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The map label for this gene is ilvC

Identifier: 150394571

GI number: 150394571

Start: 2207690

End: 2208694

Strand: Direct

Name: ilvC

Synonym: SaurJH1_2130

Alternate gene names: 150394571

Gene position: 2207690-2208694 (Clockwise)

Preceding gene: 150394570

Following gene: 150394572

Centisome position: 75.96

GC content: 35.22

Gene sequence:

>1005_bases
ATGACAACAGTTTATTATGATCAAGACGTAAAAACGGACGCTTTACAAGGCAAAAAAATTGCAGTAGTAGGTTATGGATC
ACAAGGCCACGCGCATGCACAAAACTTAAAAGACAATGGATATGATGTAGTCATCGGTATTCGCCCAGGTCGTTCTTTTG
ACAAGGCTAAAGAAGATGGATTTGATGTGTTCCCTGTTGCAGAAGCAGTTAAGCAAGCTGATGTAATTATGGTGCTATTA
CCTGATGAAATTCAAGGTGATGTATACAAAAACGAAATTGAACCAAATTTAGAAAAACATAATGCGCTTGCATTTGCTCA
TGGCTTTAACATTCATTTTGGTGTTATTCAACCACCAGCTGATGTTGATGTATTTTTAGTAGCTCCTAAAGGACCGGGTC
ATTTAGTTAGACGTACATTTGTTGAAGGTTCTGCTGTACCATCACTATTTGGTATTCAACAAGACGCTTCAGGTCAAGCA
CGTAATATTGCTTTAAGTTATGCAAAAGGTATTGGTGCAACTCGTGCAGGTGTTATTGAAACAACATTTAAAGAAGAAAC
TGAGACAGATTTATTTGGTGAACAAGCAGTACTTTGCGGTGGTGTATCGAAATTAATTCAAAGTGGCTTTGAAACATTAG
TAGAAGCGGGTTATCAACCAGAATTAGCTTATTTTGAAGTATTACATGAAATGAAATTAATCGTTGATTTGATGTATGAA
GGCGGTATGGAAAATGTACGTTACTCAATTTCAAATACTGCTGAATTTGGTGACTATGTTTCAGGACCACGTGTTATCAC
ACCAGATGTTAAAGAAAATATGAAAGCTGTATTAACTGATATCCAAAATGGTAACTTCAGTAATCGCTTTATCGAAGACA
ATAAAAATGGATTCAAAGAATTTTATAAATTACGCGAAGAACAACATGGTCATCAAATTGAAAAAGTTGGTCGTGAATTA
CGCGAAATGATGCCTTTTATTAAATCTAAAAGCATTGAAAAATAA

Upstream 100 bases:

>100_bases
AGATATATCATAGGCTGCTAGTTAACATCTGCCACTATTACAAAGTTATATTTCAGAATTTTCGAAAAACAAAACATTTA
ATTATTTGGAGGAATTTATT

Downstream 100 bases:

>100_bases
GATAGACCTACAATGAGGAGTTGTTAAATATGAGTAGTCATATTCAAATTTTTGATACGACACTAAGAGACGGTGAACAA
ACACCAGGAGTGAATTTTAC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLL
PDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQA
RNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
GGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGREL
REMMPFIKSKSIEK

Sequences:

>Translated_334_residues
MTTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLL
PDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQA
RNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
GGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGREL
REMMPFIKSKSIEK
>Mature_333_residues
TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLP
DEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQAR
NIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEG
GMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELR
EMMPFIKSKSIEK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=309, Percent_Identity=33.9805825242718, Blast_Score=154, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=310, Percent_Identity=34.5161290322581, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_STAA1 (A7X4M9)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442631.1
- ProteinModelPortal:   A7X4M9
- SMR:   A7X4M9
- STRING:   A7X4M9
- EnsemblBacteria:   EBSTAT00000003427
- GeneID:   5560238
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2041
- eggNOG:   COG0059
- GeneTree:   EBGT00050000024546
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   SAUR418127:SAHV_2041-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37014; Mature: 36883

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDG
CCEEEECCCCCHHHCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCHHHHCC
FDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPA
CCEEHHHHHHHCCCEEEEEECCCCCCCHHHCCCCCCHHHCCEEEEEECCEEEEEEECCCC
DVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIE
CCEEEEECCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCHHHEEEHHHHCCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
HHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKE
CCCCCEEEEECCCHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
FYKLREEQHGHQIEKVGRELREMMPFIKSKSIEK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDG
CEEEECCCCCHHHCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCHHHHCC
FDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPA
CCEEHHHHHHHCCCEEEEEECCCCCCCHHHCCCCCCHHHCCEEEEEECCEEEEEEECCCC
DVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIE
CCEEEEECCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCHHHEEEHHHHCCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
HHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKE
CCCCCEEEEECCCHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
FYKLREEQHGHQIEKVGRELREMMPFIKSKSIEK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA