| Definition | Parabacteroides distasonis ATCC 8503 chromosome, complete genome. |
|---|---|
| Accession | NC_009615 |
| Length | 4,811,379 |
Click here to switch to the map view.
The map label for this gene is lacZ [H]
Identifier: 150009688
GI number: 150009688
Start: 3725593
End: 3728133
Strand: Direct
Name: lacZ [H]
Synonym: BDI_3103
Alternate gene names: 150009688
Gene position: 3725593-3728133 (Clockwise)
Preceding gene: 150009687
Following gene: 150009689
Centisome position: 77.43
GC content: 53.33
Gene sequence:
>2541_bases ATGATATCACTGATGAATCGGCCATTCGCGTGGCTTCTGGGCCTATTGCTCACCGCCTGTTCCCCCACCGGGGAGCAGGT GCGTGAACGTAGCTCATGGAATGACGATTGGAAATTTGCCTTGTCGGATAGCGTTCAGGATTATTCATCCCCGGACAGCG ATGATTCCACTTGGCGTATCTTATCTTTACCGCATGATTGGAGTATCGAGGGGGATTTCTCCCTCGATAACCCGTCTACC CCGGGCGGCGGCGCGCTACCGGGCGGGATTGGCTGGTATCGAAAGACATTTACCCTTCCGGAGACGGATCGGGGTAAGGT TGTTTATGTTGATTTCGACGGGGTTTACCGGAATAGCGAGGTTTGGATCAATGGTCATTCGCTGGGATTCCGCCCGAATG GTTATGTATCGTTTCGTTATGACTTGACGCCTTATTTGAGGTATGGAAGCCAACCGAACGTAATTGTAGTGAAGGCGGAT AATAGCGAGCAGCCGAACTCCCGCTGGTATTCCGGCTCCGGTATCTACCGTAACGTATGGCTGGTGAAGGTGAATCCGGT ACATGTGGACAACTGGGGCACTTTCGTGCATGATATGAAGATCTCACCGGAGGAGGCTACCTTCTCCTTGGAGGCGAGAA TAAGGAATAGCTCGGAGGCGGATAGGGAGGCCGAAGTCTCTACCTCTATTTACGATGACCGTAACAGAGTTGTTACGGCA CCCGTAACAACTCTGTTACGGGTACCGTATACGCCCTGTTACGACACCCGTATGCGGGAGGCATCTGTCGATCATCAGTT CTCGATCTCAAATCCCAAGCTTTGGAGCCCCGATTCTCCCTCGCTCTACACGGCCGTCACGGAAGTGAAAGTGGCTGGTA AGGTGGTAGATCGTTACGAGACGGTATTCGGATTGCGTACGTTCCGTTGGGATTCCGCTACCGGCTTTTATTTGAATGAT AAGCCTTTGAAGATAAAAGGGGTTTGCCTGCATCATGATTTAGGCTGTCTGGGTGCCGCCGTGAATACACGGGCTATCGA GCGCCAGCTACAGATCATGAAGGAGATGGGTGTGAACGCGATCCGTACCAGCCATAACGCCCCGGCACCCGAGTTGCTGG ATCTTTGCGATCGTATGGGCCTTCTGGTACAGGATGAGTCTTTCGATATGTGGGAACGCCGTAAGTCCCCATACGATTAC GCCCGGTATTTCGCGGAGTGGCATGAGCGGGATTTGACGGACGAGATCTTGCGTGACCGGAATCACGCCTCTGTTTTCAT GTGGAGTATAGGCAATGAGGTACTTGAGCAATGGAGTCATGCCGACGCTACCGAGCTGGATCTGCAAGCGGCGAACCTGA TCTTGAATGCGGGCCATGCCATTGATCCCGCTTTGCTGAAGGATACGACCCTTAGTCGTCAATCCTTGATCACCCGTCAT CTGGCGGCTATCGTGAAACGGCTGGATACTTCCCGGGTCGTTACCGCCGGCTGTAACGAGGTAAACCCTGCGAATCATCT GTTCCGCTCGGATGCCTTGGACGTGCTGGGCTTCAACTACCATGAGCAATATCTTGAACCGTTTCTCCGGAATTTCCCCG GAAGGAAACTGATCGTGAGCGAATCTACCTCGGCCTTGATGACCCGTGGCTATTATGAGATGCCGTCCGATCATATTTAT ATCCGTCCGGAATCGTGGGACAAGCCTTTCGAGGCTCCCGAGCATGTTTGCTCCTCTTATGATAATTGCCATGTACCTTG GGGCTCTACGCACGAGAAGACTTGGCATCTGGTGAAGACGCTTCCGCATGTATCCGGCCTGTTCGTCTGGACGGGTTTCG ATTACTTGGGAGAGCCTACCCCCTATTGGTGGCCCAGCCGGAGCAGCTTCTTCGGTATCGTGGATCTGGCGGGTTTCCCG AAGGATGTATATTATATGTATAAAAGCGAGTGGACGGATGAACCCGTATTGCACATTTTCCCGCATTGGAACTGGAAGGA AGGCGAACGGGTGGATATCTGGGCCTATTATAACAATGCCGATGAGGTGGAACTATACCTAAACGGAAAGAGCCTAGGCG TACGACAAAAAACGGACAGTACCTATCATGTCTCTTGGCGTGTGCCTTTTACGCCCGGAACCTTGAGAGCCGTCTCCCGC TTAGGGGGTAAGGAGGTCTTGGTGAAAGAGATCCATACGGCAGGAGAGCCGGCCCGTTTGGTCTTGACCCCGGATCGTAG CGTCATCCAAGCGGATGGCTCGGACCTATCGTTTGTAACCGTAGATGTATGCGATATCGATGGTAACCGGGTTCCCGACG CTACCCCGTTGATCCGTTTCTCCGTGGAGGGCCCGGGTGAGATCGCCGGAACGGATAACGGAGATCCGAACGATCCGAAC AGCCTCCGTAAACCGAAACGGCAAGCCTACTACGGAAAAGCCTTGGTCGTGATCCGGAACAAGGGCGGACAAGGCGACAT CCACTTAAAAGCCATAGCCGAGGGCTTACCCGAGGCGACGGTAACGATTCAAGCGCAATAA
Upstream 100 bases:
>100_bases GGACGTGACAATATCTTACCAAGGTAAACCTCTAGTTGTAGAGACAGGGCACGCCCCGTCTCTACAACTGGGTAATATCA ATTAAACTATATAATCACTA
Downstream 100 bases:
>100_bases TAAACCTATAAATAAAGAGGAAATGAAAAAGATAATAGGCGTGATCGCTTGCGGGCTATTCTTGAACGCGGCTGCCGCGA GCTCGCAGGTCACGGATAAA
Product: beta-glycosidase
Products: NA
Alternate protein names: Beta-gal; Lactase [H]
Number of amino acids: Translated: 846; Mature: 846
Protein sequence:
>846_residues MISLMNRPFAWLLGLLLTACSPTGEQVRERSSWNDDWKFALSDSVQDYSSPDSDDSTWRILSLPHDWSIEGDFSLDNPST PGGGALPGGIGWYRKTFTLPETDRGKVVYVDFDGVYRNSEVWINGHSLGFRPNGYVSFRYDLTPYLRYGSQPNVIVVKAD NSEQPNSRWYSGSGIYRNVWLVKVNPVHVDNWGTFVHDMKISPEEATFSLEARIRNSSEADREAEVSTSIYDDRNRVVTA PVTTLLRVPYTPCYDTRMREASVDHQFSISNPKLWSPDSPSLYTAVTEVKVAGKVVDRYETVFGLRTFRWDSATGFYLND KPLKIKGVCLHHDLGCLGAAVNTRAIERQLQIMKEMGVNAIRTSHNAPAPELLDLCDRMGLLVQDESFDMWERRKSPYDY ARYFAEWHERDLTDEILRDRNHASVFMWSIGNEVLEQWSHADATELDLQAANLILNAGHAIDPALLKDTTLSRQSLITRH LAAIVKRLDTSRVVTAGCNEVNPANHLFRSDALDVLGFNYHEQYLEPFLRNFPGRKLIVSESTSALMTRGYYEMPSDHIY IRPESWDKPFEAPEHVCSSYDNCHVPWGSTHEKTWHLVKTLPHVSGLFVWTGFDYLGEPTPYWWPSRSSFFGIVDLAGFP KDVYYMYKSEWTDEPVLHIFPHWNWKEGERVDIWAYYNNADEVELYLNGKSLGVRQKTDSTYHVSWRVPFTPGTLRAVSR LGGKEVLVKEIHTAGEPARLVLTPDRSVIQADGSDLSFVTVDVCDIDGNRVPDATPLIRFSVEGPGEIAGTDNGDPNDPN SLRKPKRQAYYGKALVVIRNKGGQGDIHLKAIAEGLPEATVTIQAQ
Sequences:
>Translated_846_residues MISLMNRPFAWLLGLLLTACSPTGEQVRERSSWNDDWKFALSDSVQDYSSPDSDDSTWRILSLPHDWSIEGDFSLDNPST PGGGALPGGIGWYRKTFTLPETDRGKVVYVDFDGVYRNSEVWINGHSLGFRPNGYVSFRYDLTPYLRYGSQPNVIVVKAD NSEQPNSRWYSGSGIYRNVWLVKVNPVHVDNWGTFVHDMKISPEEATFSLEARIRNSSEADREAEVSTSIYDDRNRVVTA PVTTLLRVPYTPCYDTRMREASVDHQFSISNPKLWSPDSPSLYTAVTEVKVAGKVVDRYETVFGLRTFRWDSATGFYLND KPLKIKGVCLHHDLGCLGAAVNTRAIERQLQIMKEMGVNAIRTSHNAPAPELLDLCDRMGLLVQDESFDMWERRKSPYDY ARYFAEWHERDLTDEILRDRNHASVFMWSIGNEVLEQWSHADATELDLQAANLILNAGHAIDPALLKDTTLSRQSLITRH LAAIVKRLDTSRVVTAGCNEVNPANHLFRSDALDVLGFNYHEQYLEPFLRNFPGRKLIVSESTSALMTRGYYEMPSDHIY IRPESWDKPFEAPEHVCSSYDNCHVPWGSTHEKTWHLVKTLPHVSGLFVWTGFDYLGEPTPYWWPSRSSFFGIVDLAGFP KDVYYMYKSEWTDEPVLHIFPHWNWKEGERVDIWAYYNNADEVELYLNGKSLGVRQKTDSTYHVSWRVPFTPGTLRAVSR LGGKEVLVKEIHTAGEPARLVLTPDRSVIQADGSDLSFVTVDVCDIDGNRVPDATPLIRFSVEGPGEIAGTDNGDPNDPN SLRKPKRQAYYGKALVVIRNKGGQGDIHLKAIAEGLPEATVTIQAQ >Mature_846_residues MISLMNRPFAWLLGLLLTACSPTGEQVRERSSWNDDWKFALSDSVQDYSSPDSDDSTWRILSLPHDWSIEGDFSLDNPST PGGGALPGGIGWYRKTFTLPETDRGKVVYVDFDGVYRNSEVWINGHSLGFRPNGYVSFRYDLTPYLRYGSQPNVIVVKAD NSEQPNSRWYSGSGIYRNVWLVKVNPVHVDNWGTFVHDMKISPEEATFSLEARIRNSSEADREAEVSTSIYDDRNRVVTA PVTTLLRVPYTPCYDTRMREASVDHQFSISNPKLWSPDSPSLYTAVTEVKVAGKVVDRYETVFGLRTFRWDSATGFYLND KPLKIKGVCLHHDLGCLGAAVNTRAIERQLQIMKEMGVNAIRTSHNAPAPELLDLCDRMGLLVQDESFDMWERRKSPYDY ARYFAEWHERDLTDEILRDRNHASVFMWSIGNEVLEQWSHADATELDLQAANLILNAGHAIDPALLKDTTLSRQSLITRH LAAIVKRLDTSRVVTAGCNEVNPANHLFRSDALDVLGFNYHEQYLEPFLRNFPGRKLIVSESTSALMTRGYYEMPSDHIY IRPESWDKPFEAPEHVCSSYDNCHVPWGSTHEKTWHLVKTLPHVSGLFVWTGFDYLGEPTPYWWPSRSSFFGIVDLAGFP KDVYYMYKSEWTDEPVLHIFPHWNWKEGERVDIWAYYNNADEVELYLNGKSLGVRQKTDSTYHVSWRVPFTPGTLRAVSR LGGKEVLVKEIHTAGEPARLVLTPDRSVIQADGSDLSFVTVDVCDIDGNRVPDATPLIRFSVEGPGEIAGTDNGDPNDPN SLRKPKRQAYYGKALVVIRNKGGQGDIHLKAIAEGLPEATVTIQAQ
Specific function: The Wild-Type Enzyme Is An Ineffective Lactase. Two Classes Of Point Mutations Dramatically Improve Activity Of The Enzyme. [C]
COG id: COG3250
COG function: function code G; Beta-galactosidase/beta-glucuronidase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the glycosyl hydrolase 2 family [H]
Homologues:
Organism=Homo sapiens, GI268834192, Length=408, Percent_Identity=22.0588235294118, Blast_Score=87, Evalue=1e-16, Organism=Escherichia coli, GI48994920, Length=398, Percent_Identity=26.6331658291457, Blast_Score=134, Evalue=2e-32, Organism=Escherichia coli, GI1786539, Length=437, Percent_Identity=26.0869565217391, Blast_Score=113, Evalue=6e-26, Organism=Escherichia coli, GI1787903, Length=376, Percent_Identity=24.7340425531915, Blast_Score=97, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17510825, Length=392, Percent_Identity=24.7448979591837, Blast_Score=99, Evalue=1e-20, Organism=Drosophila melanogaster, GI24655438, Length=383, Percent_Identity=24.5430809399478, Blast_Score=109, Evalue=7e-24, Organism=Drosophila melanogaster, GI62471735, Length=383, Percent_Identity=24.5430809399478, Blast_Score=109, Evalue=8e-24, Organism=Drosophila melanogaster, GI19922582, Length=383, Percent_Identity=24.5430809399478, Blast_Score=109, Evalue=8e-24, Organism=Drosophila melanogaster, GI24651745, Length=551, Percent_Identity=22.1415607985481, Blast_Score=91, Evalue=3e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003344 - InterPro: IPR008979 - InterPro: IPR006101 - InterPro: IPR013812 - InterPro: IPR006104 - InterPro: IPR006102 - InterPro: IPR006103 - InterPro: IPR017853 - InterPro: IPR013781 [H]
Pfam domain/function: PF00703 Glyco_hydro_2; PF02836 Glyco_hydro_2_C; PF02837 Glyco_hydro_2_N [H]
EC number: =3.2.1.23 [H]
Molecular weight: Translated: 95924; Mature: 95924
Theoretical pI: Translated: 5.67; Mature: 5.67
Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00608 GLYCOSYL_HYDROL_F2_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MISLMNRPFAWLLGLLLTACSPTGEQVRERSSWNDDWKFALSDSVQDYSSPDSDDSTWRI CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCHHHCCCCCCCCCCEEE LSLPHDWSIEGDFSLDNPSTPGGGALPGGIGWYRKTFTLPETDRGKVVYVDFDGVYRNSE EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCEEEEEECCCEEECCE VWINGHSLGFRPNGYVSFRYDLTPYLRYGSQPNVIVVKADNSEQPNSRWYSGSGIYRNVW EEEECCEECCCCCCEEEEEECCCHHHHCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEE LVKVNPVHVDNWGTFVHDMKISPEEATFSLEARIRNSSEADREAEVSTSIYDDRNRVVTA EEEEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHEECCCCCEEEC PVTTLLRVPYTPCYDTRMREASVDHQFSISNPKLWSPDSPSLYTAVTEVKVAGKVVDRYE CHHHHHHCCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHH TVFGLRTFRWDSATGFYLNDKPLKIKGVCLHHDLGCLGAAVNTRAIERQLQIMKEMGVNA HHHHHEEEEECCCCEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCE IRTSHNAPAPELLDLCDRMGLLVQDESFDMWERRKSPYDYARYFAEWHERDLTDEILRDR EECCCCCCCHHHHHHHHHCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCC NHASVFMWSIGNEVLEQWSHADATELDLQAANLILNAGHAIDPALLKDTTLSRQSLITRH CCCEEEEEEHHHHHHHHHCCCCCCHHHHEEEHEEEECCCCCCCHHHHCCCHHHHHHHHHH LAAIVKRLDTSRVVTAGCNEVNPANHLFRSDALDVLGFNYHEQYLEPFLRNFPGRKLIVS HHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCEEEEE ESTSALMTRGYYEMPSDHIYIRPESWDKPFEAPEHVCSSYDNCHVPWGSTHEKTWHLVKT CCCHHHHHCCCEECCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHH LPHVSGLFVWTGFDYLGEPTPYWWPSRSSFFGIVDLAGFPKDVYYMYKSEWTDEPVLHIF CCCCCEEEEEECHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHEEEEECCCCCCCEEEEE PHWNWKEGERVDIWAYYNNADEVELYLNGKSLGVRQKTDSTYHVSWRVPFTPGTLRAVSR CCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEECCCCEEEEEEEECCCCHHHHHHHH LGGKEVLVKEIHTAGEPARLVLTPDRSVIQADGSDLSFVTVDVCDIDGNRVPDATPLIRF CCCHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCEEEEEEEEEECCCCCCCCCCCEEEE SVEGPGEIAGTDNGDPNDPNSLRKPKRQAYYGKALVVIRNKGGQGDIHLKAIAEGLPEAT EECCCCCCCCCCCCCCCCCHHHCCCHHHHHCCEEEEEEECCCCCCCEEEEEHHCCCCCCE VTIQAQ EEEEEC >Mature Secondary Structure MISLMNRPFAWLLGLLLTACSPTGEQVRERSSWNDDWKFALSDSVQDYSSPDSDDSTWRI CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCHHHCCCCCCCCCCEEE LSLPHDWSIEGDFSLDNPSTPGGGALPGGIGWYRKTFTLPETDRGKVVYVDFDGVYRNSE EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCEEEEEECCCEEECCE VWINGHSLGFRPNGYVSFRYDLTPYLRYGSQPNVIVVKADNSEQPNSRWYSGSGIYRNVW EEEECCEECCCCCCEEEEEECCCHHHHCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEE LVKVNPVHVDNWGTFVHDMKISPEEATFSLEARIRNSSEADREAEVSTSIYDDRNRVVTA EEEEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHEECCCCCEEEC PVTTLLRVPYTPCYDTRMREASVDHQFSISNPKLWSPDSPSLYTAVTEVKVAGKVVDRYE CHHHHHHCCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHH TVFGLRTFRWDSATGFYLNDKPLKIKGVCLHHDLGCLGAAVNTRAIERQLQIMKEMGVNA HHHHHEEEEECCCCEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCE IRTSHNAPAPELLDLCDRMGLLVQDESFDMWERRKSPYDYARYFAEWHERDLTDEILRDR EECCCCCCCHHHHHHHHHCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCC NHASVFMWSIGNEVLEQWSHADATELDLQAANLILNAGHAIDPALLKDTTLSRQSLITRH CCCEEEEEEHHHHHHHHHCCCCCCHHHHEEEHEEEECCCCCCCHHHHCCCHHHHHHHHHH LAAIVKRLDTSRVVTAGCNEVNPANHLFRSDALDVLGFNYHEQYLEPFLRNFPGRKLIVS HHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCEEEEE ESTSALMTRGYYEMPSDHIYIRPESWDKPFEAPEHVCSSYDNCHVPWGSTHEKTWHLVKT CCCHHHHHCCCEECCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHH LPHVSGLFVWTGFDYLGEPTPYWWPSRSSFFGIVDLAGFPKDVYYMYKSEWTDEPVLHIF CCCCCEEEEEECHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHEEEEECCCCCCCEEEEE PHWNWKEGERVDIWAYYNNADEVELYLNGKSLGVRQKTDSTYHVSWRVPFTPGTLRAVSR CCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEECCCCEEEEEEEECCCCHHHHHHHH LGGKEVLVKEIHTAGEPARLVLTPDRSVIQADGSDLSFVTVDVCDIDGNRVPDATPLIRF CCCHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCEEEEEEEEEECCCCCCCCCCCEEEE SVEGPGEIAGTDNGDPNDPNSLRKPKRQAYYGKALVVIRNKGGQGDIHLKAIAEGLPEAT EECCCCCCCCCCCCCCCCCHHHCCCHHHHHCCEEEEEEECCCCCCCEEEEEHHCCCCCCE VTIQAQ EEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA