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The map label for this gene is fabF [H]

Identifier: 150396941

GI number: 150396941

Start: 1818054

End: 1819337

Strand: Reverse

Name: fabF [H]

Synonym: Smed_1738

Alternate gene names: 150396941

Gene position: 1819337-1818054 (Counterclockwise)

Preceding gene: 150396942

Following gene: 150396940

Centisome position: 48.11

GC content: 63.63

Gene sequence:

>1284_bases
ATGAGCAAGGCGTATAAGGACCATCTCGGCCGTCCGATCATTGCCGTCACCGGCATGGGCGTCATAACTTCGCTCGGGCA
AGGTCTCGAAGACAATTGGTCGGCACTGACCGGGGGCGTTTCGGGCATTCACAAGATAACCCGTTTCCCGACCGACGCAC
TTTCCACCCGCATCAGCGGCACGGTCGATTTCATCGAGATTCCTGCGGAAAATGCCGTCGAGCGCTCCTATGCCATGGCG
CGCGAGACGACGCTGGAGGCTTTGGCGCAGGCCGGTCTTTCCGGCGATTTCAACGGGCCGCTTTTCCTGGCGGCCCCTCC
GATCGAGCCCGAATGGAATGCCCGCTTCGAGCTTGCCGACCGCTCGCCGCCATCGAGCCAGCCGGGAGATGCCTATAACC
GCTTCCTCGCGGCGATGCGGCAGAAGGCCGACCCGGTCTTCCACGAGGCCGTGCTCTTCGGCTCCATCTCGGAGCGCCTT
GCAGATCGTTTCGGCACACGCGGCCTTCCGGTGACTCTTTCGACTGCCTGTGCGTCGGGGGCGACAGCCATTCAGCTTGG
CGTGGAGGCTATCCGTCAGGGTCGGACCGACCGGGCGCTCACGGTCGCGACCGACGGTTCCGTCAGCGCGGAAGCGCTCA
TCCGTTTCTCGCTGCTGTCGGCACTCTCCACCCAGAACGATCCACCGGAAAAAGCCTCCAAGCCATTCACCAAGGACCGC
GACGGATTCGTGATCGCGGAAGGTGCTGCCACGCTGGTGCTTGAATCACTGGAGGCGGCGGTCGCACGCGGCGCCCGCAT
CTACGGCATTCTCAAGGGCTGCGGCGAAAAGGCCGACCTCTTCCACCGCACGCGCTCCTCGCCCGATGGCGGGCCGGCGA
TCGCGACGATCCGCGCGGCATTGGCCGATGCCGGTATTGACGAGGGCGGGATCGGTTACATCAATGCCCATGGCACCTCA
ACGCCCGAAAACGACAAGATGGAATATCTGTCGATGTCTGCGGTATTCGGCGAGCGGCTGCCGTCGATTCCGGTTTCGTC
GAACAAGTCGATGATCGGCCACACGTTGACGGCAGCCGGCGCGGTCGAGGCGGTCTTCTCGCTGCAGACGATGCTCACTG
GCACGTTGCCGCCGACGATCAACTACCAGAACCCGGACCCGGCGATCGTTCTCGATGTCGTGCCGAACGTGAAGCGCAGT
CAGCAGGTGACCGCAGTGCTGTCGAATTCCTTTGGCTTCGGCGGGCAGAACGCCAGCCTTGTCATGACCGCCGAGCCGGC
TTGA

Upstream 100 bases:

>100_bases
CCCGATGCTGGCGCCAGCAAAGGCGGCGGTCGTTACCACCATTGGCCACGCCCGCGGCGAAGGCATCGCCGTGCTTGCCG
CGGAATAAGGAGCTCGAATA

Downstream 100 bases:

>100_bases
TCCGCTCGAAGACCGAATATCTGCCTTCCGCAAAGGAAAGACCATGCGCGCCCTGCAATTGCTCGATGACCGCAAACTTG
AAATCACCGATCTGCCGGAG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSKAYKDHLGRPIIAVTGMGVITSLGQGLEDNWSALTGGVSGIHKITRFPTDALSTRISGTVDFIEIPAENAVERSYAMA
RETTLEALAQAGLSGDFNGPLFLAAPPIEPEWNARFELADRSPPSSQPGDAYNRFLAAMRQKADPVFHEAVLFGSISERL
ADRFGTRGLPVTLSTACASGATAIQLGVEAIRQGRTDRALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFTKDR
DGFVIAEGAATLVLESLEAAVARGARIYGILKGCGEKADLFHRTRSSPDGGPAIATIRAALADAGIDEGGIGYINAHGTS
TPENDKMEYLSMSAVFGERLPSIPVSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYQNPDPAIVLDVVPNVKRS
QQVTAVLSNSFGFGGQNASLVMTAEPA

Sequences:

>Translated_427_residues
MSKAYKDHLGRPIIAVTGMGVITSLGQGLEDNWSALTGGVSGIHKITRFPTDALSTRISGTVDFIEIPAENAVERSYAMA
RETTLEALAQAGLSGDFNGPLFLAAPPIEPEWNARFELADRSPPSSQPGDAYNRFLAAMRQKADPVFHEAVLFGSISERL
ADRFGTRGLPVTLSTACASGATAIQLGVEAIRQGRTDRALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFTKDR
DGFVIAEGAATLVLESLEAAVARGARIYGILKGCGEKADLFHRTRSSPDGGPAIATIRAALADAGIDEGGIGYINAHGTS
TPENDKMEYLSMSAVFGERLPSIPVSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYQNPDPAIVLDVVPNVKRS
QQVTAVLSNSFGFGGQNASLVMTAEPA
>Mature_426_residues
SKAYKDHLGRPIIAVTGMGVITSLGQGLEDNWSALTGGVSGIHKITRFPTDALSTRISGTVDFIEIPAENAVERSYAMAR
ETTLEALAQAGLSGDFNGPLFLAAPPIEPEWNARFELADRSPPSSQPGDAYNRFLAAMRQKADPVFHEAVLFGSISERLA
DRFGTRGLPVTLSTACASGATAIQLGVEAIRQGRTDRALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFTKDRD
GFVIAEGAATLVLESLEAAVARGARIYGILKGCGEKADLFHRTRSSPDGGPAIATIRAALADAGIDEGGIGYINAHGTST
PENDKMEYLSMSAVFGERLPSIPVSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYQNPDPAIVLDVVPNVKRSQ
QVTAVLSNSFGFGGQNASLVMTAEPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=427, Percent_Identity=33.7236533957845, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=40.8163265306122, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI41872631, Length=279, Percent_Identity=28.3154121863799, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=36.5384615384615, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=33.9667458432304, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71983541, Length=427, Percent_Identity=29.5081967213115, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=36.7816091954023, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=277, Percent_Identity=27.4368231046931, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=267, Percent_Identity=27.7153558052434, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=453, Percent_Identity=30.4635761589404, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=34.4339622641509, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581345, Length=278, Percent_Identity=26.6187050359712, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44804; Mature: 44673

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAYKDHLGRPIIAVTGMGVITSLGQGLEDNWSALTGGVSGIHKITRFPTDALSTRISG
CCCCCHHHCCCCEEEEECHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHCCHHHHHHHHCC
TVDFIEIPAENAVERSYAMARETTLEALAQAGLSGDFNGPLFLAAPPIEPEWNARFELAD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEECC
RSPPSSQPGDAYNRFLAAMRQKADPVFHEAVLFGSISERLADRFGTRGLPVTLSTACASG
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCC
ATAIQLGVEAIRQGRTDRALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFTKDR
CHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCC
DGFVIAEGAATLVLESLEAAVARGARIYGILKGCGEKADLFHRTRSSPDGGPAIATIRAA
CCEEEECCHHHHHHHHHHHHHHCCHHEEHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHH
LADAGIDEGGIGYINAHGTSTPENDKMEYLSMSAVFGERLPSIPVSSNKSMIGHTLTAAG
HHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AVEAVFSLQTMLTGTLPPTINYQNPDPAIVLDVVPNVKRSQQVTAVLSNSFGFGGQNASL
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEE
VMTAEPA
EEEECCC
>Mature Secondary Structure 
SKAYKDHLGRPIIAVTGMGVITSLGQGLEDNWSALTGGVSGIHKITRFPTDALSTRISG
CCCCHHHCCCCEEEEECHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHCCHHHHHHHHCC
TVDFIEIPAENAVERSYAMARETTLEALAQAGLSGDFNGPLFLAAPPIEPEWNARFELAD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEECC
RSPPSSQPGDAYNRFLAAMRQKADPVFHEAVLFGSISERLADRFGTRGLPVTLSTACASG
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCC
ATAIQLGVEAIRQGRTDRALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFTKDR
CHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCC
DGFVIAEGAATLVLESLEAAVARGARIYGILKGCGEKADLFHRTRSSPDGGPAIATIRAA
CCEEEECCHHHHHHHHHHHHHHCCHHEEHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHH
LADAGIDEGGIGYINAHGTSTPENDKMEYLSMSAVFGERLPSIPVSSNKSMIGHTLTAAG
HHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AVEAVFSLQTMLTGTLPPTINYQNPDPAIVLDVVPNVKRSQQVTAVLSNSFGFGGQNASL
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEE
VMTAEPA
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]