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The map label for this gene is cysK [H]

Identifier: 150398934

GI number: 150398934

Start: 209087

End: 210037

Strand: Reverse

Name: cysK [H]

Synonym: Mevan_0178

Alternate gene names: 150398934

Gene position: 210037-209087 (Counterclockwise)

Preceding gene: 150398935

Following gene: 150398933

Centisome position: 12.21

GC content: 33.12

Gene sequence:

>951_bases
ATGAATAATCAATTTAGAAATAAAATATATGGAAATATTATTGAAACTATTGGAAATACGCCGATTGTTAGACTAAATAA
AATCATTGGTGACTCTAAAGCAGACATTTTAGTAAAAATAGAGTCATTTAACCCATTAGGTAGTGTTAAAGATAGGATTG
GAGATGCAATGATAAAAGATGGTGAGAAAAAAGGAATAATTACTAAAAATTCAATATTAATTGAACCAACCAGTGGAAAC
ACTGGAGTAGCATTGGCGTTTGTAGCAGCCGCTAAAGGCCATAAATTAATAATTACAATGCCTGAAACAATGTCAATTGA
AAGACAAAAATTGCTTAAAATTCTTGGTGCAAAGGTAGTTTTAACACCCGGAGTTGATGGAATGCAGGGCGCAATTTTAA
AAGCTAATGACCTTTTAAAAGAAATACCTAATTCGGTAATGTTGCATCAATTTGAAAATGAAGCAAATCCAAAAATTCAC
GAAGAAACGACTGCAAAAGAAATATTGGTAGACACCGGTGGAAAAATAGATATTCTTGTTGCGGGAGTTGGAACTGGCGG
AACACTTACAGGTATTTCAAGAGCAATTAAAAAAATAAAACCTGAATTAAAAGTAATTGCTGTAGAACCCTTATCTTCAC
AAGTTTTGTCGGGAAAAGAAAAGGGGGCCCATAAAATTCAAGGCATTGGTGCAGGATTTATCCCAAAAGTTTTAGATACT
AATTTAATTGATGAAATAATCCCAGTAAGTGACGAAAATGCCGTGAAAACAATGTTTGAACTTGCTAAAAAAGAAGGAAT
TTTAACAGGGATTTCTTCCGGTGCAGCACTATATGCCGCATTAAAAGTTTCAAAAAGATATGAAAACGAAGGAAAAATAA
TTTTAGTAATACTTCCTGACACAGGGGAACGATATCTTAGTATGGACTGGTTATTTGCTGATACCGATTAA

Upstream 100 bases:

>100_bases
TATTTATATACAAAATAGATTTAATCATGTAATTTCTATAAAATATAACAATCGTTATATATCATAAATAACAATCGTTA
TATTATTAAAGGTGATAATA

Downstream 100 bases:

>100_bases
CTAATGTAAAAGGTTAAACCATGTTTAAGTTGATAAAAGAGGATATTAAAACTGTATTAATGAGGGATCCTGCTGCAAAA
ACAAAATTTGAAGTAGTTTT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNNQFRNKIYGNIIETIGNTPIVRLNKIIGDSKADILVKIESFNPLGSVKDRIGDAMIKDGEKKGIITKNSILIEPTSGN
TGVALAFVAAAKGHKLIITMPETMSIERQKLLKILGAKVVLTPGVDGMQGAILKANDLLKEIPNSVMLHQFENEANPKIH
EETTAKEILVDTGGKIDILVAGVGTGGTLTGISRAIKKIKPELKVIAVEPLSSQVLSGKEKGAHKIQGIGAGFIPKVLDT
NLIDEIIPVSDENAVKTMFELAKKEGILTGISSGAALYAALKVSKRYENEGKIILVILPDTGERYLSMDWLFADTD

Sequences:

>Translated_316_residues
MNNQFRNKIYGNIIETIGNTPIVRLNKIIGDSKADILVKIESFNPLGSVKDRIGDAMIKDGEKKGIITKNSILIEPTSGN
TGVALAFVAAAKGHKLIITMPETMSIERQKLLKILGAKVVLTPGVDGMQGAILKANDLLKEIPNSVMLHQFENEANPKIH
EETTAKEILVDTGGKIDILVAGVGTGGTLTGISRAIKKIKPELKVIAVEPLSSQVLSGKEKGAHKIQGIGAGFIPKVLDT
NLIDEIIPVSDENAVKTMFELAKKEGILTGISSGAALYAALKVSKRYENEGKIILVILPDTGERYLSMDWLFADTD
>Mature_316_residues
MNNQFRNKIYGNIIETIGNTPIVRLNKIIGDSKADILVKIESFNPLGSVKDRIGDAMIKDGEKKGIITKNSILIEPTSGN
TGVALAFVAAAKGHKLIITMPETMSIERQKLLKILGAKVVLTPGVDGMQGAILKANDLLKEIPNSVMLHQFENEANPKIH
EETTAKEILVDTGGKIDILVAGVGTGGTLTGISRAIKKIKPELKVIAVEPLSSQVLSGKEKGAHKIQGIGAGFIPKVLDT
NLIDEIIPVSDENAVKTMFELAKKEGILTGISSGAALYAALKVSKRYENEGKIILVILPDTGERYLSMDWLFADTD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=320, Percent_Identity=42.8125, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI295821200, Length=320, Percent_Identity=42.8125, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4557415, Length=320, Percent_Identity=42.8125, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=56.1514195583596, Blast_Score=287, Evalue=7e-79,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=38.5135135135135, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=294, Percent_Identity=49.3197278911565, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=50.9677419354839, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=44.1860465116279, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=45.0511945392491, Blast_Score=254, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17561720, Length=296, Percent_Identity=44.5945945945946, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=43.2558139534884, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=38.622754491018, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=38.6503067484663, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=43.9655172413793, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=38.0804953560372, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=34.6625766871166, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24643623, Length=323, Percent_Identity=39.3188854489164, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI20129101, Length=323, Percent_Identity=39.3188854489164, Blast_Score=214, Evalue=8e-56,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33943; Mature: 33943

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQFRNKIYGNIIETIGNTPIVRLNKIIGDSKADILVKIESFNPLGSVKDRIGDAMIKD
CCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
GEKKGIITKNSILIEPTSGNTGVALAFVAAAKGHKLIITMPETMSIERQKLLKILGAKVV
CCCCCEEEECCEEEEECCCCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCEEE
LTPGVDGMQGAILKANDLLKEIPNSVMLHQFENEANPKIHEETTAKEILVDTGGKIDILV
EECCCCCCCCCEECHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHEEECCCEEEEEE
AGVGTGGTLTGISRAIKKIKPELKVIAVEPLSSQVLSGKEKGAHKIQGIGAGFIPKVLDT
EECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCEEECCCCCCHHHHHHH
NLIDEIIPVSDENAVKTMFELAKKEGILTGISSGAALYAALKVSKRYENEGKIILVILPD
HHHHHHCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECC
TGERYLSMDWLFADTD
CCCCEEEEEEEEECCC
>Mature Secondary Structure
MNNQFRNKIYGNIIETIGNTPIVRLNKIIGDSKADILVKIESFNPLGSVKDRIGDAMIKD
CCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
GEKKGIITKNSILIEPTSGNTGVALAFVAAAKGHKLIITMPETMSIERQKLLKILGAKVV
CCCCCEEEECCEEEEECCCCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCEEE
LTPGVDGMQGAILKANDLLKEIPNSVMLHQFENEANPKIHEETTAKEILVDTGGKIDILV
EECCCCCCCCCEECHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHEEECCCEEEEEE
AGVGTGGTLTGISRAIKKIKPELKVIAVEPLSSQVLSGKEKGAHKIQGIGAGFIPKVLDT
EECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCEEECCCCCCHHHHHHH
NLIDEIIPVSDENAVKTMFELAKKEGILTGISSGAALYAALKVSKRYENEGKIILVILPD
HHHHHHCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECC
TGERYLSMDWLFADTD
CCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]