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The map label for this gene is guaB [H]

Identifier: 150008997

GI number: 150008997

Start: 2803607

End: 2805082

Strand: Reverse

Name: guaB [H]

Synonym: BDI_2393

Alternate gene names: 150008997

Gene position: 2805082-2803607 (Counterclockwise)

Preceding gene: 150008998

Following gene: 150008996

Centisome position: 58.3

GC content: 50.07

Gene sequence:

>1476_bases
ATGTCATTTATTGCAGACAGGGTAGTTATGGATGGGTTAACGTTTGACGATGTATTGTTAATCCCAGCTTATTCGGAAGT
TCTTCCTCGTAATGTCGATCTCACGACAAAGTTTTCACGTAATATCACATTGAATATACCGATGGTGTCGGCCGCTATGG
ATACGGTTACCGAGGCCAAGTTGGCTATCGCTATCGCCCGTGAGGGAGGTATTGGTGTGATTCATAAAAACATGACGATC
GCCGAGCAGGCAAAGCAGGTCCAGACCGTTAAACGTGCGGAGAATGGAATGATCTATGATCCGGTGACTATCACGAAGGG
CAAGCGTGTGGCGGATGCCTTGGCAATGATGGCTGAATATAAGATTGGCGGTATTCCCGTGGTGGATGAAGGCGGGTATT
TGGTAGGTATCGTGACAAACCGTGACTTGCGTTTCGAGAAGGACATGAACCGTTCTATCGACGAGGTGATGACGAAAGAG
AATTTGGTCGTAACCGGACAATCTACGGATATGGAGGCCGCCGCTCAGATCCTTCAGGAACATAAGATCGAGAAGTTACC
GGTGGTCGATAGCCATAATAAGTTGATCGGCTTGATTACCTATAAAGATATAACGAAAGCGAAAGATAAACCGAAGGCTT
GCAAGGATTCGAAAGGTCGTTTGCGTGTAGCTGCCGGTGTAGGCGTTACGTTCAATACCTTCGAGCGTGTAGCCGCTTTG
GTGGATGCCGGGGTGGATGCTTTGGTGATCGACACGGCACATGGTCACTCAAAAGGTGTGGTGGATGTCTTGAAACAGAT
TAAGGCGCAATATCCGCATATTGATTGTGTGGTCGGTAATATCGCTACGGGCGAGGCTGCTAAATATTTAGTGGAAGCCG
GGGCGGACGCCGTGAAGGTAGGTATCGGTCCGGGTTCGATTTGTACAACTCGTGTGATCGCTGGTGTGGGTGTTCCCCAG
TTGTCGGCTATTTACGATGTGGCGAAGGCGTTGGAAGGAACTGGTGTGCCTTTGATCGCCGACGGTGGCTTGCGTTACTC
CGGTGATATCGTGAAGGCGATCGCCGCTGGTGGATCTTCCGTGATGATGGGATCTCTGTTGGCGGGTGTAGAGGAGTCGC
CGGGCGATACGATTATCTTCAATGGCCGAAAGTTTAAGTCTTACCGTGGAATGGGGTCGTTGGAAGCTATGCAAAAGGGG
TCCAAGGATCGGTATTTCCAAGATGTGGAGGACGACGTGAAGAAGCTGGTTCCGGAGGGAATCGCTGCCCGTGTTCCGTT
TAAGGGTTCTTTGTATGAGGTCATTTACCAAATGGTAGGTGGTTTACGTGCGGGAATGGGTTATTGCGGGGCTCATAATA
TCGAGGAGTTGCATAAAGCTCGTTTTACTCGAATCACCAACGCAGGTGTGCAAGAGAGCCATCCGCATGACGTAGCGATC
ACGCAAGAGGCTCCGAATTATAGCCGCGGTGAATAG

Upstream 100 bases:

>100_bases
GTTTATTTTCTTCCGAATCGAATTTTTAATTTCTCCCGTATCAATTTATTGCGTGAAAAGTCGTATATTTGCGCGCAATA
ATTTTTAAAGCATAAGTTCT

Downstream 100 bases:

>100_bases
TAATACAAGTTTTACGTTTTATAAAAAACACTAATTTAATGGGATAGCATACTTTTCTTGTCGGCTCTCCGTTAGATTAG
TGTTATTTTTGTAATGTATA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSFIADRVVMDGLTFDDVLLIPAYSEVLPRNVDLTTKFSRNITLNIPMVSAAMDTVTEAKLAIAIAREGGIGVIHKNMTI
AEQAKQVQTVKRAENGMIYDPVTITKGKRVADALAMMAEYKIGGIPVVDEGGYLVGIVTNRDLRFEKDMNRSIDEVMTKE
NLVVTGQSTDMEAAAQILQEHKIEKLPVVDSHNKLIGLITYKDITKAKDKPKACKDSKGRLRVAAGVGVTFNTFERVAAL
VDAGVDALVIDTAHGHSKGVVDVLKQIKAQYPHIDCVVGNIATGEAAKYLVEAGADAVKVGIGPGSICTTRVIAGVGVPQ
LSAIYDVAKALEGTGVPLIADGGLRYSGDIVKAIAAGGSSVMMGSLLAGVEESPGDTIIFNGRKFKSYRGMGSLEAMQKG
SKDRYFQDVEDDVKKLVPEGIAARVPFKGSLYEVIYQMVGGLRAGMGYCGAHNIEELHKARFTRITNAGVQESHPHDVAI
TQEAPNYSRGE

Sequences:

>Translated_491_residues
MSFIADRVVMDGLTFDDVLLIPAYSEVLPRNVDLTTKFSRNITLNIPMVSAAMDTVTEAKLAIAIAREGGIGVIHKNMTI
AEQAKQVQTVKRAENGMIYDPVTITKGKRVADALAMMAEYKIGGIPVVDEGGYLVGIVTNRDLRFEKDMNRSIDEVMTKE
NLVVTGQSTDMEAAAQILQEHKIEKLPVVDSHNKLIGLITYKDITKAKDKPKACKDSKGRLRVAAGVGVTFNTFERVAAL
VDAGVDALVIDTAHGHSKGVVDVLKQIKAQYPHIDCVVGNIATGEAAKYLVEAGADAVKVGIGPGSICTTRVIAGVGVPQ
LSAIYDVAKALEGTGVPLIADGGLRYSGDIVKAIAAGGSSVMMGSLLAGVEESPGDTIIFNGRKFKSYRGMGSLEAMQKG
SKDRYFQDVEDDVKKLVPEGIAARVPFKGSLYEVIYQMVGGLRAGMGYCGAHNIEELHKARFTRITNAGVQESHPHDVAI
TQEAPNYSRGE
>Mature_490_residues
SFIADRVVMDGLTFDDVLLIPAYSEVLPRNVDLTTKFSRNITLNIPMVSAAMDTVTEAKLAIAIAREGGIGVIHKNMTIA
EQAKQVQTVKRAENGMIYDPVTITKGKRVADALAMMAEYKIGGIPVVDEGGYLVGIVTNRDLRFEKDMNRSIDEVMTKEN
LVVTGQSTDMEAAAQILQEHKIEKLPVVDSHNKLIGLITYKDITKAKDKPKACKDSKGRLRVAAGVGVTFNTFERVAALV
DAGVDALVIDTAHGHSKGVVDVLKQIKAQYPHIDCVVGNIATGEAAKYLVEAGADAVKVGIGPGSICTTRVIAGVGVPQL
SAIYDVAKALEGTGVPLIADGGLRYSGDIVKAIAAGGSSVMMGSLLAGVEESPGDTIIFNGRKFKSYRGMGSLEAMQKGS
KDRYFQDVEDDVKKLVPEGIAARVPFKGSLYEVIYQMVGGLRAGMGYCGAHNIEELHKARFTRITNAGVQESHPHDVAIT
QEAPNYSRGE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=40.5639913232104, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI217035146, Length=461, Percent_Identity=40.997830802603, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328930, Length=461, Percent_Identity=40.997830802603, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI34328928, Length=461, Percent_Identity=40.997830802603, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI156616279, Length=461, Percent_Identity=40.997830802603, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI217035152, Length=455, Percent_Identity=40.6593406593407, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI217035148, Length=461, Percent_Identity=40.3470715835141, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI217035150, Length=461, Percent_Identity=38.177874186551, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI50541954, Length=328, Percent_Identity=33.2317073170732, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541952, Length=328, Percent_Identity=33.2317073170732, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541948, Length=328, Percent_Identity=33.2317073170732, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541956, Length=328, Percent_Identity=33.2317073170732, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=37.6, Blast_Score=162, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=55.3497942386831, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1786293, Length=350, Percent_Identity=30.8571428571429, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=473, Percent_Identity=35.9408033826639, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=37.6190476190476, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=259, Percent_Identity=37.0656370656371, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=37.6782077393075, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=466, Percent_Identity=38.6266094420601, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=450, Percent_Identity=39.5555555555556, Blast_Score=309, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=37.2832369942197, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=100, Percent_Identity=45, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=38.2536382536383, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=38.2536382536383, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=288, Evalue=8e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52536; Mature: 52405

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIADRVVMDGLTFDDVLLIPAYSEVLPRNVDLTTKFSRNITLNIPMVSAAMDTVTEAK
CCHHHHHHHHCCCCCCCEEEEECHHHHCCCCCCEEEEECCCEEEECCHHHHHHHHHHHCE
LAIAIAREGGIGVIHKNMTIAEQAKQVQTVKRAENGMIYDPVTITKGKRVADALAMMAEY
EEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCEEECCCHHHHHHHHHHHHH
KIGGIPVVDEGGYLVGIVTNRDLRFEKDMNRSIDEVMTKENLVVTGQSTDMEAAAQILQE
CCCCEEEEECCCEEEEEEECCCEEEHHHHCCCHHHHHCCCCEEEECCCCCHHHHHHHHHH
HKIEKLPVVDSHNKLIGLITYKDITKAKDKPKACKDSKGRLRVAAGVGVTFNTFERVAAL
CCCCCCCCCCCCCCEEEEEEECHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
VDAGVDALVIDTAHGHSKGVVDVLKQIKAQYPHIDCVVGNIATGEAAKYLVEAGADAVKV
HHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEE
GIGPGSICTTRVIAGVGVPQLSAIYDVAKALEGTGVPLIADGGLRYSGDIVKAIAAGGSS
ECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCEECCHHHHHHHCCCCH
VMMGSLLAGVEESPGDTIIFNGRKFKSYRGMGSLEAMQKGSKDRYFQDVEDDVKKLVPEG
HHHHHHHHCCCCCCCCEEEECCEEEHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
IAARVPFKGSLYEVIYQMVGGLRAGMGYCGAHNIEELHKARFTRITNAGVQESHPHDVAI
CEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
TQEAPNYSRGE
ECCCCCCCCCC
>Mature Secondary Structure 
SFIADRVVMDGLTFDDVLLIPAYSEVLPRNVDLTTKFSRNITLNIPMVSAAMDTVTEAK
CHHHHHHHHCCCCCCCEEEEECHHHHCCCCCCEEEEECCCEEEECCHHHHHHHHHHHCE
LAIAIAREGGIGVIHKNMTIAEQAKQVQTVKRAENGMIYDPVTITKGKRVADALAMMAEY
EEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCEEECCCHHHHHHHHHHHHH
KIGGIPVVDEGGYLVGIVTNRDLRFEKDMNRSIDEVMTKENLVVTGQSTDMEAAAQILQE
CCCCEEEEECCCEEEEEEECCCEEEHHHHCCCHHHHHCCCCEEEECCCCCHHHHHHHHHH
HKIEKLPVVDSHNKLIGLITYKDITKAKDKPKACKDSKGRLRVAAGVGVTFNTFERVAAL
CCCCCCCCCCCCCCEEEEEEECHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
VDAGVDALVIDTAHGHSKGVVDVLKQIKAQYPHIDCVVGNIATGEAAKYLVEAGADAVKV
HHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEE
GIGPGSICTTRVIAGVGVPQLSAIYDVAKALEGTGVPLIADGGLRYSGDIVKAIAAGGSS
ECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCEECCHHHHHHHCCCCH
VMMGSLLAGVEESPGDTIIFNGRKFKSYRGMGSLEAMQKGSKDRYFQDVEDDVKKLVPEG
HHHHHHHHCCCCCCCCEEEECCEEEHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
IAARVPFKGSLYEVIYQMVGGLRAGMGYCGAHNIEELHKARFTRITNAGVQESHPHDVAI
CEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
TQEAPNYSRGE
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]