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The map label for this gene is gcvT [H]

Identifier: 150397630

GI number: 150397630

Start: 2507844

End: 2510405

Strand: Direct

Name: gcvT [H]

Synonym: Smed_2430

Alternate gene names: 150397630

Gene position: 2507844-2510405 (Clockwise)

Preceding gene: 150397629

Following gene: 150397632

Centisome position: 66.31

GC content: 62.26

Gene sequence:

>2562_bases
ATGGCAGAGTTTCCGGAAAAGGCGAAGGTCGTAATCGTAGGACTGGGCGGCATCGTCGGCGCATCGATCGCCCACCACCT
CATCGAGCGTGGCTGGGACGATATCGTCGGCATCGACAAGTCGGGCATCCCGACCGATATCGGTTCGACGGCCCATGCCT
CGGACTTCTGTTATACGACGAGCCACGACTATCTTTCGGTCTGGACGACGCAATACTCGATCGACTTTTTCGACAGGATG
GGCCACTACTCCCGCATCGGCGGCCTGGAAGTCGCACGCACCGGCGACGACGTCTGGATGGAAGAGATCAAGCGCAAGCT
TTCCTCCGCCAAGGCTTTCGGCACGCGCGCACATTACGTCTCGCCGGCCGAAATCAAGAAGCTGTTCCCGCTGATCGAGG
AAGATCAGGTCATGGGCGGCATGTTCGATCCGGATGCCGGTCTTGTCGTTCCGCGCTCGCAGACTGTCGCCGGCAAGCTG
GTCGATGCGGCGGAAAAGTCCGGCAAGCTGCGGGTCTTCGGCAATACGCCGGCAACCGCGCTTCTAGTCGAAAATGGACG
CATCAAAGGTGTCGTCACACATCGCGGCACGATTCTCGCGGACCATGTCGTCGTCTGCGCCGGCATTTGGGGCCGCCTGA
TCGCCGAAATGGTCGGCGAAGACCTGCCCGTCATGCCGGTCGATCATCCGCTCACCTTCTTCGGCCCCTACAACGAATTC
GAAGGCACCGGCAAGGAAATCGGCTTCCCGCTGCTGCGCGACCAGGGCAACTCGGCCTATATGCGCGACACCGGCGATCC
GAAGACCACCGAGGGCGGTCAGATCGAGTGGGGCTATTACGAGACCACCAATCCGCGCCTCTGCCATCCGCGCGACATTC
TCGAAAAACATCAGGCACGCCTGTCGCCGTCGCAGCGCGACCTCGAGATGGAGCAGATCATCGAGCCGCTCGAGCGCGCA
ATGGAATTGACGCCGATCCTCGGCGAGCTCGGCTATAATGAGAGCCACTCCTTCAACGGCCTGCTGCAGGTATCGGCCGC
CGGCGGGCCCTCCTGCGGCGAGAGTCAGAAGGTGCGCGGCCTCTGGTACTGCGTCGCTATCTGGGTGAAAGATGGCCCGG
GCTACGGCAAGCTGATCGCAGACTGGATGACGGACGGCCGCACCGAGATCGACCATGCGTCGATTGATTACGCCCGCTTC
TATCCGCACCAGCTCGAAGAGACGTTCATCGAGCAGCGCTGCTTCGAGGCTGCGCAGAAGATCTACTTCCCGGCCGTGCA
CCCGCGCGAGCCCTATGCGGGCGGCCGCAACGTCAAGCGCTCGCCCTTCTACGAGCGCGAAAAGGAACTCGGCGGCTACT
TCATGGAGCTCGGCGGCTGGGAGCGCGCGCACGGTTATGCCGCCAACGAGCACCTGCTCGAGAAATACGGCGACCGTGTT
CCGGTGCGCGAGAACGAGTGGGACAGCCGCCACTTCTGGCGCGTTTCCAACGCCGAACATCTGGCGATGAGCGAGGATTG
CGGCATCGTCAACCTCTCCCACTTCCACATGGTAGACATTGAAGGTCCTGACCACGTGGAGCTTCTTGAGTGGCTCTGCG
CCGCCAAGATCGGCGGCGACGGCAATATCGGCAAGGGCATCTACACGCATTTCCTCGACGACGAGGGCATGGTTCGGGCC
GATTTCACGGTTTTCCGCATGGCCGATCGCTGCCGTCTCGTGAACGGCGCCGATGCCGGGCCGCGCGACTTCCACTACAT
GCGCCGCGTCGCGGAAGACCGGGGCCTGGACGTCCGTATCACAGACGTTTCGGAGAGATTCACCACGATCGGTATCTGGG
GGCCGAATGCCCGCGAAACGCTGAAAAGGGTGGTGGCAGATCCGGCCGGTCTCGATCCCGAGAATTTCCCCTTCGCCGCA
ATCCGGCAGATGGAGATCGCCGGCAAGCCGGTCTCCGCCTTCCGCATCTCCTATGTCGGCGAACAAGGCTGGGAACTGCA
TATGAAATACGAGGACGGGCTTGCCGTCTGGGACGCGCTGCGCGCCACGGGGGTCATGGCCTTCGGCGTCGAGACCTATG
CCAACTCGCGCCGCATGGAAAAGAGCCTGCGCCTGCAGAACGCAGACCTTCTCACCCAATATAACCTTATCGAAGCCGAT
CTTGCCCGTCCGAAAGTCAAGGAAGCGGACTTCCGGGGCAAGGCGAAGCACCTGGAATACAAGGCGCGCGAGCACCAGCC
CGCCATGCTTTGCACGCTCGTGATGACGGAGAACACCGACGGGAACGGCGTGAGGCGCTACCCGGTCGGCAACCTGCCGG
TCATGGACCCGGAGACCGGCGATGTTCTGGTCGACGAACTCGGCCGCCGCTCCTACACCACTTCGATCGCATACGGTCCG
ACGATCGGCAAGAATATCGCGCTTGCCTATCTGCCCTGGTCCTACTGCCAGGTCGGACGAAGGCTCCATGTCGAGTATTT
CGCCGAGACCTATCCCGTCGAAGTGGCCGGCGTCGGTTACAAGCCTCTCTACGACCCGGAGAACCTGAAGCCGCGGACGT
AA

Upstream 100 bases:

>100_bases
CATTCTGGTCGTGCAGCACGATGATTATGTCGTAGACAGGCTCAAGTCGCGGCGCTGCAGGCTCTAATATCCGGCTTCAA
AATTAACCAGGGTCGCATCA

Downstream 100 bases:

>100_bases
GTTCCGCTGGAGACGGAGACAGGCCGCCTATGGCGCGACCAGCGCCCTTTGGAGCGTTTCGGTGTTCCTTGAAGCACTGA
AACGTTTCTGCCAGCGTTAT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 853; Mature: 852

Protein sequence:

>853_residues
MAEFPEKAKVVIVGLGGIVGASIAHHLIERGWDDIVGIDKSGIPTDIGSTAHASDFCYTTSHDYLSVWTTQYSIDFFDRM
GHYSRIGGLEVARTGDDVWMEEIKRKLSSAKAFGTRAHYVSPAEIKKLFPLIEEDQVMGGMFDPDAGLVVPRSQTVAGKL
VDAAEKSGKLRVFGNTPATALLVENGRIKGVVTHRGTILADHVVVCAGIWGRLIAEMVGEDLPVMPVDHPLTFFGPYNEF
EGTGKEIGFPLLRDQGNSAYMRDTGDPKTTEGGQIEWGYYETTNPRLCHPRDILEKHQARLSPSQRDLEMEQIIEPLERA
MELTPILGELGYNESHSFNGLLQVSAAGGPSCGESQKVRGLWYCVAIWVKDGPGYGKLIADWMTDGRTEIDHASIDYARF
YPHQLEETFIEQRCFEAAQKIYFPAVHPREPYAGGRNVKRSPFYEREKELGGYFMELGGWERAHGYAANEHLLEKYGDRV
PVRENEWDSRHFWRVSNAEHLAMSEDCGIVNLSHFHMVDIEGPDHVELLEWLCAAKIGGDGNIGKGIYTHFLDDEGMVRA
DFTVFRMADRCRLVNGADAGPRDFHYMRRVAEDRGLDVRITDVSERFTTIGIWGPNARETLKRVVADPAGLDPENFPFAA
IRQMEIAGKPVSAFRISYVGEQGWELHMKYEDGLAVWDALRATGVMAFGVETYANSRRMEKSLRLQNADLLTQYNLIEAD
LARPKVKEADFRGKAKHLEYKAREHQPAMLCTLVMTENTDGNGVRRYPVGNLPVMDPETGDVLVDELGRRSYTTSIAYGP
TIGKNIALAYLPWSYCQVGRRLHVEYFAETYPVEVAGVGYKPLYDPENLKPRT

Sequences:

>Translated_853_residues
MAEFPEKAKVVIVGLGGIVGASIAHHLIERGWDDIVGIDKSGIPTDIGSTAHASDFCYTTSHDYLSVWTTQYSIDFFDRM
GHYSRIGGLEVARTGDDVWMEEIKRKLSSAKAFGTRAHYVSPAEIKKLFPLIEEDQVMGGMFDPDAGLVVPRSQTVAGKL
VDAAEKSGKLRVFGNTPATALLVENGRIKGVVTHRGTILADHVVVCAGIWGRLIAEMVGEDLPVMPVDHPLTFFGPYNEF
EGTGKEIGFPLLRDQGNSAYMRDTGDPKTTEGGQIEWGYYETTNPRLCHPRDILEKHQARLSPSQRDLEMEQIIEPLERA
MELTPILGELGYNESHSFNGLLQVSAAGGPSCGESQKVRGLWYCVAIWVKDGPGYGKLIADWMTDGRTEIDHASIDYARF
YPHQLEETFIEQRCFEAAQKIYFPAVHPREPYAGGRNVKRSPFYEREKELGGYFMELGGWERAHGYAANEHLLEKYGDRV
PVRENEWDSRHFWRVSNAEHLAMSEDCGIVNLSHFHMVDIEGPDHVELLEWLCAAKIGGDGNIGKGIYTHFLDDEGMVRA
DFTVFRMADRCRLVNGADAGPRDFHYMRRVAEDRGLDVRITDVSERFTTIGIWGPNARETLKRVVADPAGLDPENFPFAA
IRQMEIAGKPVSAFRISYVGEQGWELHMKYEDGLAVWDALRATGVMAFGVETYANSRRMEKSLRLQNADLLTQYNLIEAD
LARPKVKEADFRGKAKHLEYKAREHQPAMLCTLVMTENTDGNGVRRYPVGNLPVMDPETGDVLVDELGRRSYTTSIAYGP
TIGKNIALAYLPWSYCQVGRRLHVEYFAETYPVEVAGVGYKPLYDPENLKPRT
>Mature_852_residues
AEFPEKAKVVIVGLGGIVGASIAHHLIERGWDDIVGIDKSGIPTDIGSTAHASDFCYTTSHDYLSVWTTQYSIDFFDRMG
HYSRIGGLEVARTGDDVWMEEIKRKLSSAKAFGTRAHYVSPAEIKKLFPLIEEDQVMGGMFDPDAGLVVPRSQTVAGKLV
DAAEKSGKLRVFGNTPATALLVENGRIKGVVTHRGTILADHVVVCAGIWGRLIAEMVGEDLPVMPVDHPLTFFGPYNEFE
GTGKEIGFPLLRDQGNSAYMRDTGDPKTTEGGQIEWGYYETTNPRLCHPRDILEKHQARLSPSQRDLEMEQIIEPLERAM
ELTPILGELGYNESHSFNGLLQVSAAGGPSCGESQKVRGLWYCVAIWVKDGPGYGKLIADWMTDGRTEIDHASIDYARFY
PHQLEETFIEQRCFEAAQKIYFPAVHPREPYAGGRNVKRSPFYEREKELGGYFMELGGWERAHGYAANEHLLEKYGDRVP
VRENEWDSRHFWRVSNAEHLAMSEDCGIVNLSHFHMVDIEGPDHVELLEWLCAAKIGGDGNIGKGIYTHFLDDEGMVRAD
FTVFRMADRCRLVNGADAGPRDFHYMRRVAEDRGLDVRITDVSERFTTIGIWGPNARETLKRVVADPAGLDPENFPFAAI
RQMEIAGKPVSAFRISYVGEQGWELHMKYEDGLAVWDALRATGVMAFGVETYANSRRMEKSLRLQNADLLTQYNLIEADL
ARPKVKEADFRGKAKHLEYKAREHQPAMLCTLVMTENTDGNGVRRYPVGNLPVMDPETGDVLVDELGRRSYTTSIAYGPT
IGKNIALAYLPWSYCQVGRRLHVEYFAETYPVEVAGVGYKPLYDPENLKPRT

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=859, Percent_Identity=26.8917345750873, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI197927446, Length=773, Percent_Identity=26.908150064683, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI21361378, Length=773, Percent_Identity=26.908150064683, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI194306651, Length=763, Percent_Identity=24.1153342070773, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1789272, Length=413, Percent_Identity=25.90799031477, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994045, Length=828, Percent_Identity=23.0676328502415, Blast_Score=149, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71994052, Length=835, Percent_Identity=22.7544910179641, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32563613, Length=834, Percent_Identity=24.1007194244604, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28571104, Length=767, Percent_Identity=25.2933507170795, Blast_Score=177, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20130091, Length=783, Percent_Identity=25.1596424010217, Blast_Score=167, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129441, Length=411, Percent_Identity=22.1411192214112, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 95606; Mature: 95475

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFPEKAKVVIVGLGGIVGASIAHHLIERGWDDIVGIDKSGIPTDIGSTAHASDFCYTT
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEC
SHDYLSVWTTQYSIDFFDRMGHYSRIGGLEVARTGDDVWMEEIKRKLSSAKAFGTRAHYV
CCCEEEEEEEEEEHHHHHHCCCHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC
SPAEIKKLFPLIEEDQVMGGMFDPDAGLVVPRSQTVAGKLVDAAEKSGKLRVFGNTPATA
CHHHHHHHHCCCCCCHHCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEE
LLVENGRIKGVVTHRGTILADHVVVCAGIWGRLIAEMVGEDLPVMPVDHPLTFFGPYNEF
EEEECCEEEEEEEECCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
EGTGKEIGFPLLRDQGNSAYMRDTGDPKTTEGGQIEWGYYETTNPRLCHPRDILEKHQAR
CCCCCCCCCCCEECCCCCEEEECCCCCCCCCCCEEEECEEECCCCCCCCHHHHHHHHHHH
LSPSQRDLEMEQIIEPLERAMELTPILGELGYNESHSFNGLLQVSAAGGPSCGESQKVRG
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCE
LWYCVAIWVKDGPGYGKLIADWMTDGRTEIDHASIDYARFYPHQLEETFIEQRCFEAAQK
EEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHH
IYFPAVHPREPYAGGRNVKRSPFYEREKELGGYFMELGGWERAHGYAANEHLLEKYGDRV
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCHHHCCCCHHHHHHHHHCCCC
PVRENEWDSRHFWRVSNAEHLAMSEDCGIVNLSHFHMVDIEGPDHVELLEWLCAAKIGGD
CCCCCCCCCCEEEEECCCCEEEECCCCCEEEECCEEEEECCCCCHHHHHHHHHHHHCCCC
GNIGKGIYTHFLDDEGMVRADFTVFRMADRCRLVNGADAGPRDFHYMRRVAEDRGLDVRI
CCCCCCCEEEECCCCCEEEECHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCEEEE
TDVSERFTTIGIWGPNARETLKRVVADPAGLDPENFPFAAIRQMEIAGKPVSAFRISYVG
EECCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHEEEEEEEC
EQGWELHMKYEDGLAVWDALRATGVMAFGVETYANSRRMEKSLRLQNADLLTQYNLIEAD
CCCCEEEEEECCCHHHHHHHHHHCEEEECHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
LARPKVKEADFRGKAKHLEYKAREHQPAMLCTLVMTENTDGNGVRRYPVGNLPVMDPETG
HCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEECCCCCCCCCCCCCC
DVLVDELGRRSYTTSIAYGPTIGKNIALAYLPWSYCQVGRRLHVEYFAETYPVEVAGVGY
CHHHHHHCCCCEEEEEEECCCCCCCEEEEECCHHHHHHCCEEEEEEHHCCCCEEEECCCC
KPLYDPENLKPRT
CCCCCCCCCCCCC
>Mature Secondary Structure 
AEFPEKAKVVIVGLGGIVGASIAHHLIERGWDDIVGIDKSGIPTDIGSTAHASDFCYTT
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEC
SHDYLSVWTTQYSIDFFDRMGHYSRIGGLEVARTGDDVWMEEIKRKLSSAKAFGTRAHYV
CCCEEEEEEEEEEHHHHHHCCCHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC
SPAEIKKLFPLIEEDQVMGGMFDPDAGLVVPRSQTVAGKLVDAAEKSGKLRVFGNTPATA
CHHHHHHHHCCCCCCHHCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEE
LLVENGRIKGVVTHRGTILADHVVVCAGIWGRLIAEMVGEDLPVMPVDHPLTFFGPYNEF
EEEECCEEEEEEEECCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
EGTGKEIGFPLLRDQGNSAYMRDTGDPKTTEGGQIEWGYYETTNPRLCHPRDILEKHQAR
CCCCCCCCCCCEECCCCCEEEECCCCCCCCCCCEEEECEEECCCCCCCCHHHHHHHHHHH
LSPSQRDLEMEQIIEPLERAMELTPILGELGYNESHSFNGLLQVSAAGGPSCGESQKVRG
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCE
LWYCVAIWVKDGPGYGKLIADWMTDGRTEIDHASIDYARFYPHQLEETFIEQRCFEAAQK
EEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHH
IYFPAVHPREPYAGGRNVKRSPFYEREKELGGYFMELGGWERAHGYAANEHLLEKYGDRV
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCHHHCCCCHHHHHHHHHCCCC
PVRENEWDSRHFWRVSNAEHLAMSEDCGIVNLSHFHMVDIEGPDHVELLEWLCAAKIGGD
CCCCCCCCCCEEEEECCCCEEEECCCCCEEEECCEEEEECCCCCHHHHHHHHHHHHCCCC
GNIGKGIYTHFLDDEGMVRADFTVFRMADRCRLVNGADAGPRDFHYMRRVAEDRGLDVRI
CCCCCCCEEEECCCCCEEEECHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCEEEE
TDVSERFTTIGIWGPNARETLKRVVADPAGLDPENFPFAAIRQMEIAGKPVSAFRISYVG
EECCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHEEEEEEEC
EQGWELHMKYEDGLAVWDALRATGVMAFGVETYANSRRMEKSLRLQNADLLTQYNLIEAD
CCCCEEEEEECCCHHHHHHHHHHCEEEECHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
LARPKVKEADFRGKAKHLEYKAREHQPAMLCTLVMTENTDGNGVRRYPVGNLPVMDPETG
HCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEECCCCCCCCCCCCCC
DVLVDELGRRSYTTSIAYGPTIGKNIALAYLPWSYCQVGRRLHVEYFAETYPVEVAGVGY
CHHHHHHCCCCEEEEEEECCCCCCCEEEEECCHHHHHHCCEEEEEEHHCCCCEEEECCCC
KPLYDPENLKPRT
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA