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The map label for this gene is pdhS [H]

Identifier: 150396809

GI number: 150396809

Start: 1695735

End: 1697270

Strand: Direct

Name: pdhS [H]

Synonym: Smed_1600

Alternate gene names: 150396809

Gene position: 1695735-1697270 (Clockwise)

Preceding gene: 150396805

Following gene: 150396810

Centisome position: 44.84

GC content: 60.61

Gene sequence:

>1536_bases
ATGAGCATCGCCGCCAGCACATCGACCGACAAGATCATAGTCGACAGATCGCGGAACCATCGAAACAAAGCTGTTTCGAA
GACCGTTCGCGCGACGCGTCAGCGGCTGCAGACCGGCTCCTCGGCACCATCCGGCTTCGAACGCGAAATGCTCCTGCTCC
ACATCGAGTCCGTACTCCACGGCGCGATGGCCCTGCCCCTCCTCGTGATCATGATCGCCGCCAGCGGCGTGTACCTCTCC
GGAGAAGCGAACATTCTCGTCTGGGCGCTGATGGCGCTTTCGGCGCACGCCGTCACCATCTTCCTTGCGCGCAAGGCCAA
GCGCGAGGATGTGGTCGCAGAAAAAGTCTCCGTCTGGCGCCGCCGTTTCCTCGCCTGCCAGGTGCTGACGGGCCTCTGTT
GGGCGATCTTCACGCTCCCGGACTGCGCGTCCTGCGGCCAGGTCGCTTCCGGTCTTTTCGAAGGAACAGTCCTCTTCATT
GCCCTCGCGATCACCGCCATGGGCACTTTCCTGTTGCGCAACGCCCTGTATTACACCTTCCTCCCGGTCCTTTGCGTGCT
CTGTTTCTCCGCGCTCGCGACCGGCGACCCGGTGGATATCGGCTTCGCGGGCATTCTGGCCCTCTCGCTGATATTCCTGG
CATTTATGACCGGCAGCATGAATCGCGCCAACGTCCATATCCTTTCCGTACAGTCCGAAAAGGACGACCTCATCGCCGAA
CTCGAGGTGGCCAAGTCCATGTCGGACGAGGCACGCCGCCGCGCGGAAGAAGCGAACCTAGCCAAATCGCGGTTCCTCGC
CTCGATGTCGCACGAGCTGCGCACTCCGCTCAATGCCATCCTCGGCTTCTCCGAGGTCATGTCCACCGAGGTGCTCGGCC
CCCTCAGCAACCCGACCTACAAGGAATACACGCTCGATATCCATCGCTCCGGCGAACACCTGTTGAATCTCATCAACGAG
ATCCTCGATCTTTCGCGTATCGAAGCCGGCAAGTACGAGCTCAGCGAGGACGCAGTGAACCTGGCAGAAATCGTAGAGGA
TTGCATCGGCATGGTTCAGCTGCGCGCCCGAAGCAAGAACATAACGATCGGTCAGCAGTTCGAACAGGCGATGCCATCAG
TCTGGGCTGACGAGAAGGCGATGCGTCAGGTGACGCTCAATCTGCTCTCGAACGCTGTCAAGTTCACGCCGTCGGGTGGC
GAAGTCAGCGTAAAGGTCGGCTGGACTGCCGGCGGCGGGCAATATCTTTCGATCAGGGACAATGGTCCTGGCATTCCGGA
AGAGGAAATCCCGATCGTTCTCTCCGCTTTCGGTCAGGGCTCGATTGCCATCAAGAGCGCCGAGCAAGGTACCGGGCTTG
GTCTGCCGATCGTCCAGGCTATTCTTGCCAAACACAATGGCCAGTTCATATTGCGCTCGAAGCTCAGGGTCGGTACTGAG
GCGATCGCCATCCTGCCGCCTCGACGTGTGCTGCAGAGCTTGCCGCCGGTCGAGGATGTCCCCTCCCTTACCCGCCGGCG
CAGAAGCTTTGCCTGA

Upstream 100 bases:

>100_bases
CGCAATCACGCCACAATGGTTGTCGAATCCTTCATGCGGGCAGCAACTTCTTAAGGATTGCATCCTACAGTGCAAGCTGA
ACCCAATCCTGATCAGAAGT

Downstream 100 bases:

>100_bases
GTGTCAGCTGCGCCTTTCCCTCGCACATTTGCAAGCGAAAGTTGCCGTAGCGCCCGCCCTTCCGCGCCGCGGACGCGGCG
CTGCTGGATTCCTGTGACAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSIAASTSTDKIIVDRSRNHRNKAVSKTVRATRQRLQTGSSAPSGFEREMLLLHIESVLHGAMALPLLVIMIAASGVYLS
GEANILVWALMALSAHAVTIFLARKAKREDVVAEKVSVWRRRFLACQVLTGLCWAIFTLPDCASCGQVASGLFEGTVLFI
ALAITAMGTFLLRNALYYTFLPVLCVLCFSALATGDPVDIGFAGILALSLIFLAFMTGSMNRANVHILSVQSEKDDLIAE
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSTEVLGPLSNPTYKEYTLDIHRSGEHLLNLINE
ILDLSRIEAGKYELSEDAVNLAEIVEDCIGMVQLRARSKNITIGQQFEQAMPSVWADEKAMRQVTLNLLSNAVKFTPSGG
EVSVKVGWTAGGGQYLSIRDNGPGIPEEEIPIVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHNGQFILRSKLRVGTE
AIAILPPRRVLQSLPPVEDVPSLTRRRRSFA

Sequences:

>Translated_511_residues
MSIAASTSTDKIIVDRSRNHRNKAVSKTVRATRQRLQTGSSAPSGFEREMLLLHIESVLHGAMALPLLVIMIAASGVYLS
GEANILVWALMALSAHAVTIFLARKAKREDVVAEKVSVWRRRFLACQVLTGLCWAIFTLPDCASCGQVASGLFEGTVLFI
ALAITAMGTFLLRNALYYTFLPVLCVLCFSALATGDPVDIGFAGILALSLIFLAFMTGSMNRANVHILSVQSEKDDLIAE
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSTEVLGPLSNPTYKEYTLDIHRSGEHLLNLINE
ILDLSRIEAGKYELSEDAVNLAEIVEDCIGMVQLRARSKNITIGQQFEQAMPSVWADEKAMRQVTLNLLSNAVKFTPSGG
EVSVKVGWTAGGGQYLSIRDNGPGIPEEEIPIVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHNGQFILRSKLRVGTE
AIAILPPRRVLQSLPPVEDVPSLTRRRRSFA
>Mature_510_residues
SIAASTSTDKIIVDRSRNHRNKAVSKTVRATRQRLQTGSSAPSGFEREMLLLHIESVLHGAMALPLLVIMIAASGVYLSG
EANILVWALMALSAHAVTIFLARKAKREDVVAEKVSVWRRRFLACQVLTGLCWAIFTLPDCASCGQVASGLFEGTVLFIA
LAITAMGTFLLRNALYYTFLPVLCVLCFSALATGDPVDIGFAGILALSLIFLAFMTGSMNRANVHILSVQSEKDDLIAEL
EVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSTEVLGPLSNPTYKEYTLDIHRSGEHLLNLINEI
LDLSRIEAGKYELSEDAVNLAEIVEDCIGMVQLRARSKNITIGQQFEQAMPSVWADEKAMRQVTLNLLSNAVKFTPSGGE
VSVKVGWTAGGGQYLSIRDNGPGIPEEEIPIVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHNGQFILRSKLRVGTEA
IAILPPRRVLQSLPPVEDVPSLTRRRRSFA

Specific function: Functions as a polar differentiation marker. Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm. Note=Localizes at the old pole of dividing cells. Colocalizes with divK (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=32.6771653543307, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=33.6996336996337, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081816, Length=316, Percent_Identity=32.5949367088608, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI48994928, Length=216, Percent_Identity=33.7962962962963, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693157, Length=335, Percent_Identity=28.6567164179104, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=30.2222222222222, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.9473684210526, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082128, Length=210, Percent_Identity=30.4761904761905, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=26.6949152542373, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=25, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=264, Percent_Identity=24.6212121212121, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=27.4038461538462, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=24.1525423728814, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=221, Percent_Identity=26.6968325791855, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55499; Mature: 55368

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAASTSTDKIIVDRSRNHRNKAVSKTVRATRQRLQTGSSAPSGFEREMLLLHIESVLH
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GAMALPLLVIMIAASGVYLSGEANILVWALMALSAHAVTIFLARKAKREDVVAEKVSVWR
HHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRFLACQVLTGLCWAIFTLPDCASCGQVASGLFEGTVLFIALAITAMGTFLLRNALYYTF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPVLCVLCFSALATGDPVDIGFAGILALSLIFLAFMTGSMNRANVHILSVQSEKDDLIAE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHH
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSTEVLGPLSNPTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KEYTLDIHRSGEHLLNLINEILDLSRIEAGKYELSEDAVNLAEIVEDCIGMVQLRARSKN
EEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ITIGQQFEQAMPSVWADEKAMRQVTLNLLSNAVKFTPSGGEVSVKVGWTAGGGQYLSIRD
CCCHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCEEEEEEC
NGPGIPEEEIPIVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHNGQFILRSKLRVGTE
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEHHHHCCCC
AIAILPPRRVLQSLPPVEDVPSLTRRRRSFA
EEEECCHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SIAASTSTDKIIVDRSRNHRNKAVSKTVRATRQRLQTGSSAPSGFEREMLLLHIESVLH
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GAMALPLLVIMIAASGVYLSGEANILVWALMALSAHAVTIFLARKAKREDVVAEKVSVWR
HHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRFLACQVLTGLCWAIFTLPDCASCGQVASGLFEGTVLFIALAITAMGTFLLRNALYYTF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPVLCVLCFSALATGDPVDIGFAGILALSLIFLAFMTGSMNRANVHILSVQSEKDDLIAE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHH
LEVAKSMSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSTEVLGPLSNPTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KEYTLDIHRSGEHLLNLINEILDLSRIEAGKYELSEDAVNLAEIVEDCIGMVQLRARSKN
EEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ITIGQQFEQAMPSVWADEKAMRQVTLNLLSNAVKFTPSGGEVSVKVGWTAGGGQYLSIRD
CCCHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCEEEEEEC
NGPGIPEEEIPIVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHNGQFILRSKLRVGTE
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEHHHHCCCC
AIAILPPRRVLQSLPPVEDVPSLTRRRRSFA
EEEECCHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA