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The map label for this gene is betA [C]

Identifier: 150397650

GI number: 150397650

Start: 2532008

End: 2533672

Strand: Reverse

Name: betA [C]

Synonym: Smed_2450

Alternate gene names: 150397650

Gene position: 2533672-2532008 (Counterclockwise)

Preceding gene: 150397651

Following gene: 150397649

Centisome position: 66.99

GC content: 64.68

Gene sequence:

>1665_bases
ATGAGCTACGAGCACATCGTCGTCGGCGGCGGAACGGCGGGTTGCCTTGCAGCCGGCAAGCTGGCGGGAGAGCACGGTGC
GCGCGTGCTGGTGCTAGAGGCCGGGCCGGATGACCGCAATCCGCTGATCCGCATGCCCGCCGGCTTCGTCAAGCTGCTCG
GCGTCGAGAAATACATGTGGTTCTACAAGTCCGTCGCGCAGGCACGTCTTGGCGGCCGCATGCCTATCGTCCCGCAGGGC
CGCGTGCTCGGCGGCGGCTCCTCGGTCAATGCGATGGTCTATATGCGGGGCCAGCCAGCCGATTACGACGGCTGGGCGGA
CGCAATCGGCGACGAGCAATGGTCTTATGATGCGCTGCTGCCCTACTTCATCGCGATGGAGGACAATGCGAGGCTGAACG
ACAATTATCACGGCGTCGGCGGCCCGTGGAAAGTGTCCGATCTCGAGCACATGTGCGAACTCTCGCGCGCCTTCGTACTG
GCCGCCCAGAGTATCGGCCTGCCGCATAACGCCGATTTCAACGGCCGAAGCCAGCGCGGCGTCGGCGCCTACCAGGTGAC
GACGCGCAACGGCCGCCGTTGCTCGGCAGTCGATGCCTTTCTGCGCCCCGCCATTGCAAGCGGCCGAGTGGAGGTGAAAA
CCTCCTGTCTCGTTCACTCGCTGATCATCGACAATGGCCGCGCGGTCGGCGTGCGTTATTCGCAGGAGGGTGGCGGCCAG
ACTGTCGAGGAAGTCCGCTGTGATGGCGAGGTGCTGCTTGCCGCTGGCGCCATTGCGACGCCGAAGCTGCTGATGCTTTC
AGGCATCGGGCCTGCGGATCACCTGAAATCCCATGGTATTGCGGCCTTCGTCGACCTGCCGGGCGTCGGCGCCAATCTCC
AGGATCATACCGAAACGCCGGTCGTGGCGCTGTGCAATGGTCCCTACGGTTATTACGGCCATGACCGCGGCTGGAAGCAA
ATACGAAACGGCCTCGAATATCTTCTCAACCGCAGCGGTCCGGTGACGTCGAACGGCGTCGAGGCAGGCGCCTTCTTCGA
TCCCGACGACCTCGACCGGGATCCGAAGATCCAGCAGTTTTGCGTGCCGACGGTCTATCTGGACAAAGATCACACCGACC
AGCAGGCGAGTCACGGGCTTACCTTGAATTCCTGCGTTGCCCGGCCGCGCTCGCGCGGGTCGGTAAAGCTCGCCTCCGCC
GATCCGAAGGACCAGCCGCTGGTCGATCCGAACTATCTCGCCGATCCGGAGGACCTGCGCCTGTCGATCGGTGGCGTGCG
CCGCGCGCGTGAAATCCTCCGTCAGGAGCCGCTGCAATCGATGATAGCGCGCGAGGTCTTCCCTGGTCCGGACAAGCTTT
CCGATGCGGACCTCGCCGAACACGCCCGACGGTTCGTCAAGACTGTATACCATCCCGTCGGCACCTGCCGCATGGCTCGA
GACGGTGACGCGGGCGGGGTGCTCGGCGCAGACATGCGGGTACGCGGGGTGCGAGGGCTCCGGGTCATCGATGCATCCGC
GATTCCCACCATCATCTCGGGCAACACCAATGCTGCCGTTCTGGTCGTCGCCGACAAGGCGGTCGAATTCATCACCGGCG
GCAAGCGCCGTCAGCCTGCGGGGCTCGCCCCGCGCAGCAATCCGACCAACCGCCAGATAGCCTAG

Upstream 100 bases:

>100_bases
TCACACCCAGGCGCGGCGAGGCGGTGCGCGTCTCGATCGATCCGGAGCATCTGCTGCTGTTCCCGCGTTCGCAGGCGGGC
AAGATCGAGAGTCTCGTCGC

Downstream 100 bases:

>100_bases
GATGCAGCCATGCCTCCCATGAAGACCGATCCCAATCCGCGCATGCCCTACCAGTATCCGATGCCGACGGAGGCGTTGCC
CGACATCGTCATTCCGGACG

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: SDH [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSYEHIVVGGGTAGCLAAGKLAGEHGARVLVLEAGPDDRNPLIRMPAGFVKLLGVEKYMWFYKSVAQARLGGRMPIVPQG
RVLGGGSSVNAMVYMRGQPADYDGWADAIGDEQWSYDALLPYFIAMEDNARLNDNYHGVGGPWKVSDLEHMCELSRAFVL
AAQSIGLPHNADFNGRSQRGVGAYQVTTRNGRRCSAVDAFLRPAIASGRVEVKTSCLVHSLIIDNGRAVGVRYSQEGGGQ
TVEEVRCDGEVLLAAGAIATPKLLMLSGIGPADHLKSHGIAAFVDLPGVGANLQDHTETPVVALCNGPYGYYGHDRGWKQ
IRNGLEYLLNRSGPVTSNGVEAGAFFDPDDLDRDPKIQQFCVPTVYLDKDHTDQQASHGLTLNSCVARPRSRGSVKLASA
DPKDQPLVDPNYLADPEDLRLSIGGVRRAREILRQEPLQSMIAREVFPGPDKLSDADLAEHARRFVKTVYHPVGTCRMAR
DGDAGGVLGADMRVRGVRGLRVIDASAIPTIISGNTNAAVLVVADKAVEFITGGKRRQPAGLAPRSNPTNRQIA

Sequences:

>Translated_554_residues
MSYEHIVVGGGTAGCLAAGKLAGEHGARVLVLEAGPDDRNPLIRMPAGFVKLLGVEKYMWFYKSVAQARLGGRMPIVPQG
RVLGGGSSVNAMVYMRGQPADYDGWADAIGDEQWSYDALLPYFIAMEDNARLNDNYHGVGGPWKVSDLEHMCELSRAFVL
AAQSIGLPHNADFNGRSQRGVGAYQVTTRNGRRCSAVDAFLRPAIASGRVEVKTSCLVHSLIIDNGRAVGVRYSQEGGGQ
TVEEVRCDGEVLLAAGAIATPKLLMLSGIGPADHLKSHGIAAFVDLPGVGANLQDHTETPVVALCNGPYGYYGHDRGWKQ
IRNGLEYLLNRSGPVTSNGVEAGAFFDPDDLDRDPKIQQFCVPTVYLDKDHTDQQASHGLTLNSCVARPRSRGSVKLASA
DPKDQPLVDPNYLADPEDLRLSIGGVRRAREILRQEPLQSMIAREVFPGPDKLSDADLAEHARRFVKTVYHPVGTCRMAR
DGDAGGVLGADMRVRGVRGLRVIDASAIPTIISGNTNAAVLVVADKAVEFITGGKRRQPAGLAPRSNPTNRQIA
>Mature_553_residues
SYEHIVVGGGTAGCLAAGKLAGEHGARVLVLEAGPDDRNPLIRMPAGFVKLLGVEKYMWFYKSVAQARLGGRMPIVPQGR
VLGGGSSVNAMVYMRGQPADYDGWADAIGDEQWSYDALLPYFIAMEDNARLNDNYHGVGGPWKVSDLEHMCELSRAFVLA
AQSIGLPHNADFNGRSQRGVGAYQVTTRNGRRCSAVDAFLRPAIASGRVEVKTSCLVHSLIIDNGRAVGVRYSQEGGGQT
VEEVRCDGEVLLAAGAIATPKLLMLSGIGPADHLKSHGIAAFVDLPGVGANLQDHTETPVVALCNGPYGYYGHDRGWKQI
RNGLEYLLNRSGPVTSNGVEAGAFFDPDDLDRDPKIQQFCVPTVYLDKDHTDQQASHGLTLNSCVARPRSRGSVKLASAD
PKDQPLVDPNYLADPEDLRLSIGGVRRAREILRQEPLQSMIAREVFPGPDKLSDADLAEHARRFVKTVYHPVGTCRMARD
GDAGGVLGADMRVRGVRGLRVIDASAIPTIISGNTNAAVLVVADKAVEFITGGKRRQPAGLAPRSNPTNRQIA

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=548, Percent_Identity=37.7737226277372, Blast_Score=336, Evalue=4e-92,
Organism=Escherichia coli, GI1786503, Length=537, Percent_Identity=35.0093109869646, Blast_Score=301, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI17532301, Length=553, Percent_Identity=35.8047016274864, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24642042, Length=567, Percent_Identity=37.3897707231041, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI45549471, Length=578, Percent_Identity=35.2941176470588, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=35.676625659051, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=35.8131487889273, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=35.4385964912281, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24650267, Length=572, Percent_Identity=34.7902097902098, Blast_Score=278, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=35.5633802816901, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24642048, Length=574, Percent_Identity=33.6236933797909, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI18859995, Length=574, Percent_Identity=34.1463414634146, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24642037, Length=580, Percent_Identity=33.1034482758621, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI17137792, Length=554, Percent_Identity=31.2274368231047, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24642051, Length=572, Percent_Identity=30.9440559440559, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI18859993, Length=582, Percent_Identity=30.4123711340206, Blast_Score=225, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24642035, Length=581, Percent_Identity=31.84165232358, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=28.1034482758621, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24642057, Length=588, Percent_Identity=27.0408163265306, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.32 [H]

Molecular weight: Translated: 59474; Mature: 59343

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYEHIVVGGGTAGCLAAGKLAGEHGARVLVLEAGPDDRNPLIRMPAGFVKLLGVEKYMW
CCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHH
FYKSVAQARLGGRMPIVPQGRVLGGGSSVNAMVYMRGQPADYDGWADAIGDEQWSYDALL
HHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCHHCCC
PYFIAMEDNARLNDNYHGVGGPWKVSDLEHMCELSRAFVLAAQSIGLPHNADFNGRSQRG
EEEEEECCCCEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VGAYQVTTRNGRRCSAVDAFLRPAIASGRVEVKTSCLVHSLIIDNGRAVGVRYSQEGGGQ
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCC
TVEEVRCDGEVLLAAGAIATPKLLMLSGIGPADHLKSHGIAAFVDLPGVGANLQDHTETP
CHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCC
VVALCNGPYGYYGHDRGWKQIRNGLEYLLNRSGPVTSNGVEAGAFFDPDDLDRDPKIQQF
EEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHE
CVPTVYLDKDHTDQQASHGLTLNSCVARPRSRGSVKLASADPKDQPLVDPNYLADPEDLR
ECCEEEECCCCCCHHHHCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHE
LSIGGVRRAREILRQEPLQSMIAREVFPGPDKLSDADLAEHARRFVKTVYHPVGTCRMAR
EEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
DGDAGGVLGADMRVRGVRGLRVIDASAIPTIISGNTNAAVLVVADKAVEFITGGKRRQPA
CCCCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCEEEEEEECCHHHHHCCCCCCCCC
GLAPRSNPTNRQIA
CCCCCCCCCCCCCC
>Mature Secondary Structure 
SYEHIVVGGGTAGCLAAGKLAGEHGARVLVLEAGPDDRNPLIRMPAGFVKLLGVEKYMW
CCCEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHH
FYKSVAQARLGGRMPIVPQGRVLGGGSSVNAMVYMRGQPADYDGWADAIGDEQWSYDALL
HHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCHHCCC
PYFIAMEDNARLNDNYHGVGGPWKVSDLEHMCELSRAFVLAAQSIGLPHNADFNGRSQRG
EEEEEECCCCEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VGAYQVTTRNGRRCSAVDAFLRPAIASGRVEVKTSCLVHSLIIDNGRAVGVRYSQEGGGQ
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCC
TVEEVRCDGEVLLAAGAIATPKLLMLSGIGPADHLKSHGIAAFVDLPGVGANLQDHTETP
CHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCC
VVALCNGPYGYYGHDRGWKQIRNGLEYLLNRSGPVTSNGVEAGAFFDPDDLDRDPKIQQF
EEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHE
CVPTVYLDKDHTDQQASHGLTLNSCVARPRSRGSVKLASADPKDQPLVDPNYLADPEDLR
ECCEEEECCCCCCHHHHCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHE
LSIGGVRRAREILRQEPLQSMIAREVFPGPDKLSDADLAEHARRFVKTVYHPVGTCRMAR
EEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
DGDAGGVLGADMRVRGVRGLRVIDASAIPTIISGNTNAAVLVVADKAVEFITGGKRRQPA
CCCCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCEEEEEEECCHHHHHCCCCCCCCC
GLAPRSNPTNRQIA
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023923 [H]