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The map label for this gene is pepE [H]

Identifier: 150008888

GI number: 150008888

Start: 2672247

End: 2674034

Strand: Direct

Name: pepE [H]

Synonym: BDI_2283

Alternate gene names: 150008888

Gene position: 2672247-2674034 (Clockwise)

Preceding gene: 150008887

Following gene: 150008889

Centisome position: 55.54

GC content: 53.8

Gene sequence:

>1788_bases
ATGAAAACAAACATTCCTGAACGTATCGCCGCCCTACGGGAGGCTATGAGACAACAGAAGGTTGACGCTTACATCATACC
CAGTTCCGACCCGCACCTAAGCGAGTATCCGGCCGATCGCTGGAAATCGAGAGAATGGATATCCGGCTTCACCGGCTCGG
CGGGAACGATCGTGGTCACCGCAGACAAGGCGGGCTTATGGACCGATTCCCGGTATTTCCTGCAAGCGGCCAGCCAACTG
GAAGGTTCCGGTATCGAACTCTATAAGTTGGCGCTTCCGGAGACACCGTCTATCACGGAATTCCTCTTGCATGAGTTACA
CGCCGGACAGGCCGTAGGGCTGGACGGGCAAACCTATAGCGCCGCCGAAGCGAGTGCCTTGGCAAATAAACTAAGCCGTA
AAGAAATCAAGCTGGATACCTCGGCCGACCTGATCGAGGGTATCTGGAAGGACCGTCCCGCCGTTCCCGGAAACCCGATA
TTCGAGATGCCGGAAGCATTAAGCGGAGCCTCCGTGCACGAGAAACTAGAACTAATCAATAACCAGTTGCGGAGCGAGGG
CGCCGATTGCTTGATCCTCGCCGCCTTGGACGAGATCGCGTGGACATTCAATATCCGGGGTACGGACGTGACCTATAACC
CGGTCGTAGTCAGCTACGCCTTCGTATCGGAGGACGAGAGCGTGCTTTTCATCAAGCCGGAGAAGCTGACCGCCGAGATC
ACCGAGCATTTGAAGAAAGAAGGGGTTACGCTGGCCGAATACTCCATGATCCAGAGGTATCTGTCCCGCCTACCGGAAAA
CAGCCGGGTATTCGTGGATATGAACAAGACGAACGTCTCCTTATACGATGCGATCCCGGGAAGCTGTACGATCGTGGAAG
GGATCTCCCCCGCCAATCACTTGAAGAGCATCAAGAACGAGACCGAGATCAAGGGATTCCAAAACGCCGTGGTAAAAGAT
GGCGTCGCCTTGACAAAATTCTATATCTGGCTGGAGAAAAAAATGGCGGAAGGAGCCCAAGTTACAGAGATCAGCGCCGC
CGAGAAGCTGACAGCCTTACGTGCGGAACAACCGCAATACATCATGGATAGCTTCGGCACGATCTGCGGTTACGCCGAGC
ATGGAGCGATCGTTCATTATTCCGCTACGCCGGAGACGGACGCGACCTTGAAACCGGAGGGATTGCTTTTGATCGATTCC
GGTGCGCAATATCTGGACGGTACGACGGATATCACCCGCACGATCGCCCTTGGAGAGCCGACGGAGCAGATGAAAAAGGA
TTTCACCCGTGTATTGAAAGGTACGATCAGCTTGGCGAAAAGCAAGTTTCCCGCTGGAACACGAGGCTCTCAGATCGATA
TCCTTGCCCGTAAGGCGCTATGGGATTCCGGCATTAATTACTTGCACGGAACCGGTCACGGTATCGGCCATTGCCTAAAC
GTACACGAAGGCCCCCAAAGCATCCGCATGGAGGAGAACCCGGTGACCTTGAAGCCCGGAATGGTGATCAGCGACGAGCC
GGCCATGTATCGTACCGGCGAATACGGTATCCGTACGGAGAACATGATCTTGGTACGTGAGGACAGCGAAACGGAATTCG
GGAAATTCCTAGGATTCGATACGCTGACGCTTTGTTTCATCGACACGAGCTTGATTATCATCCCCATGCTCTCTGTCCGT
GAGCACGCTTGGCTGAACAAGTACCACCAAATGGTCTACGACAAGATCAGCCCGTTCTTGAACGAGGAGGAGAAAGCTTG
GCTGAAAGAGAAAACAACAGAAATTTAA

Upstream 100 bases:

>100_bases
CCCATCTATATTATAAGGTAGAAGAGCCGGTTTCCGGCGAGACAAATCCAAAATAATTCATTAACTTTGCGAGTATTAAT
GTTGACTAAAATAAAATGCG

Downstream 100 bases:

>100_bases
ACAACTAAAAATGGCATTAATTAAATCCGTTCGTGGCTTTACCCCGAAGATCGGTAAAGACACTTTTTTAGCAGACAACG
CCACGATTATAGGTGACGTA

Product: putative aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MKTNIPERIAALREAMRQQKVDAYIIPSSDPHLSEYPADRWKSREWISGFTGSAGTIVVTADKAGLWTDSRYFLQAASQL
EGSGIELYKLALPETPSITEFLLHELHAGQAVGLDGQTYSAAEASALANKLSRKEIKLDTSADLIEGIWKDRPAVPGNPI
FEMPEALSGASVHEKLELINNQLRSEGADCLILAALDEIAWTFNIRGTDVTYNPVVVSYAFVSEDESVLFIKPEKLTAEI
TEHLKKEGVTLAEYSMIQRYLSRLPENSRVFVDMNKTNVSLYDAIPGSCTIVEGISPANHLKSIKNETEIKGFQNAVVKD
GVALTKFYIWLEKKMAEGAQVTEISAAEKLTALRAEQPQYIMDSFGTICGYAEHGAIVHYSATPETDATLKPEGLLLIDS
GAQYLDGTTDITRTIALGEPTEQMKKDFTRVLKGTISLAKSKFPAGTRGSQIDILARKALWDSGINYLHGTGHGIGHCLN
VHEGPQSIRMEENPVTLKPGMVISDEPAMYRTGEYGIRTENMILVREDSETEFGKFLGFDTLTLCFIDTSLIIIPMLSVR
EHAWLNKYHQMVYDKISPFLNEEEKAWLKEKTTEI

Sequences:

>Translated_595_residues
MKTNIPERIAALREAMRQQKVDAYIIPSSDPHLSEYPADRWKSREWISGFTGSAGTIVVTADKAGLWTDSRYFLQAASQL
EGSGIELYKLALPETPSITEFLLHELHAGQAVGLDGQTYSAAEASALANKLSRKEIKLDTSADLIEGIWKDRPAVPGNPI
FEMPEALSGASVHEKLELINNQLRSEGADCLILAALDEIAWTFNIRGTDVTYNPVVVSYAFVSEDESVLFIKPEKLTAEI
TEHLKKEGVTLAEYSMIQRYLSRLPENSRVFVDMNKTNVSLYDAIPGSCTIVEGISPANHLKSIKNETEIKGFQNAVVKD
GVALTKFYIWLEKKMAEGAQVTEISAAEKLTALRAEQPQYIMDSFGTICGYAEHGAIVHYSATPETDATLKPEGLLLIDS
GAQYLDGTTDITRTIALGEPTEQMKKDFTRVLKGTISLAKSKFPAGTRGSQIDILARKALWDSGINYLHGTGHGIGHCLN
VHEGPQSIRMEENPVTLKPGMVISDEPAMYRTGEYGIRTENMILVREDSETEFGKFLGFDTLTLCFIDTSLIIIPMLSVR
EHAWLNKYHQMVYDKISPFLNEEEKAWLKEKTTEI
>Mature_595_residues
MKTNIPERIAALREAMRQQKVDAYIIPSSDPHLSEYPADRWKSREWISGFTGSAGTIVVTADKAGLWTDSRYFLQAASQL
EGSGIELYKLALPETPSITEFLLHELHAGQAVGLDGQTYSAAEASALANKLSRKEIKLDTSADLIEGIWKDRPAVPGNPI
FEMPEALSGASVHEKLELINNQLRSEGADCLILAALDEIAWTFNIRGTDVTYNPVVVSYAFVSEDESVLFIKPEKLTAEI
TEHLKKEGVTLAEYSMIQRYLSRLPENSRVFVDMNKTNVSLYDAIPGSCTIVEGISPANHLKSIKNETEIKGFQNAVVKD
GVALTKFYIWLEKKMAEGAQVTEISAAEKLTALRAEQPQYIMDSFGTICGYAEHGAIVHYSATPETDATLKPEGLLLIDS
GAQYLDGTTDITRTIALGEPTEQMKKDFTRVLKGTISLAKSKFPAGTRGSQIDILARKALWDSGINYLHGTGHGIGHCLN
VHEGPQSIRMEENPVTLKPGMVISDEPAMYRTGEYGIRTENMILVREDSETEFGKFLGFDTLTLCFIDTSLIIIPMLSVR
EHAWLNKYHQMVYDKISPFLNEEEKAWLKEKTTEI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=616, Percent_Identity=39.1233766233766, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI93141226, Length=604, Percent_Identity=36.5894039735099, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI264681565, Length=616, Percent_Identity=37.012987012987, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1788728, Length=169, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=614, Percent_Identity=34.8534201954397, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25149105, Length=576, Percent_Identity=28.2986111111111, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322999, Length=651, Percent_Identity=33.6405529953917, Blast_Score=335, Evalue=1e-92,
Organism=Drosophila melanogaster, GI17137632, Length=616, Percent_Identity=39.9350649350649, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI161078230, Length=616, Percent_Identity=30.5194805194805, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI21357287, Length=616, Percent_Identity=30.5194805194805, Blast_Score=275, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 65992; Mature: 65992

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNIPERIAALREAMRQQKVDAYIIPSSDPHLSEYPADRWKSREWISGFTGSAGTIVVT
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCCHHHCCCCCCCCEEEEE
ADKAGLWTDSRYFLQAASQLEGSGIELYKLALPETPSITEFLLHELHAGQAVGLDGQTYS
ECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEECCCCCCCC
AAEASALANKLSRKEIKLDTSADLIEGIWKDRPAVPGNPIFEMPEALSGASVHEKLELIN
HHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCHHHCHHHHCCCHHHHHHHHHH
NQLRSEGADCLILAALDEIAWTFNIRGTDVTYNPVVVSYAFVSEDESVLFIKPEKLTAEI
HHHHHCCCCEEEEEECCCEEEEEEECCCCEEECCEEEEEEEECCCCCEEEECCHHHHHHH
TEHLKKEGVTLAEYSMIQRYLSRLPENSRVFVDMNKTNVSLYDAIPGSCTIVEGISPANH
HHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCEEEEECCCCHHH
LKSIKNETEIKGFQNAVVKDGVALTKFYIWLEKKMAEGAQVTEISAAEKLTALRAEQPQY
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCHH
IMDSFGTICGYAEHGAIVHYSATPETDATLKPEGLLLIDSGAQYLDGTTDITRTIALGEP
HHHHHHHHCCCCCCCEEEEEECCCCCCCEECCCCEEEECCCCCCCCCCCHHHEEEECCCC
TEQMKKDFTRVLKGTISLAKSKFPAGTRGSQIDILARKALWDSGINYLHGTGHGIGHCLN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCCEEECCCCCHHEEEE
VHEGPQSIRMEENPVTLKPGMVISDEPAMYRTGEYGIRTENMILVREDSETEFGKFLGFD
CCCCCCCCEECCCCEEECCCEEECCCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHCHH
TLTLCFIDTSLIIIPMLSVREHAWLNKYHQMVYDKISPFLNEEEKAWLKEKTTEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKTNIPERIAALREAMRQQKVDAYIIPSSDPHLSEYPADRWKSREWISGFTGSAGTIVVT
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCCHHHCCCCCCCCEEEEE
ADKAGLWTDSRYFLQAASQLEGSGIELYKLALPETPSITEFLLHELHAGQAVGLDGQTYS
ECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEECCCCCCCC
AAEASALANKLSRKEIKLDTSADLIEGIWKDRPAVPGNPIFEMPEALSGASVHEKLELIN
HHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCHHHCHHHHCCCHHHHHHHHHH
NQLRSEGADCLILAALDEIAWTFNIRGTDVTYNPVVVSYAFVSEDESVLFIKPEKLTAEI
HHHHHCCCCEEEEEECCCEEEEEEECCCCEEECCEEEEEEEECCCCCEEEECCHHHHHHH
TEHLKKEGVTLAEYSMIQRYLSRLPENSRVFVDMNKTNVSLYDAIPGSCTIVEGISPANH
HHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCEEEEECCCCHHH
LKSIKNETEIKGFQNAVVKDGVALTKFYIWLEKKMAEGAQVTEISAAEKLTALRAEQPQY
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCHH
IMDSFGTICGYAEHGAIVHYSATPETDATLKPEGLLLIDSGAQYLDGTTDITRTIALGEP
HHHHHHHHCCCCCCCEEEEEECCCCCCCEECCCCEEEECCCCCCCCCCCHHHEEEECCCC
TEQMKKDFTRVLKGTISLAKSKFPAGTRGSQIDILARKALWDSGINYLHGTGHGIGHCLN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCCEEECCCCCHHEEEE
VHEGPQSIRMEENPVTLKPGMVISDEPAMYRTGEYGIRTENMILVREDSETEFGKFLGFD
CCCCCCCCEECCCCEEECCCEEECCCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHCHH
TLTLCFIDTSLIIIPMLSVREHAWLNKYHQMVYDKISPFLNEEEKAWLKEKTTEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]