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The map label for this gene is yrpG [H]

Identifier: 150397156

GI number: 150397156

Start: 2005887

End: 2006936

Strand: Direct

Name: yrpG [H]

Synonym: Smed_1954

Alternate gene names: 150397156

Gene position: 2005887-2006936 (Clockwise)

Preceding gene: 150397155

Following gene: 150397158

Centisome position: 53.04

GC content: 63.71

Gene sequence:

>1050_bases
ATGGAATATCGTCAGCTCGGCCGATCCGGCCTCAAGATCTCGACCATCACCATGGGCACGATGACGATCGGCGGTGGCGG
CAAGTTCGCCCAGGTCGGCGACGTCGGTGTCGCGGATGCCAGCCGCCATGTCGACCTCTGCCTGGATGCCGGCGTCAACC
TCATCGATACGGCCGACATCTATTCAACCGGCGTCTGCGAGGAGATTATCGGCGAGGTTCTTGGCGGAAAGCGCAAGGAC
GGCGTGCTGATCGCCACAAAAGCACGCTTCTCCATGGGGCCGGGTCCGAACGACGGCGGCCTTTCGCGCCACCACCTGAT
CAGTGCCTGCGAGGCGAGCCTCAAGCGCTTGAAGACCGATGTGATCGACCTATACCAGGTGCATGAATGGGACGGCCAGA
CGCCGCTCGAGGAAACGATGGAAGCGCTCGATACACTCGTGCGGCAGGGCAAAGTTCGCTATATCGGCTGCTCCAACTAT
TCGGGCTGGCATATAATGAAGGCCCTCGGCGTCAGCGCCCTCGATAAACGCCAGCGTTTCGTCAGCCAGCAGATTCACTA
CACGCTGGAAGCCCGCGAGGCCGAGTACGAGCTGGTCCCGATTTCGATCGATCAGGGCCTTGGCATTCTCGTCTGGAGCC
CGCTCGCCGGCGGCCTTCTTTCAGGAAAGCACAGGCGTGGCCAGTCGCCGGAAGGCACACGCCAGCTCGCCGGCTGGAAC
GAGCCGCCGATCCGCGACGAGGAACGGCTGTGGAAAATCGTCGACATCCTGGTGGCGATCGCGGCCGAACGCGGCGTGTC
ACCGGCGCAGGTCGCCCTCGCCTGGCTGATCGGCCGCCAGGCCGTCACCTCCGTCATCATCGGTGGTCGAACCGAGCAAC
AGTTCCGCGACAATCTCGCCGCCGCCGGCCTGAGGCTCACCGAAGAGGAACGCGAGCTCCTCGAGGCCGTAAGCCGGCCG
CCGGTCATCTATCCGTACTGGCATCAGCTCTGGACCGCAAAGGACCGGCTCGGCAAAGCCGACCTCTCGCTTCTCGGACC
GCATGTGTGA

Upstream 100 bases:

>100_bases
CGAAGCCCGGCCTTATTTCCCGCTGTTCCCCTATAGGGATGCGATACCCCCGAGATTCCTCTAACAACCTTACTCGACCG
ACAACGCAAGGAGCGAGACA

Downstream 100 bases:

>100_bases
GTGACAGCACCTCTGAATTCGCGGCCGCCCCTCATGAGCTTGCTTACGCCGCCTGTGCAACCTCGCCGCGGACGAGGTCG
CCGAGTCGGCGGATGCCCTC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MEYRQLGRSGLKISTITMGTMTIGGGGKFAQVGDVGVADASRHVDLCLDAGVNLIDTADIYSTGVCEEIIGEVLGGKRKD
GVLIATKARFSMGPGPNDGGLSRHHLISACEASLKRLKTDVIDLYQVHEWDGQTPLEETMEALDTLVRQGKVRYIGCSNY
SGWHIMKALGVSALDKRQRFVSQQIHYTLEAREAEYELVPISIDQGLGILVWSPLAGGLLSGKHRRGQSPEGTRQLAGWN
EPPIRDEERLWKIVDILVAIAAERGVSPAQVALAWLIGRQAVTSVIIGGRTEQQFRDNLAAAGLRLTEEERELLEAVSRP
PVIYPYWHQLWTAKDRLGKADLSLLGPHV

Sequences:

>Translated_349_residues
MEYRQLGRSGLKISTITMGTMTIGGGGKFAQVGDVGVADASRHVDLCLDAGVNLIDTADIYSTGVCEEIIGEVLGGKRKD
GVLIATKARFSMGPGPNDGGLSRHHLISACEASLKRLKTDVIDLYQVHEWDGQTPLEETMEALDTLVRQGKVRYIGCSNY
SGWHIMKALGVSALDKRQRFVSQQIHYTLEAREAEYELVPISIDQGLGILVWSPLAGGLLSGKHRRGQSPEGTRQLAGWN
EPPIRDEERLWKIVDILVAIAAERGVSPAQVALAWLIGRQAVTSVIIGGRTEQQFRDNLAAAGLRLTEEERELLEAVSRP
PVIYPYWHQLWTAKDRLGKADLSLLGPHV
>Mature_349_residues
MEYRQLGRSGLKISTITMGTMTIGGGGKFAQVGDVGVADASRHVDLCLDAGVNLIDTADIYSTGVCEEIIGEVLGGKRKD
GVLIATKARFSMGPGPNDGGLSRHHLISACEASLKRLKTDVIDLYQVHEWDGQTPLEETMEALDTLVRQGKVRYIGCSNY
SGWHIMKALGVSALDKRQRFVSQQIHYTLEAREAEYELVPISIDQGLGILVWSPLAGGLLSGKHRRGQSPEGTRQLAGWN
EPPIRDEERLWKIVDILVAIAAERGVSPAQVALAWLIGRQAVTSVIIGGRTEQQFRDNLAAAGLRLTEEERELLEAVSRP
PVIYPYWHQLWTAKDRLGKADLSLLGPHV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=308, Percent_Identity=34.4155844155844, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4504825, Length=306, Percent_Identity=34.3137254901961, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI27436964, Length=310, Percent_Identity=34.8387096774194, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI27436962, Length=309, Percent_Identity=34.3042071197411, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI27436966, Length=309, Percent_Identity=33.9805825242718, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI27436971, Length=310, Percent_Identity=30.3225806451613, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI223718702, Length=276, Percent_Identity=32.2463768115942, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI41327764, Length=278, Percent_Identity=32.7338129496403, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI41152114, Length=278, Percent_Identity=31.294964028777, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI223718708, Length=146, Percent_Identity=34.9315068493151, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081735, Length=329, Percent_Identity=34.6504559270517, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1789199, Length=364, Percent_Identity=31.5934065934066, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789375, Length=324, Percent_Identity=31.4814814814815, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788070, Length=343, Percent_Identity=31.1953352769679, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788081, Length=274, Percent_Identity=32.1167883211679, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI48994888, Length=284, Percent_Identity=27.8169014084507, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212645785, Length=327, Percent_Identity=25.3822629969419, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325169, Length=339, Percent_Identity=32.1533923303835, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323998, Length=329, Percent_Identity=29.1793313069909, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319958, Length=306, Percent_Identity=29.0849673202614, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319951, Length=330, Percent_Identity=27.5757575757576, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6322615, Length=260, Percent_Identity=29.2307692307692, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321052, Length=163, Percent_Identity=33.1288343558282, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640980, Length=353, Percent_Identity=27.4787535410765, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45549126, Length=358, Percent_Identity=26.8156424581006, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646155, Length=332, Percent_Identity=29.5180722891566, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646159, Length=320, Percent_Identity=27.5, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 38221; Mature: 38221

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRQLGRSGLKISTITMGTMTIGGGGKFAQVGDVGVADASRHVDLCLDAGVNLIDTADI
CCHHHHCCCCCEEEEEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHCCCCEEECHHH
YSTGVCEEIIGEVLGGKRKDGVLIATKARFSMGPGPNDGGLSRHHLISACEASLKRLKTD
HHCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VIDLYQVHEWDGQTPLEETMEALDTLVRQGKVRYIGCSNYSGWHIMKALGVSALDKRQRF
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VSQQIHYTLEAREAEYELVPISIDQGLGILVWSPLAGGLLSGKHRRGQSPEGTRQLAGWN
HHHHHHEEEEECCCCEEEEEEEECCCCCEEEECCHHCHHHCCCCCCCCCCCCHHHHCCCC
EPPIRDEERLWKIVDILVAIAAERGVSPAQVALAWLIGRQAVTSVIIGGRTEQQFRDNLA
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AAGLRLTEEERELLEAVSRPPVIYPYWHQLWTAKDRLGKADLSLLGPHV
HHCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure
MEYRQLGRSGLKISTITMGTMTIGGGGKFAQVGDVGVADASRHVDLCLDAGVNLIDTADI
CCHHHHCCCCCEEEEEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHCCCCEEECHHH
YSTGVCEEIIGEVLGGKRKDGVLIATKARFSMGPGPNDGGLSRHHLISACEASLKRLKTD
HHCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VIDLYQVHEWDGQTPLEETMEALDTLVRQGKVRYIGCSNYSGWHIMKALGVSALDKRQRF
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VSQQIHYTLEAREAEYELVPISIDQGLGILVWSPLAGGLLSGKHRRGQSPEGTRQLAGWN
HHHHHHEEEEECCCCEEEEEEEECCCCCEEEECCHHCHHHCCCCCCCCCCCCHHHHCCCC
EPPIRDEERLWKIVDILVAIAAERGVSPAQVALAWLIGRQAVTSVIIGGRTEQQFRDNLA
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AAGLRLTEEERELLEAVSRPPVIYPYWHQLWTAKDRLGKADLSLLGPHV
HHCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]