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The map label for this gene is upp [H]

Identifier: 150398532

GI number: 150398532

Start: 3543425

End: 3544054

Strand: Reverse

Name: upp [H]

Synonym: Smed_3343

Alternate gene names: 150398532

Gene position: 3544054-3543425 (Counterclockwise)

Preceding gene: 150398533

Following gene: 150398518

Centisome position: 93.71

GC content: 60.95

Gene sequence:

>630_bases
ATGGACGGCGTAACGGTGATCGGTCATCCGCTGGTGCAGCACAAGCTGACCATCATGCGCAAGAAGGAAACGTCGACTGC
GGGCTTCCGCCGGCTGCTCAAGGAAATATCGACGCTGCTCTGTTACGAGGTCACACGCGATCTGGAATTGACGACGGAGC
GGATCGAGACGCCTCTGGAGGAAACGGACGCGCCGGTGCTCGAGGGCAAGAAGCTTGTCTTCGCTTCGATCCTGCGCGCC
GGCAACGGCCTGCTCGAGGGCATGCTCGAACTGGTCCCCTCGGCACGCGTTGCGCATATCGGCGTCTACAGGGACCACGA
GACGCTGCAGGCGGTCGAATATTTTTTCAAGGCGCCGGACAACATCAACGAACGCCTCGTCATCGTCGTCGACCCGATGC
TCGCCACCGGCAACTCTTCGATCGCAGCGGTCGAGAAACTCAAAGAGCGTGGTGCGCGGAACATCCGTTTCCTCTGCCTC
CTTGCGGCTCCCGAGGGCATCCGCAACTTCCAGGGCGTACATCCGGACGTGCCGATCTTCACGGCCTCGATCGACAGCCA
CCTCAACGAGTTGGGCTATATCGTTCCAGGTCTTGGGGATGCCGGCGACCGCATGTACGGAACGAAGTAG

Upstream 100 bases:

>100_bases
GGAGCGCCATCTGCCATCAACTTCCACCTACACCCTTGCAGCCCCCGCCCTTTCCATGGAAAAGAGGGTGGATAGCCAAT
TTTCGCGGAGAAGGTGAGCC

Downstream 100 bases:

>100_bases
CGCTGCCGGATAACGGCGCGCTTCATCCGGTCAAACGAGCCTTGACGCGATCACCGGGCGTTGCGCGGGCGCCTCCTCCG
CGATCGCGTAGAGCGTTGCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MDGVTVIGHPLVQHKLTIMRKKETSTAGFRRLLKEISTLLCYEVTRDLELTTERIETPLEETDAPVLEGKKLVFASILRA
GNGLLEGMLELVPSARVAHIGVYRDHETLQAVEYFFKAPDNINERLVIVVDPMLATGNSSIAAVEKLKERGARNIRFLCL
LAAPEGIRNFQGVHPDVPIFTASIDSHLNELGYIVPGLGDAGDRMYGTK

Sequences:

>Translated_209_residues
MDGVTVIGHPLVQHKLTIMRKKETSTAGFRRLLKEISTLLCYEVTRDLELTTERIETPLEETDAPVLEGKKLVFASILRA
GNGLLEGMLELVPSARVAHIGVYRDHETLQAVEYFFKAPDNINERLVIVVDPMLATGNSSIAAVEKLKERGARNIRFLCL
LAAPEGIRNFQGVHPDVPIFTASIDSHLNELGYIVPGLGDAGDRMYGTK
>Mature_209_residues
MDGVTVIGHPLVQHKLTIMRKKETSTAGFRRLLKEISTLLCYEVTRDLELTTERIETPLEETDAPVLEGKKLVFASILRA
GNGLLEGMLELVPSARVAHIGVYRDHETLQAVEYFFKAPDNINERLVIVVDPMLATGNSSIAAVEKLKERGARNIRFLCL
LAAPEGIRNFQGVHPDVPIFTASIDSHLNELGYIVPGLGDAGDRMYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=52.1739130434783, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=22.8855721393035, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=22.8855721393035, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21358379, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23078; Mature: 23078

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVTVIGHPLVQHKLTIMRKKETSTAGFRRLLKEISTLLCYEVTRDLELTTERIETPLE
CCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHH
ETDAPVLEGKKLVFASILRAGNGLLEGMLELVPSARVAHIGVYRDHETLQAVEYFFKAPD
HCCCCHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCCC
NINERLVIVVDPMLATGNSSIAAVEKLKERGARNIRFLCLLAAPEGIRNFQGVHPDVPIF
CCCCEEEEEECCEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHCCCCCCCCCEE
TASIDSHLNELGYIVPGLGDAGDRMYGTK
EHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDGVTVIGHPLVQHKLTIMRKKETSTAGFRRLLKEISTLLCYEVTRDLELTTERIETPLE
CCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHH
ETDAPVLEGKKLVFASILRAGNGLLEGMLELVPSARVAHIGVYRDHETLQAVEYFFKAPD
HCCCCHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCCC
NINERLVIVVDPMLATGNSSIAAVEKLKERGARNIRFLCLLAAPEGIRNFQGVHPDVPIF
CCCCEEEEEECCEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHCCCCCCCCCEE
TASIDSHLNELGYIVPGLGDAGDRMYGTK
EHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]