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The map label for this gene is mdh [H]

Identifier: 150397329

GI number: 150397329

Start: 2193177

End: 2194322

Strand: Reverse

Name: mdh [H]

Synonym: Smed_2128

Alternate gene names: 150397329

Gene position: 2194322-2193177 (Counterclockwise)

Preceding gene: 150397330

Following gene: 150397328

Centisome position: 58.02

GC content: 64.14

Gene sequence:

>1146_bases
ATGACCATCACCGCCAACTGGAGCTATCCGACCGCCGTCAAATTCGGCGCGGGCCGCATCAAGGAGCTCGCCGACCACTG
CAAGGCGCTCGGCATGAAGAAGCCGCTCCTGATCACAGATCGCGGTCTGGCGCCGATGCCGATCACGCAGAAGGCGCTTG
ACATTCTCGAGGCCGGCGGGCTCGGACGGGCGATCTTTGCCGACGTCGATCCCAACCCCAACGACAAGAACCTGGAAGCC
GGCGTGAAGGCATTCCGAAATGGCGGCCATGACGGCGTCGTCGCCTTCGGCGGCGGCTCGGGCCTCGATCTCGGCAAATG
CGTCGCCTTCATGGCCGGACAAACGCGGCCGGTCTGGGATTTCGAGGATATCGGCGACTGGTGGACGCGCGCGAGCGTCG
AAGGCATCGCTCCGATCGTCGCCGTTCCGACGACCGCCGGCACCGGTTCCGAGGTGGGCCGCGCCAGCGTCATCACCAAT
TCGGCAAGCCACGTCAAGAAGGTGATCTTCCACCCGAAATTCCTGCCGGGCGTGACCATCTGCGATCCGGAGCTCACCGT
CGGTATGCCCGAGGTGATCACCGCCGGCACAGGCATGGACGCCTTTGCCCATTGCCTGGAGGCCTATTCGTCGCCCTTCT
ATCATCCGATGTCGGCGGGTATAGCGCTGGAGGGGATGCGGCTCGTCAAGGAATACCTGCCGCGGGCCTACAAGGACGGT
ACGGATCTTGAAGCCCGGGCGAACATGATGAGCGCGGCGGCGATGGGAGCGGTCGCGTTCCAGAAGGGGCTCGGCGCGAT
CCACTCGCTGTCGCATCCCATCGGGGCGATCTATAACACCCATCACGGCATGACCAACGCTGTGGTGATGCCCCCGGTCC
TGCGGTTCAACCGTTTCGCAATCGATGAGAAGATCGGTCGCGCCGCCGCCTATCTCGGCATTGCCGGCGGCTTCGACGGT
TTCTACGACTATGTACTGCGGCTGCGGGAGGAACTCGGCGTTCCGGACAAGCTGTCGGCGCTTGGTGTCGGCACGGACCG
TATCGACGAGATGGCCGAGATGGCGATCGTCGATCCGACGGCCGGCGGCAATCCCGTCGAGCTGACGCTCGATGCCGCGA
AGAAGCTCTTCGCCGAATGCATTTGA

Upstream 100 bases:

>100_bases
GGACCGGCGTCAAGGAGACGGGGCGCGGCGGCTCGCTCTCGGTCCTCGGCTTCCACAATCTGACCCGCCCGAAATCCTAT
CATCTGAAGAAAGCGACCGC

Downstream 100 bases:

>100_bases
CCGGAGCCGTCGTTAATTTTTTCGAGCCCGGAAAACGCATGTTTTCCGGGCTTTTTCGTTAGTCTTCAATCGAAAATGCG
CCCTCCGGTTAACTTTTGGG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTITANWSYPTAVKFGAGRIKELADHCKALGMKKPLLITDRGLAPMPITQKALDILEAGGLGRAIFADVDPNPNDKNLEA
GVKAFRNGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWDFEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITN
SASHVKKVIFHPKFLPGVTICDPELTVGMPEVITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEYLPRAYKDG
TDLEARANMMSAAAMGAVAFQKGLGAIHSLSHPIGAIYNTHHGMTNAVVMPPVLRFNRFAIDEKIGRAAAYLGIAGGFDG
FYDYVLRLREELGVPDKLSALGVGTDRIDEMAEMAIVDPTAGGNPVELTLDAAKKLFAECI

Sequences:

>Translated_381_residues
MTITANWSYPTAVKFGAGRIKELADHCKALGMKKPLLITDRGLAPMPITQKALDILEAGGLGRAIFADVDPNPNDKNLEA
GVKAFRNGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWDFEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITN
SASHVKKVIFHPKFLPGVTICDPELTVGMPEVITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEYLPRAYKDG
TDLEARANMMSAAAMGAVAFQKGLGAIHSLSHPIGAIYNTHHGMTNAVVMPPVLRFNRFAIDEKIGRAAAYLGIAGGFDG
FYDYVLRLREELGVPDKLSALGVGTDRIDEMAEMAIVDPTAGGNPVELTLDAAKKLFAECI
>Mature_380_residues
TITANWSYPTAVKFGAGRIKELADHCKALGMKKPLLITDRGLAPMPITQKALDILEAGGLGRAIFADVDPNPNDKNLEAG
VKAFRNGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWDFEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITNS
ASHVKKVIFHPKFLPGVTICDPELTVGMPEVITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEYLPRAYKDGT
DLEARANMMSAAAMGAVAFQKGLGAIHSLSHPIGAIYNTHHGMTNAVVMPPVLRFNRFAIDEKIGRAAAYLGIAGGFDGF
YDYVLRLREELGVPDKLSALGVGTDRIDEMAEMAIVDPTAGGNPVELTLDAAKKLFAECI

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=351, Percent_Identity=29.3447293447293, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI48994951, Length=368, Percent_Identity=30.4347826086957, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789163, Length=378, Percent_Identity=31.7460317460317, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082107, Length=375, Percent_Identity=30.6666666666667, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787493, Length=390, Percent_Identity=28.974358974359, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789386, Length=402, Percent_Identity=27.1144278606965, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=389, Percent_Identity=25.9640102827763, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=373, Percent_Identity=34.0482573726542, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24657991, Length=387, Percent_Identity=26.0981912144703, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40333; Mature: 40202

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITANWSYPTAVKFGAGRIKELADHCKALGMKKPLLITDRGLAPMPITQKALDILEAGG
CEEECCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCCC
LGRAIFADVDPNPNDKNLEAGVKAFRNGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWD
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITNSASHVKKVIFHPKFLPGVTI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCEE
CDPELTVGMPEVITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEYLPRAYKDG
ECCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCC
TDLEARANMMSAAAMGAVAFQKGLGAIHSLSHPIGAIYNTHHGMTNAVVMPPVLRFNRFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEECCHHHHHHHHH
IDEKIGRAAAYLGIAGGFDGFYDYVLRLREELGVPDKLSALGVGTDRIDEMAEMAIVDPT
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHEEECCC
AGGNPVELTLDAAKKLFAECI
CCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
TITANWSYPTAVKFGAGRIKELADHCKALGMKKPLLITDRGLAPMPITQKALDILEAGG
EEECCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCCC
LGRAIFADVDPNPNDKNLEAGVKAFRNGGHDGVVAFGGGSGLDLGKCVAFMAGQTRPVWD
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITNSASHVKKVIFHPKFLPGVTI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCEE
CDPELTVGMPEVITAGTGMDAFAHCLEAYSSPFYHPMSAGIALEGMRLVKEYLPRAYKDG
ECCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCC
TDLEARANMMSAAAMGAVAFQKGLGAIHSLSHPIGAIYNTHHGMTNAVVMPPVLRFNRFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEECCHHHHHHHHH
IDEKIGRAAAYLGIAGGFDGFYDYVLRLREELGVPDKLSALGVGTDRIDEMAEMAIVDPT
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHEEECCC
AGGNPVELTLDAAKKLFAECI
CCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]