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The map label for this gene is serA [H]

Identifier: 150397666

GI number: 150397666

Start: 2547275

End: 2548207

Strand: Direct

Name: serA [H]

Synonym: Smed_2466

Alternate gene names: 150397666

Gene position: 2547275-2548207 (Clockwise)

Preceding gene: 150397665

Following gene: 150397667

Centisome position: 67.35

GC content: 68.06

Gene sequence:

>933_bases
GTGAAGCGCATTCTCGTCACGCCCCGCTCCCTCTCGCTCGACCCGCCTCCGGAGCTAGAGCCGCTTCGGCAGGCCGGCTT
CGAGCTCGTATTCCCCACGCCGGGCCGCATGCCGAGCGAGGCTGAACTGATCGGCCTCGTGCCGGGCTGTATCGGCTGGC
TGGCAGGCGTCGAGCCCGTCTCGGACAAAGTCATCGCCGCCGCCGACAGCCTGCGGGCGATCAGCCGCAACGGCACCGGC
ATCGACAATCTGCCGCTCCCCCTGCTGAAGGAGCGGGGCATCGGCATTCTCAAGGCCGAAGGAGCCAACGCAGTCGGCGT
GGCGGAACTCTCGGTCGGACTTATGCTGGCTGCCCTGCGTCACATTCCGGCCGAAACGGCAGGCATCCGCGCCGGCGGCT
GGCCCCGGTCGCGCGGCAGGGAAATTGCCGAACGCACGGTAGGGATCATCGGGTGCGGCGCAATCGGAAAGCGTGTCGCG
CGCGCCGTCTCGGCGATGCGGGCCAGCGTCATCGCGTGCGATCCGTTCCGGCCGAACGTAGAGGTGTACGGGCCGTTCAA
ATGGGCGAGCCTGGACGAGGTTTTCGCAGGGGCGGACATCGTTTCGTTGCATTGCCCGGCACCGGCCGACGGCAAGCCGA
TCGTCGATGCGCCGCGTCTGGCGACCGTGCCGCCGCACGCTATTCTTATCAACACCGCGCGCGCAACGCTGGTGGATGAG
GACGCGGTGCGCGCCGCGCTCGACGAAGGCAGGCTGCAGGCTTACGCGACCGATGTCTTCACCACGGAGCCGCCGGCGCC
CGGCTCACTTGCAAGCCATCCCCGCGTCATTGCGACCAGTCATATCGGCGGCCTGACCGACGAGAGCGTCGGCAAGGCGA
CGAAGATTGCCGTTGCGAACCTTCTCTCGGCCCTTGTGGAGGAGACCGCGTGA

Upstream 100 bases:

>100_bases
CAGGTCATCGCGGAAGTGTTCGACATCGCCATTCCGACTTCGGGACCGCCCTTCGACGACATCTCGCGGATCGCCATAGA
GGCAGCAAGGGAGTAAGGCC

Downstream 100 bases:

>100_bases
CCCCGCCCTCATCCATGCCGTTTTTGGAATCGCCGTTTTCAGAACCGCTCGCCGAGCGGCTGAGGGCGGCAGCCCGCGGC
GTTCGGCTCTACTGGCTGGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKRILVTPRSLSLDPPPELEPLRQAGFELVFPTPGRMPSEAELIGLVPGCIGWLAGVEPVSDKVIAAADSLRAISRNGTG
IDNLPLPLLKERGIGILKAEGANAVGVAELSVGLMLAALRHIPAETAGIRAGGWPRSRGREIAERTVGIIGCGAIGKRVA
RAVSAMRASVIACDPFRPNVEVYGPFKWASLDEVFAGADIVSLHCPAPADGKPIVDAPRLATVPPHAILINTARATLVDE
DAVRAALDEGRLQAYATDVFTTEPPAPGSLASHPRVIATSHIGGLTDESVGKATKIAVANLLSALVEETA

Sequences:

>Translated_310_residues
MKRILVTPRSLSLDPPPELEPLRQAGFELVFPTPGRMPSEAELIGLVPGCIGWLAGVEPVSDKVIAAADSLRAISRNGTG
IDNLPLPLLKERGIGILKAEGANAVGVAELSVGLMLAALRHIPAETAGIRAGGWPRSRGREIAERTVGIIGCGAIGKRVA
RAVSAMRASVIACDPFRPNVEVYGPFKWASLDEVFAGADIVSLHCPAPADGKPIVDAPRLATVPPHAILINTARATLVDE
DAVRAALDEGRLQAYATDVFTTEPPAPGSLASHPRVIATSHIGGLTDESVGKATKIAVANLLSALVEETA
>Mature_310_residues
MKRILVTPRSLSLDPPPELEPLRQAGFELVFPTPGRMPSEAELIGLVPGCIGWLAGVEPVSDKVIAAADSLRAISRNGTG
IDNLPLPLLKERGIGILKAEGANAVGVAELSVGLMLAALRHIPAETAGIRAGGWPRSRGREIAERTVGIIGCGAIGKRVA
RAVSAMRASVIACDPFRPNVEVYGPFKWASLDEVFAGADIVSLHCPAPADGKPIVDAPRLATVPPHAILINTARATLVDE
DAVRAALDEGRLQAYATDVFTTEPPAPGSLASHPRVIATSHIGGLTDESVGKATKIAVANLLSALVEETA

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=293, Percent_Identity=30.7167235494881, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI6912396, Length=269, Percent_Identity=28.6245353159851, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI145580578, Length=233, Percent_Identity=30.4721030042918, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4557499, Length=233, Percent_Identity=30.4721030042918, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI61743967, Length=233, Percent_Identity=29.6137339055794, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4557497, Length=233, Percent_Identity=29.6137339055794, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=29.2, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI87082289, Length=262, Percent_Identity=30.1526717557252, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789279, Length=278, Percent_Identity=29.8561151079137, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787645, Length=247, Percent_Identity=22.2672064777328, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788660, Length=221, Percent_Identity=33.4841628959276, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081824, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=282, Percent_Identity=30.4964539007092, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=234, Percent_Identity=27.3504273504274, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=265, Percent_Identity=28.6792452830189, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=28.1967213114754, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=245, Percent_Identity=25.3061224489796, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=294, Percent_Identity=24.1496598639456, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=230, Percent_Identity=29.1304347826087, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585516, Length=302, Percent_Identity=28.8079470198675, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646446, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646448, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646452, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646450, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI28574284, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551003, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45552429, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574286, Length=252, Percent_Identity=28.1746031746032, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28571528, Length=275, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32252; Mature: 32252

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILVTPRSLSLDPPPELEPLRQAGFELVFPTPGRMPSEAELIGLVPGCIGWLAGVEPV
CCCEEECCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCCC
SDKVIAAADSLRAISRNGTGIDNLPLPLLKERGIGILKAEGANAVGVAELSVGLMLAALR
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHHHH
HIPAETAGIRAGGWPRSRGREIAERTVGIIGCGAIGKRVARAVSAMRASVIACDPFRPNV
HCCCHHCCCCCCCCCCHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHEEEECCCCCCE
EVYGPFKWASLDEVFAGADIVSLHCPAPADGKPIVDAPRLATVPPHAILINTARATLVDE
EEECCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCHHEEECH
DAVRAALDEGRLQAYATDVFTTEPPAPGSLASHPRVIATSHIGGLTDESVGKATKIAVAN
HHHHHHHHHCHHEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHCHHHHHHHHH
LLSALVEETA
HHHHHHHHCC
>Mature Secondary Structure
MKRILVTPRSLSLDPPPELEPLRQAGFELVFPTPGRMPSEAELIGLVPGCIGWLAGVEPV
CCCEEECCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCCC
SDKVIAAADSLRAISRNGTGIDNLPLPLLKERGIGILKAEGANAVGVAELSVGLMLAALR
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHHHH
HIPAETAGIRAGGWPRSRGREIAERTVGIIGCGAIGKRVARAVSAMRASVIACDPFRPNV
HCCCHHCCCCCCCCCCHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHEEEECCCCCCE
EVYGPFKWASLDEVFAGADIVSLHCPAPADGKPIVDAPRLATVPPHAILINTARATLVDE
EEECCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCHHEEECH
DAVRAALDEGRLQAYATDVFTTEPPAPGSLASHPRVIATSHIGGLTDESVGKATKIAVAN
HHHHHHHHHCHHEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHCHHHHHHHHH
LLSALVEETA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]