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The map label for this gene is lpxK [H]

Identifier: 150395651

GI number: 150395651

Start: 459818

End: 460858

Strand: Direct

Name: lpxK [H]

Synonym: Smed_0426

Alternate gene names: 150395651

Gene position: 459818-460858 (Clockwise)

Preceding gene: 150395650

Following gene: 150395654

Centisome position: 12.16

GC content: 64.55

Gene sequence:

>1041_bases
ATGGTTTCAGAAGCGCCCCCATTCTGGTGGACCAAGGCCGACTGGCGCGCCTATGCTCTTTGGCCCTTCTCCTGGCTCTA
TGGCCGTATCGCCGGAATGCGGATGGACCGCGCGCGCCGGGCCACCTCGGCCGTGCCGCTGATCTGCATCGGCAACTTCA
CAGTCGGTGGAGCCGGAAAGACACCGACGGCCATTGCGATTGCGCGGGCCGCCAAGGCAAGGGGCTTGAAGCCGGCTTTC
CTGAGCCGCGGCTATGGAGGATCGCTTGATGTCACGACCTTGGTCGACCCCGAACACCATCGCGCCCGCGACGTAGGCGA
CGAGCCGCTGCTGCTTGCCCGCGAGGCGCTCACGGTGATCTGCCGTCGCAGGGTGGACGGAGCACGGAAGCTTGCCGCGG
AAGGTGCGGATATCATCATCATGGACGATGGGTTCCAGAGTGCCCGGCTCGTGTTCGATTTTGCTCTTATCGTGGTCGAT
TCCGGCCGCGGCATCGGCAATGGCCATCTTGTCCCTTCCGGACCGGTCCGGGCGCCGATCGGCAATCAGCTGCGCCACGC
CACGGCCCTTCTGAAGCTCGGCCACGGTTCCGCTGCCGATCCCGTGGTTCGCCGAGCGTCCCGGGCAGGCAAGCCCGTCT
ATGTGGCTGAAACCGTGCGCATCGACGAGGGATCTCTCGTCGGCGTCAAGGTTCTCGCCTGGGCCGGGATTGCGGATACG
GAGAAGTTCTTCAAAACGGTGCGCGAAACCGGCGCGATCATCGAGGAAACCCGAAGCTTTCCGGATCACCATCATTTCTC
CGAGGACGAGATTGCCGACCTCATCGATCGTGCAACAAGCCGGGGCTACACGCTCGTGACCACGGCCAAGGACATTGTTC
GTCTGGAGCCTGGCCACGGACGGGCAGGGGAACTGGCGGCAAAGAGCCGCGTCATCGAGATCGAGGTGCGCTTCGACGAT
CCGGCAGCGCCGGGGAAGATCATCGACGCGGCGCTTGCTTCCGCACGCGCACGCCGGCTGCGCGAGCACAAGTCGGGTTA
A

Upstream 100 bases:

>100_bases
GGTATACCGCTAACGGCCGATGCTCGCGGCGGAAGTTCTGGATATTGCTTCTTCTGCCCATGGGGACAGGAGCGGCCCTG
CGGATATTTTTGGGTAAAAG

Downstream 100 bases:

>100_bases
GTCGAGGCCTTTTTCATGCTGGTGTCGCACCGCGTCCCTTCGCGCCGCCTGCGGCGAGACGGTGCGGACGGGCGGATAAG
GGGCCTTTTCGGGCGCGTAC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVSEAPPFWWTKADWRAYALWPFSWLYGRIAGMRMDRARRATSAVPLICIGNFTVGGAGKTPTAIAIARAAKARGLKPAF
LSRGYGGSLDVTTLVDPEHHRARDVGDEPLLLAREALTVICRRRVDGARKLAAEGADIIIMDDGFQSARLVFDFALIVVD
SGRGIGNGHLVPSGPVRAPIGNQLRHATALLKLGHGSAADPVVRRASRAGKPVYVAETVRIDEGSLVGVKVLAWAGIADT
EKFFKTVRETGAIIEETRSFPDHHHFSEDEIADLIDRATSRGYTLVTTAKDIVRLEPGHGRAGELAAKSRVIEIEVRFDD
PAAPGKIIDAALASARARRLREHKSG

Sequences:

>Translated_346_residues
MVSEAPPFWWTKADWRAYALWPFSWLYGRIAGMRMDRARRATSAVPLICIGNFTVGGAGKTPTAIAIARAAKARGLKPAF
LSRGYGGSLDVTTLVDPEHHRARDVGDEPLLLAREALTVICRRRVDGARKLAAEGADIIIMDDGFQSARLVFDFALIVVD
SGRGIGNGHLVPSGPVRAPIGNQLRHATALLKLGHGSAADPVVRRASRAGKPVYVAETVRIDEGSLVGVKVLAWAGIADT
EKFFKTVRETGAIIEETRSFPDHHHFSEDEIADLIDRATSRGYTLVTTAKDIVRLEPGHGRAGELAAKSRVIEIEVRFDD
PAAPGKIIDAALASARARRLREHKSG
>Mature_346_residues
MVSEAPPFWWTKADWRAYALWPFSWLYGRIAGMRMDRARRATSAVPLICIGNFTVGGAGKTPTAIAIARAAKARGLKPAF
LSRGYGGSLDVTTLVDPEHHRARDVGDEPLLLAREALTVICRRRVDGARKLAAEGADIIIMDDGFQSARLVFDFALIVVD
SGRGIGNGHLVPSGPVRAPIGNQLRHATALLKLGHGSAADPVVRRASRAGKPVYVAETVRIDEGSLVGVKVLAWAGIADT
EKFFKTVRETGAIIEETRSFPDHHHFSEDEIADLIDRATSRGYTLVTTAKDIVRLEPGHGRAGELAAKSRVIEIEVRFDD
PAAPGKIIDAALASARARRLREHKSG

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=291, Percent_Identity=32.6460481099656, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37430; Mature: 37430

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEAPPFWWTKADWRAYALWPFSWLYGRIAGMRMDRARRATSAVPLICIGNFTVGGAGK
CCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEECCCCC
TPTAIAIARAAKARGLKPAFLSRGYGGSLDVTTLVDPEHHRARDVGDEPLLLAREALTVI
CCHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHH
CRRRVDGARKLAAEGADIIIMDDGFQSARLVFDFALIVVDSGRGIGNGHLVPSGPVRAPI
HHHHCCHHHHHHHCCCCEEEECCCCCHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCC
GNQLRHATALLKLGHGSAADPVVRRASRAGKPVYVAETVRIDEGSLVGVKVLAWAGIADT
CHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEEEEEECCCCCH
EKFFKTVRETGAIIEETRSFPDHHHFSEDEIADLIDRATSRGYTLVTTAKDIVRLEPGHG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHEEECCCCC
RAGELAAKSRVIEIEVRFDDPAAPGKIIDAALASARARRLREHKSG
CCCCHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSEAPPFWWTKADWRAYALWPFSWLYGRIAGMRMDRARRATSAVPLICIGNFTVGGAGK
CCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEECCCCC
TPTAIAIARAAKARGLKPAFLSRGYGGSLDVTTLVDPEHHRARDVGDEPLLLAREALTVI
CCHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHH
CRRRVDGARKLAAEGADIIIMDDGFQSARLVFDFALIVVDSGRGIGNGHLVPSGPVRAPI
HHHHCCHHHHHHHCCCCEEEECCCCCHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCC
GNQLRHATALLKLGHGSAADPVVRRASRAGKPVYVAETVRIDEGSLVGVKVLAWAGIADT
CHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEEEEEECCCCCH
EKFFKTVRETGAIIEETRSFPDHHHFSEDEIADLIDRATSRGYTLVTTAKDIVRLEPGHG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHEEECCCCC
RAGELAAKSRVIEIEVRFDDPAAPGKIIDAALASARARRLREHKSG
CCCCHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]