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The map label for this gene is murC

Identifier: 150009085

GI number: 150009085

Start: 2930070

End: 2931458

Strand: Reverse

Name: murC

Synonym: BDI_2486

Alternate gene names: 150009085

Gene position: 2931458-2930070 (Counterclockwise)

Preceding gene: 150009086

Following gene: 150009084

Centisome position: 60.93

GC content: 48.16

Gene sequence:

>1389_bases
ATGGATATAAATAAAGTGACAGCGGTGTATTTCGTAGGTGCCGGGGGCATTGGAATGAGTGCCTTGATCCGTTATTTCCT
CGCTAAGGGAAAACGAGTGGGCGGATACGATAAGACCCCTTCCGATTTAACCGAGGAGTTGAAAAAGGAGGGAGCCGATA
TTCACTATGAGGATAATGTAGCTTTGATCGGGGAGGCGTTCAAGTCGCCCGATGATACGCTGGTGGTTTATACGCCGGCG
GTCCCGGAGTCGCATACGGAATTGACCTATTTCCGGGCGCACGGTTTTGAGGTGATGAAGCGGGCACGTGTCTTGGGAGA
GATCACGAAAAGCAGCCGGGGTTTATGCGTGGCGGGCACGCACGGCAAGACAACGACCTCTTCTATGCTAGCTCATTTGC
TGAAACAATCGCCGGTGGATTGCAATGCTTTCCTCGGAGGAATCCTAAAGAACTACGAGAGTAATTTGATGTTGTCGGAT
ACGAGCGACTTTACCGTGATCGAGGCGGATGAGTTCGATCGTTCTTTCCATTGGCTTACTCCTTATATGGCAGTGATTAC
TTCTGCGGATCCGGATCATCTGGATATTTACGGTACGGCGGAGGCTTACCGGGAGAGTTTTGAGAAATTTACCTCCTTAA
TTCGTCCCGATGGTTGTCTACTGATCAAGAAAGGAATCAACGTAACGCCCCGTTTACAGGAGGGTGTCAAGAAATATACC
TATTCCGTTACGGAAATAGCGGACTTTTACGCTGAAAATATTCGTATTTGCGACGGAAATATTACCTTTGACTTCGTTGG
TCCGGAAATCCGTATTCCTGATGTGGAATTAGGTGTTCCCGTAAAGGTTAATATAGAGAACGGGGTAGCGGCTATGGCGA
TCGCTTGGTTGAACGGAGTGAAACCTGAGGATTTGAAAAAGGGTATGGCTACATTTGCCGGACCTCGCCGCCGTTTCGAT
TTCCATTTGAAGACTGATCAAGTGGTATTGATCGATGATTATGCCCATCATCCGGCCGAATTGCGACAGAGTATCTTGTC
GGTGAAGGAATTATATGCGGGTCGTAAGGTGACAGGTATTTTCCAGCCGCATCTATATACCCGTACCCGAGATTTCGCTG
GAGATTTCGCTGCGAGTCTCTCTTTATTGGATGAGTTGATCTTGCTGGATATCTATCCGGCTCGTGAGGAACCGATTCCG
GGGGTGAGCTCTCGGATCATTTTTGATAAGGTGACGATCCCTTCCAAGACGCTGTGTAAGAAGGAAGAGCTTTTGGACGT
GGTTGCCGCCGGGAAATATGAGGTAGTATTAATGGTAGGCGCCGGCAATATCGACCGTTTGGTGGAGCCTGTAAAAGAGA
TTTTATGTAAACAAATAAGGAAACCGTGA

Upstream 100 bases:

>100_bases
TGTGTACGTTGAGCCGTAATATCGAGACCTTGGCGCAACGCCATAGCGCGGACCGTATCGTGGATGAGATTGTTAAGATT
ATAGATAAGAAATAAGGAAT

Downstream 100 bases:

>100_bases
TCCGAATAATTTCCATAGTAGTAGCCACGTTGTTGTTCTGTTACATCGTGTTTGTGTCGTTTTTCTTTCGGGAAATACGT
CAAGACTCTATTTGCCAAGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDINKVTAVYFVGAGGIGMSALIRYFLAKGKRVGGYDKTPSDLTEELKKEGADIHYEDNVALIGEAFKSPDDTLVVYTPA
VPESHTELTYFRAHGFEVMKRARVLGEITKSSRGLCVAGTHGKTTTSSMLAHLLKQSPVDCNAFLGGILKNYESNLMLSD
TSDFTVIEADEFDRSFHWLTPYMAVITSADPDHLDIYGTAEAYRESFEKFTSLIRPDGCLLIKKGINVTPRLQEGVKKYT
YSVTEIADFYAENIRICDGNITFDFVGPEIRIPDVELGVPVKVNIENGVAAMAIAWLNGVKPEDLKKGMATFAGPRRRFD
FHLKTDQVVLIDDYAHHPAELRQSILSVKELYAGRKVTGIFQPHLYTRTRDFAGDFAASLSLLDELILLDIYPAREEPIP
GVSSRIIFDKVTIPSKTLCKKEELLDVVAAGKYEVVLMVGAGNIDRLVEPVKEILCKQIRKP

Sequences:

>Translated_462_residues
MDINKVTAVYFVGAGGIGMSALIRYFLAKGKRVGGYDKTPSDLTEELKKEGADIHYEDNVALIGEAFKSPDDTLVVYTPA
VPESHTELTYFRAHGFEVMKRARVLGEITKSSRGLCVAGTHGKTTTSSMLAHLLKQSPVDCNAFLGGILKNYESNLMLSD
TSDFTVIEADEFDRSFHWLTPYMAVITSADPDHLDIYGTAEAYRESFEKFTSLIRPDGCLLIKKGINVTPRLQEGVKKYT
YSVTEIADFYAENIRICDGNITFDFVGPEIRIPDVELGVPVKVNIENGVAAMAIAWLNGVKPEDLKKGMATFAGPRRRFD
FHLKTDQVVLIDDYAHHPAELRQSILSVKELYAGRKVTGIFQPHLYTRTRDFAGDFAASLSLLDELILLDIYPAREEPIP
GVSSRIIFDKVTIPSKTLCKKEELLDVVAAGKYEVVLMVGAGNIDRLVEPVKEILCKQIRKP
>Mature_462_residues
MDINKVTAVYFVGAGGIGMSALIRYFLAKGKRVGGYDKTPSDLTEELKKEGADIHYEDNVALIGEAFKSPDDTLVVYTPA
VPESHTELTYFRAHGFEVMKRARVLGEITKSSRGLCVAGTHGKTTTSSMLAHLLKQSPVDCNAFLGGILKNYESNLMLSD
TSDFTVIEADEFDRSFHWLTPYMAVITSADPDHLDIYGTAEAYRESFEKFTSLIRPDGCLLIKKGINVTPRLQEGVKKYT
YSVTEIADFYAENIRICDGNITFDFVGPEIRIPDVELGVPVKVNIENGVAAMAIAWLNGVKPEDLKKGMATFAGPRRRFD
FHLKTDQVVLIDDYAHHPAELRQSILSVKELYAGRKVTGIFQPHLYTRTRDFAGDFAASLSLLDELILLDIYPAREEPIP
GVSSRIIFDKVTIPSKTLCKKEELLDVVAAGKYEVVLMVGAGNIDRLVEPVKEILCKQIRKP

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=482, Percent_Identity=30.2904564315353, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1790680, Length=291, Percent_Identity=27.8350515463918, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PARD8 (A6LEU2)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001303828.1
- ProteinModelPortal:   A6LEU2
- SMR:   A6LEU2
- STRING:   A6LEU2
- GeneID:   5307635
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_2486
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   PDIS435591:BDI_2486-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51299; Mature: 51299

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINKVTAVYFVGAGGIGMSALIRYFLAKGKRVGGYDKTPSDLTEELKKEGADIHYEDNV
CCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCE
ALIGEAFKSPDDTLVVYTPAVPESHTELTYFRAHGFEVMKRARVLGEITKSSRGLCVAGT
EEEEHHHCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECC
HGKTTTSSMLAHLLKQSPVDCNAFLGGILKNYESNLMLSDTSDFTVIEADEFDRSFHWLT
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCHHHHH
PYMAVITSADPDHLDIYGTAEAYRESFEKFTSLIRPDGCLLIKKGINVTPRLQEGVKKYT
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
YSVTEIADFYAENIRICDGNITFDFVGPEIRIPDVELGVPVKVNIENGVAAMAIAWLNGV
HHHHHHHHHHHCCEEEECCCEEEEEECCEEECCCEEECCEEEEEECCCHHHHHHHHHCCC
KPEDLKKGMATFAGPRRRFDFHLKTDQVVLIDDYAHHPAELRQSILSVKELYAGRKVTGI
CHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEE
FQPHLYTRTRDFAGDFAASLSLLDELILLDIYPAREEPIPGVSSRIIFDKVTIPSKTLCK
ECCCHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEEECCCCHHHHH
KEELLDVVAAGKYEVVLMVGAGNIDRLVEPVKEILCKQIRKP
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDINKVTAVYFVGAGGIGMSALIRYFLAKGKRVGGYDKTPSDLTEELKKEGADIHYEDNV
CCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCE
ALIGEAFKSPDDTLVVYTPAVPESHTELTYFRAHGFEVMKRARVLGEITKSSRGLCVAGT
EEEEHHHCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECC
HGKTTTSSMLAHLLKQSPVDCNAFLGGILKNYESNLMLSDTSDFTVIEADEFDRSFHWLT
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCHHHHH
PYMAVITSADPDHLDIYGTAEAYRESFEKFTSLIRPDGCLLIKKGINVTPRLQEGVKKYT
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
YSVTEIADFYAENIRICDGNITFDFVGPEIRIPDVELGVPVKVNIENGVAAMAIAWLNGV
HHHHHHHHHHHCCEEEECCCEEEEEECCEEECCCEEECCEEEEEECCCHHHHHHHHHCCC
KPEDLKKGMATFAGPRRRFDFHLKTDQVVLIDDYAHHPAELRQSILSVKELYAGRKVTGI
CHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEE
FQPHLYTRTRDFAGDFAASLSLLDELILLDIYPAREEPIPGVSSRIIFDKVTIPSKTLCK
ECCCHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEEECCCCHHHHH
KEELLDVVAAGKYEVVLMVGAGNIDRLVEPVKEILCKQIRKP
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA