEEHHHHHHHHHCCCCCCCCCEEEEECCEECCCEECCCEEEE
WGNSEKEDFVSGSEAAIFGGVVFAIDMPNNNPPVTTKEIFYKKMNEGNEKSKVNLYFSYG
ECCCCHHHHCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEC
VTENNYLETISDAKFYKIFTVKSVGDLFISDYSKLREILDQNKIFAVHAEHKDVILKNSE
CCCCCHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCC
TYNLDSFENHCKIRSRESEIEAVREILDALKEVDKNSRNTPHVHFCHISVKEALELIKNA
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHH
KKMFKNVKISVEVSPHHLFLNSEMAGNLKGSGKFNPPLRTKEDNLALLNGIIEGTVDIVS
HHHHHCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEE
TDHAPHKDCEKLNPVENCPSGISGIETLVPLIMNLVHDKKISIFDVYRVLSKNPSEIFKI
CCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHEEE
NNKIEIGNFANMSIIDLDKKMTISGKNFKSKSKITPFENWEVMGVPVYTIVNGNIIQTNI
CCEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEECC
>Mature Secondary Structure
MVLLKNCKIVSENSINEADILIEDRIIQKIGKNIEYSGEKIDLTGKYVFPGIIDSHVHFR
CEEEECCEEEECCCCCHHHEEHHHHHHHHHCCCCCCCCCEEEEECCEECCCEECCCEEEE
WGNSEKEDFVSGSEAAIFGGVVFAIDMPNNNPPVTTKEIFYKKMNEGNEKSKVNLYFSYG
ECCCCHHHHCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEC
VTENNYLETISDAKFYKIFTVKSVGDLFISDYSKLREILDQNKIFAVHAEHKDVILKNSE
CCCCCHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCC
TYNLDSFENHCKIRSRESEIEAVREILDALKEVDKNSRNTPHVHFCHISVKEALELIKNA
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHH
KKMFKNVKISVEVSPHHLFLNSEMAGNLKGSGKFNPPLRTKEDNLALLNGIIEGTVDIVS
HHHHHCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEE
TDHAPHKDCEKLNPVENCPSGISGIETLVPLIMNLVHDKKISIFDVYRVLSKNPSEIFKI
CCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHEEE
NNKIEIGNFANMSIIDLDKKMTISGKNFKSKSKITPFENWEVMGVPVYTIVNGNIIQTNI
CCEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]