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The map label for this gene is hutH [H]

Identifier: 150397784

GI number: 150397784

Start: 2686947

End: 2688461

Strand: Direct

Name: hutH [H]

Synonym: Smed_2586

Alternate gene names: 150397784

Gene position: 2686947-2688461 (Clockwise)

Preceding gene: 150397783

Following gene: 150397785

Centisome position: 71.05

GC content: 65.28

Gene sequence:

>1515_bases
ATGCGTGAGATGATCTCGGTCGATGGACCGCTCAACTGGCGCGAGATCGCTTCGGTCGCCGAGGGCGCTCGCCTCGGTCT
GTCGGAGCCGGCACGCGAGCGGATCGTCCACGCCAGGCGGATCGTCGATGCCCTGGTGGAGCGCGGCATCCGCGGCTACG
GCATCAACACCGGCGTCGGGGCACTCTGCGACGTAATCATCGACCGCGAGAACCAGCAGGCGCTTTCGCGCAATATCATC
CTGAGCCACGCCTGCGGCGTCGGCGATGCGCTCGGCCGTGCGGAAGCGCGGGCGGTGATGGCAGCACAGATAGCCAATTT
CGCTCACGGCTATTCCGGTGTGCGGATCGAGACGGTCGAGGCGCTCCTGACGTTGCTCAATGCCGACATGATCCCTCTCA
TTCCGTCGCGCGGTTCGGTTGGATATCTTACCCATGCCGCCGCGATCGGCCTCGTCCTGATCGGTCATGGCTGGGCCATG
CAGGGGACGGAAAGGCTGAGCGGCGATGCGGCGCTTTCCCGCCTTGGGCTGGCGCCGTTGCGGCTCGAAGCGAAAGAGGG
CCTGAGTCTCGTCAACGGGACCCCGTGCGCGACCGGTCTCGCGGCGCTGGCGCTCGCGCACACGGAAAGGCTCTTCGCCT
GGGCGGATGCAGCCGCGGCCATGACATACGAAAATCTCGGCAGCCAGGCCAATGCGTTTGCCGAATTGCCCCTGGCTTTG
CGGCAATCCCCCGGCCTGAGGGCCGTCGGCAAAGACTTGCGTGACTGGCTGGCAGGGAGCGCAATGCTTGCAGAAACCGC
CGGTACGCGCACACAGGATCCGCTAAGCCTCAGGGCAGTGCCGCAAGTGCACGGCGCCGCCCGCGACGCTTTCGGACAGG
TAGCCGAAATCGTCGACCGCGAACTTTCAAGCGTAACCGACAACCCGGCCGTCGGCGGTTCGCCGGAGGCACCTGAGGTG
CATTCGCAGGCACATGCCGTCGGTGCCGCCCTCGGCCTGGCCATGGATGGTCTCGCTGTCGCGGTGGCGGAACTCGCGGC
GATTTCCGAGCGCCGTATCGACCGGCTCGTAAACCCTCTGGTGAGCGGTCTTTCCGCCTTCCTGGCTGCCGATAGCGGCG
TTTCTTCGGGTTACATGATCGCGCAGTACACGGCTGCTGCGCTCGTGGCGGAGAACCGCCGTCTGGCGGCACCGGCCAGC
CTCGATGGCGGTATCACCTCTGCGCTTCAGGAAGACATTCTTACCCATGCGACGCCTGCCGCCTGGAAGGTGCACGCGAT
CCTCAACAATCTCGAGCAGATCCTGGCGATCGAACTGCTTGCGGCCGTTCAGGCCTATGATCTGCAGCCGCAAGTGCGCG
CCAAGGCGCAAGGCACCGCTGCCCTTTACGGGCGCATACGCTCGGTAATTCCCGCCTATCGCGACGATCGCCCGATGAAC
GAAGACTTCGACCGTATGCGGCGCCTGATGCAGGGGGCCGCCGACCAACAGAAATCGACAGGTAAACCGCTCTGA

Upstream 100 bases:

>100_bases
CAGGTCGTTCAGGTCGGTAATCCGAGCGAGATTCTCGACAATCCCGCCAACGACTATGTCGCCCGGTTCGTCCAGCGCCG
TCATGAAAGGCCGGAGACCC

Downstream 100 bases:

>100_bases
AAAGGAACGGAGGAGACGACATGACGCACATCACTACCGAGGCAAAGGGCTCGCGCGGCGGCGCCGCATTGCGGCTCGTG
CTCTGCAGCTTCATCGGCAT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MREMISVDGPLNWREIASVAEGARLGLSEPARERIVHARRIVDALVERGIRGYGINTGVGALCDVIIDRENQQALSRNII
LSHACGVGDALGRAEARAVMAAQIANFAHGYSGVRIETVEALLTLLNADMIPLIPSRGSVGYLTHAAAIGLVLIGHGWAM
QGTERLSGDAALSRLGLAPLRLEAKEGLSLVNGTPCATGLAALALAHTERLFAWADAAAAMTYENLGSQANAFAELPLAL
RQSPGLRAVGKDLRDWLAGSAMLAETAGTRTQDPLSLRAVPQVHGAARDAFGQVAEIVDRELSSVTDNPAVGGSPEAPEV
HSQAHAVGAALGLAMDGLAVAVAELAAISERRIDRLVNPLVSGLSAFLAADSGVSSGYMIAQYTAAALVAENRRLAAPAS
LDGGITSALQEDILTHATPAAWKVHAILNNLEQILAIELLAAVQAYDLQPQVRAKAQGTAALYGRIRSVIPAYRDDRPMN
EDFDRMRRLMQGAADQQKSTGKPL

Sequences:

>Translated_504_residues
MREMISVDGPLNWREIASVAEGARLGLSEPARERIVHARRIVDALVERGIRGYGINTGVGALCDVIIDRENQQALSRNII
LSHACGVGDALGRAEARAVMAAQIANFAHGYSGVRIETVEALLTLLNADMIPLIPSRGSVGYLTHAAAIGLVLIGHGWAM
QGTERLSGDAALSRLGLAPLRLEAKEGLSLVNGTPCATGLAALALAHTERLFAWADAAAAMTYENLGSQANAFAELPLAL
RQSPGLRAVGKDLRDWLAGSAMLAETAGTRTQDPLSLRAVPQVHGAARDAFGQVAEIVDRELSSVTDNPAVGGSPEAPEV
HSQAHAVGAALGLAMDGLAVAVAELAAISERRIDRLVNPLVSGLSAFLAADSGVSSGYMIAQYTAAALVAENRRLAAPAS
LDGGITSALQEDILTHATPAAWKVHAILNNLEQILAIELLAAVQAYDLQPQVRAKAQGTAALYGRIRSVIPAYRDDRPMN
EDFDRMRRLMQGAADQQKSTGKPL
>Mature_504_residues
MREMISVDGPLNWREIASVAEGARLGLSEPARERIVHARRIVDALVERGIRGYGINTGVGALCDVIIDRENQQALSRNII
LSHACGVGDALGRAEARAVMAAQIANFAHGYSGVRIETVEALLTLLNADMIPLIPSRGSVGYLTHAAAIGLVLIGHGWAM
QGTERLSGDAALSRLGLAPLRLEAKEGLSLVNGTPCATGLAALALAHTERLFAWADAAAAMTYENLGSQANAFAELPLAL
RQSPGLRAVGKDLRDWLAGSAMLAETAGTRTQDPLSLRAVPQVHGAARDAFGQVAEIVDRELSSVTDNPAVGGSPEAPEV
HSQAHAVGAALGLAMDGLAVAVAELAAISERRIDRLVNPLVSGLSAFLAADSGVSSGYMIAQYTAAALVAENRRLAAPAS
LDGGITSALQEDILTHATPAAWKVHAILNNLEQILAIELLAAVQAYDLQPQVRAKAQGTAALYGRIRSVIPAYRDDRPMN
EDFDRMRRLMQGAADQQKSTGKPL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=501, Percent_Identity=35.9281437125749, Blast_Score=266, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17567831, Length=474, Percent_Identity=35.6540084388186, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 52974; Mature: 52974

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREMISVDGPLNWREIASVAEGARLGLSEPARERIVHARRIVDALVERGIRGYGINTGVG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ALCDVIIDRENQQALSRNIILSHACGVGDALGRAEARAVMAAQIANFAHGYSGVRIETVE
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALLTLLNADMIPLIPSRGSVGYLTHAAAIGLVLIGHGWAMQGTERLSGDAALSRLGLAPL
HHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHCCCCE
RLEAKEGLSLVNGTPCATGLAALALAHTERLFAWADAAAAMTYENLGSQANAFAELPLAL
EEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHH
RQSPGLRAVGKDLRDWLAGSAMLAETAGTRTQDPLSLRAVPQVHGAARDAFGQVAEIVDR
HCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHH
ELSSVTDNPAVGGSPEAPEVHSQAHAVGAALGLAMDGLAVAVAELAAISERRIDRLVNPL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGLSAFLAADSGVSSGYMIAQYTAAALVAENRRLAAPASLDGGITSALQEDILTHATPA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
AWKVHAILNNLEQILAIELLAAVQAYDLQPQVRAKAQGTAALYGRIRSVIPAYRDDRPMN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
EDFDRMRRLMQGAADQQKSTGKPL
HHHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure
MREMISVDGPLNWREIASVAEGARLGLSEPARERIVHARRIVDALVERGIRGYGINTGVG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ALCDVIIDRENQQALSRNIILSHACGVGDALGRAEARAVMAAQIANFAHGYSGVRIETVE
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALLTLLNADMIPLIPSRGSVGYLTHAAAIGLVLIGHGWAMQGTERLSGDAALSRLGLAPL
HHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHCCCCE
RLEAKEGLSLVNGTPCATGLAALALAHTERLFAWADAAAAMTYENLGSQANAFAELPLAL
EEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHH
RQSPGLRAVGKDLRDWLAGSAMLAETAGTRTQDPLSLRAVPQVHGAARDAFGQVAEIVDR
HCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHH
ELSSVTDNPAVGGSPEAPEVHSQAHAVGAALGLAMDGLAVAVAELAAISERRIDRLVNPL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGLSAFLAADSGVSSGYMIAQYTAAALVAENRRLAAPASLDGGITSALQEDILTHATPA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
AWKVHAILNNLEQILAIELLAAVQAYDLQPQVRAKAQGTAALYGRIRSVIPAYRDDRPMN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
EDFDRMRRLMQGAADQQKSTGKPL
HHHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA