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The map label for this gene is katA [H]

Identifier: 150395608

GI number: 150395608

Start: 410335

End: 411819

Strand: Direct

Name: katA [H]

Synonym: Smed_0383

Alternate gene names: 150395608

Gene position: 410335-411819 (Clockwise)

Preceding gene: 150395606

Following gene: 150395610

Centisome position: 10.85

GC content: 61.01

Gene sequence:

>1485_bases
ATGACAGATCGTCCGACGATGACCACGACCGCCGGTGCACCGGTGCCGGACAACCAGAACGCGCTGACTGCGGGGCCGCG
CGGCGGCATCATGATGCAGGACTACCAGCTCATCGAGAAGCTGGCGCACCAGAACCGCGAGCGCATTCCGGAACGCGTCG
TGCATGCCAAGGGCTGGGGTGCCTTCGGGACGTTGAAGATCACGGGCGACATCTCGGAATATACAAAGGCAATGTGTCTC
CAGCCCGGCGCCGAAACGCCGATGCTTGCCCGCTTCTCGACCGTGGCCGGCGAGCAGGGCGCCGCCGATCACGAGCGTGA
CGTCCGCGGTTTCGCGCTGAAGTTCTATACCGGGGAGGGGAACTGGGATCTCGTCGGCAACAACACGCCCGTCTTCTTCA
TCCGGGATCCCTACAAGTTCCCGGACTTCATCCATACGCAGAAGCGGCATCCGAAGACCAATCTTCGCTCCGCCACCGCC
ATGTGGGACTACTGGTCACTCTCGCCGGAAAGCTTGCATCAGGTGACGATCCTGATGTCCGATCGCGGCCTGCCGCAGAC
GCCGATGCATATGAACGGCTATGGCTCGCACACCTACTCCTTCTGGAACGACGCAGGCGAGCGCTATTGGGTCAAGTTCC
ACTTCAAGACACAGCAGGACCACAAGTTCTTTACCAATGAAGAAGGCGAAGCGGTCATAGGCAAGACCCGCGAGGGCTAT
CAGGAGGCGCTGTTTTACGCCATAGAGAACGGCGCGTTTCCGCGCTGGACCGTGCAGGTCCAGATCATGCCGGAGCTCGA
TTCCGAAAAGACGCCGTACAACCCGTTCGACCTGACGAAGGTTTGGCCGCACGCCGATTTCCCGCCGATCGAGATCGGCG
TGCTGGAACTCAACCGCAACCCCGAAAATTACTTCGCCGAGATCGAAAACGCGGCCTTCTCGCCTTCCAACATCGTTCCG
GGCATCGGCTTCTCGCCGGACAAAGTGCTGCAGGCGCGACTGTTCTCCTATGCGGACGCCCACCGCTATCGCCTCGGCAC
CCATTACGAAAACATCCCGGTCAACCAGCCGCGCTGCCCGGTTCACCATTATCATCGCGATGGTCAGATGAACACCTATG
GCGGCATTCGCACCGGCAACCCGGAGGCCTATTACGAGCCGAACTCCTTCGATGGTCCGGCGGAACAACCGCTTGCCAAG
GAACCGCCGCTAAAGGTGGACGGCGACATGTCGCGCTACGATCACCGCGTGGGCAATGACGATTATGTCCAGGTGCGCGC
CTTGTTCAACCTCTTCGACGAAGGGCAGAAGTCGCGCCTCTTCTCCAACATCGCAGCTGCGATGGGCGGCGTTCCGAGCG
AGATCATCGAGCGGCAGCTCATTCATTTCGCCCGGGTTCATCCGGACTATGAGACAGGCGTTCGCGCGGCGTTGAAGGCC
GCCCACGGCTACGGGGCGGATACGATCAGTACGGCTGCCGAGTAA

Upstream 100 bases:

>100_bases
CGTATATAGCAGAAAATACAATTGGAGATTATTGCCGACGGGTGGGAGAAAACGACGCAAGGCATTTGCCGTGCCGAAAC
GTTGAAAGATGAGGGATGTA

Downstream 100 bases:

>100_bases
AAGGCGCCGGTCGGCGAAAAACGAAGGCCACGCCCATGCAGGACGTGGCCTTCGTCATTGAGGAGAGGAGGCAGGTAGGG
AGGTCACCAGCCCGGCAGCA

Product: catalase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTDRPTMTTTAGAPVPDNQNALTAGPRGGIMMQDYQLIEKLAHQNRERIPERVVHAKGWGAFGTLKITGDISEYTKAMCL
QPGAETPMLARFSTVAGEQGAADHERDVRGFALKFYTGEGNWDLVGNNTPVFFIRDPYKFPDFIHTQKRHPKTNLRSATA
MWDYWSLSPESLHQVTILMSDRGLPQTPMHMNGYGSHTYSFWNDAGERYWVKFHFKTQQDHKFFTNEEGEAVIGKTREGY
QEALFYAIENGAFPRWTVQVQIMPELDSEKTPYNPFDLTKVWPHADFPPIEIGVLELNRNPENYFAEIENAAFSPSNIVP
GIGFSPDKVLQARLFSYADAHRYRLGTHYENIPVNQPRCPVHHYHRDGQMNTYGGIRTGNPEAYYEPNSFDGPAEQPLAK
EPPLKVDGDMSRYDHRVGNDDYVQVRALFNLFDEGQKSRLFSNIAAAMGGVPSEIIERQLIHFARVHPDYETGVRAALKA
AHGYGADTISTAAE

Sequences:

>Translated_494_residues
MTDRPTMTTTAGAPVPDNQNALTAGPRGGIMMQDYQLIEKLAHQNRERIPERVVHAKGWGAFGTLKITGDISEYTKAMCL
QPGAETPMLARFSTVAGEQGAADHERDVRGFALKFYTGEGNWDLVGNNTPVFFIRDPYKFPDFIHTQKRHPKTNLRSATA
MWDYWSLSPESLHQVTILMSDRGLPQTPMHMNGYGSHTYSFWNDAGERYWVKFHFKTQQDHKFFTNEEGEAVIGKTREGY
QEALFYAIENGAFPRWTVQVQIMPELDSEKTPYNPFDLTKVWPHADFPPIEIGVLELNRNPENYFAEIENAAFSPSNIVP
GIGFSPDKVLQARLFSYADAHRYRLGTHYENIPVNQPRCPVHHYHRDGQMNTYGGIRTGNPEAYYEPNSFDGPAEQPLAK
EPPLKVDGDMSRYDHRVGNDDYVQVRALFNLFDEGQKSRLFSNIAAAMGGVPSEIIERQLIHFARVHPDYETGVRAALKA
AHGYGADTISTAAE
>Mature_493_residues
TDRPTMTTTAGAPVPDNQNALTAGPRGGIMMQDYQLIEKLAHQNRERIPERVVHAKGWGAFGTLKITGDISEYTKAMCLQ
PGAETPMLARFSTVAGEQGAADHERDVRGFALKFYTGEGNWDLVGNNTPVFFIRDPYKFPDFIHTQKRHPKTNLRSATAM
WDYWSLSPESLHQVTILMSDRGLPQTPMHMNGYGSHTYSFWNDAGERYWVKFHFKTQQDHKFFTNEEGEAVIGKTREGYQ
EALFYAIENGAFPRWTVQVQIMPELDSEKTPYNPFDLTKVWPHADFPPIEIGVLELNRNPENYFAEIENAAFSPSNIVPG
IGFSPDKVLQARLFSYADAHRYRLGTHYENIPVNQPRCPVHHYHRDGQMNTYGGIRTGNPEAYYEPNSFDGPAEQPLAKE
PPLKVDGDMSRYDHRVGNDDYVQVRALFNLFDEGQKSRLFSNIAAAMGGVPSEIIERQLIHFARVHPDYETGVRAALKAA
HGYGADTISTAAE

Specific function: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide [H]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=477, Percent_Identity=51.3626834381551, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI48994891, Length=399, Percent_Identity=44.8621553884712, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71998444, Length=478, Percent_Identity=49.163179916318, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI25147792, Length=477, Percent_Identity=47.7987421383648, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI25151141, Length=476, Percent_Identity=47.8991596638655, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320462, Length=493, Percent_Identity=44.2190669371197, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321525, Length=490, Percent_Identity=36.3265306122449, Blast_Score=300, Evalue=2e-82,
Organism=Drosophila melanogaster, GI17981717, Length=480, Percent_Identity=46.4583333333333, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI19920968, Length=480, Percent_Identity=41.6666666666667, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002226
- InterPro:   IPR020835
- InterPro:   IPR010582
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase; PF06628 Catalase-rel [H]

EC number: =1.11.1.6 [H]

Molecular weight: Translated: 55825; Mature: 55694

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00437 CATALASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRPTMTTTAGAPVPDNQNALTAGPRGGIMMQDYQLIEKLAHQNRERIPERVVHAKGWG
CCCCCCEEECCCCCCCCCCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AFGTLKITGDISEYTKAMCLQPGAETPMLARFSTVAGEQGAADHERDVRGFALKFYTGEG
CEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NWDLVGNNTPVFFIRDPYKFPDFIHTQKRHPKTNLRSATAMWDYWSLSPESLHQVTILMS
CEEEECCCCCEEEEECCCCCCHHHHHHCCCCCCCCCHHHHEEHCCCCCHHHHEEEEEEEE
DRGLPQTPMHMNGYGSHTYSFWNDAGERYWVKFHFKTQQDHKFFTNEEGEAVIGKTREGY
CCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCCHHHH
QEALFYAIENGAFPRWTVQVQIMPELDSEKTPYNPFDLTKVWPHADFPPIEIGVLELNRN
HHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEECCC
PENYFAEIENAAFSPSNIVPGIGFSPDKVLQARLFSYADAHRYRLGTHYENIPVNQPRCP
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VHHYHRDGQMNTYGGIRTGNPEAYYEPNSFDGPAEQPLAKEPPLKVDGDMSRYDHRVGND
HHHHCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
DYVQVRALFNLFDEGQKSRLFSNIAAAMGGVPSEIIERQLIHFARVHPDYETGVRAALKA
CHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AHGYGADTISTAAE
HCCCCCCHHHHCCC
>Mature Secondary Structure 
TDRPTMTTTAGAPVPDNQNALTAGPRGGIMMQDYQLIEKLAHQNRERIPERVVHAKGWG
CCCCCEEECCCCCCCCCCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AFGTLKITGDISEYTKAMCLQPGAETPMLARFSTVAGEQGAADHERDVRGFALKFYTGEG
CEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NWDLVGNNTPVFFIRDPYKFPDFIHTQKRHPKTNLRSATAMWDYWSLSPESLHQVTILMS
CEEEECCCCCEEEEECCCCCCHHHHHHCCCCCCCCCHHHHEEHCCCCCHHHHEEEEEEEE
DRGLPQTPMHMNGYGSHTYSFWNDAGERYWVKFHFKTQQDHKFFTNEEGEAVIGKTREGY
CCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCCHHHH
QEALFYAIENGAFPRWTVQVQIMPELDSEKTPYNPFDLTKVWPHADFPPIEIGVLELNRN
HHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEECCC
PENYFAEIENAAFSPSNIVPGIGFSPDKVLQARLFSYADAHRYRLGTHYENIPVNQPRCP
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VHHYHRDGQMNTYGGIRTGNPEAYYEPNSFDGPAEQPLAKEPPLKVDGDMSRYDHRVGND
HHHHCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
DYVQVRALFNLFDEGQKSRLFSNIAAAMGGVPSEIIERQLIHFARVHPDYETGVRAALKA
CHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AHGYGADTISTAAE
HCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955300; 11481430 [H]