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The map label for this gene is ahcY [H]

Identifier: 150009367

GI number: 150009367

Start: 3309502

End: 3310920

Strand: Direct

Name: ahcY [H]

Synonym: BDI_2775

Alternate gene names: 150009367

Gene position: 3309502-3310920 (Clockwise)

Preceding gene: 150009366

Following gene: 150009368

Centisome position: 68.78

GC content: 49.96

Gene sequence:

>1419_bases
ATGTCACAATTATTTCCAACTAATCTGCCTTATAAAGTGGCAGATATGAGTTTGGCTGAATTCGGTCGCAAAGAGATCGA
GATCGCCGAACACGAAATGCCGGGATTAATGGCGCTACGCCAGAAATACGCCGATCAGAAACCCTTGAAAGGCGCACGTA
TCACCGGCTCACTGCATATGACTATTCAGACGGCGGTGTTAATCGAAACATTAGTTGCGTTGGGAGCGGACGTTCGCTGG
GCTAGCTGTAACATCTTCTCCACACAAGATCATGCCGCTGCCGCTATCGCAGCGGACGGCGTACCGGTATTCGCTTGGAA
AGGCGAGACGCTGGAGGAGTATTGGTGGTGTACGGACATGGCGCTTCGTTTCCCGGAAGGTAAAGGCCCTCACATGATTG
TTGACGATGGCGGCGACGCTTCCTTGCTGATTCACATGGGCTATCGTGCGGAGAACGATGCGGAGACTATCAACCGCAAA
GGCGGAAATCATGAGGAACAGGTAATCCTGGATACATTAAATCGTATCCTTCAAGAAGATAACAGCCGTTGGCACCGTAC
GGTAGCCGAGATGAAAGGGGTATCGGAAGAGACGACCACCGGCGTTCACCGTCTGTATCAGATGATGGAGAAAGGTGAGT
TGCTGGTTCCGGCTATCAATGTTAATGACTCCGTGACGAAATCCAAGTTCGATAACCTATACGGTTGCCGTGAGTCTTTG
GCGGACGGCATCAAGCGGGCTACGGACGTAATGATCGCCGGCAAGGTGGTAGTCGTTGCCGGATATGGTGACGTAGGTAA
AGGCTGCTCTCACTCCATGCGCTCTTACGGGGCCCGTGTACTCGTGACCGAGATCGATCCGATCTGCGCCCTGCAAGCCG
CTATGGAAGGTTTCGAGGTTACGACCATGGAAGAGGCCGTGAAAGAGGGTAACATCTTCGTTACGACCACCGGAAACTGC
GATATCATCACGATCGAGCATATGACACAGATGAAAGACCAATCGATCGTATGTAACATCGGTCACTTCGACAACGAGAT
ACAGGTGGATAAGCTTGTCAACTATCCGAATATCAAGCACACGAATATCAAGCCTCAAGTGGACAAATATACGTTCCCGA
ACGGAAACTCCATCTTCTTATTGGCAGAGGGACGCTTGGTAAACTTAGGTTGCGCTACGGGACACCCATCATTCGTAATG
AGCAACTCATTTACGAACCAAGTTCTTGCCCAGATGGATTTATGGCAAATGGCCTATGAGGTAGGCGTATATCGTTTGCC
GAAACGTTTGGATGAGGAAGTTGCCCGCCTACACTTGGAACGTATCGGCGTGAAATTATCTACATTATCACAAAAGCAAG
CTGATTATATCGGCGTACCGGTAGAAGGACCGTACAAGGCTGATCATTACAGATACTAA

Upstream 100 bases:

>100_bases
TCGGCAAGCCTCTGCCCTAGATGGAAATTCATAGATAAAGAACACCTACTATCAACGCTTTTTCGTACCTTTGCGTCTCA
ACCATTTATAGTATTAATTT

Downstream 100 bases:

>100_bases
TTAATTGAAGATTGAAAGTTGAGAATTGATAATGAAGGGAGGGCAGCTCCTGTAGTTCTCGATTCTTAATTTTCAATTTT
CAATTCTTAATTTTCAATTA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSQLFPTNLPYKVADMSLAEFGRKEIEIAEHEMPGLMALRQKYADQKPLKGARITGSLHMTIQTAVLIETLVALGADVRW
ASCNIFSTQDHAAAAIAADGVPVFAWKGETLEEYWWCTDMALRFPEGKGPHMIVDDGGDASLLIHMGYRAENDAETINRK
GGNHEEQVILDTLNRILQEDNSRWHRTVAEMKGVSEETTTGVHRLYQMMEKGELLVPAINVNDSVTKSKFDNLYGCRESL
ADGIKRATDVMIAGKVVVVAGYGDVGKGCSHSMRSYGARVLVTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTTTGNC
DIITIEHMTQMKDQSIVCNIGHFDNEIQVDKLVNYPNIKHTNIKPQVDKYTFPNGNSIFLLAEGRLVNLGCATGHPSFVM
SNSFTNQVLAQMDLWQMAYEVGVYRLPKRLDEEVARLHLERIGVKLSTLSQKQADYIGVPVEGPYKADHYRY

Sequences:

>Translated_472_residues
MSQLFPTNLPYKVADMSLAEFGRKEIEIAEHEMPGLMALRQKYADQKPLKGARITGSLHMTIQTAVLIETLVALGADVRW
ASCNIFSTQDHAAAAIAADGVPVFAWKGETLEEYWWCTDMALRFPEGKGPHMIVDDGGDASLLIHMGYRAENDAETINRK
GGNHEEQVILDTLNRILQEDNSRWHRTVAEMKGVSEETTTGVHRLYQMMEKGELLVPAINVNDSVTKSKFDNLYGCRESL
ADGIKRATDVMIAGKVVVVAGYGDVGKGCSHSMRSYGARVLVTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTTTGNC
DIITIEHMTQMKDQSIVCNIGHFDNEIQVDKLVNYPNIKHTNIKPQVDKYTFPNGNSIFLLAEGRLVNLGCATGHPSFVM
SNSFTNQVLAQMDLWQMAYEVGVYRLPKRLDEEVARLHLERIGVKLSTLSQKQADYIGVPVEGPYKADHYRY
>Mature_471_residues
SQLFPTNLPYKVADMSLAEFGRKEIEIAEHEMPGLMALRQKYADQKPLKGARITGSLHMTIQTAVLIETLVALGADVRWA
SCNIFSTQDHAAAAIAADGVPVFAWKGETLEEYWWCTDMALRFPEGKGPHMIVDDGGDASLLIHMGYRAENDAETINRKG
GNHEEQVILDTLNRILQEDNSRWHRTVAEMKGVSEETTTGVHRLYQMMEKGELLVPAINVNDSVTKSKFDNLYGCRESLA
DGIKRATDVMIAGKVVVVAGYGDVGKGCSHSMRSYGARVLVTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTTTGNCD
IITIEHMTQMKDQSIVCNIGHFDNEIQVDKLVNYPNIKHTNIKPQVDKYTFPNGNSIFLLAEGRLVNLGCATGHPSFVMS
NSFTNQVLAQMDLWQMAYEVGVYRLPKRLDEEVARLHLERIGVKLSTLSQKQADYIGVPVEGPYKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=466, Percent_Identity=62.8755364806867, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=62.6696832579185, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=48.1720430107527, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=48.1720430107527, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=48.1720430107527, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=48.1720430107527, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=46.8817204301075, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=477, Percent_Identity=61.8448637316562, Blast_Score=585, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=60.8333333333333, Blast_Score=548, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=65.0862068965517, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24656245, Length=455, Percent_Identity=49.010989010989, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=47.6293103448276, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=47.5161987041037, Blast_Score=423, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52527; Mature: 52395

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLFPTNLPYKVADMSLAEFGRKEIEIAEHEMPGLMALRQKYADQKPLKGARITGSLHM
CCCCCCCCCCCHHHCCCHHHCCCHHEEEHHHCCCHHHHHHHHHCCCCCCCCCEEECEEEE
TIQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAADGVPVFAWKGETLEEYWWCTDM
EHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCEEEEEECCCCHHHHHHHHHH
ALRFPEGKGPHMIVDDGGDASLLIHMGYRAENDAETINRKGGNHEEQVILDTLNRILQED
HEECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHC
NSRWHRTVAEMKGVSEETTTGVHRLYQMMEKGELLVPAINVNDSVTKSKFDNLYGCRESL
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
ADGIKRATDVMIAGKVVVVAGYGDVGKGCSHSMRSYGARVLVTEIDPICALQAAMEGFEV
HHHHHHHHHEEEECEEEEEECCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEE
TTMEEAVKEGNIFVTTTGNCDIITIEHMTQMKDQSIVCNIGHFDNEIQVDKLVNYPNIKH
EHHHHHHHCCCEEEEECCCEEEEEEHHHHHCCCCCEEEEECCCCCCEEHHHHCCCCCCCC
TNIKPQVDKYTFPNGNSIFLLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQMDLWQMAYE
CCCCCCCCCEECCCCCEEEEEECCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHH
VGVYRLPKRLDEEVARLHLERIGVKLSTLSQKQADYIGVPVEGPYKADHYRY
HHHHHHHHHHHHHHHHHHHHHHCEEHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SQLFPTNLPYKVADMSLAEFGRKEIEIAEHEMPGLMALRQKYADQKPLKGARITGSLHM
CCCCCCCCCCHHHCCCHHHCCCHHEEEHHHCCCHHHHHHHHHCCCCCCCCCEEECEEEE
TIQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAADGVPVFAWKGETLEEYWWCTDM
EHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCEEEEEECCCCHHHHHHHHHH
ALRFPEGKGPHMIVDDGGDASLLIHMGYRAENDAETINRKGGNHEEQVILDTLNRILQED
HEECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHC
NSRWHRTVAEMKGVSEETTTGVHRLYQMMEKGELLVPAINVNDSVTKSKFDNLYGCRESL
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
ADGIKRATDVMIAGKVVVVAGYGDVGKGCSHSMRSYGARVLVTEIDPICALQAAMEGFEV
HHHHHHHHHEEEECEEEEEECCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEE
TTMEEAVKEGNIFVTTTGNCDIITIEHMTQMKDQSIVCNIGHFDNEIQVDKLVNYPNIKH
EHHHHHHHCCCEEEEECCCEEEEEEHHHHHCCCCCEEEEECCCCCCEEHHHHCCCCCCCC
TNIKPQVDKYTFPNGNSIFLLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQMDLWQMAYE
CCCCCCCCCEECCCCCEEEEEECCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHH
VGVYRLPKRLDEEVARLHLERIGVKLSTLSQKQADYIGVPVEGPYKADHYRY
HHHHHHHHHHHHHHHHHHHHHHCEEHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA