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The map label for this gene is proC [H]

Identifier: 150397449

GI number: 150397449

Start: 2326652

End: 2327476

Strand: Reverse

Name: proC [H]

Synonym: Smed_2249

Alternate gene names: 150397449

Gene position: 2327476-2326652 (Counterclockwise)

Preceding gene: 150397450

Following gene: 150397448

Centisome position: 61.54

GC content: 66.18

Gene sequence:

>825_bases
GTGAGCATCGCCGTTAAGGGTCCGATCGTGCTTGTCGGTGCCGGCAATATGGGCGGCGCCATGCTCGCGGGTTGGCTGAA
AAGCGGGATCGCTGGTGGCGATCTTCTCGTAATCGATCCCGGACCGCCGCCTTCCATGGCGAAGCTGTTGGCGGATAACG
GTGTCCGACATTCGACGTCAGCTCCGGCGGGGATCAAAGCGCGCGTGGTCTTCCTTGCCGTCAAGCCGCAGGTGATGGAG
TCGGCTCTGCCGCCCGTAAAGGGGCTGGTCGGTTCCGAAACCGTGATCGTTTCCGTCGCCGCGGGCAAGACGCTCGGCTT
CATCGAGCGCCACCTCGGCGAGGCTGCAACGGTTCGCGCCATGCCGAACACGCCCGCCATGATCGGGCGCGGTGTGACCG
GTGCCTTCGCAAATGCCCGCGTCAGCGAAGCGCAGCGCGCGCTGGTGCACGATCTGCTGAAAGTCAGCGGTCCGGTTGAA
TGGGTCCGGACCGAAGCGGATATAGATGCCGTGACCGCCGTCTCCGGCAGCGGCCCCGCTTACGTCTTCTATCTCGTCGA
GTGCATGGCAGAGGCCGGGCGCAAGGCCGGCCTCGAGGCGGACCTAGCCATGCGTCTCGCTCGGGAAACCGTCGCGGGGG
CTGGTGAACTCCTCCATCAGTCCCCCGACGATGCAGCGCGCCTGCGCCAGAACGTTACGTCACCCGGCGGCACCACGGCT
GCGGCGCTCGACGTTCTGATGGGAGAGGGCGGCATGCAGCCGCTCTTCGATAAGGCCATTGCAACAGCCCGCAAGCGCGC
AGAAGAGCTGGCCGGCTCGCGGTAG

Upstream 100 bases:

>100_bases
GAATCCTATTTCCAGGCGTTCCAGTTCGTCGTCTGGTCGGGCATGGATGCGCAGCGCGCGGTGGACGCGGTTCTGTTCGA
GACCGTTGGGGAGGCATGAA

Downstream 100 bases:

>100_bases
TCTCGCCGTACAGTGCCGCGTGCGAACAAGATTTGAAGCGCCGTACGCACCACCCGAAGACAGAAGTCGCCGATTGCGTG
GCTGCGCTGGCGTCGTGCAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSIAVKGPIVLVGAGNMGGAMLAGWLKSGIAGGDLLVIDPGPPPSMAKLLADNGVRHSTSAPAGIKARVVFLAVKPQVME
SALPPVKGLVGSETVIVSVAAGKTLGFIERHLGEAATVRAMPNTPAMIGRGVTGAFANARVSEAQRALVHDLLKVSGPVE
WVRTEADIDAVTAVSGSGPAYVFYLVECMAEAGRKAGLEADLAMRLARETVAGAGELLHQSPDDAARLRQNVTSPGGTTA
AALDVLMGEGGMQPLFDKAIATARKRAEELAGSR

Sequences:

>Translated_274_residues
MSIAVKGPIVLVGAGNMGGAMLAGWLKSGIAGGDLLVIDPGPPPSMAKLLADNGVRHSTSAPAGIKARVVFLAVKPQVME
SALPPVKGLVGSETVIVSVAAGKTLGFIERHLGEAATVRAMPNTPAMIGRGVTGAFANARVSEAQRALVHDLLKVSGPVE
WVRTEADIDAVTAVSGSGPAYVFYLVECMAEAGRKAGLEADLAMRLARETVAGAGELLHQSPDDAARLRQNVTSPGGTTA
AALDVLMGEGGMQPLFDKAIATARKRAEELAGSR
>Mature_273_residues
SIAVKGPIVLVGAGNMGGAMLAGWLKSGIAGGDLLVIDPGPPPSMAKLLADNGVRHSTSAPAGIKARVVFLAVKPQVMES
ALPPVKGLVGSETVIVSVAAGKTLGFIERHLGEAATVRAMPNTPAMIGRGVTGAFANARVSEAQRALVHDLLKVSGPVEW
VRTEADIDAVTAVSGSGPAYVFYLVECMAEAGRKAGLEADLAMRLARETVAGAGELLHQSPDDAARLRQNVTSPGGTTAA
ALDVLMGEGGMQPLFDKAIATARKRAEELAGSR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=32.8358208955224, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=32.8358208955224, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=33.0855018587361, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=32.319391634981, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=34.9624060150376, Blast_Score=130, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=266, Percent_Identity=31.9548872180451, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17540664, Length=286, Percent_Identity=27.6223776223776, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320861, Length=229, Percent_Identity=31.8777292576419, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=36.4312267657993, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24648116, Length=271, Percent_Identity=29.8892988929889, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=38.3720930232558, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27976; Mature: 27845

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAVKGPIVLVGAGNMGGAMLAGWLKSGIAGGDLLVIDPGPPPSMAKLLADNGVRHSTS
CCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCC
APAGIKARVVFLAVKPQVMESALPPVKGLVGSETVIVSVAAGKTLGFIERHLGEAATVRA
CCCCCEEEEEEEEECHHHHHHCCCCHHHCCCCCEEEEEEECCCHHHHHHHHHCCCEEEEE
MPNTPAMIGRGVTGAFANARVSEAQRALVHDLLKVSGPVEWVRTEADIDAVTAVSGSGPA
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCC
YVFYLVECMAEAGRKAGLEADLAMRLARETVAGAGELLHQSPDDAARLRQNVTSPGGTTA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
AALDVLMGEGGMQPLFDKAIATARKRAEELAGSR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SIAVKGPIVLVGAGNMGGAMLAGWLKSGIAGGDLLVIDPGPPPSMAKLLADNGVRHSTS
CEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCC
APAGIKARVVFLAVKPQVMESALPPVKGLVGSETVIVSVAAGKTLGFIERHLGEAATVRA
CCCCCEEEEEEEEECHHHHHHCCCCHHHCCCCCEEEEEEECCCHHHHHHHHHCCCEEEEE
MPNTPAMIGRGVTGAFANARVSEAQRALVHDLLKVSGPVEWVRTEADIDAVTAVSGSGPA
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCC
YVFYLVECMAEAGRKAGLEADLAMRLARETVAGAGELLHQSPDDAARLRQNVTSPGGTTA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
AALDVLMGEGGMQPLFDKAIATARKRAEELAGSR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]