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The map label for this gene is msrA2 [H]

Identifier: 150398152

GI number: 150398152

Start: 3103659

End: 3104255

Strand: Reverse

Name: msrA2 [H]

Synonym: Smed_2955

Alternate gene names: 150398152

Gene position: 3104255-3103659 (Counterclockwise)

Preceding gene: 150398153

Following gene: 150398151

Centisome position: 82.08

GC content: 64.66

Gene sequence:

>597_bases
ATGCTTCGCCTGCTGCTCGGTTTTTTCGTCACTTGTTTCCTGTTGTTGCCGGCGCGGGCGGCAGAACCGCAATATGCGAT
CTTTGCCGGCGGCTGCTTCTGGTGCGTCGAGAGCGACTTCGACGCGGTGCCGGGCGTCCTTGAAACGATCTCCGGCTATG
CCGGCGGCAAGAGCGCCAATCCCACCTATGAGACCTATGTGAGGGGCGGGCACCGCGAAGTGGTCCGCATCAAATTCGAT
CCGGACCGGGTCTCCTTTGCCGCGCTCGTCGGCGTCCTCTTCCGCACGACCGACCCGACGGATGGCGGCGGCCAGTTCTG
CGACCGGGGCTTTGCCTATACGACCGCCATCTATGCGTTGAACGAGCGCCAGGCGATGGGCGCGAAGGCGGAGAAGATAA
AGGCCGAGGCGGAACTCGGGCGGCCGATCGTCACGCCCGTCGAGGGTGCGGCGAAGTTCTGGCCCGCGGAAGACTACCAC
CAGGACTTCGGCAAGCGGAACCCCATCCGCTACTGGTACTATCGCAACGGCTGCGGCAGGAACCGGACGGTCGAGAAGCT
CTGGGGCGATCGCGCCTATGCCGGCGTCAGCCACTGA

Upstream 100 bases:

>100_bases
CTCGCCGTTTGCTTTCACGTCCGTCACATCGACGTGTTGCTAAGTGATTTGAAACGCGCGGCGAGGCAGTTAGGTAATAG
TTTAGGATGGAGGGCCGTCG

Downstream 100 bases:

>100_bases
CCGGCCGTGCCGGCACGCGGATGTGGCCGCAGCAGAGGGTGATGGATAGGCCTTGCATTCCCAACGAATTGTGTACGCAT
TTCCTAGAGATGGAGCGAAG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MLRLLLGFFVTCFLLLPARAAEPQYAIFAGGCFWCVESDFDAVPGVLETISGYAGGKSANPTYETYVRGGHREVVRIKFD
PDRVSFAALVGVLFRTTDPTDGGGQFCDRGFAYTTAIYALNERQAMGAKAEKIKAEAELGRPIVTPVEGAAKFWPAEDYH
QDFGKRNPIRYWYYRNGCGRNRTVEKLWGDRAYAGVSH

Sequences:

>Translated_198_residues
MLRLLLGFFVTCFLLLPARAAEPQYAIFAGGCFWCVESDFDAVPGVLETISGYAGGKSANPTYETYVRGGHREVVRIKFD
PDRVSFAALVGVLFRTTDPTDGGGQFCDRGFAYTTAIYALNERQAMGAKAEKIKAEAELGRPIVTPVEGAAKFWPAEDYH
QDFGKRNPIRYWYYRNGCGRNRTVEKLWGDRAYAGVSH
>Mature_198_residues
MLRLLLGFFVTCFLLLPARAAEPQYAIFAGGCFWCVESDFDAVPGVLETISGYAGGKSANPTYETYVRGGHREVVRIKFD
PDRVSFAALVGVLFRTTDPTDGGGQFCDRGFAYTTAIYALNERQAMGAKAEKIKAEAELGRPIVTPVEGAAKFWPAEDYH
QDFGKRNPIRYWYYRNGCGRNRTVEKLWGDRAYAGVSH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=164, Percent_Identity=39.0243902439024, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI208609995, Length=164, Percent_Identity=39.0243902439024, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI208609993, Length=156, Percent_Identity=32.6923076923077, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=42.1052631578947, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=33.7837837837838, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=27.9503105590062, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664627, Length=140, Percent_Identity=37.8571428571429, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45553131, Length=135, Percent_Identity=37.7777777777778, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664631, Length=140, Percent_Identity=37.1428571428571, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22028; Mature: 22028

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLLLGFFVTCFLLLPARAAEPQYAIFAGGCFWCVESDFDAVPGVLETISGYAGGKSAN
CHHHHHHHHHHHHHHHCCCCCCCCEEEEECEEEEEECCCCCCCHHHHHHHHCCCCCCCCC
PTYETYVRGGHREVVRIKFDPDRVSFAALVGVLFRTTDPTDGGGQFCDRGFAYTTAIYAL
CCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHEEE
NERQAMGAKAEKIKAEAELGRPIVTPVEGAAKFWPAEDYHQDFGKRNPIRYWYYRNGCGR
CCHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHCCCCCEEEEEEECCCCC
NRTVEKLWGDRAYAGVSH
CCHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLRLLLGFFVTCFLLLPARAAEPQYAIFAGGCFWCVESDFDAVPGVLETISGYAGGKSAN
CHHHHHHHHHHHHHHHCCCCCCCCEEEEECEEEEEECCCCCCCHHHHHHHHCCCCCCCCC
PTYETYVRGGHREVVRIKFDPDRVSFAALVGVLFRTTDPTDGGGQFCDRGFAYTTAIYAL
CCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHEEE
NERQAMGAKAEKIKAEAELGRPIVTPVEGAAKFWPAEDYHQDFGKRNPIRYWYYRNGCGR
CCHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHCCCCCEEEEEEECCCCC
NRTVEKLWGDRAYAGVSH
CCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]