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The map label for this gene is hmuU [H]

Identifier: 150397540

GI number: 150397540

Start: 2417275

End: 2418390

Strand: Direct

Name: hmuU [H]

Synonym: Smed_2340

Alternate gene names: 150397540

Gene position: 2417275-2418390 (Clockwise)

Preceding gene: 150397539

Following gene: 150397541

Centisome position: 63.92

GC content: 67.29

Gene sequence:

>1116_bases
ATGGGCAACGGGGTCATGGAAAGTCCGATGCGCAAGCCCGCTTTCGCAGCTCGCGTCGTCCGCGACTGGCGCAGCGGGGA
CCGGGCAGGCCTGGCGCGCTGCCTGATCGTCGTCCTGACTCTGCTTGCGGTGGCGACGTTCATGACCTCCATCACCACCG
GCGCAGCGGACGCCTCGCTTGCCAATATCCTTCGATGGCTCACCGGCGAGGCCGATCAGGCGATGAGCGCACGCGACCGC
ATCATCATCCTCGATATCCGCCTGCCCCGCGCCGTGCTCGGGATGCTCGTCGGCGCATCGCTCGCAGTGTCGGGCGTGGT
AATGCAGGGCCTCTTCCGCAATCCGCTGGCCGATCCCGGCCTCGTCGGCGTCTCCTCCGGCGCAAGCCTCGGCGCGGTGC
TGCTGATCGTGCTCGGCGACGTCGCCTTCGGCCCGCTGTTCGCGGTTCTGGGCTTCTATGCCCTCCCCTTCGGCGCCTTT
CTGGGCGGGCTTGCCACGACGCTGCTGCTTTACCGGATCGCGACCCGCGGCGGCCAGACATCGGTCGCAACGATGCTGCT
TGCCGGCATCGCCCTCGGTGCGCTTGCCGGCGCGGTCACCGGGGTGCTCGTCTTCATCGCCGACGACAAACAATTGCGCG
ATCTCACCTTCTGGGGTCTTGGATCGCTGGCGGGCGCCAATTGGACCAAGATCGCCGCCGCCGGACCGATCATCCTCGTG
TCGCTGGCAGTCGTCCCGTTCCTGGCACGCGGCCTAAACGCCATCACCCTCGGCGAAGCCGCGGCGTACCACATGGGCAT
CCCGGTGCAGCGCCTGAAAAACATCGCCGTCTTCAGCGTCGCCGGAGCGACCGGCGCCTCGGTTGCGGTCAGCGGCGGCA
TCGGCTTCGTCGGCATCGTCGTTCCGCATCTCCTGCGGCTGGTGATCGGCCCGGATCATCGCTACCTGCTGCCGGCATCC
GCCCTCCTTGGAGGCACGTTGCTGATCTTCGCCGACATGCTCGCCCGCACCATCGTGTCGCCGGCGGAACTGCCGATCGG
CATCATCACCGCCTTCGTCGGAGCGCCGTTCTTCCTATGGGTCCTGCTGCGGGGCCGATCGAATATAGGACTTTGA

Upstream 100 bases:

>100_bases
GGACTGCATCTGCTCGGTTTCGGCCCTCGCACGGCAGGCGCGATCCGCGAATTGAATGCCGCGATCTACGGAAAGAAGAC
CAATGTCTCCCAGTAAGGCC

Downstream 100 bases:

>100_bases
CTGCAGCCATGATCAGAGCATTCGACATTTCCGTCCGCCTTGCGGGAAGGCAGGTCCTCCACGGCATCTCCTTCGACGCC
GCTCCCGGAGCCATGACGGC

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MGNGVMESPMRKPAFAARVVRDWRSGDRAGLARCLIVVLTLLAVATFMTSITTGAADASLANILRWLTGEADQAMSARDR
IIILDIRLPRAVLGMLVGASLAVSGVVMQGLFRNPLADPGLVGVSSGASLGAVLLIVLGDVAFGPLFAVLGFYALPFGAF
LGGLATTLLLYRIATRGGQTSVATMLLAGIALGALAGAVTGVLVFIADDKQLRDLTFWGLGSLAGANWTKIAAAGPIILV
SLAVVPFLARGLNAITLGEAAAYHMGIPVQRLKNIAVFSVAGATGASVAVSGGIGFVGIVVPHLLRLVIGPDHRYLLPAS
ALLGGTLLIFADMLARTIVSPAELPIGIITAFVGAPFFLWVLLRGRSNIGL

Sequences:

>Translated_371_residues
MGNGVMESPMRKPAFAARVVRDWRSGDRAGLARCLIVVLTLLAVATFMTSITTGAADASLANILRWLTGEADQAMSARDR
IIILDIRLPRAVLGMLVGASLAVSGVVMQGLFRNPLADPGLVGVSSGASLGAVLLIVLGDVAFGPLFAVLGFYALPFGAF
LGGLATTLLLYRIATRGGQTSVATMLLAGIALGALAGAVTGVLVFIADDKQLRDLTFWGLGSLAGANWTKIAAAGPIILV
SLAVVPFLARGLNAITLGEAAAYHMGIPVQRLKNIAVFSVAGATGASVAVSGGIGFVGIVVPHLLRLVIGPDHRYLLPAS
ALLGGTLLIFADMLARTIVSPAELPIGIITAFVGAPFFLWVLLRGRSNIGL
>Mature_370_residues
GNGVMESPMRKPAFAARVVRDWRSGDRAGLARCLIVVLTLLAVATFMTSITTGAADASLANILRWLTGEADQAMSARDRI
IILDIRLPRAVLGMLVGASLAVSGVVMQGLFRNPLADPGLVGVSSGASLGAVLLIVLGDVAFGPLFAVLGFYALPFGAFL
GGLATTLLLYRIATRGGQTSVATMLLAGIALGALAGAVTGVLVFIADDKQLRDLTFWGLGSLAGANWTKIAAAGPIILVS
LAVVPFLARGLNAITLGEAAAYHMGIPVQRLKNIAVFSVAGATGASVAVSGGIGFVGIVVPHLLRLVIGPDHRYLLPASA
LLGGTLLIFADMLARTIVSPAELPIGIITAFVGAPFFLWVLLRGRSNIGL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=40.6779661016949, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1790740, Length=301, Percent_Identity=37.5415282392027, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786805, Length=318, Percent_Identity=36.7924528301887, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1790741, Length=287, Percent_Identity=35.191637630662, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786347, Length=293, Percent_Identity=33.4470989761092, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786804, Length=337, Percent_Identity=29.673590504451, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 38140; Mature: 38009

Theoretical pI: Translated: 11.07; Mature: 11.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNGVMESPMRKPAFAARVVRDWRSGDRAGLARCLIVVLTLLAVATFMTSITTGAADASL
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ANILRWLTGEADQAMSARDRIIILDIRLPRAVLGMLVGASLAVSGVVMQGLFRNPLADPG
HHHHHHHCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LVGVSSGASLGAVLLIVLGDVAFGPLFAVLGFYALPFGAFLGGLATTLLLYRIATRGGQT
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SVATMLLAGIALGALAGAVTGVLVFIADDKQLRDLTFWGLGSLAGANWTKIAAAGPIILV
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCHHHCCCCCHHHHHCCHHHHH
SLAVVPFLARGLNAITLGEAAAYHMGIPVQRLKNIAVFSVAGATGASVAVSGGIGFVGIV
HHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHCCCCEEEECCCCCCCEEEECCCHHHHHH
VPHLLRLVIGPDHRYLLPASALLGGTLLIFADMLARTIVSPAELPIGIITAFVGAPFFLW
HHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHH
VLLRGRSNIGL
HHHHCCCCCCC
>Mature Secondary Structure 
GNGVMESPMRKPAFAARVVRDWRSGDRAGLARCLIVVLTLLAVATFMTSITTGAADASL
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ANILRWLTGEADQAMSARDRIIILDIRLPRAVLGMLVGASLAVSGVVMQGLFRNPLADPG
HHHHHHHCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LVGVSSGASLGAVLLIVLGDVAFGPLFAVLGFYALPFGAFLGGLATTLLLYRIATRGGQT
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SVATMLLAGIALGALAGAVTGVLVFIADDKQLRDLTFWGLGSLAGANWTKIAAAGPIILV
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCHHHCCCCCHHHHHCCHHHHH
SLAVVPFLARGLNAITLGEAAAYHMGIPVQRLKNIAVFSVAGATGASVAVSGGIGFVGIV
HHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHCCCCEEEECCCCCCCEEEECCCHHHHHH
VPHLLRLVIGPDHRYLLPASALLGGTLLIFADMLARTIVSPAELPIGIITAFVGAPFFLW
HHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHH
VLLRGRSNIGL
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]