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The map label for this gene is aslA [H]

Identifier: 150010478

GI number: 150010478

Start: 4749342

End: 4750364

Strand: Direct

Name: aslA [H]

Synonym: BDI_3919

Alternate gene names: 150010478

Gene position: 4749342-4750364 (Clockwise)

Preceding gene: 150010477

Following gene: 150010479

Centisome position: 98.71

GC content: 41.06

Gene sequence:

>1023_bases
ATGCAGGATATTAGAAAATTGTTATTTATAACTGGGGTAGCAACTGTTACCCCGGTTATTATACAAGCCCGGGACAAACT
TCCTAATATCGTGATCTTTTTTATGGATGATATGGGATATGGCGATTTAACAATCACCGGTGCTTCTGGATATAACACGC
CTACTATTGACCGACTGGCCTCTGAAGGAATGTTTTTTACCCACTTTTATGCAGCCCAACCTATAAGTAGCGCATCGAGA
GCCGGATTAATTACAGGGTGTTATCCAAATCGAGTGGGGATTTCGGGGGCATTGATGCCTCAAGGCCGTATAGGAGTGGC
CCCTAATGAGGAAACTCTTCCGGAAATGTTAAAAACTAGAGGTTATTCTTGTGGAATGGTCGGTAAATGGCATTTAGGTC
ACCTTTATCCATTTTTGCCTTTGCAACAAGGATTTGATGAGTATCTTGGGTTGCCTTATTCCAATGATATGTGGCCAGTA
GATTATGACGGGAATAGAGTGACTCCAGCATCTAATTTACCAAACAAATTACGGCATCCGGCATTACCATTAATCGACGG
AAATGAAAAAATAAGAGAATTGTGGACATTGAATGATCAAGCCGAGCTTACTACATTATATACGGAACGGGCGATCCAGT
TTATCAAAAAGAATCGTGAACAACCATTTTTTCTTTACTTTGCTCACTCGATGCCACATGTTCCGCTTGCTGTATCCAAC
AAATTTAAAGGAAAGAGTAAACAAGGTTTATATGGGGATGTCATGCTTGAGGTAGATTGGAGTGTCCAACAAGTTCTAGA
AACAATAGAGGAATTAAACCTAGATGAAAATACTTTGATTATCTTTACGTCGGATAATGGGCCTTGGTTTAGTTTTGGTA
ATCATGCCGGGAGTACCGGAGGTTTGAGAGAAGCGAAAGCTACCACGTTTGAGGGAGGACAACGCGTTCCTTGTATCATG
CGTTGGAAAGGAGTGATTCCTAGAGGTACTGTTTGCAATCAATTAGCCAGTACGATTATATGA

Upstream 100 bases:

>100_bases
GAAGCTAATAAAACTGAGATTGCGCAAAATATCAAGGAGCATATGATCCTTATGCCGATCCCTCAATCCGAGATAGACTT
GAATCCTAATTTAGTACAAA

Downstream 100 bases:

>100_bases
TTTGCGTAGAGATCCGGGAGAAAGATATGATGTGAAAGATCAATATCCGGAGGTGGTTCGTCTATTACAATCTATAGCAG
AAGAGGCTCGGTTGGATCTG

Product: arylsulfatase A

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQDIRKLLFITGVATVTPVIIQARDKLPNIVIFFMDDMGYGDLTITGASGYNTPTIDRLASEGMFFTHFYAAQPISSASR
AGLITGCYPNRVGISGALMPQGRIGVAPNEETLPEMLKTRGYSCGMVGKWHLGHLYPFLPLQQGFDEYLGLPYSNDMWPV
DYDGNRVTPASNLPNKLRHPALPLIDGNEKIRELWTLNDQAELTTLYTERAIQFIKKNREQPFFLYFAHSMPHVPLAVSN
KFKGKSKQGLYGDVMLEVDWSVQQVLETIEELNLDENTLIIFTSDNGPWFSFGNHAGSTGGLREAKATTFEGGQRVPCIM
RWKGVIPRGTVCNQLASTII

Sequences:

>Translated_340_residues
MQDIRKLLFITGVATVTPVIIQARDKLPNIVIFFMDDMGYGDLTITGASGYNTPTIDRLASEGMFFTHFYAAQPISSASR
AGLITGCYPNRVGISGALMPQGRIGVAPNEETLPEMLKTRGYSCGMVGKWHLGHLYPFLPLQQGFDEYLGLPYSNDMWPV
DYDGNRVTPASNLPNKLRHPALPLIDGNEKIRELWTLNDQAELTTLYTERAIQFIKKNREQPFFLYFAHSMPHVPLAVSN
KFKGKSKQGLYGDVMLEVDWSVQQVLETIEELNLDENTLIIFTSDNGPWFSFGNHAGSTGGLREAKATTFEGGQRVPCIM
RWKGVIPRGTVCNQLASTII
>Mature_340_residues
MQDIRKLLFITGVATVTPVIIQARDKLPNIVIFFMDDMGYGDLTITGASGYNTPTIDRLASEGMFFTHFYAAQPISSASR
AGLITGCYPNRVGISGALMPQGRIGVAPNEETLPEMLKTRGYSCGMVGKWHLGHLYPFLPLQQGFDEYLGLPYSNDMWPV
DYDGNRVTPASNLPNKLRHPALPLIDGNEKIRELWTLNDQAELTTLYTERAIQFIKKNREQPFFLYFAHSMPHVPLAVSN
KFKGKSKQGLYGDVMLEVDWSVQQVLETIEELNLDENTLIIFTSDNGPWFSFGNHAGSTGGLREAKATTFEGGQRVPCIM
RWKGVIPRGTVCNQLASTII

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=328, Percent_Identity=40.5487804878049, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI146229331, Length=330, Percent_Identity=38.7878787878788, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI146229329, Length=330, Percent_Identity=38.7878787878788, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI6005990, Length=330, Percent_Identity=38.7878787878788, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI146229324, Length=330, Percent_Identity=38.7878787878788, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI45430057, Length=341, Percent_Identity=36.3636363636364, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI157266309, Length=383, Percent_Identity=32.3759791122715, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI146229327, Length=259, Percent_Identity=37.0656370656371, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI109389362, Length=317, Percent_Identity=29.6529968454259, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI59797060, Length=296, Percent_Identity=33.1081081081081, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI38569407, Length=298, Percent_Identity=32.8859060402685, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI38569405, Length=298, Percent_Identity=32.8859060402685, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI53831991, Length=142, Percent_Identity=43.6619718309859, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI58743319, Length=145, Percent_Identity=40.6896551724138, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI31742482, Length=178, Percent_Identity=36.5168539325843, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI71852586, Length=148, Percent_Identity=36.4864864864865, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI71852584, Length=148, Percent_Identity=36.4864864864865, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790233, Length=322, Percent_Identity=34.472049689441, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87081924, Length=367, Percent_Identity=27.5204359673025, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1790112, Length=342, Percent_Identity=23.9766081871345, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559078, Length=246, Percent_Identity=35.3658536585366, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI115533416, Length=336, Percent_Identity=26.4880952380952, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115533418, Length=316, Percent_Identity=26.5822784810127, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363223, Length=355, Percent_Identity=29.2957746478873, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24666109, Length=328, Percent_Identity=30.1829268292683, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366397, Length=338, Percent_Identity=30.4733727810651, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI281366395, Length=338, Percent_Identity=30.4733727810651, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24666163, Length=338, Percent_Identity=30.4733727810651, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24666175, Length=322, Percent_Identity=28.8819875776398, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 37887; Mature: 37887

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIRKLLFITGVATVTPVIIQARDKLPNIVIFFMDDMGYGDLTITGASGYNTPTIDRLA
CHHHHHHHHHHHHHHHHHHHEEHHCCCCCEEEEEEECCCCCCEEEECCCCCCCCHHHHHH
SEGMFFTHFYAAQPISSASRAGLITGCYPNRVGISGALMPQGRIGVAPNEETLPEMLKTR
HCCEEEEEEEHHCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHC
GYSCGMVGKWHLGHLYPFLPLQQGFDEYLGLPYSNDMWPVDYDGNRVTPASNLPNKLRHP
CCCCCCCCCCCCCCCCCCCCHHHCHHHHCCCCCCCCCCCCCCCCCEECCCCCCCHHHCCC
ALPLIDGNEKIRELWTLNDQAELTTLYTERAIQFIKKNREQPFFLYFAHSMPHVPLAVSN
CCCEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECC
KFKGKSKQGLYGDVMLEVDWSVQQVLETIEELNLDENTLIIFTSDNGPWFSFGNHAGSTG
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCC
GLREAKATTFEGGQRVPCIMRWKGVIPRGTVCNQLASTII
CCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MQDIRKLLFITGVATVTPVIIQARDKLPNIVIFFMDDMGYGDLTITGASGYNTPTIDRLA
CHHHHHHHHHHHHHHHHHHHEEHHCCCCCEEEEEEECCCCCCEEEECCCCCCCCHHHHHH
SEGMFFTHFYAAQPISSASRAGLITGCYPNRVGISGALMPQGRIGVAPNEETLPEMLKTR
HCCEEEEEEEHHCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHC
GYSCGMVGKWHLGHLYPFLPLQQGFDEYLGLPYSNDMWPVDYDGNRVTPASNLPNKLRHP
CCCCCCCCCCCCCCCCCCCCHHHCHHHHCCCCCCCCCCCCCCCCCEECCCCCCCHHHCCC
ALPLIDGNEKIRELWTLNDQAELTTLYTERAIQFIKKNREQPFFLYFAHSMPHVPLAVSN
CCCEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECC
KFKGKSKQGLYGDVMLEVDWSVQQVLETIEELNLDENTLIIFTSDNGPWFSFGNHAGSTG
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCC
GLREAKATTFEGGQRVPCIMRWKGVIPRGTVCNQLASTII
CCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]