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The map label for this gene is flhA [H]

Identifier: 150395510

GI number: 150395510

Start: 301717

End: 303804

Strand: Direct

Name: flhA [H]

Synonym: Smed_0283

Alternate gene names: 150395510

Gene position: 301717-303804 (Clockwise)

Preceding gene: 150395509

Following gene: 150395511

Centisome position: 7.98

GC content: 60.97

Gene sequence:

>2088_bases
ATGGCACAACAGGCTACGCTGATCATCCCGAAACTTGCACCCAAGGGCCGGGACATCGGCTTTGCGCTTGGGATCGTGAT
GATCCTGTCGATTCTGTTCCTGCCGATCCCTCCTTTCCTGATCGACCTCGGGCTTGCCTTCTCCATTTCATTCTCGGTGC
TGATCCTGATGGTCGCGCTGTGGATACAGCGGCCGCTCGATTTCTCGTCCTTTCCGACGATCCTGCTGATCTCGACCATG
ACCCGCCTGGCGCTGAACATCGCCACCACGCGTGTCATCCTTTCCCATGGTCATGAGGGCCATGGTGCCGCCGGCGGAGT
CATCTCCGGCTTCGCAAGCCTGGTCATGTCCGGCGATTTCGTCATCGGCCTTATCGTTTTCCTGATCCTGATCACCGTGA
ACTTCATCGTCATCACGAAAGGTGCCACGCGCATCGCCGAAGTTGGCGCGCGCTTCACCCTTGATGCTATCCCCGGCAAG
CAGATGTCCATCGATGCCGATCTCTCGGCCGGTCTGATCGACGAAAAGGAAGCCCAGCGCCGCCGCCGCGAACTGGAGGA
GGAAAGCTCCTTTTTCGGCGCCATGGACGGCGCGTCGAAATTTGTGCGGGGCGATGCAATCGCCGGCCTGATCATCACCG
CGATCAACGTCTTCGGCGGGATCATCATCGGCTATCTCCGTCACGACATGGAGATCGGCGAGGCGGCCGACGTCTTCGTC
AAGCTTTCCGTCGGCGACGGTCTCGTCTCCCAGATCCCGGCGCTGATCGTATCGCTCGCCGCCGGCCTGCTCGTCTCGCG
CGGGGGCACCGCCGGCTCCACCGATCAGGCGGTCATGGGCCAGCTCAGCAACTATCCCCGCGCCCTGATGGTCGCCTCCG
GTCTTATCGTCTTGCTCTCCGTCATGCCGGGCCTGCCTTTCCTTCCCTTCGCGGCACTTGGCGGCGGCATGGCATTCCTC
AGCTGGTTCATTCCGCGGCAAGTAGAGGCCCAGAAGGCGGCAAAGCGGGATGAGGAGGCAGCAAAGGCGCAGCAGAGCAA
GGAAAGTGACAAGGATTCCGTCAAATCGGTGCTGAAGACGGCGGAGATCGAGCTCTTGCTTGGCAAGCAGGTCTCCACGA
GGCTGCTGGGCGCCCACCAGGAACTCGCTTTCCGTGTTGGCAAAATGCGCCGGAAATTCGCGCTTCAGTACGGTCTCGTC
GTTCCGGAGATCAAGGTTTCCGATGACATCACAATACCCGACAAGGCTTACCATGTCCGGATTCACGGAACCACGATCGC
CTCCAACACCGTCCGCGTGGGCGAAGTGCTCGTGGTAACCGGGGGCGGGCGGCGGCCGAGCGTGCCCGGCGACGACATCC
GGGAACCGGCTTTCGGTATGCCCGCGGTATCGATTCTCGAGACGTTCACGGAAGACCTCAAGCGCGAGGGCTTCCACCCG
ATCGACAATGTGTCGGTGGTGCTGACGCATCTGAGCGAAGTGATCCGCAACAACCTGCCGCAGCTTCTCTCCTACAAGGA
CGTAAAGGTCCTGATCGAACGGCTGGACCCGGAATACCGCAAGCTTGCGGACGAGATCTGTACCTCACACATGTCCTACT
CCGGCCTGCAGGCGGTGTTGAAGCTGCTGCTCGCCGAGCGCGTCTCGATCCGCAACCTGCATCTGATCCTCGAAGCCGTG
GCGGAGCTGGCCCCGCATGTGCGCAAGACAGAGCAGATCGTCGAACATGTACGCGTGCGCATGTCGCAGCAGCTCTGCGG
AGATCTCGCCGACAACGGCGTGCTGCGCGTGCTGCGGCTGGGCAATAAGTGGGACATGGTCTTCCACCAGGCGCTGAAGC
GTGACGCCAAGGGCGAGATCGTCGAGTTCGATATCGATCCGCGCCATCTCGAGGAATTCAGCGAGCAGGCGACGAAGGTT
ATCCGTGAACATCTCGACCGGGGCATGCCGTTCGTGCTGGTAAGTTCGCCCGAATCCCGCTCTTATGTGCGCATGATCAT
CGAACGCCTCTTCGCCACATTGCCCGTGCTCTCGCATGTCGAACTCGCCAAGGGGCTCGAGATCAAGATCATCGGCTCGA
TTTCATGA

Upstream 100 bases:

>100_bases
GATACCACCTTCGCGCAAGCTTGGTGCTCTAGGTCTTCTGCCATAACCTTGGGCAGATCATATGACCGCTGCCCGCCTCT
CATGAAGAGACGGAAGAGAC

Downstream 100 bases:

>100_bases
TCACCGATCCCGAGGGTACGGTGCTGGCGCTGTTTGCGGCCTTCTGCCGGATCGGCGGCTGCATCATGATCATGCCCGGC
TTCTCGACCGCACGCGTCCC

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MAQQATLIIPKLAPKGRDIGFALGIVMILSILFLPIPPFLIDLGLAFSISFSVLILMVALWIQRPLDFSSFPTILLISTM
TRLALNIATTRVILSHGHEGHGAAGGVISGFASLVMSGDFVIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGLIDEKEAQRRRRELEEESSFFGAMDGASKFVRGDAIAGLIITAINVFGGIIIGYLRHDMEIGEAADVFV
KLSVGDGLVSQIPALIVSLAAGLLVSRGGTAGSTDQAVMGQLSNYPRALMVASGLIVLLSVMPGLPFLPFAALGGGMAFL
SWFIPRQVEAQKAAKRDEEAAKAQQSKESDKDSVKSVLKTAEIELLLGKQVSTRLLGAHQELAFRVGKMRRKFALQYGLV
VPEIKVSDDITIPDKAYHVRIHGTTIASNTVRVGEVLVVTGGGRRPSVPGDDIREPAFGMPAVSILETFTEDLKREGFHP
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKVLIERLDPEYRKLADEICTSHMSYSGLQAVLKLLLAERVSIRNLHLILEAV
AELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRLGNKWDMVFHQALKRDAKGEIVEFDIDPRHLEEFSEQATKV
IREHLDRGMPFVLVSSPESRSYVRMIIERLFATLPVLSHVELAKGLEIKIIGSIS

Sequences:

>Translated_695_residues
MAQQATLIIPKLAPKGRDIGFALGIVMILSILFLPIPPFLIDLGLAFSISFSVLILMVALWIQRPLDFSSFPTILLISTM
TRLALNIATTRVILSHGHEGHGAAGGVISGFASLVMSGDFVIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGLIDEKEAQRRRRELEEESSFFGAMDGASKFVRGDAIAGLIITAINVFGGIIIGYLRHDMEIGEAADVFV
KLSVGDGLVSQIPALIVSLAAGLLVSRGGTAGSTDQAVMGQLSNYPRALMVASGLIVLLSVMPGLPFLPFAALGGGMAFL
SWFIPRQVEAQKAAKRDEEAAKAQQSKESDKDSVKSVLKTAEIELLLGKQVSTRLLGAHQELAFRVGKMRRKFALQYGLV
VPEIKVSDDITIPDKAYHVRIHGTTIASNTVRVGEVLVVTGGGRRPSVPGDDIREPAFGMPAVSILETFTEDLKREGFHP
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKVLIERLDPEYRKLADEICTSHMSYSGLQAVLKLLLAERVSIRNLHLILEAV
AELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRLGNKWDMVFHQALKRDAKGEIVEFDIDPRHLEEFSEQATKV
IREHLDRGMPFVLVSSPESRSYVRMIIERLFATLPVLSHVELAKGLEIKIIGSIS
>Mature_694_residues
AQQATLIIPKLAPKGRDIGFALGIVMILSILFLPIPPFLIDLGLAFSISFSVLILMVALWIQRPLDFSSFPTILLISTMT
RLALNIATTRVILSHGHEGHGAAGGVISGFASLVMSGDFVIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGKQ
MSIDADLSAGLIDEKEAQRRRRELEEESSFFGAMDGASKFVRGDAIAGLIITAINVFGGIIIGYLRHDMEIGEAADVFVK
LSVGDGLVSQIPALIVSLAAGLLVSRGGTAGSTDQAVMGQLSNYPRALMVASGLIVLLSVMPGLPFLPFAALGGGMAFLS
WFIPRQVEAQKAAKRDEEAAKAQQSKESDKDSVKSVLKTAEIELLLGKQVSTRLLGAHQELAFRVGKMRRKFALQYGLVV
PEIKVSDDITIPDKAYHVRIHGTTIASNTVRVGEVLVVTGGGRRPSVPGDDIREPAFGMPAVSILETFTEDLKREGFHPI
DNVSVVLTHLSEVIRNNLPQLLSYKDVKVLIERLDPEYRKLADEICTSHMSYSGLQAVLKLLLAERVSIRNLHLILEAVA
ELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRLGNKWDMVFHQALKRDAKGEIVEFDIDPRHLEEFSEQATKVI
REHLDRGMPFVLVSSPESRSYVRMIIERLFATLPVLSHVELAKGLEIKIIGSIS

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=676, Percent_Identity=36.8343195266272, Blast_Score=417, Evalue=1e-117,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 75803; Mature: 75672

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQATLIIPKLAPKGRDIGFALGIVMILSILFLPIPPFLIDLGLAFSISFSVLILMVAL
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WIQRPLDFSSFPTILLISTMTRLALNIATTRVILSHGHEGHGAAGGVISGFASLVMSGDF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCH
VIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGLIDEKEAQR
HHHHHHHHHHHHHHHHEEECCHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCHHHHHH
RRRELEEESSFFGAMDGASKFVRGDAIAGLIITAINVFGGIIIGYLRHDMEIGEAADVFV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
KLSVGDGLVSQIPALIVSLAAGLLVSRGGTAGSTDQAVMGQLSNYPRALMVASGLIVLLS
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VMPGLPFLPFAALGGGMAFLSWFIPRQVEAQKAAKRDEEAAKAQQSKESDKDSVKSVLKT
HHCCCCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHH
AEIELLLGKQVSTRLLGAHQELAFRVGKMRRKFALQYGLVVPEIKVSDDITIPDKAYHVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEE
IHGTTIASNTVRVGEVLVVTGGGRRPSVPGDDIREPAFGMPAVSILETFTEDLKREGFHP
EEEEEEECCCEEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKVLIERLDPEYRKLADEICTSHMSYSGLQAVL
CCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHH
KLLLAERVSIRNLHLILEAVAELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GNKWDMVFHQALKRDAKGEIVEFDIDPRHLEEFSEQATKVIREHLDRGMPFVLVSSPESR
CCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCH
SYVRMIIERLFATLPVLSHVELAKGLEIKIIGSIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
AQQATLIIPKLAPKGRDIGFALGIVMILSILFLPIPPFLIDLGLAFSISFSVLILMVAL
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WIQRPLDFSSFPTILLISTMTRLALNIATTRVILSHGHEGHGAAGGVISGFASLVMSGDF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCH
VIGLIVFLILITVNFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGLIDEKEAQR
HHHHHHHHHHHHHHHHEEECCHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCHHHHHH
RRRELEEESSFFGAMDGASKFVRGDAIAGLIITAINVFGGIIIGYLRHDMEIGEAADVFV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
KLSVGDGLVSQIPALIVSLAAGLLVSRGGTAGSTDQAVMGQLSNYPRALMVASGLIVLLS
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VMPGLPFLPFAALGGGMAFLSWFIPRQVEAQKAAKRDEEAAKAQQSKESDKDSVKSVLKT
HHCCCCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHH
AEIELLLGKQVSTRLLGAHQELAFRVGKMRRKFALQYGLVVPEIKVSDDITIPDKAYHVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEE
IHGTTIASNTVRVGEVLVVTGGGRRPSVPGDDIREPAFGMPAVSILETFTEDLKREGFHP
EEEEEEECCCEEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
IDNVSVVLTHLSEVIRNNLPQLLSYKDVKVLIERLDPEYRKLADEICTSHMSYSGLQAVL
CCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHH
KLLLAERVSIRNLHLILEAVAELAPHVRKTEQIVEHVRVRMSQQLCGDLADNGVLRVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GNKWDMVFHQALKRDAKGEIVEFDIDPRHLEEFSEQATKVIREHLDRGMPFVLVSSPESR
CCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCH
SYVRMIIERLFATLPVLSHVELAKGLEIKIIGSIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]