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The map label for this gene is hexR [H]

Identifier: 150397668

GI number: 150397668

Start: 2549200

End: 2550090

Strand: Direct

Name: hexR [H]

Synonym: Smed_2468

Alternate gene names: 150397668

Gene position: 2549200-2550090 (Clockwise)

Preceding gene: 150397667

Following gene: 150397669

Centisome position: 67.41

GC content: 61.17

Gene sequence:

>891_bases
ATGTCAACCAACGCGCTCCAGCCCAAATCGATCGGCGGCAACAACAATATCCTGGAAGTCATTCGGCTGAGGCGCGCGGA
TCTGCGCAAATCGGACCGCAAGGTCGCAGAGCTCGTTCTGGCCGATCCCAAGCGCGTGATCAATGCAACGATCGCCGAGG
CGGCGGAATGGGCGGGGGTAAGCCAGCCGACGGTTATCCGTTTCTGCGCCTCGATCGGATGCCAGGGATACCAGGATTTC
AAGCTCCGCCTCGCTCAGAGCCTCGCGCTCGGCATGTCGGCGACACACTCGGTCATCGACGCGAGCGACACGCCGGCCCA
GGTCTCGGCGAAGATCTTCGATTATACGATCACCAGTCTGGACTGGGTCCGCAACCATCTCGACCCGGTCCAGGTCAGCC
GGGCCATAGACGCGCTCTCCAAGGCCAGCCGCATCGAATTCTTCGGTTTCGGCGCATCCGGCATCGTTGCACGTGACGCC
CAGCAGAAGTTTCCTCTCTTCGGCGTGCCCTGCGGCGCCGAAACGGACGCCCACCAGCAGATCATGGTCGTATCCATGCT
GAAACCGGGCGACGTCGCAGTCGTCATCTCCAATACCGGCGCGACGCTTGCGATCATTGAAACCGCGCGCCGGGCGCGCG
AAAGCGGCTGTCAGGTCATCGGCATCGTTGGCTCGGACGGTCCGCTCGTCGAGTTCTGCGACATAGTGCTGATGGTCGAG
ACCCTAGAGAACACCAATATCTATACCCCGACGATCTCCCGAATTGCCGCGCTGACCGTTATCGACATCCTTTCCACCAG
CGTCGCACTGCGACGCGGCGCCGAACATGTCGACCTTTTCACGGGCATGAAGCGCAACCTTCGTTATCTGCGCATGAGCA
ACGAGACATAG

Upstream 100 bases:

>100_bases
TGCCCTCCCCCATCCCGCTCTCGCTTATTGGAACCGATCGCGATGATTTCAGGTCAGCGCCACCTGAAACCAGCGCGATC
TTCGTGAACCGGGGGTCTAC

Downstream 100 bases:

>100_bases
AGATGAACGACAATCGCCACCGCTCCAAACCGCCGGCATCGCTCGCTCCCCGCGACCTCGCCGCCCTGATCGATATCAGC
GCCGTCCAGGCCTTCCACAC

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSTNALQPKSIGGNNNILEVIRLRRADLRKSDRKVAELVLADPKRVINATIAEAAEWAGVSQPTVIRFCASIGCQGYQDF
KLRLAQSLALGMSATHSVIDASDTPAQVSAKIFDYTITSLDWVRNHLDPVQVSRAIDALSKASRIEFFGFGASGIVARDA
QQKFPLFGVPCGAETDAHQQIMVVSMLKPGDVAVVISNTGATLAIIETARRARESGCQVIGIVGSDGPLVEFCDIVLMVE
TLENTNIYTPTISRIAALTVIDILSTSVALRRGAEHVDLFTGMKRNLRYLRMSNET

Sequences:

>Translated_296_residues
MSTNALQPKSIGGNNNILEVIRLRRADLRKSDRKVAELVLADPKRVINATIAEAAEWAGVSQPTVIRFCASIGCQGYQDF
KLRLAQSLALGMSATHSVIDASDTPAQVSAKIFDYTITSLDWVRNHLDPVQVSRAIDALSKASRIEFFGFGASGIVARDA
QQKFPLFGVPCGAETDAHQQIMVVSMLKPGDVAVVISNTGATLAIIETARRARESGCQVIGIVGSDGPLVEFCDIVLMVE
TLENTNIYTPTISRIAALTVIDILSTSVALRRGAEHVDLFTGMKRNLRYLRMSNET
>Mature_295_residues
STNALQPKSIGGNNNILEVIRLRRADLRKSDRKVAELVLADPKRVINATIAEAAEWAGVSQPTVIRFCASIGCQGYQDFK
LRLAQSLALGMSATHSVIDASDTPAQVSAKIFDYTITSLDWVRNHLDPVQVSRAIDALSKASRIEFFGFGASGIVARDAQ
QKFPLFGVPCGAETDAHQQIMVVSMLKPGDVAVVISNTGATLAIIETARRARESGCQVIGIVGSDGPLVEFCDIVLMVET
LENTNIYTPTISRIAALTVIDILSTSVALRRGAEHVDLFTGMKRNLRYLRMSNET

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=41.4285714285714, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1788767, Length=247, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082369, Length=263, Percent_Identity=23.574144486692, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082130, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32047; Mature: 31916

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNALQPKSIGGNNNILEVIRLRRADLRKSDRKVAELVLADPKRVINATIAEAAEWAGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
SQPTVIRFCASIGCQGYQDFKLRLAQSLALGMSATHSVIDASDTPAQVSAKIFDYTITSL
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DWVRNHLDPVQVSRAIDALSKASRIEFFGFGASGIVARDAQQKFPLFGVPCGAETDAHQQ
HHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEECCHHHCCCEEECCCCCCCCCCCE
IMVVSMLKPGDVAVVISNTGATLAIIETARRARESGCQVIGIVGSDGPLVEFCDIVLMVE
EEEEEEECCCCEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
TLENTNIYTPTISRIAALTVIDILSTSVALRRGAEHVDLFTGMKRNLRYLRMSNET
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCC
>Mature Secondary Structure 
STNALQPKSIGGNNNILEVIRLRRADLRKSDRKVAELVLADPKRVINATIAEAAEWAGV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
SQPTVIRFCASIGCQGYQDFKLRLAQSLALGMSATHSVIDASDTPAQVSAKIFDYTITSL
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DWVRNHLDPVQVSRAIDALSKASRIEFFGFGASGIVARDAQQKFPLFGVPCGAETDAHQQ
HHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEECCHHHCCCEEECCCCCCCCCCCE
IMVVSMLKPGDVAVVISNTGATLAIIETARRARESGCQVIGIVGSDGPLVEFCDIVLMVE
EEEEEEECCCCEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
TLENTNIYTPTISRIAALTVIDILSTSVALRRGAEHVDLFTGMKRNLRYLRMSNET
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]