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The map label for this gene is ydeN [H]

Identifier: 150008918

GI number: 150008918

Start: 2716974

End: 2718425

Strand: Reverse

Name: ydeN [H]

Synonym: BDI_2314

Alternate gene names: 150008918

Gene position: 2718425-2716974 (Counterclockwise)

Preceding gene: 150008919

Following gene: 150008917

Centisome position: 56.5

GC content: 40.36

Gene sequence:

>1452_bases
ATGAATTATAAAGAGATCTTTGTTGCGGTTAATAGTGCCGCATTGATGTTGTCAACCGTAAGTTGTGACGCAAAAGAGGA
AGCTGTTCCTAAGCCGAATATCATAATTTTATTAGCGGATGATTTGGGATATAATGATGTCTCTTGTTATCGAAATGAGA
ATTTTCCGCAGCAGTCGGATAGCTTTCCTACTTCCCAAACTCCGAATTTGGACTTATTGGCCCGGCAAGGTATTCGCTTT
ACGAATTTTTATTGTGGTGCGGCTGTTAGCTCTCCATCTCGTGCGGCTCTAATGACCGGTCGGAATTGTACTCGTACAGG
GGTTTATAATTATCTGGAGCAAAACTCACCGATGCATTTGAGAGATAGTGAGGTTACTATAGCAGAAGTACTGAAACAAG
CAGATTATGCGACGGGGCATTTTGGAAAGTGGCATTTAAGTTCGGGACGTCCGGATCAACCTTATCCCAATGATCAAGGT
TTTGATTATAGTTTTTATGCCTTGAATAATTCAGTCCCGTCTCATCATAATCCCACGAACTTTTTCCGGAATGGAGAACC
GCAAGGTGAGATCGAAGGTTATTCCTGTGATATTGTGGTAACGGAAGCACTCCAATGGCTAGACAAGAATAAACAGGAAC
CTTTCTTCTTAAATGTTTGGTTCAATGAGCCTCATTTTCCAATGGAGGCCCCGGAGGAGTTGAAGAAAAGGCATGCTATT
AATCCTGAGTATTATGGGTGTATCGAAAATATGGATATAGCGATTGGTAAATTAATGAATTATCTAAAAGAACAGAATCT
GGAAGATAATACGATTGTCATATTTGCTTCTGATAATGGTTCTCAGTGGGATTATTCTAATTTGCCATTTCGGGGAGAGA
AACATTTTAATTATGAGGGAGGATTGCGAGTTCCATGTATTGTTAGATGGCATAAACATGTACCAACCGGTGTGATTAGT
GAGTTTAACGGTTGTTTCACGGATATATTACCAACGTTAGCGTCTTTAGCGGATGCTCCGGTTCCTACAGATCGTGTTAT
TGATGGTATGGATATTTCTCCGGTGTTTTTGGGGAAAGCTGAAACGTTGGAAAGAGAAAACCCTTTGTTCTTTTTCCGGT
ATATTCATGATCCTATTTGTATGATACGTGAAGGCGACTGGTGTCTACTGGGATACGATGAGCCTCTACCATGGGCTTTT
AGTTTGGATGAATTAGCGCTTGGTAAAGTGAAGCCTTGGTATTTGACAAAAGAACATATGGAGTTCGCCAAGAAGGTGTT
TCCAAAATATTTTGAGTTATATAATTTGAGAGATGATCGTGAGGAACGAATAGATGTGGCAGATAAACATCCTGAAATTG
TAGCGAGACTGAAATCAAAGATGTTGAAACTTAAGCAGGAAGTTGTAGCTGAAGGTGGAGATTGGTTTGCGGAAGACGTG
GATGAAAGATGA

Upstream 100 bases:

>100_bases
TACCTATTCCTGATAGTGAGCGCTCTTTGAATCCAAATTTAGAGCAAAATCCGGGTTGGTGATTTAGAGAATATATTTAT
TAGAATTTAGATTATATAAA

Downstream 100 bases:

>100_bases
CAAAGTTGCTTGCGTGTCAAATGATATGAGAAAATAAGTCCTAATAACTTGTTTAAAATTCATAGTTATGATTTTCTTGA
GACATAGTTATGTTTTGAGT

Product: arylsulfatase A

Products: cerebroside; sulfate

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYKEIFVAVNSAALMLSTVSCDAKEEAVPKPNIIILLADDLGYNDVSCYRNENFPQQSDSFPTSQTPNLDLLARQGIRF
TNFYCGAAVSSPSRAALMTGRNCTRTGVYNYLEQNSPMHLRDSEVTIAEVLKQADYATGHFGKWHLSSGRPDQPYPNDQG
FDYSFYALNNSVPSHHNPTNFFRNGEPQGEIEGYSCDIVVTEALQWLDKNKQEPFFLNVWFNEPHFPMEAPEELKKRHAI
NPEYYGCIENMDIAIGKLMNYLKEQNLEDNTIVIFASDNGSQWDYSNLPFRGEKHFNYEGGLRVPCIVRWHKHVPTGVIS
EFNGCFTDILPTLASLADAPVPTDRVIDGMDISPVFLGKAETLERENPLFFFRYIHDPICMIREGDWCLLGYDEPLPWAF
SLDELALGKVKPWYLTKEHMEFAKKVFPKYFELYNLRDDREERIDVADKHPEIVARLKSKMLKLKQEVVAEGGDWFAEDV
DER

Sequences:

>Translated_483_residues
MNYKEIFVAVNSAALMLSTVSCDAKEEAVPKPNIIILLADDLGYNDVSCYRNENFPQQSDSFPTSQTPNLDLLARQGIRF
TNFYCGAAVSSPSRAALMTGRNCTRTGVYNYLEQNSPMHLRDSEVTIAEVLKQADYATGHFGKWHLSSGRPDQPYPNDQG
FDYSFYALNNSVPSHHNPTNFFRNGEPQGEIEGYSCDIVVTEALQWLDKNKQEPFFLNVWFNEPHFPMEAPEELKKRHAI
NPEYYGCIENMDIAIGKLMNYLKEQNLEDNTIVIFASDNGSQWDYSNLPFRGEKHFNYEGGLRVPCIVRWHKHVPTGVIS
EFNGCFTDILPTLASLADAPVPTDRVIDGMDISPVFLGKAETLERENPLFFFRYIHDPICMIREGDWCLLGYDEPLPWAF
SLDELALGKVKPWYLTKEHMEFAKKVFPKYFELYNLRDDREERIDVADKHPEIVARLKSKMLKLKQEVVAEGGDWFAEDV
DER
>Mature_483_residues
MNYKEIFVAVNSAALMLSTVSCDAKEEAVPKPNIIILLADDLGYNDVSCYRNENFPQQSDSFPTSQTPNLDLLARQGIRF
TNFYCGAAVSSPSRAALMTGRNCTRTGVYNYLEQNSPMHLRDSEVTIAEVLKQADYATGHFGKWHLSSGRPDQPYPNDQG
FDYSFYALNNSVPSHHNPTNFFRNGEPQGEIEGYSCDIVVTEALQWLDKNKQEPFFLNVWFNEPHFPMEAPEELKKRHAI
NPEYYGCIENMDIAIGKLMNYLKEQNLEDNTIVIFASDNGSQWDYSNLPFRGEKHFNYEGGLRVPCIVRWHKHVPTGVIS
EFNGCFTDILPTLASLADAPVPTDRVIDGMDISPVFLGKAETLERENPLFFFRYIHDPICMIREGDWCLLGYDEPLPWAF
SLDELALGKVKPWYLTKEHMEFAKKVFPKYFELYNLRDDREERIDVADKHPEIVARLKSKMLKLKQEVVAEGGDWFAEDV
DER

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=376, Percent_Identity=35.1063829787234, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI146229329, Length=376, Percent_Identity=35.1063829787234, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI6005990, Length=376, Percent_Identity=35.1063829787234, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI146229324, Length=376, Percent_Identity=35.1063829787234, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4503899, Length=389, Percent_Identity=32.3907455012853, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI45430057, Length=415, Percent_Identity=29.3975903614458, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI38569405, Length=496, Percent_Identity=29.0322580645161, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI59797060, Length=480, Percent_Identity=28.5416666666667, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI38569407, Length=349, Percent_Identity=32.378223495702, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI109389362, Length=484, Percent_Identity=26.8595041322314, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI146229327, Length=283, Percent_Identity=31.8021201413428, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI53831991, Length=197, Percent_Identity=31.9796954314721, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI71852586, Length=158, Percent_Identity=39.2405063291139, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI71852584, Length=158, Percent_Identity=39.2405063291139, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI157266309, Length=169, Percent_Identity=36.094674556213, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI31742482, Length=234, Percent_Identity=32.9059829059829, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI58743319, Length=149, Percent_Identity=37.5838926174497, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4506919, Length=379, Percent_Identity=25.3298153034301, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87081924, Length=395, Percent_Identity=29.3670886075949, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790233, Length=392, Percent_Identity=26.530612244898, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790112, Length=366, Percent_Identity=25.6830601092896, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533416, Length=486, Percent_Identity=27.7777777777778, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115533418, Length=474, Percent_Identity=27.6371308016878, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17559078, Length=149, Percent_Identity=36.241610738255, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24666109, Length=366, Percent_Identity=31.4207650273224, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281366397, Length=416, Percent_Identity=29.0865384615385, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281366395, Length=416, Percent_Identity=29.0865384615385, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24666163, Length=416, Percent_Identity=29.0865384615385, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24666175, Length=365, Percent_Identity=30.958904109589, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI281363223, Length=526, Percent_Identity=24.9049429657795, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: 3.1.6.8

Molecular weight: Translated: 55371; Mature: 55371

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKEIFVAVNSAALMLSTVSCDAKEEAVPKPNIIILLADDLGYNDVSCYRNENFPQQSD
CCCCEEEEEECCCEEEEEEECCCCHHHCCCCCCEEEEEECCCCCCCEEHCCCCCCCCCCC
SFPTSQTPNLDLLARQGIRFTNFYCGAAVSSPSRAALMTGRNCTRTGVYNYLEQNSPMHL
CCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEE
RDSEVTIAEVLKQADYATGHFGKWHLSSGRPDQPYPNDQGFDYSFYALNNSVPSHHNPTN
CCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHH
FFRNGEPQGEIEGYSCDIVVTEALQWLDKNKQEPFFLNVWFNEPHFPMEAPEELKKRHAI
HCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCC
NPEYYGCIENMDIAIGKLMNYLKEQNLEDNTIVIFASDNGSQWDYSNLPFRGEKHFNYEG
CCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GLRVPCIVRWHKHVPTGVISEFNGCFTDILPTLASLADAPVPTDRVIDGMDISPVFLGKA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEECCH
ETLERENPLFFFRYIHDPICMIREGDWCLLGYDEPLPWAFSLDELALGKVKPWYLTKEHM
HHHCCCCCEEEEEECCCCEEEEECCCEEEEECCCCCCCEECHHHHHHCCCCCCEECHHHH
EFAKKVFPKYFELYNLRDDREERIDVADKHPEIVARLKSKMLKLKQEVVAEGGDWFAEDV
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
DER
CCC
>Mature Secondary Structure
MNYKEIFVAVNSAALMLSTVSCDAKEEAVPKPNIIILLADDLGYNDVSCYRNENFPQQSD
CCCCEEEEEECCCEEEEEEECCCCHHHCCCCCCEEEEEECCCCCCCEEHCCCCCCCCCCC
SFPTSQTPNLDLLARQGIRFTNFYCGAAVSSPSRAALMTGRNCTRTGVYNYLEQNSPMHL
CCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEE
RDSEVTIAEVLKQADYATGHFGKWHLSSGRPDQPYPNDQGFDYSFYALNNSVPSHHNPTN
CCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHH
FFRNGEPQGEIEGYSCDIVVTEALQWLDKNKQEPFFLNVWFNEPHFPMEAPEELKKRHAI
HCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCC
NPEYYGCIENMDIAIGKLMNYLKEQNLEDNTIVIFASDNGSQWDYSNLPFRGEKHFNYEG
CCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GLRVPCIVRWHKHVPTGVISEFNGCFTDILPTLASLADAPVPTDRVIDGMDISPVFLGKA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEECCH
ETLERENPLFFFRYIHDPICMIREGDWCLLGYDEPLPWAFSLDELALGKVKPWYLTKEHM
HHHCCCCCEEEEEECCCCEEEEECCCEEEEECCCCCCCEECHHHHHHCCCCCCEECHHHH
EFAKKVFPKYFELYNLRDDREERIDVADKHPEIVARLKSKMLKLKQEVVAEGGDWFAEDV
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
DER
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cerebroside 3-sulfate; H2O

Specific reaction: A cerebroside 3-sulfate + H2O = a cerebroside + sulfate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]