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The map label for this gene is ispD [H]

Identifier: 150010202

GI number: 150010202

Start: 4438248

End: 4438958

Strand: Direct

Name: ispD [H]

Synonym: BDI_3625

Alternate gene names: 150010202

Gene position: 4438248-4438958 (Clockwise)

Preceding gene: 150010201

Following gene: 150010203

Centisome position: 92.24

GC content: 37.55

Gene sequence:

>711_bases
ATGAATATCGCATTATTAACCGCCGGAGGAACCGGCACTCGTATGCATCAAGATATACCCAAGCAATTTCTTCATGTTAA
GAATAAACCTATTTTAATTTATACATTGGAGGCTTTTGAGCGGCATCCTAGTATAGATGCTATTATTGTAGTAGGGTTGG
AACGTTGGATTGATATTATATGGGCATATGCGAAGCAATTTAATATAACTAAATTGAAATGGGTGGTATCAGGTGGAAAC
ACTGGTCATGAATCGATTCGCAATGGCTTATTAGAATTGGAGAAACATTGTGACATTTCTGATGTTGTAATGATACATGA
TGGGAATCGACCGATGATAAGTCCGGATATTATATCGGATAGTTTGGCCAAACAAAAAGAGTTTGGAAGTGCCGTTGCAG
TAATTCCTTGTGTGGAGGTGGTCTTTAAAAGTAAAGATGGTCAATCATCCACTATAAATATACCTAGAGATGAACTACTT
CGTACACAAACTCCTCATACTTATGAGCTAGGAAAATTATTGTGGGCACATAGGGAAAGTGATCGATTGGGCATTTCAAA
TACGGTTGCTTCTTGTGATTTGATGTGTAGACTGGGGGAGACTGTATATTTTTCGAAAGGATCAGAGCGGAATTTAAAGA
TAACGACAGTGGAAGATATAGAGATTTTTACTTCGTTGTTAGATTATAGGAAAGAGGAGGGATTGAAGTGA

Upstream 100 bases:

>100_bases
GTAATTATATGGAACCTGATTTGAAGTGGGGAAAAGGATATATTAGGGCTTTGAGAGAAGCCTTGGAAGAGGATGCTAAA
TGATTTAAAATTAATACATT

Downstream 100 bases:

>100_bases
ATGTTGGAACGTTGATAGGTGATTTAAAAAGCAAGTCTATTTTGATAACTGGAGCATCTGGTTTGATATGTTCAGCTTTT
ATAGATCAATTAATGGGCGA

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MNIALLTAGGTGTRMHQDIPKQFLHVKNKPILIYTLEAFERHPSIDAIIVVGLERWIDIIWAYAKQFNITKLKWVVSGGN
TGHESIRNGLLELEKHCDISDVVMIHDGNRPMISPDIISDSLAKQKEFGSAVAVIPCVEVVFKSKDGQSSTINIPRDELL
RTQTPHTYELGKLLWAHRESDRLGISNTVASCDLMCRLGETVYFSKGSERNLKITTVEDIEIFTSLLDYRKEEGLK

Sequences:

>Translated_236_residues
MNIALLTAGGTGTRMHQDIPKQFLHVKNKPILIYTLEAFERHPSIDAIIVVGLERWIDIIWAYAKQFNITKLKWVVSGGN
TGHESIRNGLLELEKHCDISDVVMIHDGNRPMISPDIISDSLAKQKEFGSAVAVIPCVEVVFKSKDGQSSTINIPRDELL
RTQTPHTYELGKLLWAHRESDRLGISNTVASCDLMCRLGETVYFSKGSERNLKITTVEDIEIFTSLLDYRKEEGLK
>Mature_236_residues
MNIALLTAGGTGTRMHQDIPKQFLHVKNKPILIYTLEAFERHPSIDAIIVVGLERWIDIIWAYAKQFNITKLKWVVSGGN
TGHESIRNGLLELEKHCDISDVVMIHDGNRPMISPDIISDSLAKQKEFGSAVAVIPCVEVVFKSKDGQSSTINIPRDELL
RTQTPHTYELGKLLWAHRESDRLGISNTVASCDLMCRLGETVYFSKGSERNLKITTVEDIEIFTSLLDYRKEEGLK

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=150, Percent_Identity=34, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI157671913, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 26576; Mature: 26576

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIALLTAGGTGTRMHQDIPKQFLHVKNKPILIYTLEAFERHPSIDAIIVVGLERWIDII
CEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCEEEEEEHHHHHHHH
WAYAKQFNITKLKWVVSGGNTGHESIRNGLLELEKHCDISDVVMIHDGNRPMISPDIISD
HHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
SLAKQKEFGSAVAVIPCVEVVFKSKDGQSSTINIPRDELLRTQTPHTYELGKLLWAHRES
HHHHHHHHCCEEHHHHHHHHHHCCCCCCCCEEECCHHHHHHCCCCCHHHHHHHHHHCCCC
DRLGISNTVASCDLMCRLGETVYFSKGSERNLKITTVEDIEIFTSLLDYRKEEGLK
CCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIALLTAGGTGTRMHQDIPKQFLHVKNKPILIYTLEAFERHPSIDAIIVVGLERWIDII
CEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCEEEEEEHHHHHHHH
WAYAKQFNITKLKWVVSGGNTGHESIRNGLLELEKHCDISDVVMIHDGNRPMISPDIISD
HHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
SLAKQKEFGSAVAVIPCVEVVFKSKDGQSSTINIPRDELLRTQTPHTYELGKLLWAHRES
HHHHHHHHCCEEHHHHHHHHHHCCCCCCCCEEECCHHHHHHCCCCCHHHHHHHHHHCCCC
DRLGISNTVASCDLMCRLGETVYFSKGSERNLKITTVEDIEIFTSLLDYRKEEGLK
CCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA