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The map label for this gene is agaI [H]

Identifier: 150009464

GI number: 150009464

Start: 3428254

End: 3428976

Strand: Direct

Name: agaI [H]

Synonym: BDI_2877

Alternate gene names: 150009464

Gene position: 3428254-3428976 (Clockwise)

Preceding gene: 150009463

Following gene: 150009465

Centisome position: 71.25

GC content: 49.52

Gene sequence:

>723_bases
ATGAGAATAGAGATTTGTCAATCTTATGAGGCATTAAGCCTTAAGGCAAAAGAGATTGTTACCTCAGAGTTAGGGCAGCA
CAAGGCACTTACGCTTTGTGCCGCCACTGGGGGCTCTCCTACCCGGATGTATGAGTTACTGGTAGAGGAAGCCGGTCGCC
AACCGGAATTATTCTCCCAATTCACGGTACTAAAGCTCGATGAATGGGGAGGAATCCCGATGGATCACCCGGGTACGTGC
GAGTCGTATCTACGGAACTATTTCGTAGGTCCGCTTCAAATCCCGGAAGACCGGTATATAGCGTTCCAAAGCGATCCGGA
GAACCCTGAGGCGGAATGTGAGCGGATCCAACAGATACTGGACCAAAAAGGCCCTATCGACATTTGTATATTAGGAATAG
GGATGAACGGCCATATCGCCTTGAACGAGCCGGCTCCTTCCTTACATACGAATTGCCATGTGGCTCATCTGTCCCAGAAA
TCCTTGCAACATCCCATGATCGCCGGGGATATGGAGAAACCGGGATACGGACTGACATTGGGCATGGCGAATATCTTTCA
GTCACGCCTGATTATCCTTCTTATCAACGGGATAAAGAAAAGGGAGATTACTCAAGCTTTCCTTGAACAGAAGATCTCGA
CGGAGTTGCCGGCCTCCTTATTGTGGCTGCACCCGAACGTGATTTGCCTGATCGACAGGGAAGCGGCGCATAGTTCTAAT
TAA

Upstream 100 bases:

>100_bases
GATGCTACAATGCGGAAAACAACCGGGTTACATCGGTATGCAAGACCACGGTTATGGTGTTTGCTTCCGCAATATCCGAA
TCAAAGAGCTCTAAAATCGT

Downstream 100 bases:

>100_bases
GCTTTTACAATTATCATGAAATACGCTATCGCATTAGACATTGGAGGAACAAGCATAAAATATACTCTTGTGAACCAGAA
TGGCGACATTCTTTACGAAT

Product: galactosamine-6-phosphate isomerase

Products: D-Tagatose 6-Phosphate; NH3. [C]

Alternate protein names: Galactosamine-6-phosphate deaminase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MRIEICQSYEALSLKAKEIVTSELGQHKALTLCAATGGSPTRMYELLVEEAGRQPELFSQFTVLKLDEWGGIPMDHPGTC
ESYLRNYFVGPLQIPEDRYIAFQSDPENPEAECERIQQILDQKGPIDICILGIGMNGHIALNEPAPSLHTNCHVAHLSQK
SLQHPMIAGDMEKPGYGLTLGMANIFQSRLIILLINGIKKREITQAFLEQKISTELPASLLWLHPNVICLIDREAAHSSN

Sequences:

>Translated_240_residues
MRIEICQSYEALSLKAKEIVTSELGQHKALTLCAATGGSPTRMYELLVEEAGRQPELFSQFTVLKLDEWGGIPMDHPGTC
ESYLRNYFVGPLQIPEDRYIAFQSDPENPEAECERIQQILDQKGPIDICILGIGMNGHIALNEPAPSLHTNCHVAHLSQK
SLQHPMIAGDMEKPGYGLTLGMANIFQSRLIILLINGIKKREITQAFLEQKISTELPASLLWLHPNVICLIDREAAHSSN
>Mature_240_residues
MRIEICQSYEALSLKAKEIVTSELGQHKALTLCAATGGSPTRMYELLVEEAGRQPELFSQFTVLKLDEWGGIPMDHPGTC
ESYLRNYFVGPLQIPEDRYIAFQSDPENPEAECERIQQILDQKGPIDICILGIGMNGHIALNEPAPSLHTNCHVAHLSQK
SLQHPMIAGDMEKPGYGLTLGMANIFQSRLIILLINGIKKREITQAFLEQKISTELPASLLWLHPNVICLIDREAAHSSN

Specific function: N-acetylgalactosamine utilization. [C]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI19923881, Length=244, Percent_Identity=27.0491803278689, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI13027378, Length=245, Percent_Identity=26.9387755102041, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1789530, Length=226, Percent_Identity=42.0353982300885, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1786893, Length=208, Percent_Identity=27.4038461538462, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI48994958, Length=243, Percent_Identity=21.8106995884774, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554876, Length=212, Percent_Identity=27.8301886792453, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581960, Length=244, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920764, Length=244, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: 5.3.1.- [C]

Molecular weight: Translated: 26699; Mature: 26699

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEICQSYEALSLKAKEIVTSELGQHKALTLCAATGGSPTRMYELLVEEAGRQPELFSQ
CEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHC
FTVLKLDEWGGIPMDHPGTCESYLRNYFVGPLQIPEDRYIAFQSDPENPEAECERIQQIL
EEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEECCCCCEEEECCCCCCHHHHHHHHHHHH
DQKGPIDICILGIGMNGHIALNEPAPSLHTNCHVAHLSQKSLQHPMIAGDMEKPGYGLTL
HCCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEEECCHHHHCCCCEECCCCCCCCEEEH
GMANIFQSRLIILLINGIKKREITQAFLEQKISTELPASLLWLHPNVICLIDREAAHSSN
HHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRIEICQSYEALSLKAKEIVTSELGQHKALTLCAATGGSPTRMYELLVEEAGRQPELFSQ
CEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHC
FTVLKLDEWGGIPMDHPGTCESYLRNYFVGPLQIPEDRYIAFQSDPENPEAECERIQQIL
EEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEECCCCCEEEECCCCCCHHHHHHHHHHHH
DQKGPIDICILGIGMNGHIALNEPAPSLHTNCHVAHLSQKSLQHPMIAGDMEKPGYGLTL
HCCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEEECCHHHHCCCCEECCCCCCCCEEEH
GMANIFQSRLIILLINGIKKREITQAFLEQKISTELPASLLWLHPNVICLIDREAAHSSN
HHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Galactosamine 6-Phosphate; H2O [C]

Specific reaction: D-Galactosamine 6-Phosphate + H2O = D-Tagatose 6-Phosphate + NH3. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10931310; 9278503; 8932697 [H]