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The map label for this gene is folP [H]

Identifier: 150009949

GI number: 150009949

Start: 4084092

End: 4084931

Strand: Direct

Name: folP [H]

Synonym: BDI_3367

Alternate gene names: 150009949

Gene position: 4084092-4084931 (Clockwise)

Preceding gene: 150009947

Following gene: 150009950

Centisome position: 84.88

GC content: 47.02

Gene sequence:

>840_bases
ATGTTAGATAAAATGCTCAATATTAGAGGGACACTTACTTCTTTAGCGACACCGTTGGTGATGGGAATCTTGAATATTAC
CCCTGATTCTTTTTATGCGGGCAGCCGCAAACAGACCGAGACCGCTATCGAGGACCGTATCCGGGAAATCTTATCGGAGG
GAGGGGATTGGATCGATATCGGTGGTTATTCATCCCGTCCGGATGCCGCTGAGGTTACCCCGGAGGAAGAGATGCGCCGT
TTGGAGTTTGCCTTACATATATTAAATAAGCATTACCCGGATATCCCGGTGTCCGTAGATACGTTTCGTGCGGGGATTGC
CCGTCGTTGCGTAGAGGAATATGGAGTGGCTGTCATTAACGATATCTCCGGCGGTGAGTTGGATGCGGATATGTTCCAAA
CGGTAGCGGATTTGAAGGTGCCTTATATCATGATGCATATGCGTGGAACCCCTCAAACTATGCAGAGGCATACTGATTAC
CCGGATATGATGGAGGAGATCATGCTGTACTTTTCCCGGAAGGTACGCCAGCTTCGGCTTTTAGGGGTGAATGATATCAT
CCTCGATCCCGGCTTTGGCTTTAGTAAGACGTTGGAGCAGAATTACCAATTGATGAGCCATTTAAAGGAGTTCTCTATTT
TTGAGTTGCCTTTATTAGTTGGAGTCTCCCGTAAAAGCATGATTTATAAATTACTGGGTGGAACCCCTGCGGATAGCTTG
AACGGAACGACTGTATTGAATACGTACGCTCTCTTGAACGGCGCTAATATCCTTCGTGTACATGATGTGCGGGAAGCAGT
GGAAGCCATTCGCGTCATAGGTCAAATGACCAACAAATAA

Upstream 100 bases:

>100_bases
TCTAATTCGGCGCAAATGTAGCAATTAAATAAAGAATGAAGAATCTAGAAGGAGATTTTAAGAGAGAAACCTGTATCTTT
GCTGGAAATAAGGAAAGATC

Downstream 100 bases:

>100_bases
TTTTCAATTTTCAACTTTCAATTCTCAATTAACTATGTGGATGCATTTCGGTATAAAAGACTTGATTGACGTATTGCTGG
TGGCTTTCTTCCTGTACCAG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MLDKMLNIRGTLTSLATPLVMGILNITPDSFYAGSRKQTETAIEDRIREILSEGGDWIDIGGYSSRPDAAEVTPEEEMRR
LEFALHILNKHYPDIPVSVDTFRAGIARRCVEEYGVAVINDISGGELDADMFQTVADLKVPYIMMHMRGTPQTMQRHTDY
PDMMEEIMLYFSRKVRQLRLLGVNDIILDPGFGFSKTLEQNYQLMSHLKEFSIFELPLLVGVSRKSMIYKLLGGTPADSL
NGTTVLNTYALLNGANILRVHDVREAVEAIRVIGQMTNK

Sequences:

>Translated_279_residues
MLDKMLNIRGTLTSLATPLVMGILNITPDSFYAGSRKQTETAIEDRIREILSEGGDWIDIGGYSSRPDAAEVTPEEEMRR
LEFALHILNKHYPDIPVSVDTFRAGIARRCVEEYGVAVINDISGGELDADMFQTVADLKVPYIMMHMRGTPQTMQRHTDY
PDMMEEIMLYFSRKVRQLRLLGVNDIILDPGFGFSKTLEQNYQLMSHLKEFSIFELPLLVGVSRKSMIYKLLGGTPADSL
NGTTVLNTYALLNGANILRVHDVREAVEAIRVIGQMTNK
>Mature_279_residues
MLDKMLNIRGTLTSLATPLVMGILNITPDSFYAGSRKQTETAIEDRIREILSEGGDWIDIGGYSSRPDAAEVTPEEEMRR
LEFALHILNKHYPDIPVSVDTFRAGIARRCVEEYGVAVINDISGGELDADMFQTVADLKVPYIMMHMRGTPQTMQRHTDY
PDMMEEIMLYFSRKVRQLRLLGVNDIILDPGFGFSKTLEQNYQLMSHLKEFSIFELPLLVGVSRKSMIYKLLGGTPADSL
NGTTVLNTYALLNGANILRVHDVREAVEAIRVIGQMTNK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=270, Percent_Identity=40, Blast_Score=197, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=29.746835443038, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31405; Mature: 31405

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKMLNIRGTLTSLATPLVMGILNITPDSFYAGSRKQTETAIEDRIREILSEGGDWIDI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
GGYSSRPDAAEVTPEEEMRRLEFALHILNKHYPDIPVSVDTFRAGIARRCVEEYGVAVIN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
DISGGELDADMFQTVADLKVPYIMMHMRGTPQTMQRHTDYPDMMEEIMLYFSRKVRQLRL
CCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LGVNDIILDPGFGFSKTLEQNYQLMSHLKEFSIFELPLLVGVSRKSMIYKLLGGTPADSL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
NGTTVLNTYALLNGANILRVHDVREAVEAIRVIGQMTNK
CCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDKMLNIRGTLTSLATPLVMGILNITPDSFYAGSRKQTETAIEDRIREILSEGGDWIDI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
GGYSSRPDAAEVTPEEEMRRLEFALHILNKHYPDIPVSVDTFRAGIARRCVEEYGVAVIN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
DISGGELDADMFQTVADLKVPYIMMHMRGTPQTMQRHTDYPDMMEEIMLYFSRKVRQLRL
CCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LGVNDIILDPGFGFSKTLEQNYQLMSHLKEFSIFELPLLVGVSRKSMIYKLLGGTPADSL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
NGTTVLNTYALLNGANILRVHDVREAVEAIRVIGQMTNK
CCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]