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The map label for this gene is penA [H]

Identifier: 150397289

GI number: 150397289

Start: 2146974

End: 2148722

Strand: Reverse

Name: penA [H]

Synonym: Smed_2088

Alternate gene names: 150397289

Gene position: 2148722-2146974 (Counterclockwise)

Preceding gene: 150397290

Following gene: 150397288

Centisome position: 56.82

GC content: 61.46

Gene sequence:

>1749_bases
ATGTCGTTTCTCTCCCGTATCATGGTGCTGAAGAGCAAGGCGCATTTCTCGGCTGGCGGCGATCATCGCACCACCGATGG
TGGTCTCAACGTTACCTTCGAAGGAACGCGCAAGAGGAGCGCAAGCCGGGCGAAGAGCCGCGTCGCGATCATGATAGCCA
GTTTCGGTGTCGTCTATGCGGTGATTGGAGGGCGTCTGGTTCAATACGGTCTGGCGCAACCGGAAACAGTGTCTTCGATC
GGCCGCGCCGACACTCTCATGGCATCGCGTCCGGATATTCTCGATCGCAATGGCGAGGTGCTCGCGACCGACATTCGCAC
CGTCTCGCTTTACGCGGAGCCGCACAAGATCGTCGACGCCGATGAGGCGGTGGAGCGATTGGCGACTGTTTTGCCCGACC
TCAATGCGCGCGAAATCTATAACAAGCTCAAGTCGGATTCGCGCTTCCAGTGGCTGCGCCGGCAGCTCACTCCGAAGCAG
CAGAGCGAAATCCTTGCGCTCGGCATTCCAGGTATCGGTTTCCGGCCGGAGAAGCGGCGCTTTTATCCCGGCGGACCGAC
CGCGGCTCACATTCTTGGCCACGTCAACATCGACAACCGCGGCGTCGCCGGTATGGAGCGCTACATCGACGAACAGGGGC
TCGCCGATCTTGCCGCCATCGGCATGACAAGCGATGCCAAGCTGGAGCCGGTCAGGCTGTCGATCGATGTACGCGTGCAG
AACATCGTGCGCGACGTCGTTGATTCCGGCATGAAGAATTATGAGGCGATCGCCGCCGGGGCCGTGGTGCTCGACGTGCA
TACCGGCGAAGTGCTGGCTATGGCCTCCGTTCCGGACTACGACCCGAACAGGCCCGCGGAAGGCGCCGAAGAGGGCTGGA
TGAACCGCATGTCGAACGGCACGTTCGAGATGGGCTCCACCTTCAAGACATTCACCATCGCAATGGGCCTCGACTCCGGC
AAGGTGACGCTCAATGACAGTTTCGATGCGACCCGGCCGATCCGCATCGGCGGCTTCACGATCAAGGACTTCCATGGCAA
GCGCCGCGTTCTGACAGTGCCGGAAATTTTCCAGTACTCATCGAATATCGGCACGGCCAAGATCGCCGACCTGATAGGCA
TTCCCGGCCACAAGGAGTTCCTCACGCGGATGGGCCTGCTGACGCGGCTCCCGACCGAACTGCCGGAGGTCAAGTCGCCG
AGCCAGCCTCGGGAGTGGAAGAAGATCAACTCGATCACGATCTCCTTCGGTCATGGCGTCTCCACGACGCCGCTGCAGAC
GGCTGTTGCAGGTGCCGCGCTGGTCAATGGCGGCAAGCTCATTCCGCCGAGCTTTCTGCCGCGCAGCGAGGAAGAGGCGA
GCGAACTCGCGAGCGCGGTGGTGAAAAAGAGCACGAGCGATGACATGCGCTACCTGCTGCGCCGGAACGGCATTGCCGGT
TCGGGCAAGCGGGCGCTCGTACCCGGCTTCAACGTCGGCGGCAAAACCGGCACGGCGGACAAGGTCGTCAATGGCCGCTA
TGCCAGCGACTTGAACTTCAATGCGTTCCTGGCCGCGTTTCCGATCGACAATCCCAAATATATGGTGCTGACCTTCATCG
ACGCGCCGAAAACGGGCGAGGGTGGGGGGCGTACCGCCGGCTCGAATGCCGCCCCTATGGTGCGCGACATCATCAGCCGC
TCCGCTCCGCTGCTCGGGGTCGAGCCTAAGTTTGGAGAAGACGGTTCTGCCTTGCTTGTGTCTTATTGA

Upstream 100 bases:

>100_bases
CTTCCGAAGAGGATAAGAAGGCCAAGGACAAGGCGGCGGCAGACAGCATCGCCGCAGTCATCGAGGCCGACAATATCAAA
ACAGGTTCGGTGGCGCGCTG

Downstream 100 bases:

>100_bases
CCGTGAAATGAAAGTGCGGACGATTCGCGATTCCGCTGCATGGCTCCTTGGATCGGAGTCGACCAAGGAAGAGACCATGC
TGCATTCTAAAGCCTATGGC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MSFLSRIMVLKSKAHFSAGGDHRTTDGGLNVTFEGTRKRSASRAKSRVAIMIASFGVVYAVIGGRLVQYGLAQPETVSSI
GRADTLMASRPDILDRNGEVLATDIRTVSLYAEPHKIVDADEAVERLATVLPDLNAREIYNKLKSDSRFQWLRRQLTPKQ
QSEILALGIPGIGFRPEKRRFYPGGPTAAHILGHVNIDNRGVAGMERYIDEQGLADLAAIGMTSDAKLEPVRLSIDVRVQ
NIVRDVVDSGMKNYEAIAAGAVVLDVHTGEVLAMASVPDYDPNRPAEGAEEGWMNRMSNGTFEMGSTFKTFTIAMGLDSG
KVTLNDSFDATRPIRIGGFTIKDFHGKRRVLTVPEIFQYSSNIGTAKIADLIGIPGHKEFLTRMGLLTRLPTELPEVKSP
SQPREWKKINSITISFGHGVSTTPLQTAVAGAALVNGGKLIPPSFLPRSEEEASELASAVVKKSTSDDMRYLLRRNGIAG
SGKRALVPGFNVGGKTGTADKVVNGRYASDLNFNAFLAAFPIDNPKYMVLTFIDAPKTGEGGGRTAGSNAAPMVRDIISR
SAPLLGVEPKFGEDGSALLVSY

Sequences:

>Translated_582_residues
MSFLSRIMVLKSKAHFSAGGDHRTTDGGLNVTFEGTRKRSASRAKSRVAIMIASFGVVYAVIGGRLVQYGLAQPETVSSI
GRADTLMASRPDILDRNGEVLATDIRTVSLYAEPHKIVDADEAVERLATVLPDLNAREIYNKLKSDSRFQWLRRQLTPKQ
QSEILALGIPGIGFRPEKRRFYPGGPTAAHILGHVNIDNRGVAGMERYIDEQGLADLAAIGMTSDAKLEPVRLSIDVRVQ
NIVRDVVDSGMKNYEAIAAGAVVLDVHTGEVLAMASVPDYDPNRPAEGAEEGWMNRMSNGTFEMGSTFKTFTIAMGLDSG
KVTLNDSFDATRPIRIGGFTIKDFHGKRRVLTVPEIFQYSSNIGTAKIADLIGIPGHKEFLTRMGLLTRLPTELPEVKSP
SQPREWKKINSITISFGHGVSTTPLQTAVAGAALVNGGKLIPPSFLPRSEEEASELASAVVKKSTSDDMRYLLRRNGIAG
SGKRALVPGFNVGGKTGTADKVVNGRYASDLNFNAFLAAFPIDNPKYMVLTFIDAPKTGEGGGRTAGSNAAPMVRDIISR
SAPLLGVEPKFGEDGSALLVSY
>Mature_581_residues
SFLSRIMVLKSKAHFSAGGDHRTTDGGLNVTFEGTRKRSASRAKSRVAIMIASFGVVYAVIGGRLVQYGLAQPETVSSIG
RADTLMASRPDILDRNGEVLATDIRTVSLYAEPHKIVDADEAVERLATVLPDLNAREIYNKLKSDSRFQWLRRQLTPKQQ
SEILALGIPGIGFRPEKRRFYPGGPTAAHILGHVNIDNRGVAGMERYIDEQGLADLAAIGMTSDAKLEPVRLSIDVRVQN
IVRDVVDSGMKNYEAIAAGAVVLDVHTGEVLAMASVPDYDPNRPAEGAEEGWMNRMSNGTFEMGSTFKTFTIAMGLDSGK
VTLNDSFDATRPIRIGGFTIKDFHGKRRVLTVPEIFQYSSNIGTAKIADLIGIPGHKEFLTRMGLLTRLPTELPEVKSPS
QPREWKKINSITISFGHGVSTTPLQTAVAGAALVNGGKLIPPSFLPRSEEEASELASAVVKKSTSDDMRYLLRRNGIAGS
GKRALVPGFNVGGKTGTADKVVNGRYASDLNFNAFLAAFPIDNPKYMVLTFIDAPKTGEGGGRTAGSNAAPMVRDIISRS
APLLGVEPKFGEDGSALLVSY

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=556, Percent_Identity=28.9568345323741, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1786854, Length=560, Percent_Identity=25, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62750; Mature: 62618

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLSRIMVLKSKAHFSAGGDHRTTDGGLNVTFEGTRKRSASRAKSRVAIMIASFGVVYA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHEEEEEEHHHHHHHH
VIGGRLVQYGLAQPETVSSIGRADTLMASRPDILDRNGEVLATDIRTVSLYAEPHKIVDA
HHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCCHHCCH
DEAVERLATVLPDLNAREIYNKLKSDSRFQWLRRQLTPKQQSEILALGIPGIGFRPEKRR
HHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCCCC
FYPGGPTAAHILGHVNIDNRGVAGMERYIDEQGLADLAAIGMTSDAKLEPVRLSIDVRVQ
CCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEEEHHHH
NIVRDVVDSGMKNYEAIAAGAVVLDVHTGEVLAMASVPDYDPNRPAEGAEEGWMNRMSNG
HHHHHHHHCCHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCC
TFEMGSTFKTFTIAMGLDSGKVTLNDSFDATRPIRIGGFTIKDFHGKRRVLTVPEIFQYS
CEECCCCEEEEEEEEECCCCEEEECCCCCCCCCEEECCEEEECCCCCCEEEECHHHHHHH
SNIGTAKIADLIGIPGHKEFLTRMGLLTRLPTELPEVKSPSQPREWKKINSITISFGHGV
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCEEEEEECCCC
STTPLQTAVAGAALVNGGKLIPPSFLPRSEEEASELASAVVKKSTSDDMRYLLRRNGIAG
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SGKRALVPGFNVGGKTGTADKVVNGRYASDLNFNAFLAAFPIDNPKYMVLTFIDAPKTGE
CCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCC
GGGRTAGSNAAPMVRDIISRSAPLLGVEPKFGEDGSALLVSY
CCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SFLSRIMVLKSKAHFSAGGDHRTTDGGLNVTFEGTRKRSASRAKSRVAIMIASFGVVYA
CHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHEEEEEEHHHHHHHH
VIGGRLVQYGLAQPETVSSIGRADTLMASRPDILDRNGEVLATDIRTVSLYAEPHKIVDA
HHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCCHHCCH
DEAVERLATVLPDLNAREIYNKLKSDSRFQWLRRQLTPKQQSEILALGIPGIGFRPEKRR
HHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCCCC
FYPGGPTAAHILGHVNIDNRGVAGMERYIDEQGLADLAAIGMTSDAKLEPVRLSIDVRVQ
CCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEEEHHHH
NIVRDVVDSGMKNYEAIAAGAVVLDVHTGEVLAMASVPDYDPNRPAEGAEEGWMNRMSNG
HHHHHHHHCCHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCC
TFEMGSTFKTFTIAMGLDSGKVTLNDSFDATRPIRIGGFTIKDFHGKRRVLTVPEIFQYS
CEECCCCEEEEEEEEECCCCEEEECCCCCCCCCEEECCEEEECCCCCCEEEECHHHHHHH
SNIGTAKIADLIGIPGHKEFLTRMGLLTRLPTELPEVKSPSQPREWKKINSITISFGHGV
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCEEEEEECCCC
STTPLQTAVAGAALVNGGKLIPPSFLPRSEEEASELASAVVKKSTSDDMRYLLRRNGIAG
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SGKRALVPGFNVGGKTGTADKVVNGRYASDLNFNAFLAAFPIDNPKYMVLTFIDAPKTGE
CCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCC
GGGRTAGSNAAPMVRDIISRSAPLLGVEPKFGEDGSALLVSY
CCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]