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The map label for this gene is lpd [H]

Identifier: 150398133

GI number: 150398133

Start: 3082285

End: 3083691

Strand: Reverse

Name: lpd [H]

Synonym: Smed_2936

Alternate gene names: 150398133

Gene position: 3083691-3082285 (Counterclockwise)

Preceding gene: 150398134

Following gene: 150398132

Centisome position: 81.54

GC content: 63.04

Gene sequence:

>1407_bases
ATGGCCTATGATCTCATCGTTATCGGAAGCGGCCCCGGCGGCTATGTCTGCGCCATCAAGGCGGCGCAGCTGGGCATGAA
GGTTGCCGTGGTCGAGAAGCGCAGCACCTATGGCGGTACCTGCCTGAATGTAGGCTGCATCCCCTCCAAGGCGCTGCTGC
ATGCTTCCGAAATGTTCCATGTCGCCGAGCACGGGCTTGACGCCCTGGGCGTCGAGGTCGCAACCCCGAAGCTCAACCTT
CAGAAGATGATGGCGCACAAGGACGCGACCGTTAAGTCCAACGTCGACGGAGTCGCCTTCCTCTTCAAGAAGAACAAGAT
CGACGGATTTCAGGGCCTGGGCAAAGTCCTCGGCCAGGGCAAGGTTGCCGTTGCGAACGAGAAGGGCGAGGAGCAGGTGC
TCGAGGCGAAGAATGTCGTTATCGCCACCGGTTCGGACGTCGCCGGCATTCCCGGGGTAGAGGTCCCTTTCGATGAAAAG
ATCATCGTCTCCTCGACCGGGGCGCTCGCGCTCGAAAAGGTCCCCGCGAGCATGATCGTCGTCGGCGGCGGCGTCATCGG
TCTCGAGCTCGGCTCGGTCTGGGCGCGCCTCGGCGCCAAGGTGACGGTGGTCGAATATCTCGACACCATTCTCGGTGGCA
TGGACGGCGAAGTCGCCAAGCAGCTCCAGCGGATGCTGACGAAACAGGGCCTCGACTTCAAGCTCGGCGCAAAAGTCACC
GGAGTGGTGAAGTCTGACGAGGGTGCGAAGGTCACCTTCGAGCCGGTGAAGGGCGGCGAGGCGACGACGCTCGATGCCGA
AGTCGTGCTCATCGCTACCGGCCGCAAGCCCTCCACGGAAGGTTTGGGCCTCGCCAAGGCGGGCGTCGTTCTCGATCAGC
GTGGCCGCGTCGAGATCGACCAGCACTTTCAGACGAGCATCACCGGCGTCTACGCGATCGGTGATGTCGTGCGCGGTCCG
ATGCTGGCCCACAAGGCCGAGGATGAAGGCATCGCCGTCGCGGAGATCATCGCCGGCCAGGCCGGCCACGTGAACTACGA
CGTCATCCCGGGTGTGGTCTATACCCAGCCCGAGGTTGCCTCCGTCGGCAGGACCGAGGAAGAGCTGAAGGCCGCAGGCG
TTGCCTATAAGGTCGGAAAATTCCCCTTTACCGCCAACGGCCGCGCCCGCGCCATGCTGCAAACGGACGGTTTCGCGAAG
ATCCTGGCGGACAAGGAGACCGACCGCGTCCTTGGCGGCCACATCATCGGCTTCGGCGCCGGAGAGATGATTCACGAGAT
CGCCGTGCTGATGGAATTCGGCGGATCGTCCGAAGACCTCGGCCGCACCTGCCACGCCCATCCGACCATGTCGGAAGCGG
TGAAGGAAGCGGCGCTTTCCACCTTCTTCAAGCCGATCCATATGTGA

Upstream 100 bases:

>100_bases
AGGCAACGTATGTCACGGGAACCATTCTCACGGTCAGCGGCGGGCGGTAGCCCTCCCACGACTGCCCTCCAAAGACCGTC
CTCCCAAGAAGGATTATCAA

Downstream 100 bases:

>100_bases
CAAATGGCGCGGGGGCTGCGACAAGTGGCCCCTCGCTTCGTGCCGGCAACCGGCGCAATCATGAACCACTCACCGCAGAC
ATGACCGCCTCCGATCGGCG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFHVAEHGLDALGVEVATPKLNL
QKMMAHKDATVKSNVDGVAFLFKKNKIDGFQGLGKVLGQGKVAVANEKGEEQVLEAKNVVIATGSDVAGIPGVEVPFDEK
IIVSSTGALALEKVPASMIVVGGGVIGLELGSVWARLGAKVTVVEYLDTILGGMDGEVAKQLQRMLTKQGLDFKLGAKVT
GVVKSDEGAKVTFEPVKGGEATTLDAEVVLIATGRKPSTEGLGLAKAGVVLDQRGRVEIDQHFQTSITGVYAIGDVVRGP
MLAHKAEDEGIAVAEIIAGQAGHVNYDVIPGVVYTQPEVASVGRTEEELKAAGVAYKVGKFPFTANGRARAMLQTDGFAK
ILADKETDRVLGGHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIHM

Sequences:

>Translated_468_residues
MAYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFHVAEHGLDALGVEVATPKLNL
QKMMAHKDATVKSNVDGVAFLFKKNKIDGFQGLGKVLGQGKVAVANEKGEEQVLEAKNVVIATGSDVAGIPGVEVPFDEK
IIVSSTGALALEKVPASMIVVGGGVIGLELGSVWARLGAKVTVVEYLDTILGGMDGEVAKQLQRMLTKQGLDFKLGAKVT
GVVKSDEGAKVTFEPVKGGEATTLDAEVVLIATGRKPSTEGLGLAKAGVVLDQRGRVEIDQHFQTSITGVYAIGDVVRGP
MLAHKAEDEGIAVAEIIAGQAGHVNYDVIPGVVYTQPEVASVGRTEEELKAAGVAYKVGKFPFTANGRARAMLQTDGFAK
ILADKETDRVLGGHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIHM
>Mature_467_residues
AYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFHVAEHGLDALGVEVATPKLNLQ
KMMAHKDATVKSNVDGVAFLFKKNKIDGFQGLGKVLGQGKVAVANEKGEEQVLEAKNVVIATGSDVAGIPGVEVPFDEKI
IVSSTGALALEKVPASMIVVGGGVIGLELGSVWARLGAKVTVVEYLDTILGGMDGEVAKQLQRMLTKQGLDFKLGAKVTG
VVKSDEGAKVTFEPVKGGEATTLDAEVVLIATGRKPSTEGLGLAKAGVVLDQRGRVEIDQHFQTSITGVYAIGDVVRGPM
LAHKAEDEGIAVAEIIAGQAGHVNYDVIPGVVYTQPEVASVGRTEEELKAAGVAYKVGKFPFTANGRARAMLQTDGFAKI
LADKETDRVLGGHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIHM

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=55.1724137931034, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=28.7234042553192, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI22035672, Length=482, Percent_Identity=31.3278008298755, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=29.8319327731092, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=28.2700421940928, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=28.2700421940928, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=28.2700421940928, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=28.2700421940928, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=28.2700421940928, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=28.2051282051282, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=40.4395604395604, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=31.7494600431965, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI87081717, Length=469, Percent_Identity=28.3582089552239, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=29.5454545454545, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789065, Length=194, Percent_Identity=30.9278350515464, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=54.3478260869565, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=29.535864978903, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=27.1604938271605, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=452, Percent_Identity=26.5486725663717, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=452, Percent_Identity=26.5486725663717, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17559934, Length=174, Percent_Identity=28.735632183908, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=50.3157894736842, Blast_Score=458, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=31.6455696202532, Blast_Score=239, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=28.2978723404255, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=54.2735042735043, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=30.0207039337474, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=30.0207039337474, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=30.0207039337474, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17737741, Length=488, Percent_Identity=27.4590163934426, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48869; Mature: 48738

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFH
CCEEEEEEECCCCCEEEEEEEHHCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
VAEHGLDALGVEVATPKLNLQKMMAHKDATVKSNVDGVAFLFKKNKIDGFQGLGKVLGQG
HHHCCCCCCCEEEECCCCCHHHHHHHCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
KVAVANEKGEEQVLEAKNVVIATGSDVAGIPGVEVPFDEKIIVSSTGALALEKVPASMIV
CEEEECCCCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCEEEE
VGGGVIGLELGSVWARLGAKVTVVEYLDTILGGMDGEVAKQLQRMLTKQGLDFKLGAKVT
EECCEEEEHHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCEEE
GVVKSDEGAKVTFEPVKGGEATTLDAEVVLIATGRKPSTEGLGLAKAGVVLDQRGRVEID
EEEECCCCCEEEEEECCCCCEEEECEEEEEEEECCCCCCCCCCEECCCEEECCCCCEEEC
QHFQTSITGVYAIGDVVRGPMLAHKAEDEGIAVAEIIAGQAGHVNYDVIPGVVYTQPEVA
CHHHHHHHHHEEHHHHHCCCHHEECCCCCCEEEEHHHCCCCCCCCEEECCCEEECCCCHH
SVGRTEEELKAAGVAYKVGKFPFTANGRARAMLQTDGFAKILADKETDRVLGGHIIGFGA
HCCCCHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCEECCCCCCCHHHCCEEEEECH
GEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIHM
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFH
CEEEEEEECCCCCEEEEEEEHHCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
VAEHGLDALGVEVATPKLNLQKMMAHKDATVKSNVDGVAFLFKKNKIDGFQGLGKVLGQG
HHHCCCCCCCEEEECCCCCHHHHHHHCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
KVAVANEKGEEQVLEAKNVVIATGSDVAGIPGVEVPFDEKIIVSSTGALALEKVPASMIV
CEEEECCCCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCEEEE
VGGGVIGLELGSVWARLGAKVTVVEYLDTILGGMDGEVAKQLQRMLTKQGLDFKLGAKVT
EECCEEEEHHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCEEE
GVVKSDEGAKVTFEPVKGGEATTLDAEVVLIATGRKPSTEGLGLAKAGVVLDQRGRVEID
EEEECCCCCEEEEEECCCCCEEEECEEEEEEEECCCCCCCCCCEECCCEEECCCCCEEEC
QHFQTSITGVYAIGDVVRGPMLAHKAEDEGIAVAEIIAGQAGHVNYDVIPGVVYTQPEVA
CHHHHHHHHHEEHHHHHCCCHHEECCCCCCEEEEHHHCCCCCCCCEEECCCEEECCCCHH
SVGRTEEELKAAGVAYKVGKFPFTANGRARAMLQTDGFAKILADKETDRVLGGHIIGFGA
HCCCCHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCEECCCCCCCHHHCCEEEEECH
GEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIHM
HHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226266 [H]