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The map label for this gene is ilvA [H]

Identifier: 150394576

GI number: 150394576

Start: 2213274

End: 2214542

Strand: Direct

Name: ilvA [H]

Synonym: SaurJH1_2135

Alternate gene names: 150394576

Gene position: 2213274-2214542 (Clockwise)

Preceding gene: 150394575

Following gene: 150394583

Centisome position: 76.15

GC content: 31.76

Gene sequence:

>1269_bases
ATGACAGTCAAAACAACAGTTTCTACGAAAGATATCGATGAAGCATTTTTAAGACTTAAAGATATTGTCAAAGAAACACC
TTTACAATTAGACCATTACTTATCTCAAAAGTATGATTGTAAAGTTTATTTAAAACGAGAAGATTTACAATGGGTACGTT
CTTTTAAATTAAGAGGTGCTTACAACGCTATTTCTGTTTTATCAGATGAAGCTAAAAGTAAAGGTATTACATGTGCGAGT
GCAGGTAATCATGCTCAAGGTGTTGCCTATACAGCTAAAAAACTTAATTTAAACGCTGTTATCTTTATGCCAGTCACTAC
ACCTTTACAAAAGGTAAATCAAGTAAAGTTCTTTGGAAATAGTAACGTTGAAGTTGTACTCACTGGTGATACATTTGATC
ACTGTTTAGCTGAAGCTTTAACTTATACAAGTGAACATCAAATGAACTTTATAGATCCATTCAATAATGTTCATACAATT
TCTGGACAAGGTACGCTTGCTAAAGAAATGCTAGAACAATCAAAGACTGACAATGTTAACTTTGATTATTTATTTGCCGC
TATTGGTGGTGGTGGATTAATTTCAGGTATTAGTACTTACTTTAAAACCTATTCACCTACTACGAAAATTATAGGTGTTG
AACCTTCAGGTGCAAGTAGTATGTATGAATCTGTTGTCGTAAATAATCAGGTAGTCACATTGCCTAATATCGATAAATTT
GTGGACGGTGCATCTGTAGCTAGAGTTGGCGATATTACATTTGAAATTGCAAAAGAAAATGTAGATGATTACGTTCAAGT
AGATGAAGGTGCAGTTTGTTCTACGATTTTAGACATGTATTCAAAACAAGCAATTGTAGCAGAACCTGCTGGCGCATTAA
GTGTGAGTGCTCTTGAAAACTACAAAGACCACATTAAGGGTAAAACTGTTGTTTGTGTCATTAGTGGTGGTAATAATGAT
ATTAATCGTATGAAGGAAATTGAAGAACGTTCTTTATTATATGAAGAAATGAAACATTATTTTATTTTAAACTTCCCTCA
ACGCCCTGGTGCATTAAGAGAATTTGTAAATGATGTTTTAGGCCCACAAGACGATATTACAAAATTTGAATACTTAAAAA
AATCTTCTCAAAATACAGGTACTGTCATTATTGGTATTCAACTTAAAGATCATGATGATTTAATACAACTCAAACAACGT
GTAAATCATTTCGATCCTTCCAATATTTATATTAATGAAAATAAGATGTTATATTCATTGTTAATTTAA

Upstream 100 bases:

>100_bases
AAAATAAACTTGTAAATGGCTTAGATGACATTGCAATCACCCTACAATATGAATCATTAATAGAAAAATATGAAAAATCA
CTTTAAGGGAGTTGAATATT

Downstream 100 bases:

>100_bases
CACATAGTAAGAAAAACAGTCATAAATTGATTTCTAATTGAAATCATCTTATGACTGCTTTTTATTATACTTTACATTTC
TCGTTTCGTCAGATTCAAAC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGAYNAISVLSDEAKSKGITCAS
AGNHAQGVAYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGNSNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTI
SGQGTLAKEMLEQSKTDNVNFDYLFAAIGGGGLISGISTYFKTYSPTTKIIGVEPSGASSMYESVVVNNQVVTLPNIDKF
VDGASVARVGDITFEIAKENVDDYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALENYKDHIKGKTVVCVISGGNND
INRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQR
VNHFDPSNIYINENKMLYSLLI

Sequences:

>Translated_422_residues
MTVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGAYNAISVLSDEAKSKGITCAS
AGNHAQGVAYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGNSNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTI
SGQGTLAKEMLEQSKTDNVNFDYLFAAIGGGGLISGISTYFKTYSPTTKIIGVEPSGASSMYESVVVNNQVVTLPNIDKF
VDGASVARVGDITFEIAKENVDDYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALENYKDHIKGKTVVCVISGGNND
INRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQR
VNHFDPSNIYINENKMLYSLLI
>Mature_421_residues
TVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGAYNAISVLSDEAKSKGITCASA
GNHAQGVAYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGNSNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTIS
GQGTLAKEMLEQSKTDNVNFDYLFAAIGGGGLISGISTYFKTYSPTTKIIGVEPSGASSMYESVVVNNQVVTLPNIDKFV
DGASVARVGDITFEIAKENVDDYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALENYKDHIKGKTVVCVISGGNNDI
NRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVLGPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQRV
NHFDPSNIYINENKMLYSLLI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=331, Percent_Identity=29.607250755287, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790207, Length=365, Percent_Identity=35.0684931506849, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789505, Length=329, Percent_Identity=34.9544072948328, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789235, Length=271, Percent_Identity=23.6162361623616, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=350, Percent_Identity=31.7142857142857, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=411, Percent_Identity=28.9537712895377, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17508781, Length=322, Percent_Identity=27.0186335403727, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320930, Length=358, Percent_Identity=39.1061452513966, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=34.5047923322684, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=332, Percent_Identity=25, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355833, Length=350, Percent_Identity=31.4285714285714, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24645328, Length=254, Percent_Identity=29.5275590551181, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 46968; Mature: 46837

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGA
CEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCC
YNAISVLSDEAKSKGITCASAGNHAQGVAYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGN
HHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHEEECCEEEEEEECCCHHHHCCEEEEECC
SNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTISGQGTLAKEMLEQSKTDNVN
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCC
FDYLFAAIGGGGLISGISTYFKTYSPTTKIIGVEPSGASSMYESVVVNNQVVTLPNIDKF
EEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEEECCCHHHH
VDGASVARVGDITFEIAKENVDDYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALEN
HCCCCCEEECCEEEEEECCCCCCCEECCCCHHHHHHHHHHCCCEEEECCCCCEEHHHHHH
YKDHIKGKTVVCVISGGNNDINRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVL
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHC
GPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQRVNHFDPSNIYINENKMLYSL
CCCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCEEECCCCEEEEE
LI
CC
>Mature Secondary Structure 
TVKTTVSTKDIDEAFLRLKDIVKETPLQLDHYLSQKYDCKVYLKREDLQWVRSFKLRGA
EEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCC
YNAISVLSDEAKSKGITCASAGNHAQGVAYTAKKLNLNAVIFMPVTTPLQKVNQVKFFGN
HHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHEEECCEEEEEEECCCHHHHCCEEEEECC
SNVEVVLTGDTFDHCLAEALTYTSEHQMNFIDPFNNVHTISGQGTLAKEMLEQSKTDNVN
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCC
FDYLFAAIGGGGLISGISTYFKTYSPTTKIIGVEPSGASSMYESVVVNNQVVTLPNIDKF
EEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEEECCCHHHH
VDGASVARVGDITFEIAKENVDDYVQVDEGAVCSTILDMYSKQAIVAEPAGALSVSALEN
HCCCCCEEECCEEEEEECCCCCCCEECCCCHHHHHHHHHHCCCEEEECCCCCEEHHHHHH
YKDHIKGKTVVCVISGGNNDINRMKEIEERSLLYEEMKHYFILNFPQRPGALREFVNDVL
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHC
GPQDDITKFEYLKKSSQNTGTVIIGIQLKDHDDLIQLKQRVNHFDPSNIYINENKMLYSL
CCCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCEEECCCCEEEEE
LI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA