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The map label for this gene is mepA [H]

Identifier: 150009495

GI number: 150009495

Start: 3471418

End: 3472518

Strand: Direct

Name: mepA [H]

Synonym: BDI_2908

Alternate gene names: 150009495

Gene position: 3471418-3472518 (Clockwise)

Preceding gene: 150009494

Following gene: 150009496

Centisome position: 72.15

GC content: 45.78

Gene sequence:

>1101_bases
ATGGTTATGAGTTCAAAATGGATGAGACTAATAGGATTAGTCGGTTTTACGGCAGTATTGGTGTCTTGCAAACAAACACC
TCAAGCTCCAATGAATGCCAATTATGCAACAATGAAAATAACAGTAAGTGACAAGAAATTCTCTACCTCTTATTCAGCCA
CGATCCGTGGACGGCAGGATATCGATATTTATCCACAGGTATCCGGAACTATCGAGCGCCTTTGCGTAACAGAAGGTGAG
AAAGTCCGGAAAGGACAAATTCTTTTCGTCATAGACCAAGTACCCTACAAGGCAGCCTTGAATACGGCTATAGCCAACGT
TAAATCAGCAAAGGCAGGCTTAGCCACGGCGGAATTAACCTACAACAGCAATAAAGAGCTATATGCCCAGAAAGTAGTAT
CAGAGTTCAGCCTAAAGACCTCCGAGAACAGTTATCTCACCGCACAAGCAGCTTTGGCACAAGCTGAGGCTCAAGAGACA
AACGCCCGCAACAACCTCTCTTATACCGAAGTAAAAAGTCCGAGTGACGGAGTGGTAGGAGCGTTACCCTATCGGGTCGG
AGCCTTAGTCAGCGCCAATATTCCACAGCCATTGACTACAGTATCCGACAACTCGAACATGTATGTGTATTTCTCTATGA
ATGAGAACCAGCTTTTATCCTTGACCCGTCAATATGGTTCCATGGATGACGCACTGAAGAACATGCCGGAAGTAGAACTT
AGACTAAATGACAACTCCATCTACGAACATAAAGGAAAGATCGAGTCGATCAGCGGCGTGATCGATCGCCAGACCGGTAC
GGTAACCGTCCGTTCTGTCTTCCCAAACGAGGCACGCCTACTACATAGCGGAGCCTCTGGAGCGGTAATCATCCCCAGTA
CATATGAGAATTGTATCGTAATCCCACAGGAAGCGACAATACGTCTACAGGATAAAACAATGGTATATAAAGTAGTGGAT
GGCAAAGCAGTCTCATCCTTGATCACGGTAGCTGAATTGAACGATGGACGCGAGTATGTCGTATTAGACGGACTGAAAGC
CGGTGAAGAAATCGTATCACAAGGAGCCGGATTGGTACGTGAGGGAACACAAGTTAAATGA

Upstream 100 bases:

>100_bases
CTACAAGATATTACAATCAGAACACTTCACCAGCACATTTGGTATATAAAAATGAGCTATCTCCTTTTAACTTTGCGCGG
AATTTTAAAAGGATATACAA

Downstream 100 bases:

>100_bases
AAAGAAATCAGTGCATTATGAAAGGGAATATATTTATCAAACGGCCTGTTATGGCTATATCCATTTCCATCCTGATCTTG
GTAGTCGGGCTGATTTCGCT

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MVMSSKWMRLIGLVGFTAVLVSCKQTPQAPMNANYATMKITVSDKKFSTSYSATIRGRQDIDIYPQVSGTIERLCVTEGE
KVRKGQILFVIDQVPYKAALNTAIANVKSAKAGLATAELTYNSNKELYAQKVVSEFSLKTSENSYLTAQAALAQAEAQET
NARNNLSYTEVKSPSDGVVGALPYRVGALVSANIPQPLTTVSDNSNMYVYFSMNENQLLSLTRQYGSMDDALKNMPEVEL
RLNDNSIYEHKGKIESISGVIDRQTGTVTVRSVFPNEARLLHSGASGAVIIPSTYENCIVIPQEATIRLQDKTMVYKVVD
GKAVSSLITVAELNDGREYVVLDGLKAGEEIVSQGAGLVREGTQVK

Sequences:

>Translated_366_residues
MVMSSKWMRLIGLVGFTAVLVSCKQTPQAPMNANYATMKITVSDKKFSTSYSATIRGRQDIDIYPQVSGTIERLCVTEGE
KVRKGQILFVIDQVPYKAALNTAIANVKSAKAGLATAELTYNSNKELYAQKVVSEFSLKTSENSYLTAQAALAQAEAQET
NARNNLSYTEVKSPSDGVVGALPYRVGALVSANIPQPLTTVSDNSNMYVYFSMNENQLLSLTRQYGSMDDALKNMPEVEL
RLNDNSIYEHKGKIESISGVIDRQTGTVTVRSVFPNEARLLHSGASGAVIIPSTYENCIVIPQEATIRLQDKTMVYKVVD
GKAVSSLITVAELNDGREYVVLDGLKAGEEIVSQGAGLVREGTQVK
>Mature_366_residues
MVMSSKWMRLIGLVGFTAVLVSCKQTPQAPMNANYATMKITVSDKKFSTSYSATIRGRQDIDIYPQVSGTIERLCVTEGE
KVRKGQILFVIDQVPYKAALNTAIANVKSAKAGLATAELTYNSNKELYAQKVVSEFSLKTSENSYLTAQAALAQAEAQET
NARNNLSYTEVKSPSDGVVGALPYRVGALVSANIPQPLTTVSDNSNMYVYFSMNENQLLSLTRQYGSMDDALKNMPEVEL
RLNDNSIYEHKGKIESISGVIDRQTGTVTVRSVFPNEARLLHSGASGAVIIPSTYENCIVIPQEATIRLQDKTMVYKVVD
GKAVSSLITVAELNDGREYVVLDGLKAGEEIVSQGAGLVREGTQVK

Specific function: The periplasmic linker protein component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=373, Percent_Identity=28.1501340482574, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786668, Length=309, Percent_Identity=30.7443365695793, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789665, Length=311, Percent_Identity=30.5466237942122, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87082036, Length=314, Percent_Identity=23.5668789808917, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081796, Length=379, Percent_Identity=26.3852242744063, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081951, Length=164, Percent_Identity=31.7073170731707, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39805; Mature: 39805

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMSSKWMRLIGLVGFTAVLVSCKQTPQAPMNANYATMKITVSDKKFSTSYSATIRGRQD
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEECCCEEEEECCCCC
IDIYPQVSGTIERLCVTEGEKVRKGQILFVIDQVPYKAALNTAIANVKSAKAGLATAELT
CEECCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEE
YNSNKELYAQKVVSEFSLKTSENSYLTAQAALAQAEAQETNARNNLSYTEVKSPSDGVVG
ECCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEE
ALPYRVGALVSANIPQPLTTVSDNSNMYVYFSMNENQLLSLTRQYGSMDDALKNMPEVEL
ECCHHHCEEEECCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHCCCCEEE
RLNDNSIYEHKGKIESISGVIDRQTGTVTVRSVFPNEARLLHSGASGAVIIPSTYENCIV
EECCCCEEECCCCHHHHHHEEECCCCEEEEEEECCCCCEEEECCCCCEEEECCCCCCEEE
IPQEATIRLQDKTMVYKVVDGKAVSSLITVAELNDGREYVVLDGLKAGEEIVSQGAGLVR
ECCCCEEEEECCEEEEEEECCHHHHHEEEEEEECCCCEEEEEECCCCCHHHHHCCCCEEC
EGTQVK
CCCCCC
>Mature Secondary Structure
MVMSSKWMRLIGLVGFTAVLVSCKQTPQAPMNANYATMKITVSDKKFSTSYSATIRGRQD
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEECCCEEEEECCCCC
IDIYPQVSGTIERLCVTEGEKVRKGQILFVIDQVPYKAALNTAIANVKSAKAGLATAELT
CEECCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEE
YNSNKELYAQKVVSEFSLKTSENSYLTAQAALAQAEAQETNARNNLSYTEVKSPSDGVVG
ECCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEE
ALPYRVGALVSANIPQPLTTVSDNSNMYVYFSMNENQLLSLTRQYGSMDDALKNMPEVEL
ECCHHHCEEEECCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHCCCCEEE
RLNDNSIYEHKGKIESISGVIDRQTGTVTVRSVFPNEARLLHSGASGAVIIPSTYENCIV
EECCCCEEECCCCHHHHHHEEECCCCEEEEEEECCCCCEEEECCCCCEEEECCCCCCEEE
IPQEATIRLQDKTMVYKVVDGKAVSSLITVAELNDGREYVVLDGLKAGEEIVSQGAGLVR
ECCCCEEEEECCEEEEEEECCHHHHHEEEEEEECCCCEEEEEECCCCCHHHHHCCCCEEC
EGTQVK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9827328 [H]