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The map label for this gene is groL

Identifier: 150398979

GI number: 150398979

Start: 258085

End: 259695

Strand: Reverse

Name: groL

Synonym: Mevan_0224

Alternate gene names: 150398979

Gene position: 259695-258085 (Counterclockwise)

Preceding gene: 150398980

Following gene: 150398978

Centisome position: 15.1

GC content: 34.2

Gene sequence:

>1611_bases
ATGGCTAAAATTATAAAATTTAATGAAGAAGCAAGAAAAAAATTGGAAAACGGTGTGGACGTATTATCAAATACTGTAAA
AGTTACCCTTGGACCAAAGGGCAGAAACGTAGTTATTGAAAAATCATACGGTTCCCCACTTATTACAAACGATGGGGTTA
CAATAGCAAAAGAGATTGAATTAGAGGATCCTTTTGAAAACATGGGTGCTCAACTCATAAAAGAAGTTGCAACCAAAGCA
AATGACGTTGCAGGTGACGGTACAACAACTGCAACAGTTCTTGCACAGGCAATGGTAAAAGAAGGATTAAAAATGATAAC
TGCTGGTTCAAATCCGGTATTTGTTAAAAGAGGAATTGAAAAAGCAACAAAAAAAGCAGTGTCCATTCTAGAAACTAAAT
CTAAAAAAATAGCTGGAAACAGTGAAATTGCACAAGTTGCATCAATTTCTGCTGGGGATGAAGAAATCGGAAATTTAATT
GCAAAAGCAATGGAAAAAGTAGGGGAAAATGGGGTTATAACTGTTGAAGAAGCAAAATCTCTTGAAACTACTCTTGAGGT
AGTTGAAGGAATGCAGTTTGATAAGGGATACATTTCTTCATACCTTGTAACTGATCCAGAGAGAATGACTGCTGAATTGG
ATGACCCATATATCTTGATAACCGATAAAAAAATTTCAAACATGAAAGAAATTTTACCAGTTTTAGAAGCAACAGCAAGG
TCTTCAAGACCCTTATTGATTATTGCGGAGGATATTGAAGGGGATGTATTAACAACACTTGTGGTTAATAAGTTAAGAGG
AACATTAAATGTTGTGGGCGTAAAAGCACCTTACTTTGGAGATAAGCGAATAGGTGCCCTTGAAGACATTGCAATTTTAA
CTAGTTCACAGGTAATTTCTAAAGATAAAGGAATGGAACTTGAAAAAGTTGATATTTCAAGTTTAGGTTCAGCAAAAAAA
GTCAAAGTTACAAAGGACAATACATTAATTATTGGAGGAATTGGAAAAGAAAAAGACATTACTTCAAGAATTAGCCAGAT
AAAAACCCAAATATCATCAACAACCTCAGAATATGAAAAAGATTCTTTAAAAGAAAGGCTTGCAAAACTTTCAGGCGGAG
TTGCAGTTATAAAAGTAGGTTCAGCAACTGAAACTGAATTAAAAGAGAAGAAATTGCGAATAGAAGATGCATTAAATGCA
ACAAAAGCAGCAATTGAAGAAGGAATCGTTTCTGGTGGTGGAACTGTATTAATTGAAATTTTAAAAGAGATGGAATCATT
CGAACTTTCTGGTGAAGAGAGGATTGGTGTAAATATTGTTAAAAAAGCACTAACTGCGCCATTAAAACAGATTGCTGAAA
ACGCAGGATTAGAAGGAAGCATTGTAGTTGAAAAAGTTAAAAATGCAGAATCAGGAATTGGATTTGATGCTGCAAAAGAA
GAATATGTGGATATGATTAAATCAGGAATAATAGATCCAGCAAAAGTTACAAGAAGTGCACTACAAAATTCTGCATCAGT
TGCAGCATTAGTATTGACTACGGAAGCAATAATTGTGGATAAACCAAAAAAAGAAGAATCAGACACTCCAAATATGCCAA
TGATGATGTAA

Upstream 100 bases:

>100_bases
ATATTCTGGAACAGAATTCAATGAAGATAACCAAAAATACATTATAATAAAAATTGAAGACGTTTTAGCGTTTATTGAAT
AATCTGGTCAAGGTGATAAT

Downstream 100 bases:

>100_bases
TTTCAAATTTTATTTAATTTTTTTATTCTTTAATTATAAATTCAAACAAAAAGTTCTATTTTTGCATTTGCTGACAAAAT
ATCATTTAAATATAATTTAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MAKIIKFNEEARKKLENGVDVLSNTVKVTLGPKGRNVVIEKSYGSPLITNDGVTIAKEIELEDPFENMGAQLIKEVATKA
NDVAGDGTTTATVLAQAMVKEGLKMITAGSNPVFVKRGIEKATKKAVSILETKSKKIAGNSEIAQVASISAGDEEIGNLI
AKAMEKVGENGVITVEEAKSLETTLEVVEGMQFDKGYISSYLVTDPERMTAELDDPYILITDKKISNMKEILPVLEATAR
SSRPLLIIAEDIEGDVLTTLVVNKLRGTLNVVGVKAPYFGDKRIGALEDIAILTSSQVISKDKGMELEKVDISSLGSAKK
VKVTKDNTLIIGGIGKEKDITSRISQIKTQISSTTSEYEKDSLKERLAKLSGGVAVIKVGSATETELKEKKLRIEDALNA
TKAAIEEGIVSGGGTVLIEILKEMESFELSGEERIGVNIVKKALTAPLKQIAENAGLEGSIVVEKVKNAESGIGFDAAKE
EYVDMIKSGIIDPAKVTRSALQNSASVAALVLTTEAIIVDKPKKEESDTPNMPMMM

Sequences:

>Translated_536_residues
MAKIIKFNEEARKKLENGVDVLSNTVKVTLGPKGRNVVIEKSYGSPLITNDGVTIAKEIELEDPFENMGAQLIKEVATKA
NDVAGDGTTTATVLAQAMVKEGLKMITAGSNPVFVKRGIEKATKKAVSILETKSKKIAGNSEIAQVASISAGDEEIGNLI
AKAMEKVGENGVITVEEAKSLETTLEVVEGMQFDKGYISSYLVTDPERMTAELDDPYILITDKKISNMKEILPVLEATAR
SSRPLLIIAEDIEGDVLTTLVVNKLRGTLNVVGVKAPYFGDKRIGALEDIAILTSSQVISKDKGMELEKVDISSLGSAKK
VKVTKDNTLIIGGIGKEKDITSRISQIKTQISSTTSEYEKDSLKERLAKLSGGVAVIKVGSATETELKEKKLRIEDALNA
TKAAIEEGIVSGGGTVLIEILKEMESFELSGEERIGVNIVKKALTAPLKQIAENAGLEGSIVVEKVKNAESGIGFDAAKE
EYVDMIKSGIIDPAKVTRSALQNSASVAALVLTTEAIIVDKPKKEESDTPNMPMMM
>Mature_535_residues
AKIIKFNEEARKKLENGVDVLSNTVKVTLGPKGRNVVIEKSYGSPLITNDGVTIAKEIELEDPFENMGAQLIKEVATKAN
DVAGDGTTTATVLAQAMVKEGLKMITAGSNPVFVKRGIEKATKKAVSILETKSKKIAGNSEIAQVASISAGDEEIGNLIA
KAMEKVGENGVITVEEAKSLETTLEVVEGMQFDKGYISSYLVTDPERMTAELDDPYILITDKKISNMKEILPVLEATARS
SRPLLIIAEDIEGDVLTTLVVNKLRGTLNVVGVKAPYFGDKRIGALEDIAILTSSQVISKDKGMELEKVDISSLGSAKKV
KVTKDNTLIIGGIGKEKDITSRISQIKTQISSTTSEYEKDSLKERLAKLSGGVAVIKVGSATETELKEKKLRIEDALNAT
KAAIEEGIVSGGGTVLIEILKEMESFELSGEERIGVNIVKKALTAPLKQIAENAGLEGSIVVEKVKNAESGIGFDAAKEE
YVDMIKSGIIDPAKVTRSALQNSASVAALVLTTEAIIVDKPKKEESDTPNMPMMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=48.4848484848485, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=48.4848484848485, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI58331173, Length=531, Percent_Identity=24.105461393597, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4502643, Length=531, Percent_Identity=23.3521657250471, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38455427, Length=117, Percent_Identity=31.6239316239316, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI24307939, Length=171, Percent_Identity=26.9005847953216, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=56.3327032136106, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=49.1493383742911, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=50, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17564182, Length=551, Percent_Identity=23.049001814882, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25144674, Length=169, Percent_Identity=28.4023668639053, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32566944, Length=130, Percent_Identity=32.3076923076923, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50.5725190839695, Blast_Score=511, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322350, Length=558, Percent_Identity=22.7598566308244, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322524, Length=153, Percent_Identity=31.3725490196078, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320058, Length=117, Percent_Identity=29.9145299145299, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=50.4743833017078, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=50.4743833017078, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=46.1100569259962, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=46.1100569259962, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=46.1100569259962, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=42.2562141491396, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24584129, Length=539, Percent_Identity=35.621521335807, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI19921262, Length=539, Percent_Identity=35.621521335807, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24583944, Length=117, Percent_Identity=34.1880341880342, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_METVS (A6UNR2)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001322746.1
- ProteinModelPortal:   A6UNR2
- SMR:   A6UNR2
- STRING:   A6UNR2
- GeneID:   5324992
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0224
- eggNOG:   arNOG05164
- HOGENOM:   HBG625289
- OMA:   SGEERIG
- ProtClustDB:   CLSK2518849
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57339; Mature: 57208

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIKFNEEARKKLENGVDVLSNTVKVTLGPKGRNVVIEKSYGSPLITNDGVTIAKEIE
CCCEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCEEECCCCEEEEEEC
LEDPFENMGAQLIKEVATKANDVAGDGTTTATVLAQAMVKEGLKMITAGSNPVFVKRGIE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEEHHHHH
KATKKAVSILETKSKKIAGNSEIAQVASISAGDEEIGNLIAKAMEKVGENGVITVEEAKS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHH
LETTLEVVEGMQFDKGYISSYLVTDPERMTAELDDPYILITDKKISNMKEILPVLEATAR
HHHHHHHHHCCCCCCHHHHHEEEECHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHC
SSRPLLIIAEDIEGDVLTTLVVNKLRGTLNVVGVKAPYFGDKRIGALEDIAILTSSQVIS
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
KDKGMELEKVDISSLGSAKKVKVTKDNTLIIGGIGKEKDITSRISQIKTQISSTTSEYEK
HCCCCEEEEECHHHCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
DSLKERLAKLSGGVAVIKVGSATETELKEKKLRIEDALNATKAAIEEGIVSGGGTVLIEI
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LKEMESFELSGEERIGVNIVKKALTAPLKQIAENAGLEGSIVVEKVKNAESGIGFDAAKE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHH
EYVDMIKSGIIDPAKVTRSALQNSASVAALVLTTEAIIVDKPKKEESDTPNMPMMM
HHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKIIKFNEEARKKLENGVDVLSNTVKVTLGPKGRNVVIEKSYGSPLITNDGVTIAKEIE
CCEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCEEECCCCEEEEEEC
LEDPFENMGAQLIKEVATKANDVAGDGTTTATVLAQAMVKEGLKMITAGSNPVFVKRGIE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEEHHHHH
KATKKAVSILETKSKKIAGNSEIAQVASISAGDEEIGNLIAKAMEKVGENGVITVEEAKS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHH
LETTLEVVEGMQFDKGYISSYLVTDPERMTAELDDPYILITDKKISNMKEILPVLEATAR
HHHHHHHHHCCCCCCHHHHHEEEECHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHC
SSRPLLIIAEDIEGDVLTTLVVNKLRGTLNVVGVKAPYFGDKRIGALEDIAILTSSQVIS
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
KDKGMELEKVDISSLGSAKKVKVTKDNTLIIGGIGKEKDITSRISQIKTQISSTTSEYEK
HCCCCEEEEECHHHCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
DSLKERLAKLSGGVAVIKVGSATETELKEKKLRIEDALNATKAAIEEGIVSGGGTVLIEI
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LKEMESFELSGEERIGVNIVKKALTAPLKQIAENAGLEGSIVVEKVKNAESGIGFDAAKE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHH
EYVDMIKSGIIDPAKVTRSALQNSASVAALVLTTEAIIVDKPKKEESDTPNMPMMM
HHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA