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The map label for this gene is cobD [H]

Identifier: 150008941

GI number: 150008941

Start: 2753655

End: 2754683

Strand: Reverse

Name: cobD [H]

Synonym: BDI_2337

Alternate gene names: 150008941

Gene position: 2754683-2753655 (Counterclockwise)

Preceding gene: 150008942

Following gene: 150008939

Centisome position: 57.25

GC content: 45.0

Gene sequence:

>1029_bases
ATGTTATACGGACACGGTGATGATTTTTATAACGCAAAGAACGAGGTAAAGATAAACTTTAGCTCGAATGTGTGGCACGG
AGCTAATTTAGATAAACTGAAGGAACATTTGATCGAGCATTTTGATAAGCTGACTCGTTATCCGGAGCCGGACGCCGCTA
CTTTGAAAAGATTGTTGGCCCGCCGGTATGAGATCAAGGAAGAGAATATTGTAGTGACGAATGGCTCGATCACGGCTTTT
TATTTGTTAGCGCAAGCTTGGCGAGGTGCGAAATCCATGATCGCTATTCCTTCTTTCTCTGAATATGAGGACGCTTGCCG
TTTGCATGAGCATGAGATCTCTTTCTTCCCGACATCGGACGATTTATCAGAGTTATCCTTGGAGGGACAGGATTTCTGTT
GGATTTGTAATCCGAATAATCCGGATGGAAAGCTGATCCACCGTACGGAGCTTCTCCGTTTGATCTCGGCGAATCCGCAG
ACTACCTTCATTATTGACCAGGCATACGTGGCTTTTACGACGGAAGACATGCTAAAGCCGAGTGACGTGAAAACGCATAA
GAACTTAATCCTTGTCCAGTCTATCTCGAAGGCCTATAATATCCCCGGCTTGCGTATCGGTTATCTGGTCGCTTCTCCGG
AGATTGCGGAGAAAGTGAACAAGTATATCATACCTTGGTCGGTAAATGCTATCGCTATCGAGGCAAGTAAATATATCTTG
ATCCATCCGGCGCAATTTACGTTGCCGATCCGTAAATGGCAGCGTGAGACAGCGGATTTTATTTATCAATTAAGTAAATT
GGATGGCTTGGAGGTAATCCCGACCTCTACGACTTTCTTCCTTGTCCGTTTGAAGAAGGGTACAGCCGCTGATTTAAAGC
AATTCCTTTTAGATAATTACGGGATCTTGATCCGTGACGCTTCGAATTTCCGGGGCTTGGATGAGACTTATCTACGGCTC
TCTACCCAGAAGTCTGATGAGAACCAGATCTTACTTGAAGGGGTGAAGGTTTGGTTGGAGCAACAATAA

Upstream 100 bases:

>100_bases
ATACAGGATGCGATCTATAAGGCGATTGATAGGAAAAGCCAAAAAGATTCGTAATTTTGTGACAGTTTTAACAGATAGGT
ATTAATTAAAAAGCAGGTAT

Downstream 100 bases:

>100_bases
ATTGAGGACGAGAAACTTCCGGAGGTATGTGGGTATTTCCGGAAGTTTTTGTTAAAATAGCCAACCAATGAACAGGGGCA
AGTAGTCTTTCAACTCTGTC

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLYGHGDDFYNAKNEVKINFSSNVWHGANLDKLKEHLIEHFDKLTRYPEPDAATLKRLLARRYEIKEENIVVTNGSITAF
YLLAQAWRGAKSMIAIPSFSEYEDACRLHEHEISFFPTSDDLSELSLEGQDFCWICNPNNPDGKLIHRTELLRLISANPQ
TTFIIDQAYVAFTTEDMLKPSDVKTHKNLILVQSISKAYNIPGLRIGYLVASPEIAEKVNKYIIPWSVNAIAIEASKYIL
IHPAQFTLPIRKWQRETADFIYQLSKLDGLEVIPTSTTFFLVRLKKGTAADLKQFLLDNYGILIRDASNFRGLDETYLRL
STQKSDENQILLEGVKVWLEQQ

Sequences:

>Translated_342_residues
MLYGHGDDFYNAKNEVKINFSSNVWHGANLDKLKEHLIEHFDKLTRYPEPDAATLKRLLARRYEIKEENIVVTNGSITAF
YLLAQAWRGAKSMIAIPSFSEYEDACRLHEHEISFFPTSDDLSELSLEGQDFCWICNPNNPDGKLIHRTELLRLISANPQ
TTFIIDQAYVAFTTEDMLKPSDVKTHKNLILVQSISKAYNIPGLRIGYLVASPEIAEKVNKYIIPWSVNAIAIEASKYIL
IHPAQFTLPIRKWQRETADFIYQLSKLDGLEVIPTSTTFFLVRLKKGTAADLKQFLLDNYGILIRDASNFRGLDETYLRL
STQKSDENQILLEGVKVWLEQQ
>Mature_342_residues
MLYGHGDDFYNAKNEVKINFSSNVWHGANLDKLKEHLIEHFDKLTRYPEPDAATLKRLLARRYEIKEENIVVTNGSITAF
YLLAQAWRGAKSMIAIPSFSEYEDACRLHEHEISFFPTSDDLSELSLEGQDFCWICNPNNPDGKLIHRTELLRLISANPQ
TTFIIDQAYVAFTTEDMLKPSDVKTHKNLILVQSISKAYNIPGLRIGYLVASPEIAEKVNKYIIPWSVNAIAIEASKYIL
IHPAQFTLPIRKWQRETADFIYQLSKLDGLEVIPTSTTFFLVRLKKGTAADLKQFLLDNYGILIRDASNFRGLDETYLRL
STQKSDENQILLEGVKVWLEQQ

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=333, Percent_Identity=24.024024024024, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 39204; Mature: 39204

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYGHGDDFYNAKNEVKINFSSNVWHGANLDKLKEHLIEHFDKLTRYPEPDAATLKRLLA
CCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
RRYEIKEENIVVTNGSITAFYLLAQAWRGAKSMIAIPSFSEYEDACRLHEHEISFFPTSD
HHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCEEEEECCCC
DLSELSLEGQDFCWICNPNNPDGKLIHRTELLRLISANPQTTFIIDQAYVAFTTEDMLKP
CHHHHCCCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCCEEEEEECEEEEEEHHHHCCC
SDVKTHKNLILVQSISKAYNIPGLRIGYLVASPEIAEKVNKYIIPWSVNAIAIEASKYIL
CCCCCCCCEEEEEEHHHHHCCCCEEEEEEEECCHHHHHHHCEEEEEECCEEEEECCCEEE
IHPAQFTLPIRKWQRETADFIYQLSKLDGLEVIPTSTTFFLVRLKKGTAADLKQFLLDNY
EECCCEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCHHHHHHHHHCCC
GILIRDASNFRGLDETYLRLSTQKSDENQILLEGVKVWLEQQ
CEEEEECCCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLYGHGDDFYNAKNEVKINFSSNVWHGANLDKLKEHLIEHFDKLTRYPEPDAATLKRLLA
CCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
RRYEIKEENIVVTNGSITAFYLLAQAWRGAKSMIAIPSFSEYEDACRLHEHEISFFPTSD
HHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCEEEEECCCC
DLSELSLEGQDFCWICNPNNPDGKLIHRTELLRLISANPQTTFIIDQAYVAFTTEDMLKP
CHHHHCCCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCCEEEEEECEEEEEEHHHHCCC
SDVKTHKNLILVQSISKAYNIPGLRIGYLVASPEIAEKVNKYIIPWSVNAIAIEASKYIL
CCCCCCCCEEEEEEHHHHHCCCCEEEEEEEECCHHHHHHHCEEEEEECCEEEEECCCEEE
IHPAQFTLPIRKWQRETADFIYQLSKLDGLEVIPTSTTFFLVRLKKGTAADLKQFLLDNY
EECCCEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCHHHHHHHHHCCC
GILIRDASNFRGLDETYLRLSTQKSDENQILLEGVKVWLEQQ
CEEEEECCCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]