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The map label for this gene is lysC [H]

Identifier: 150010495

GI number: 150010495

Start: 4772985

End: 4774331

Strand: Direct

Name: lysC [H]

Synonym: BDI_3936

Alternate gene names: 150010495

Gene position: 4772985-4774331 (Clockwise)

Preceding gene: 150010494

Following gene: 150010496

Centisome position: 99.2

GC content: 44.32

Gene sequence:

>1347_bases
ATGAAAGTATTAAAATTTGGTGGTACTTCAGTCGGTTCTGCCCAGCGGATCAAGAATGTCGCATCAATCATTTGCGATCA
GGAACAGAAAATAGTAGTACTCTCTGCCATGGCAGGGACAACAAACTCTTTAGTGGAGATATCTGAGTGCTTCCATAAGA
AAGATCCGGAAAAAGCCAATGCGGTCCTTTCTTCCTTGGAGCAGGCTTATGTCAATCATATAGAAGAATTATACCGGAGC
GATGTCTACAAGGAAAAAGCCATGCAATACATGCTCGAACGGTCTCAACATGTCTGGTCTTTCTCTAATATGCCTTTCAG
CATGTTCGATGAAAAGGAAATCTTGGCGCAGGGTGAGCTAATATCAACCTTTCTGATGACCTGCTATCTGGAAGAACAAG
GAGTGAAGGTAGTTTTATTGCCTGCGTTGAACTTCATGCGGATTACAATGGACAATGAACCGGACATGGAATATATCGCT
AAACACCTAAATACACTTTTGGAGCAAAACAAAGAGGCAGAAATATATATTACGCAAGGTTTCATCTGCCGGAATGCTTA
CGGCAGCATTGACAACTTGGAAAGAGGAGGAAGCGATTACACCGCCTCTCTAATTGGGGCGGCTATCCAAGCAGAAGAGA
TACAGATATGGACGGATATTGATGGGATGCACAACAACGATCCACGGTTTGTCAATGACACCGCTCCTGTTAGGCAGTTG
AACTTCGACGAAGCCGCTAAGTTGGCACATTTCGGTGCCAAGATACTACATCCGACTTGCATCCTGCCTGCCAAGGAAAA
GAACATACCGGTACGTCTCTTGAACGCATTGCAGCCAAGTGCGTCGGGTACATTGATCTCGAACACGGCGGAAAAGGGTG
CGATCAAAGCTGTTGCCGCCAAAGACAACATCACGTATGTCAAGATCAAGTCGCTCCATATGATACCGACACCTCATTTT
CTGAGCATCGTGTTTGATACGTTCTATAATTACAATACGCCGGTGGACATGGTGACCACTTCCGATATCGGGGTTTCCGT
AACGATTGATGATGACAAGCATATAGACGAGATTGTGGGTGTATTACGGAAATACGCAACGATTACAGTCGAAAAGAATA
TGGTGATTGTTTGTGTTGTTGGTGACCTGGAATGGCAAAATGTCGGTTTTGAGGCACGCATCATCAATGCATTGAAAGAT
ATTCCCGTACGGATGATTTCATACGGCGGAAGTAGTAGTAATGTATCGTTGGTGATGAAAGCGGAAGATAAAGTGCATGC
TTTGAAGGCGCTTAGTGAGCACTTGTTTTCCGTATCAGACAAACCTGTGTTATCATCCGTTTCTTAA

Upstream 100 bases:

>100_bases
CATGGTGGTACGATCCGTATCGAAAGCGAAGTCGGTAAAGGTAGCACGTTCGTGATCAGATTCAATGTATAAAAAGTAAA
ATCAAAAATCAGATAGTCTA

Downstream 100 bases:

>100_bases
AAGAAAATTAAGATTAATAGTTGAGCATATTTGTTTTTTGATTTGTTTTAGAAATGAAGCAGAAGCAGTCTTTTTTTGTA
GAGACTGCTTCTATTTTTCG

Product: aspartokinase

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKVLKFGGTSVGSAQRIKNVASIICDQEQKIVVLSAMAGTTNSLVEISECFHKKDPEKANAVLSSLEQAYVNHIEELYRS
DVYKEKAMQYMLERSQHVWSFSNMPFSMFDEKEILAQGELISTFLMTCYLEEQGVKVVLLPALNFMRITMDNEPDMEYIA
KHLNTLLEQNKEAEIYITQGFICRNAYGSIDNLERGGSDYTASLIGAAIQAEEIQIWTDIDGMHNNDPRFVNDTAPVRQL
NFDEAAKLAHFGAKILHPTCILPAKEKNIPVRLLNALQPSASGTLISNTAEKGAIKAVAAKDNITYVKIKSLHMIPTPHF
LSIVFDTFYNYNTPVDMVTTSDIGVSVTIDDDKHIDEIVGVLRKYATITVEKNMVIVCVVGDLEWQNVGFEARIINALKD
IPVRMISYGGSSSNVSLVMKAEDKVHALKALSEHLFSVSDKPVLSSVS

Sequences:

>Translated_448_residues
MKVLKFGGTSVGSAQRIKNVASIICDQEQKIVVLSAMAGTTNSLVEISECFHKKDPEKANAVLSSLEQAYVNHIEELYRS
DVYKEKAMQYMLERSQHVWSFSNMPFSMFDEKEILAQGELISTFLMTCYLEEQGVKVVLLPALNFMRITMDNEPDMEYIA
KHLNTLLEQNKEAEIYITQGFICRNAYGSIDNLERGGSDYTASLIGAAIQAEEIQIWTDIDGMHNNDPRFVNDTAPVRQL
NFDEAAKLAHFGAKILHPTCILPAKEKNIPVRLLNALQPSASGTLISNTAEKGAIKAVAAKDNITYVKIKSLHMIPTPHF
LSIVFDTFYNYNTPVDMVTTSDIGVSVTIDDDKHIDEIVGVLRKYATITVEKNMVIVCVVGDLEWQNVGFEARIINALKD
IPVRMISYGGSSSNVSLVMKAEDKVHALKALSEHLFSVSDKPVLSSVS
>Mature_448_residues
MKVLKFGGTSVGSAQRIKNVASIICDQEQKIVVLSAMAGTTNSLVEISECFHKKDPEKANAVLSSLEQAYVNHIEELYRS
DVYKEKAMQYMLERSQHVWSFSNMPFSMFDEKEILAQGELISTFLMTCYLEEQGVKVVLLPALNFMRITMDNEPDMEYIA
KHLNTLLEQNKEAEIYITQGFICRNAYGSIDNLERGGSDYTASLIGAAIQAEEIQIWTDIDGMHNNDPRFVNDTAPVRQL
NFDEAAKLAHFGAKILHPTCILPAKEKNIPVRLLNALQPSASGTLISNTAEKGAIKAVAAKDNITYVKIKSLHMIPTPHF
LSIVFDTFYNYNTPVDMVTTSDIGVSVTIDDDKHIDEIVGVLRKYATITVEKNMVIVCVVGDLEWQNVGFEARIINALKD
IPVRMISYGGSSSNVSLVMKAEDKVHALKALSEHLFSVSDKPVLSSVS

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=448, Percent_Identity=32.1428571428571, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1786183, Length=476, Percent_Identity=27.5210084033613, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790376, Length=313, Percent_Identity=28.1150159744409, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320893, Length=363, Percent_Identity=25.6198347107438, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49795; Mature: 49795

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLKFGGTSVGSAQRIKNVASIICDQEQKIVVLSAMAGTTNSLVEISECFHKKDPEKAN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHH
AVLSSLEQAYVNHIEELYRSDVYKEKAMQYMLERSQHVWSFSNMPFSMFDEKEILAQGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHHHHHH
ISTFLMTCYLEEQGVKVVLLPALNFMRITMDNEPDMEYIAKHLNTLLEQNKEAEIYITQG
HHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECC
FICRNAYGSIDNLERGGSDYTASLIGAAIQAEEIQIWTDIDGMHNNDPRFVNDTAPVRQL
EEEECCCCCCCCHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCCEECCCCCCHHC
NFDEAAKLAHFGAKILHPTCILPAKEKNIPVRLLNALQPSASGTLISNTAEKGAIKAVAA
CHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCEEEEEE
KDNITYVKIKSLHMIPTPHFLSIVFDTFYNYNTPVDMVTTSDIGVSVTIDDDKHIDEIVG
CCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHH
VLRKYATITVEKNMVIVCVVGDLEWQNVGFEARIINALKDIPVRMISYGGSSSNVSLVMK
HHHHHEEEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEE
AEDKVHALKALSEHLFSVSDKPVLSSVS
CCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKVLKFGGTSVGSAQRIKNVASIICDQEQKIVVLSAMAGTTNSLVEISECFHKKDPEKAN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHH
AVLSSLEQAYVNHIEELYRSDVYKEKAMQYMLERSQHVWSFSNMPFSMFDEKEILAQGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHHHHHH
ISTFLMTCYLEEQGVKVVLLPALNFMRITMDNEPDMEYIAKHLNTLLEQNKEAEIYITQG
HHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECC
FICRNAYGSIDNLERGGSDYTASLIGAAIQAEEIQIWTDIDGMHNNDPRFVNDTAPVRQL
EEEECCCCCCCCHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCCEECCCCCCHHC
NFDEAAKLAHFGAKILHPTCILPAKEKNIPVRLLNALQPSASGTLISNTAEKGAIKAVAA
CHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCEEEEEE
KDNITYVKIKSLHMIPTPHFLSIVFDTFYNYNTPVDMVTTSDIGVSVTIDDDKHIDEIVG
CCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHH
VLRKYATITVEKNMVIVCVVGDLEWQNVGFEARIINALKDIPVRMISYGGSSSNVSLVMK
HHHHHEEEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEE
AEDKVHALKALSEHLFSVSDKPVLSSVS
CCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]