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The map label for this gene is mutL

Identifier: 150008991

GI number: 150008991

Start: 2795877

End: 2797724

Strand: Reverse

Name: mutL

Synonym: BDI_2387

Alternate gene names: 150008991

Gene position: 2797724-2795877 (Counterclockwise)

Preceding gene: 150008992

Following gene: 150008989

Centisome position: 58.15

GC content: 49.19

Gene sequence:

>1848_bases
ATGAGCGATATCATTCATTTACTTCCGGACCATATCGCCAATCAAATCGCGGCGGGAGAGGTGATTCAACGTCCGGCCTC
TGTCGTTAAAGAGTTGGTCGAGAATGCGGTGGACGCTGGCGCTTCCAATATCCAAGTGAACATTAAGGATGCGGGTAAGA
CATTGATACAGGTGATCGATGACGGGAAAGGTATGTCCGAGACGGATGCTCGCATGGCTTTTGAGCGGCACGCTACTTCT
AAGATTTCTACGGCCGAGGATTTATTCTCTTTGCATACGATGGGTTTCCGAGGTGAGGCATTGGCCTCTATCGCCGCTGT
CGCCCATATAGAGTTGCGTACCCGGGCTAGAGGGACCGAGCTTGGCACTTGCCTATCCATCGCGGGTTCCAATCTGGAGA
GTATCGAGCCGGAGGCTTGTAACGAGGGAAGTATCTTCTCGGTAAAGAATCTTTTCTTTAATGTTCCCGCCCGCCGGAAA
TTCTTGAAGTCGAATGAGACGGAATTCCGGAATATCATCAATGAGTTCGAGCGAATCGCCTTGGTGAATCCGCAGGTGGG
TATGTCTCTTTATCATAATGATGCGGAGATATTCAATCTGCCCGAGTCGGGGTTACGTCAGCGCATCATTAATATATATG
GTAAGAGTTTAAACCAGAAGTTGCTCTCTCTGGATGCCCAAAGTTCCATGGTGACTATTTCCGGTTTCGTGGGGCGTCCG
GACTCGGCGAAGAAGCGAGGGGCATTGCAGTTTTTTTTTGTGAATGGTCGTTATATGAAGCATCCTTATTTCCATAAGGC
GATCATGCAGGCCTATGAGCAATTGATTCCTGCCGGGGATATGCCGAATTATTTTGTTTATTTCACGTTGGATCCCTCCT
CGATCGATGTCAATATCCATCCGACAAAGACGGAGATTAAGTTTGAGAACGAGCAACCGATCTGGCAGATCTTGATGGCC
GCTACCCGGGAGGCGTTGGCTAAATCGAGCGCTATCCCTACGATTGATTTCGATGTGGAGGACGCGATCGATATTCCTGT
TTACAACCCGGTCAAGAAAAGTGAGCCTAGTACTTATAAGGCCCCGAAAGTGCAAGTGGATTCCAGTTATAATCCGTTTG
ACACTACTTCCTATAAAAAACCGGAATTCGATTGGTCTAAATTATATCAAGGGTTTGAGAACGACCGAGTGGCTGTCCAA
CGGGAGTCCGAGACTTTCGAGGATGCCCCGATCGAGGAATTGCCGGCCGAGGCTTCGGATCCGGAAAAACTGTTTACGGA
GGTAAGCAATCCTTGCTATCAATATAAAGGGCGATATATCGTGACATCCTTGAAATCGGGTCTGGCGATTATTGACCAGC
ATCGTGCGCATGTGCGTATCTTGTTTGACCAATACCTGTCGAATATCCGTCAGCAACAAGGTGTATCCCAACAAGTCTTA
TTCCCGGAGATCGTAGAGTTTACCGCTGCCGAGGCGGCTGTACTGCCTTCCTTATTGGAGGATTTGTGCTTCGTCGGCTT
TGATCTGAGCAATCTGGGAAATGACAATTACGCGATCAATGGCCTGCCCGCCGGTATAGAGAACCTTGATCCGGTAAATT
TGGTAAAGGATATCGTGGACCGGGCGATCGAGACCGGATGCGCAGTGCATGAGAAAATCTGCGAGGCCATCGCCTTGTCT
TTAGCCAAAGCCGCCGCTATCCGTCCCGGCAAATCCTTATCCTTGGAAGAGATGGATCATCTGATCGCCTCCCTGTTCTC
TTGTTCGGACTCGAACCTGACCCCGGATGGAAAGACGATTATCTCCATGCTGACAGATGAGGAGCTGGAGAGAAGATTTA
AGTGCTAG

Upstream 100 bases:

>100_bases
TGGGGCGAGGCGAGGATTCCCGGGCTCGTAGGTATAAGAATGTGAAACTGGCGGTGGCCTTGGCGGTCTTGGCTGCTTTC
TTTTGGTATTTGTTCTGGTA

Downstream 100 bases:

>100_bases
GGATGATTTCGATGACATAGGTTTCACGGCTGCATTTACATTTAGGTTTCCTGGACATGCGGCCCGGAAGCAGGCGTGGA
ACACATCTTCCTCGATCGGA

Product: DNA mismatch repair protein mutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSDIIHLLPDHIANQIAAGEVIQRPASVVKELVENAVDAGASNIQVNIKDAGKTLIQVIDDGKGMSETDARMAFERHATS
KISTAEDLFSLHTMGFRGEALASIAAVAHIELRTRARGTELGTCLSIAGSNLESIEPEACNEGSIFSVKNLFFNVPARRK
FLKSNETEFRNIINEFERIALVNPQVGMSLYHNDAEIFNLPESGLRQRIINIYGKSLNQKLLSLDAQSSMVTISGFVGRP
DSAKKRGALQFFFVNGRYMKHPYFHKAIMQAYEQLIPAGDMPNYFVYFTLDPSSIDVNIHPTKTEIKFENEQPIWQILMA
ATREALAKSSAIPTIDFDVEDAIDIPVYNPVKKSEPSTYKAPKVQVDSSYNPFDTTSYKKPEFDWSKLYQGFENDRVAVQ
RESETFEDAPIEELPAEASDPEKLFTEVSNPCYQYKGRYIVTSLKSGLAIIDQHRAHVRILFDQYLSNIRQQQGVSQQVL
FPEIVEFTAAEAAVLPSLLEDLCFVGFDLSNLGNDNYAINGLPAGIENLDPVNLVKDIVDRAIETGCAVHEKICEAIALS
LAKAAAIRPGKSLSLEEMDHLIASLFSCSDSNLTPDGKTIISMLTDEELERRFKC

Sequences:

>Translated_615_residues
MSDIIHLLPDHIANQIAAGEVIQRPASVVKELVENAVDAGASNIQVNIKDAGKTLIQVIDDGKGMSETDARMAFERHATS
KISTAEDLFSLHTMGFRGEALASIAAVAHIELRTRARGTELGTCLSIAGSNLESIEPEACNEGSIFSVKNLFFNVPARRK
FLKSNETEFRNIINEFERIALVNPQVGMSLYHNDAEIFNLPESGLRQRIINIYGKSLNQKLLSLDAQSSMVTISGFVGRP
DSAKKRGALQFFFVNGRYMKHPYFHKAIMQAYEQLIPAGDMPNYFVYFTLDPSSIDVNIHPTKTEIKFENEQPIWQILMA
ATREALAKSSAIPTIDFDVEDAIDIPVYNPVKKSEPSTYKAPKVQVDSSYNPFDTTSYKKPEFDWSKLYQGFENDRVAVQ
RESETFEDAPIEELPAEASDPEKLFTEVSNPCYQYKGRYIVTSLKSGLAIIDQHRAHVRILFDQYLSNIRQQQGVSQQVL
FPEIVEFTAAEAAVLPSLLEDLCFVGFDLSNLGNDNYAINGLPAGIENLDPVNLVKDIVDRAIETGCAVHEKICEAIALS
LAKAAAIRPGKSLSLEEMDHLIASLFSCSDSNLTPDGKTIISMLTDEELERRFKC
>Mature_614_residues
SDIIHLLPDHIANQIAAGEVIQRPASVVKELVENAVDAGASNIQVNIKDAGKTLIQVIDDGKGMSETDARMAFERHATSK
ISTAEDLFSLHTMGFRGEALASIAAVAHIELRTRARGTELGTCLSIAGSNLESIEPEACNEGSIFSVKNLFFNVPARRKF
LKSNETEFRNIINEFERIALVNPQVGMSLYHNDAEIFNLPESGLRQRIINIYGKSLNQKLLSLDAQSSMVTISGFVGRPD
SAKKRGALQFFFVNGRYMKHPYFHKAIMQAYEQLIPAGDMPNYFVYFTLDPSSIDVNIHPTKTEIKFENEQPIWQILMAA
TREALAKSSAIPTIDFDVEDAIDIPVYNPVKKSEPSTYKAPKVQVDSSYNPFDTTSYKKPEFDWSKLYQGFENDRVAVQR
ESETFEDAPIEELPAEASDPEKLFTEVSNPCYQYKGRYIVTSLKSGLAIIDQHRAHVRILFDQYLSNIRQQQGVSQQVLF
PEIVEFTAAEAAVLPSLLEDLCFVGFDLSNLGNDNYAINGLPAGIENLDPVNLVKDIVDRAIETGCAVHEKICEAIALSL
AKAAAIRPGKSLSLEEMDHLIASLFSCSDSNLTPDGKTIISMLTDEELERRFKC

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=322, Percent_Identity=32.9192546583851, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=27.4390243902439, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=27.4390243902439, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI310128478, Length=355, Percent_Identity=27.0422535211268, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI4505913, Length=355, Percent_Identity=27.0422535211268, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=27.5, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI91992162, Length=353, Percent_Identity=27.7620396600567, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI91992160, Length=354, Percent_Identity=27.683615819209, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI263191589, Length=227, Percent_Identity=27.3127753303965, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI310128480, Length=328, Percent_Identity=24.390243902439, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790612, Length=525, Percent_Identity=30.6666666666667, Blast_Score=234, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71991825, Length=422, Percent_Identity=29.8578199052133, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=374, Percent_Identity=25.9358288770053, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=342, Percent_Identity=31.8713450292398, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=346, Percent_Identity=25.4335260115607, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=288, Percent_Identity=24.6527777777778, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136968, Length=318, Percent_Identity=34.5911949685535, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17136970, Length=360, Percent_Identity=25.2777777777778, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_PARD8 (A6LEJ8)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001303734.1
- ProteinModelPortal:   A6LEJ8
- SMR:   A6LEJ8
- STRING:   A6LEJ8
- GeneID:   5307536
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_2387
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   MACKAAV
- ProtClustDB:   CLSK823666
- BioCyc:   PDIS435591:BDI_2387-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 68349; Mature: 68218

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIIHLLPDHIANQIAAGEVIQRPASVVKELVENAVDAGASNIQVNIKDAGKTLIQVID
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHH
DGKGMSETDARMAFERHATSKISTAEDLFSLHTMGFRGEALASIAAVAHIELRTRARGTE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
LGTCLSIAGSNLESIEPEACNEGSIFSVKNLFFNVPARRKFLKSNETEFRNIINEFERIA
HHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHEE
LVNPQVGMSLYHNDAEIFNLPESGLRQRIINIYGKSLNQKLLSLDAQSSMVTISGFVGRP
ECCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
DSAKKRGALQFFFVNGRYMKHPYFHKAIMQAYEQLIPAGDMPNYFVYFTLDPSSIDVNIH
CCHHHCCCEEEEEECCEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEEC
PTKTEIKFENEQPIWQILMAATREALAKSSAIPTIDFDVEDAIDIPVYNPVKKSEPSTYK
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCC
APKVQVDSSYNPFDTTSYKKPEFDWSKLYQGFENDRVAVQRESETFEDAPIEELPAEASD
CCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCHHHCCCCCCC
PEKLFTEVSNPCYQYKGRYIVTSLKSGLAIIDQHRAHVRILFDQYLSNIRQQQGVSQQVL
HHHHHHHHCCCHHHHCCCEEEEEHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHH
FPEIVEFTAAEAAVLPSLLEDLCFVGFDLSNLGNDNYAINGLPAGIENLDPVNLVKDIVD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHH
RAIETGCAVHEKICEAIALSLAKAAAIRPGKSLSLEEMDHLIASLFSCSDSNLTPDGKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
ISMLTDEELERRFKC
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDIIHLLPDHIANQIAAGEVIQRPASVVKELVENAVDAGASNIQVNIKDAGKTLIQVID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHH
DGKGMSETDARMAFERHATSKISTAEDLFSLHTMGFRGEALASIAAVAHIELRTRARGTE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
LGTCLSIAGSNLESIEPEACNEGSIFSVKNLFFNVPARRKFLKSNETEFRNIINEFERIA
HHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHEE
LVNPQVGMSLYHNDAEIFNLPESGLRQRIINIYGKSLNQKLLSLDAQSSMVTISGFVGRP
ECCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
DSAKKRGALQFFFVNGRYMKHPYFHKAIMQAYEQLIPAGDMPNYFVYFTLDPSSIDVNIH
CCHHHCCCEEEEEECCEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEEC
PTKTEIKFENEQPIWQILMAATREALAKSSAIPTIDFDVEDAIDIPVYNPVKKSEPSTYK
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCC
APKVQVDSSYNPFDTTSYKKPEFDWSKLYQGFENDRVAVQRESETFEDAPIEELPAEASD
CCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCHHHCCCCCCC
PEKLFTEVSNPCYQYKGRYIVTSLKSGLAIIDQHRAHVRILFDQYLSNIRQQQGVSQQVL
HHHHHHHHCCCHHHHCCCEEEEEHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHH
FPEIVEFTAAEAAVLPSLLEDLCFVGFDLSNLGNDNYAINGLPAGIENLDPVNLVKDIVD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHH
RAIETGCAVHEKICEAIALSLAKAAAIRPGKSLSLEEMDHLIASLFSCSDSNLTPDGKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
ISMLTDEELERRFKC
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA