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The map label for this gene is dxr [H]

Identifier: 150398077

GI number: 150398077

Start: 3012811

End: 3013986

Strand: Direct

Name: dxr [H]

Synonym: Smed_2879

Alternate gene names: 150398077

Gene position: 3012811-3013986 (Clockwise)

Preceding gene: 150398074

Following gene: 150398082

Centisome position: 79.66

GC content: 65.48

Gene sequence:

>1176_bases
ATGGCATCCGGCGATGAGTTGAAGCGCCGCCTGACGATATTGGGCTCCACCGGATCGATCGGAACCAGCACGCTCGACGT
GATCGAGCGGCTCGGCGGACGCGATCGGTTCGAGGTTGCTGCACTGACGGGTAACGGCAACATACCGCTGCTTGCCGCGC
AGGCCCGCCGTATGGGTGCAGAGCTCGCGGTCACCGCAGACGGGGATCGTTATGGCGAACTCAAGGATGCGTTGAGCGGC
AGCGGCATCGAGGTCGCGGCCGGCCGAACTGGTCTGAGCGAGGCGGCAGAGCGCGATGCCGGCTGGGTGATGGCCGCCAT
CGTCGGGAATGCCGGCCTTGGCCCCACCCTTGCAGCTGCCCGTCGCGGCGCCGACATCGCGCTGGCCAACAAGGAATGCC
TTGTTTCCGCCGGCAGCCTTTTCATCGATGCCGTGGCCGAGGGCGGCGGCCGGCTGCTGCCCGTCGACAGCGAACACAAT
GCAATCTTTCAGGTCTTGGAGAACGATCAGCGTCATGCCGTGGAACGCATCGTGCTCACCGCCTCCGGCGGCCCCTTTCG
CACCAAGTCGCTCGACGAGATGCAGCACGTGACCGCAGAGGCCGCCCGCGCCCATCCGAACTGGTCGATGGGGCTCAAGA
TTTCGATCGACAGTGCCTCGATGTTCAACAAGGCGCTCGAGATGATCGAGGCGCGCCACCTTTTCAACCTGCGACCGGAT
CAGATCGAGGTGATCGTTCATCCACAATCGGTGGTCCACTCGATGGTCGGTTACGCGGACGGCTCGGTGCTGGCACAACT
CGGCTGCCCCGACATGCGCACCGCGATCGGCTACGCCCTTTCCTACCCCAGACGCTGCGATCTGCCAGTCGAACGGCTCG
ACTTCGCCAGGCTCGCGCGGCTCGATTTCGAGGCGCCGGACGAGGTGCGGTTCCCGGCGCTCAGGCTCGCACGCCGTGCG
ATGGAGGAAGGCGGCCTACAGGGCGCAGTGCTGAACGGTGCCAAGGAAACGGCGCTGGGGGCCTTCATCGAAGGCCGGGT
CGGCTTCCTCGACATGGCTGAAATCGTCGAAGAGGTGATGAACGATCTTGCCGGCCTGCCGGCCGCCACGAGCATGGACG
ACGTTTTCGCGGCGGATGAGCAGGCCAGGCAGGCGGCCGCTGGGATGATCCCTTAG

Upstream 100 bases:

>100_bases
TGTCTCTTAGAGAAGGGCAATGACTCCGCCCTTGTTGCCGGGAGCGTTCGGCTGTAGAGCCTAGTTAAATCGATAAAACG
AGAAGAATACGGGATTGGCA

Downstream 100 bases:

>100_bases
AGATTGTCGGGAAACCTGCCCCTTATCCGCCTGCCGGACCTTCTGGACGCAGGCCGGGCAAAGGGACAAGTGGCGGTGCG
CCTCGCCCCACACAAGCGTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MASGDELKRRLTILGSTGSIGTSTLDVIERLGGRDRFEVAALTGNGNIPLLAAQARRMGAELAVTADGDRYGELKDALSG
SGIEVAAGRTGLSEAAERDAGWVMAAIVGNAGLGPTLAAARRGADIALANKECLVSAGSLFIDAVAEGGGRLLPVDSEHN
AIFQVLENDQRHAVERIVLTASGGPFRTKSLDEMQHVTAEAARAHPNWSMGLKISIDSASMFNKALEMIEARHLFNLRPD
QIEVIVHPQSVVHSMVGYADGSVLAQLGCPDMRTAIGYALSYPRRCDLPVERLDFARLARLDFEAPDEVRFPALRLARRA
MEEGGLQGAVLNGAKETALGAFIEGRVGFLDMAEIVEEVMNDLAGLPAATSMDDVFAADEQARQAAAGMIP

Sequences:

>Translated_391_residues
MASGDELKRRLTILGSTGSIGTSTLDVIERLGGRDRFEVAALTGNGNIPLLAAQARRMGAELAVTADGDRYGELKDALSG
SGIEVAAGRTGLSEAAERDAGWVMAAIVGNAGLGPTLAAARRGADIALANKECLVSAGSLFIDAVAEGGGRLLPVDSEHN
AIFQVLENDQRHAVERIVLTASGGPFRTKSLDEMQHVTAEAARAHPNWSMGLKISIDSASMFNKALEMIEARHLFNLRPD
QIEVIVHPQSVVHSMVGYADGSVLAQLGCPDMRTAIGYALSYPRRCDLPVERLDFARLARLDFEAPDEVRFPALRLARRA
MEEGGLQGAVLNGAKETALGAFIEGRVGFLDMAEIVEEVMNDLAGLPAATSMDDVFAADEQARQAAAGMIP
>Mature_390_residues
ASGDELKRRLTILGSTGSIGTSTLDVIERLGGRDRFEVAALTGNGNIPLLAAQARRMGAELAVTADGDRYGELKDALSGS
GIEVAAGRTGLSEAAERDAGWVMAAIVGNAGLGPTLAAARRGADIALANKECLVSAGSLFIDAVAEGGGRLLPVDSEHNA
IFQVLENDQRHAVERIVLTASGGPFRTKSLDEMQHVTAEAARAHPNWSMGLKISIDSASMFNKALEMIEARHLFNLRPDQ
IEVIVHPQSVVHSMVGYADGSVLAQLGCPDMRTAIGYALSYPRRCDLPVERLDFARLARLDFEAPDEVRFPALRLARRAM
EEGGLQGAVLNGAKETALGAFIEGRVGFLDMAEIVEEVMNDLAGLPAATSMDDVFAADEQARQAAAGMIP

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=47.3145780051151, Blast_Score=317, Evalue=7e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41402; Mature: 41270

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGDELKRRLTILGSTGSIGTSTLDVIERLGGRDRFEVAALTGNGNIPLLAAQARRMGA
CCCHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEHHHHHCCC
ELAVTADGDRYGELKDALSGSGIEVAAGRTGLSEAAERDAGWVMAAIVGNAGLGPTLAAA
EEEEEECCCCHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHH
RRGADIALANKECLVSAGSLFIDAVAEGGGRLLPVDSEHNAIFQVLENDQRHAVERIVLT
HCCCCEEEECHHHHHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCHHHHEEEEEEE
ASGGPFRTKSLDEMQHVTAEAARAHPNWSMGLKISIDSASMFNKALEMIEARHLFNLRPD
ECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCC
QIEVIVHPQSVVHSMVGYADGSVLAQLGCPDMRTAIGYALSYPRRCDLPVERLDFARLAR
EEEEEECCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LDFEAPDEVRFPALRLARRAMEEGGLQGAVLNGAKETALGAFIEGRVGFLDMAEIVEEVM
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHH
NDLAGLPAATSMDDVFAADEQARQAAAGMIP
HHHHCCCCCCCCHHHHHCHHHHHHHHCCCCC
>Mature Secondary Structure 
ASGDELKRRLTILGSTGSIGTSTLDVIERLGGRDRFEVAALTGNGNIPLLAAQARRMGA
CCHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEHHHHHCCC
ELAVTADGDRYGELKDALSGSGIEVAAGRTGLSEAAERDAGWVMAAIVGNAGLGPTLAAA
EEEEEECCCCHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHH
RRGADIALANKECLVSAGSLFIDAVAEGGGRLLPVDSEHNAIFQVLENDQRHAVERIVLT
HCCCCEEEECHHHHHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCHHHHEEEEEEE
ASGGPFRTKSLDEMQHVTAEAARAHPNWSMGLKISIDSASMFNKALEMIEARHLFNLRPD
ECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCC
QIEVIVHPQSVVHSMVGYADGSVLAQLGCPDMRTAIGYALSYPRRCDLPVERLDFARLAR
EEEEEECCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LDFEAPDEVRFPALRLARRAMEEGGLQGAVLNGAKETALGAFIEGRVGFLDMAEIVEEVM
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHH
NDLAGLPAATSMDDVFAADEQARQAAAGMIP
HHHHCCCCCCCCHHHHHCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]