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The map label for this gene is hpt [H]

Identifier: 150397739

GI number: 150397739

Start: 2640280

End: 2640825

Strand: Reverse

Name: hpt [H]

Synonym: Smed_2541

Alternate gene names: 150397739

Gene position: 2640825-2640280 (Counterclockwise)

Preceding gene: 150397740

Following gene: 150397738

Centisome position: 69.83

GC content: 58.61

Gene sequence:

>546_bases
ATGCCCGTCGTCCGTGGCAAGAATATCGAAGTCCTCTACAGTGCCGAAACCATTGCAGCGCGGAACCAGGAATTGGCCGC
CGATATCGTTCGCGGGCCGCACAAGGACCTTCTGGTTATCTCGATCCTCAAGGGGTCTTTCATCTTTGCGGCGGATCTGA
TTCGCGCCATGCACGCTGCAGGCCTTGCGCCGGAGGTCGAATTCATCACGCTTTCGAGCTACGGAACCGGGACCGAATCC
AAGGGCGTCAAGATCACCAAGGATATAGACAGCGATGTGCGAGACCGGGACGTACTTCTCATCGACGACATTTTGGAGTC
CGGCCGGACCTTGCGCTTCGCCAAGGAACTCCTCCTTGAGCGCGGCGCCCGCAACGTCACCATCGCGGTCCTGCTCGACA
AGCGGGTGAAACGCCGCGTCGATCTCGAAGCGGATTATGTCGGCTTCGAATGCCCGGACCATTTCGTCGTCGGTTACGGC
ATGGATGTCGCTTATGCATTCCGGGAGCTGCCGTTCGTCGGAGTGGTGACGGGTGACGCAAAATAA

Upstream 100 bases:

>100_bases
AGCTGACATGCGATCACGATGATTTGAATCGACCGAACTTCGGTCGGCGTGATCCACAAGGGAAGGCCGGTGTTCTTCCT
TACGAAATGGAGAAACCCGC

Downstream 100 bases:

>100_bases
CCGGACCGCACACGCCTGTCGGTCTCCTTCGGGGGCGCCGTCGCCGAATGATTAAAATGCCTCCTATCGCGTTTACCGGA
ATCGAACGAAAAGCTGGTTG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MPVVRGKNIEVLYSAETIAARNQELAADIVRGPHKDLLVISILKGSFIFAADLIRAMHAAGLAPEVEFITLSSYGTGTES
KGVKITKDIDSDVRDRDVLLIDDILESGRTLRFAKELLLERGARNVTIAVLLDKRVKRRVDLEADYVGFECPDHFVVGYG
MDVAYAFRELPFVGVVTGDAK

Sequences:

>Translated_181_residues
MPVVRGKNIEVLYSAETIAARNQELAADIVRGPHKDLLVISILKGSFIFAADLIRAMHAAGLAPEVEFITLSSYGTGTES
KGVKITKDIDSDVRDRDVLLIDDILESGRTLRFAKELLLERGARNVTIAVLLDKRVKRRVDLEADYVGFECPDHFVVGYG
MDVAYAFRELPFVGVVTGDAK
>Mature_180_residues
PVVRGKNIEVLYSAETIAARNQELAADIVRGPHKDLLVISILKGSFIFAADLIRAMHAAGLAPEVEFITLSSYGTGTESK
GVKITKDIDSDVRDRDVLLIDDILESGRTLRFAKELLLERGARNVTIAVLLDKRVKRRVDLEADYVGFECPDHFVVGYGM
DVAYAFRELPFVGVVTGDAK

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=175, Percent_Identity=34.8571428571429, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI9910262, Length=179, Percent_Identity=30.7262569832402, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=41.0404624277457, Blast_Score=136, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=164, Percent_Identity=36.5853658536585, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19922; Mature: 19791

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVVRGKNIEVLYSAETIAARNQELAADIVRGPHKDLLVISILKGSFIFAADLIRAMHAA
CCCCCCCCEEEEEECHHHHHCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
GLAPEVEFITLSSYGTGTESKGVKITKDIDSDVRDRDVLLIDDILESGRTLRFAKELLLE
CCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHH
RGARNVTIAVLLDKRVKRRVDLEADYVGFECPDHFVVGYGMDVAYAFRELPFVGVVTGDA
CCCCCEEEEEEECHHHHHHCCCCCCEECCCCCCCEEEEECCHHHHHHHHCCEEEEEECCC
K
C
>Mature Secondary Structure 
PVVRGKNIEVLYSAETIAARNQELAADIVRGPHKDLLVISILKGSFIFAADLIRAMHAA
CCCCCCCEEEEEECHHHHHCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
GLAPEVEFITLSSYGTGTESKGVKITKDIDSDVRDRDVLLIDDILESGRTLRFAKELLLE
CCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHH
RGARNVTIAVLLDKRVKRRVDLEADYVGFECPDHFVVGYGMDVAYAFRELPFVGVVTGDA
CCCCCEEEEEEECHHHHHHCCCCCCEECCCCCCCEEEEECCHHHHHHHHCCEEEEEECCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]