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The map label for this gene is hutC [H]

Identifier: 150397779

GI number: 150397779

Start: 2681831

End: 2682574

Strand: Reverse

Name: hutC [H]

Synonym: Smed_2581

Alternate gene names: 150397779

Gene position: 2682574-2681831 (Counterclockwise)

Preceding gene: 150397787

Following gene: 150397778

Centisome position: 70.93

GC content: 61.83

Gene sequence:

>744_bases
ATGGCGGTATTGGGGCGCAGGAGCGATAGGGCGGTCTTCGACGACGGACCGGTGCCGCGCTATGAGGCGGTCAAGCAGTT
CATCCGGAGCCGCATCGAAAGCGGCGAGTGGCCGCCACACCATCGCATTCCTTCCGAAAACGATATCGTCGCCGATCTCG
GCGTCAGCCGCATGACCGCCAATCGCGCCCTTCGCGAGTTGGCGAGCGAGGGAGCGATCACGCGGGTACAGGGGGTGGGA
TCGTTTGTCGCTGCCCATAAAGGAAGCACGGCCCTTCTGGAGGTCCGCAATATTGCCGACGAGATCCGCGAGCGCGGCCA
CAGGCATACCTCGCGGACAGCGCTCATGGAAGAGGAGCAGGCAAGCCCCGAAATCGCGGAGGCGCTCGGGCTTACGACTA
AGGCGCGGGTCTTTCACTCGATCATCGTTCATGCGGAGAACGACGTTCCGATCCAGATCGAAGACCGCTTCGTCAATCCC
GCAATCTGCCCCAATTATCTGGAACAGGATTTTGCCAGCATGACCCCGAACGTCTATCTGACCCTGGTGGCGCCGATCAC
GCGCACGGAGCAGATCGTCGAGGCCGTGCAGCCAAAGCCGTGGGAATGCAAGCTTCTTTCGATCAGCCGCGGCGAGCCGT
GCCTGATGATCCGCCGCCGGACCTGGTCGGAAACCGCGAATGTGACGGTCGCACGTCTTGTTTATCCGGGCACACGCTAT
CGTCTCGAGGGTGTTTCGCAGTAA

Upstream 100 bases:

>100_bases
TATGGAACTATAGATATTTTCTTGTGGCGCGCAAGTTGGAAATAAAGGAAAACAATTCCTGATTTCCGGCCCCGGCGGGC
GGTCGCATATGGAGCATCGA

Downstream 100 bases:

>100_bases
CAGATACACCTTTGACCGACGGGAAGGATAGGATGGTAGACGAATTGCTGAAGCACCGGACGCAGCTTGCAAGACCGGAC
GTGTCGACCGACGAAGCGCA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MAVLGRRSDRAVFDDGPVPRYEAVKQFIRSRIESGEWPPHHRIPSENDIVADLGVSRMTANRALRELASEGAITRVQGVG
SFVAAHKGSTALLEVRNIADEIRERGHRHTSRTALMEEEQASPEIAEALGLTTKARVFHSIIVHAENDVPIQIEDRFVNP
AICPNYLEQDFASMTPNVYLTLVAPITRTEQIVEAVQPKPWECKLLSISRGEPCLMIRRRTWSETANVTVARLVYPGTRY
RLEGVSQ

Sequences:

>Translated_247_residues
MAVLGRRSDRAVFDDGPVPRYEAVKQFIRSRIESGEWPPHHRIPSENDIVADLGVSRMTANRALRELASEGAITRVQGVG
SFVAAHKGSTALLEVRNIADEIRERGHRHTSRTALMEEEQASPEIAEALGLTTKARVFHSIIVHAENDVPIQIEDRFVNP
AICPNYLEQDFASMTPNVYLTLVAPITRTEQIVEAVQPKPWECKLLSISRGEPCLMIRRRTWSETANVTVARLVYPGTRY
RLEGVSQ
>Mature_246_residues
AVLGRRSDRAVFDDGPVPRYEAVKQFIRSRIESGEWPPHHRIPSENDIVADLGVSRMTANRALRELASEGAITRVQGVGS
FVAAHKGSTALLEVRNIADEIRERGHRHTSRTALMEEEQASPEIAEALGLTTKARVFHSIIVHAENDVPIQIEDRFVNPA
ICPNYLEQDFASMTPNVYLTLVAPITRTEQIVEAVQPKPWECKLLSISRGEPCLMIRRRTWSETANVTVARLVYPGTRYR
LEGVSQ

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=202, Percent_Identity=25.2475247524752, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082252, Length=204, Percent_Identity=25.9803921568627, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27689; Mature: 27558

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLGRRSDRAVFDDGPVPRYEAVKQFIRSRIESGEWPPHHRIPSENDIVADLGVSRMTA
CCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCHHHHHH
NRALRELASEGAITRVQGVGSFVAAHKGSTALLEVRNIADEIRERGHRHTSRTALMEEEQ
HHHHHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
ASPEIAEALGLTTKARVFHSIIVHAENDVPIQIEDRFVNPAICPNYLEQDFASMTPNVYL
CCHHHHHHHCCCHHHHHHHHHHEECCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
TLVAPITRTEQIVEAVQPKPWECKLLSISRGEPCLMIRRRTWSETANVTVARLVYPGTRY
EEEECCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCCCE
RLEGVSQ
ECCCCCC
>Mature Secondary Structure 
AVLGRRSDRAVFDDGPVPRYEAVKQFIRSRIESGEWPPHHRIPSENDIVADLGVSRMTA
CCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCHHHHHH
NRALRELASEGAITRVQGVGSFVAAHKGSTALLEVRNIADEIRERGHRHTSRTALMEEEQ
HHHHHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
ASPEIAEALGLTTKARVFHSIIVHAENDVPIQIEDRFVNPAICPNYLEQDFASMTPNVYL
CCHHHHHHHCCCHHHHHHHHHHEECCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
TLVAPITRTEQIVEAVQPKPWECKLLSISRGEPCLMIRRRTWSETANVTVARLVYPGTRY
EEEECCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCCCE
RLEGVSQ
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]