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The map label for this gene is fabI1 [H]

Identifier: 150395736

GI number: 150395736

Start: 556171

End: 556989

Strand: Direct

Name: fabI1 [H]

Synonym: Smed_0512

Alternate gene names: 150395736

Gene position: 556171-556989 (Clockwise)

Preceding gene: 150395735

Following gene: 150395737

Centisome position: 14.71

GC content: 59.58

Gene sequence:

>819_bases
ATGGCTCAGGCATCGGGTCTGATGAATGGCAAGCGTGGCGTCATTATGGGCGTCGCAAACAATCGCTCGATCGCGTGGGG
CATCGCCAAGGCCTTGTCCGAGGCCGGGGCCGAGATCGCATTGACGTGGCAGGGGGACGCTCTGAAAAAGCGCGTCGAGC
CGCTTGCACAGGAGCTTGGTGCCTTCATGGCCGGCCATTGCGACGTGACCGACCTCACCACGATCGATGCCGTATTCTCG
GCCCTCGAAGAGAAATGGGGCAAGATCGACTTCGTCGTGCATGCGATTGCTTTCTCGGACAAGGACGAGTTGACGGGACG
CTACCTGGATACGAGCCGCGATAACTTCGCGCGAACGATGGATATCTCCGTTTACTCCTTCACGGCGGTCGCGGCGCGGG
CGGATCGCATCATGAATGATGGCGGTTCGATCCTGACGCTGACCTATTACGGTGCCGAGAAGGTGATGCCGCACTATAAT
GTCATGGGTGTCGCCAAGGCCGCCCTGGAGGCAAGCGTTCGTTATCTGGCGGTCGATCTCGGCAATCGCGGTATCCGTGT
CAACGCGATCTCCGCCGGCCCCATCAAGACGCTTGCGGCCTCCGGCATCGGTGATTTCCGCTATATCCTGAAGTGGAACG
AATACAACGCACCGCTGAAGCGGACGGTCTCGATCGAGGAGGTCGGCAATTCCGCACTCTACCTGCTTTCCGATCTGTCG
AGCGGTGTGACCGGCGAAGTCCATCATGTCGATTCGGGCTATCACACCGTTGGAATGAAGGCCGTCGACGCGCCGGACAT
CAGCGTACTCAAGGACTGA

Upstream 100 bases:

>100_bases
ACAATTGCCGCACGCACCTGCGCAGGCGCGGCATCATGACATTCGGTGAACATTGCCACCGGCGATAGCCGGTGGAGGCA
GACAGTATTGGGGACATTCC

Downstream 100 bases:

>100_bases
CAGCGTCGATCAAAAGCTACGAACTGCCGCATGGTCCTCGGATCCGCTCCGGTGTAAGGAAGTTGCGGCAGTTATGATTC
TAGAGCGGGATGAGGAAAGT

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAQASGLMNGKRGVIMGVANNRSIAWGIAKALSEAGAEIALTWQGDALKKRVEPLAQELGAFMAGHCDVTDLTTIDAVFS
ALEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTMDISVYSFTAVAARADRIMNDGGSILTLTYYGAEKVMPHYN
VMGVAKAALEASVRYLAVDLGNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLS
SGVTGEVHHVDSGYHTVGMKAVDAPDISVLKD

Sequences:

>Translated_272_residues
MAQASGLMNGKRGVIMGVANNRSIAWGIAKALSEAGAEIALTWQGDALKKRVEPLAQELGAFMAGHCDVTDLTTIDAVFS
ALEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTMDISVYSFTAVAARADRIMNDGGSILTLTYYGAEKVMPHYN
VMGVAKAALEASVRYLAVDLGNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLS
SGVTGEVHHVDSGYHTVGMKAVDAPDISVLKD
>Mature_271_residues
AQASGLMNGKRGVIMGVANNRSIAWGIAKALSEAGAEIALTWQGDALKKRVEPLAQELGAFMAGHCDVTDLTTIDAVFSA
LEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTMDISVYSFTAVAARADRIMNDGGSILTLTYYGAEKVMPHYNV
MGVAKAALEASVRYLAVDLGNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLSS
GVTGEVHHVDSGYHTVGMKAVDAPDISVLKD

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=50.5791505791506, Blast_Score=264, Evalue=4e-72,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=29.0836653386454, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=29.6577946768061, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=27.0992366412214, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=26.8482490272374, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=224, Percent_Identity=31.25, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29209; Mature: 29077

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQASGLMNGKRGVIMGVANNRSIAWGIAKALSEAGAEIALTWQGDALKKRVEPLAQELG
CCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
AFMAGHCDVTDLTTIDAVFSALEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTM
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHCCCEEECCCCCCCEEEE
DISVYSFTAVAARADRIMNDGGSILTLTYYGAEKVMPHYNVMGVAKAALEASVRYLAVDL
EEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHEEEEEEEE
GNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLS
CCCCEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCCHHHEEEHHHHCCCCEEEEEHHC
SGVTGEVHHVDSGYHTVGMKAVDAPDISVLKD
CCCCCEEEEECCCCEEECEEEECCCCCCEECC
>Mature Secondary Structure 
AQASGLMNGKRGVIMGVANNRSIAWGIAKALSEAGAEIALTWQGDALKKRVEPLAQELG
CCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
AFMAGHCDVTDLTTIDAVFSALEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTM
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHCCCEEECCCCCCCEEEE
DISVYSFTAVAARADRIMNDGGSILTLTYYGAEKVMPHYNVMGVAKAALEASVRYLAVDL
EEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHEEEEEEEE
GNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLS
CCCCEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCCHHHEEEHHHHCCCCEEEEEHHC
SGVTGEVHHVDSGYHTVGMKAVDAPDISVLKD
CCCCCEEEEECCCCEEECEEEECCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]