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The map label for this gene is msrA1 [H]

Identifier: 150398606

GI number: 150398606

Start: 3624476

End: 3625129

Strand: Reverse

Name: msrA1 [H]

Synonym: Smed_3417

Alternate gene names: 150398606

Gene position: 3625129-3624476 (Counterclockwise)

Preceding gene: 150398607

Following gene: 150398605

Centisome position: 95.85

GC content: 61.77

Gene sequence:

>654_bases
ATGTTTCTGATCGATATGTTCAACAAGAAGACCATCCTGCCCGATGCGGCGACCGCGCTGGCCGGCCGGGAAGGGGAAAT
CTCGACCGCAGCCGACCACTTCGTCTCCGGCCGGCCGCTCAAGGGCCCCTACCCGGACGGCATGAAGAAGGTGCTTTTCG
GCATGGGCTGCTTCTGGGGAGCGGAACGTCTTCTGTGGGAGATCCCGGGCGTCTACGTGACGGCAGCCGGCTATTCCGGC
GGTCTCACGCCCAATCCGACCTATCAGGAGACGACGACGGGGCTGACCGGCCACACCGAGGTGGTGCTCGTGGTCTACGA
TCCGGCCAGAGTTTCGTTTCAGCGCCTGCTGAAGACATTCTTCGAGGAGCACGACCCGACCCAGGGCATGCGCCAGGGAA
ACGATGTCGGCACGACCTATCGTTCGGCCATCTATGTCTATGACGAGGAGCAGCTTGCCGAGGCGAATGCCGCGCGAAAC
GCTTTCCGGAAAGCTCTGAAGGCGTACAAGCACGATCGCGAGATCACCACCGAGATCGCGATGGCCGGACCATTCTATTT
CGCCGAAGAATATCACCAGCAATATCTCGCCAAGAATCCGGACGGCTATTGCGGGCTGCGCGGTACCGGCGTCAGCTGCC
CGATCGGCGCCTGA

Upstream 100 bases:

>100_bases
GGATACAGGAGAAAACCCGCCGCGGGGCGCTTTGCCGCCTGAGCGCCGGACCCGTCCAGCTGGTTTCATGCCTGGCGAGC
GCTGACGAAAGGAGCCGCAG

Downstream 100 bases:

>100_bases
CCCCTCCTGTCGAGCGGAAGTGCGGGGGCACTTCCGCTCCTGATTTCAGCCGGAAGACGCCTTCGGCCAAGCCCGTTTCG
GCGGCCGGTTAGCTTTTTAC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MFLIDMFNKKTILPDAATALAGREGEISTAADHFVSGRPLKGPYPDGMKKVLFGMGCFWGAERLLWEIPGVYVTAAGYSG
GLTPNPTYQETTTGLTGHTEVVLVVYDPARVSFQRLLKTFFEEHDPTQGMRQGNDVGTTYRSAIYVYDEEQLAEANAARN
AFRKALKAYKHDREITTEIAMAGPFYFAEEYHQQYLAKNPDGYCGLRGTGVSCPIGA

Sequences:

>Translated_217_residues
MFLIDMFNKKTILPDAATALAGREGEISTAADHFVSGRPLKGPYPDGMKKVLFGMGCFWGAERLLWEIPGVYVTAAGYSG
GLTPNPTYQETTTGLTGHTEVVLVVYDPARVSFQRLLKTFFEEHDPTQGMRQGNDVGTTYRSAIYVYDEEQLAEANAARN
AFRKALKAYKHDREITTEIAMAGPFYFAEEYHQQYLAKNPDGYCGLRGTGVSCPIGA
>Mature_217_residues
MFLIDMFNKKTILPDAATALAGREGEISTAADHFVSGRPLKGPYPDGMKKVLFGMGCFWGAERLLWEIPGVYVTAAGYSG
GLTPNPTYQETTTGLTGHTEVVLVVYDPARVSFQRLLKTFFEEHDPTQGMRQGNDVGTTYRSAIYVYDEEQLAEANAARN
AFRKALKAYKHDREITTEIAMAGPFYFAEEYHQQYLAKNPDGYCGLRGTGVSCPIGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=211, Percent_Identity=52.132701421801, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI208609995, Length=190, Percent_Identity=53.6842105263158, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI208609993, Length=211, Percent_Identity=40.7582938388626, Blast_Score=154, Evalue=6e-38,
Organism=Escherichia coli, GI1790665, Length=197, Percent_Identity=55.3299492385787, Blast_Score=223, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=32.2147651006711, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=33.5329341317365, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=41.3793103448276, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=40.6896551724138, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=40.5594405594406, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23942; Mature: 23942

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLIDMFNKKTILPDAATALAGREGEISTAADHFVSGRPLKGPYPDGMKKVLFGMGCFWG
CEEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERLLWEIPGVYVTAAGYSGGLTPNPTYQETTTGLTGHTEVVLVVYDPARVSFQRLLKTF
HHHHHHHCCCEEEEECCCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCHHHHHHHHHHHH
FEEHDPTQGMRQGNDVGTTYRSAIYVYDEEQLAEANAARNAFRKALKAYKHDREITTEIA
HHHCCCCHHHHCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MAGPFYFAEEYHQQYLAKNPDGYCGLRGTGVSCPIGA
HCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFLIDMFNKKTILPDAATALAGREGEISTAADHFVSGRPLKGPYPDGMKKVLFGMGCFWG
CEEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERLLWEIPGVYVTAAGYSGGLTPNPTYQETTTGLTGHTEVVLVVYDPARVSFQRLLKTF
HHHHHHHCCCEEEEECCCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCHHHHHHHHHHHH
FEEHDPTQGMRQGNDVGTTYRSAIYVYDEEQLAEANAARNAFRKALKAYKHDREITTEIA
HHHCCCCHHHHCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MAGPFYFAEEYHQQYLAKNPDGYCGLRGTGVSCPIGA
HCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]