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The map label for this gene is aslA [H]

Identifier: 150010518

GI number: 150010518

Start: 4804247

End: 4805791

Strand: Direct

Name: aslA [H]

Synonym: BDI_3965

Alternate gene names: 150010518

Gene position: 4804247-4805791 (Clockwise)

Preceding gene: 150010517

Following gene: 150010519

Centisome position: 99.85

GC content: 48.8

Gene sequence:

>1545_bases
ATGAAGATCAAGTTGTCTTTATTAGCCACCGGTTTACTATATGTGCCGGTGGTGTTCGCCCAAAAGCAACCCAATGTCGT
GATCATTCTGGCGGATGATATGGGTTACGGGGATGTTGGATGCAATAATCCATATGCTAGGGTACGTACACCGGCCATCG
ATCAATTGGCCCGGAACGGTATCCGTTTTACGGATGCCCATTCTGCGGGTGCGTTGAGTGGGCCTTCACGCTACGGTTTA
GTGACAGGACGTTATTTTTTCCGTACGCCGAAGAAGTCCGAGTATTGGGGGTACTTGTCTCCATATATCGAACCGGAGCG
TTTGACGATCGGTTCCTTGATGCGTAATGCCGGCTATACGACCGCTTGTGTCGGGAAATGGCATCTAGGGCTCGACTGGC
AGTTGAAAGATGACTCGAAACCACAGATTCTTACCCCTAAGAAATTTGGTTATACGAATACGGATTTCTCCGCCCCTGTA
AAAAGAGGCCCTACGGAATTAGGGTTTGACTATTCTTTCATCCTTCCGGCTTCCTTGGATATGCCGCCTTATGCGTTCGT
GCGTAATGACCGTGTCGTGGACCCGGATGTCATCTTGACGGCGGACGCTTATCCGAAGAAACAGGATGAGACGGTTTACG
CTTGGGATCGTAAACATACGAACGAGAATGATATTTATTGGGAACGGGGCGTTTGGTGGCGTAACGGAGAGATGTCGCGC
TCCTTTAAGTTTGAGGAATGTTTCCCGACAATCGTAGATGAGGGTATCGCTTTTATCGATCGGGAAGGACGAAAGGACAA
GCCATTCTTTTTATATATGCCGTTAACCGGTCCGCACACCCCATGGCTGCCCACCGTTCAGTTTAAGGGATCTACTGAGT
TAGGTACCTATGGCGATTTTATGGGCGATATCGATAATGTCGTGGCTCGGGTGAATGCCAAACTAAAGGAATTAGGTCTG
GAGAAGAATACGATTGTCATTTTCGCCAGTGATAACGGAGGCGCATGGGAAGAGGAGGATATCCAGCAATACGGGCATCA
AAGTAACTGGAGCCGCCGTGGGCAGAAAGGTGATGCGTGGGACGGCGGTCATCATGTTCCGCTGATTGTTCATTGGCCGG
ATCATATCAAGTGCCCCGGGGTTTGTTCCCAAACGGTTGGCTTGGTAGATATATTGGCTACATTGGCGGATTTAACCGGG
CAATCCCTTCCTAAAGGACAGGCAGAGGATAGCTTTAGCTTTAAGAAAGTATTGGATGGTGATATGAATGCCTCGACGAG
AGACCAGATCATGTACTTGTCCGGCTCCGGCAAATTAGCGATCAAGAAGGGAGATTGGAAATATATCGATTGTCTGGGCT
CCGGTGGTTTTACGGCTCCCGCCCGTTTATCCCCGGTGAAGAATGGACCGAAAGGCCAACTTTATAATATGCGGACCGAT
TCTTTGGAGAGTAATAATCTCTTCTTGCGTGAGAAAGGCATTGCGAATGAGCTTTCCGCGTTGTTGAAGAAATTGTTGGA
TCAAGGATATAGCCGTCCGCAATAA

Upstream 100 bases:

>100_bases
ATACGGAAACCCAGCTATTGTTCCCGATTCCATTAAGCGAACGGCAGGCGAATCCGAACCTGACTCAGAATCAAGGTTAT
TAACGAATAGAAAATAATAT

Downstream 100 bases:

>100_bases
AGGTAATCTTGATTAGGCAAAAAGTTGAATCGAATGACAAAGTTAGGCGTATTGTTTAGTGTTTTGGGAGTGGGGGCCGG
TTGTATTCCGGCTTTCGCTC

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKIKLSLLATGLLYVPVVFAQKQPNVVIILADDMGYGDVGCNNPYARVRTPAIDQLARNGIRFTDAHSAGALSGPSRYGL
VTGRYFFRTPKKSEYWGYLSPYIEPERLTIGSLMRNAGYTTACVGKWHLGLDWQLKDDSKPQILTPKKFGYTNTDFSAPV
KRGPTELGFDYSFILPASLDMPPYAFVRNDRVVDPDVILTADAYPKKQDETVYAWDRKHTNENDIYWERGVWWRNGEMSR
SFKFEECFPTIVDEGIAFIDREGRKDKPFFLYMPLTGPHTPWLPTVQFKGSTELGTYGDFMGDIDNVVARVNAKLKELGL
EKNTIVIFASDNGGAWEEEDIQQYGHQSNWSRRGQKGDAWDGGHHVPLIVHWPDHIKCPGVCSQTVGLVDILATLADLTG
QSLPKGQAEDSFSFKKVLDGDMNASTRDQIMYLSGSGKLAIKKGDWKYIDCLGSGGFTAPARLSPVKNGPKGQLYNMRTD
SLESNNLFLREKGIANELSALLKKLLDQGYSRPQ

Sequences:

>Translated_514_residues
MKIKLSLLATGLLYVPVVFAQKQPNVVIILADDMGYGDVGCNNPYARVRTPAIDQLARNGIRFTDAHSAGALSGPSRYGL
VTGRYFFRTPKKSEYWGYLSPYIEPERLTIGSLMRNAGYTTACVGKWHLGLDWQLKDDSKPQILTPKKFGYTNTDFSAPV
KRGPTELGFDYSFILPASLDMPPYAFVRNDRVVDPDVILTADAYPKKQDETVYAWDRKHTNENDIYWERGVWWRNGEMSR
SFKFEECFPTIVDEGIAFIDREGRKDKPFFLYMPLTGPHTPWLPTVQFKGSTELGTYGDFMGDIDNVVARVNAKLKELGL
EKNTIVIFASDNGGAWEEEDIQQYGHQSNWSRRGQKGDAWDGGHHVPLIVHWPDHIKCPGVCSQTVGLVDILATLADLTG
QSLPKGQAEDSFSFKKVLDGDMNASTRDQIMYLSGSGKLAIKKGDWKYIDCLGSGGFTAPARLSPVKNGPKGQLYNMRTD
SLESNNLFLREKGIANELSALLKKLLDQGYSRPQ
>Mature_514_residues
MKIKLSLLATGLLYVPVVFAQKQPNVVIILADDMGYGDVGCNNPYARVRTPAIDQLARNGIRFTDAHSAGALSGPSRYGL
VTGRYFFRTPKKSEYWGYLSPYIEPERLTIGSLMRNAGYTTACVGKWHLGLDWQLKDDSKPQILTPKKFGYTNTDFSAPV
KRGPTELGFDYSFILPASLDMPPYAFVRNDRVVDPDVILTADAYPKKQDETVYAWDRKHTNENDIYWERGVWWRNGEMSR
SFKFEECFPTIVDEGIAFIDREGRKDKPFFLYMPLTGPHTPWLPTVQFKGSTELGTYGDFMGDIDNVVARVNAKLKELGL
EKNTIVIFASDNGGAWEEEDIQQYGHQSNWSRRGQKGDAWDGGHHVPLIVHWPDHIKCPGVCSQTVGLVDILATLADLTG
QSLPKGQAEDSFSFKKVLDGDMNASTRDQIMYLSGSGKLAIKKGDWKYIDCLGSGGFTAPARLSPVKNGPKGQLYNMRTD
SLESNNLFLREKGIANELSALLKKLLDQGYSRPQ

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI31742482, Length=441, Percent_Identity=29.9319727891156, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI53831991, Length=460, Percent_Identity=26.304347826087, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI71852584, Length=450, Percent_Identity=27.1111111111111, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI45430057, Length=538, Percent_Identity=27.1375464684015, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI146229331, Length=434, Percent_Identity=28.3410138248848, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI146229329, Length=434, Percent_Identity=28.3410138248848, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI6005990, Length=434, Percent_Identity=28.3410138248848, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI146229324, Length=434, Percent_Identity=28.3410138248848, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI157266309, Length=450, Percent_Identity=26, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4503899, Length=438, Percent_Identity=27.3972602739726, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI38569407, Length=353, Percent_Identity=29.4617563739377, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38569405, Length=353, Percent_Identity=29.4617563739377, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI71852586, Length=323, Percent_Identity=26.9349845201238, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI59797060, Length=415, Percent_Identity=24.8192771084337, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI146229327, Length=188, Percent_Identity=32.4468085106383, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI58743319, Length=125, Percent_Identity=38.4, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI109389362, Length=117, Percent_Identity=32.4786324786325, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790233, Length=497, Percent_Identity=29.1750503018109, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081924, Length=455, Percent_Identity=25.0549450549451, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI115533416, Length=512, Percent_Identity=25.390625, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI115533418, Length=502, Percent_Identity=24.9003984063745, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559078, Length=282, Percent_Identity=24.468085106383, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666109, Length=469, Percent_Identity=26.6524520255864, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24666175, Length=132, Percent_Identity=40.1515151515151, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI281366397, Length=119, Percent_Identity=36.9747899159664, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366395, Length=119, Percent_Identity=36.9747899159664, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666163, Length=119, Percent_Identity=36.9747899159664, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363223, Length=131, Percent_Identity=35.1145038167939, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57557; Mature: 57557

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKLSLLATGLLYVPVVFAQKQPNVVIILADDMGYGDVGCNNPYARVRTPAIDQLARNG
CEEEEHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCCHHEECCCHHHHHHHCC
IRFTDAHSAGALSGPSRYGLVTGRYFFRTPKKSEYWGYLSPYIEPERLTIGSLMRNAGYT
CEEEECCCCCCCCCCCCCCEEECEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
TACVGKWHLGLDWQLKDDSKPQILTPKKFGYTNTDFSAPVKRGPTELGFDYSFILPASLD
EEEEEEEEECEEEEECCCCCCCEECCHHCCCCCCCCCCCHHCCCHHHCCCEEEEEECCCC
MPPYAFVRNDRVVDPDVILTADAYPKKQDETVYAWDRKHTNENDIYWERGVWWRNGEMSR
CCCEEEECCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEECCEEEECCCCCC
SFKFEECFPTIVDEGIAFIDREGRKDKPFFLYMPLTGPHTPWLPTVQFKGSTELGTYGDF
CEEHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCHHH
MGDIDNVVARVNAKLKELGLEKNTIVIFASDNGGAWEEEDIQQYGHQSNWSRRGQKGDAW
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHCCCCCCCC
DGGHHVPLIVHWPDHIKCPGVCSQTVGLVDILATLADLTGQSLPKGQAEDSFSFKKVLDG
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCC
DMNASTRDQIMYLSGSGKLAIKKGDWKYIDCLGSGGFTAPARLSPVKNGPKGQLYNMRTD
CCCCCCCCEEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCC
SLESNNLFLREKGIANELSALLKKLLDQGYSRPQ
CCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIKLSLLATGLLYVPVVFAQKQPNVVIILADDMGYGDVGCNNPYARVRTPAIDQLARNG
CEEEEHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCCHHEECCCHHHHHHHCC
IRFTDAHSAGALSGPSRYGLVTGRYFFRTPKKSEYWGYLSPYIEPERLTIGSLMRNAGYT
CEEEECCCCCCCCCCCCCCEEECEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
TACVGKWHLGLDWQLKDDSKPQILTPKKFGYTNTDFSAPVKRGPTELGFDYSFILPASLD
EEEEEEEEECEEEEECCCCCCCEECCHHCCCCCCCCCCCHHCCCHHHCCCEEEEEECCCC
MPPYAFVRNDRVVDPDVILTADAYPKKQDETVYAWDRKHTNENDIYWERGVWWRNGEMSR
CCCEEEECCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEECCEEEECCCCCC
SFKFEECFPTIVDEGIAFIDREGRKDKPFFLYMPLTGPHTPWLPTVQFKGSTELGTYGDF
CEEHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCHHH
MGDIDNVVARVNAKLKELGLEKNTIVIFASDNGGAWEEEDIQQYGHQSNWSRRGQKGDAW
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHCCCCCCCC
DGGHHVPLIVHWPDHIKCPGVCSQTVGLVDILATLADLTGQSLPKGQAEDSFSFKKVLDG
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCC
DMNASTRDQIMYLSGSGKLAIKKGDWKYIDCLGSGGFTAPARLSPVKNGPKGQLYNMRTD
CCCCCCCCEEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCC
SLESNNLFLREKGIANELSALLKKLLDQGYSRPQ
CCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]