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The map label for this gene is proC [H]

Identifier: 150008860

GI number: 150008860

Start: 2639003

End: 2639806

Strand: Direct

Name: proC [H]

Synonym: BDI_2250

Alternate gene names: 150008860

Gene position: 2639003-2639806 (Clockwise)

Preceding gene: 150008858

Following gene: 150008863

Centisome position: 54.85

GC content: 49.0

Gene sequence:

>804_bases
ATGAGAATATCTATTATCGGTTCGGGTAATATCGGTGGAGCGATCGCCCGAGGTTTAGCGAAAGGAACCATGTTCAAAGC
CTCTGATATCACTTGTACCGCCCAATCGGACGAGACCTTGGAGAAGATGAGAAAGATCGATCCGGACTTTATCTTGACCC
ATGATAACGTGGAAGCGGCACGAAACGCTGATATCATCATCATCGCCGTTAAACCTTGGCGTGTAGAAATGATTATAGAT
GAGATTAAGTCGGTGCTCGACTTCGAGAAACAAATCATCGTATCCGTAGCGGCTGGCGTGACTTTCGACCTGTTGAATAC
TTATTTGACCAAGAATACAGACTTCGATTGTCTGGCTACTCCCACGATCTTCCGGATCATGCCCAACACGGCTATCGAGG
TGATGAGCAGCATGACTTTCGTTTCCGCCCGCAACGCCTCCAAGGAGCAAACGGATCTAATCATCCATATCTTCAACGAG
CTTGGCAACGCCATGTTGGTAGAAGAACGGTTGATGGGCGCAGGAACAGCATTGGCTTCCAGCGGCATCGCTTTCGCCTT
GCGTTATATCCGCGCGGCGATAGAAGGCGGCGTGGAATTGGGTTTCTATCCGAAACAAGCGCAAGAGATCGTGGTGCATA
CCGTGAAAGGCGCCGTTGATTTATTGCTCGAGAACAAAAGTAACCCGGAGATGGAAATCGATAAGGTAACAACTCCGGGC
GGAATCACGATCAAGGGTCTAAATGAGATGGAACTTTCCGGTTTTACCTCTTCCGTGATCCGGGGACTGAAGGCCAGTAA
ATAA

Upstream 100 bases:

>100_bases
TTTTTATCCGTAGCTAACTCTACAAAGTCGTACGTATTTGAGATATTTTATCTAAGTTTGCCTCTTCAGAAAACATAATA
TATAACTAATTATCTGCAAA

Downstream 100 bases:

>100_bases
AAATAGGCAGACAAAGTAGTTTGCCAGCACCAATACGCCCCGAAATATGCTGACAAACTACTTTACCTGCCCTCGGCAGG
TTTATGTTCTTTCCGCCTAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MRISIIGSGNIGGAIARGLAKGTMFKASDITCTAQSDETLEKMRKIDPDFILTHDNVEAARNADIIIIAVKPWRVEMIID
EIKSVLDFEKQIIVSVAAGVTFDLLNTYLTKNTDFDCLATPTIFRIMPNTAIEVMSSMTFVSARNASKEQTDLIIHIFNE
LGNAMLVEERLMGAGTALASSGIAFALRYIRAAIEGGVELGFYPKQAQEIVVHTVKGAVDLLLENKSNPEMEIDKVTTPG
GITIKGLNEMELSGFTSSVIRGLKASK

Sequences:

>Translated_267_residues
MRISIIGSGNIGGAIARGLAKGTMFKASDITCTAQSDETLEKMRKIDPDFILTHDNVEAARNADIIIIAVKPWRVEMIID
EIKSVLDFEKQIIVSVAAGVTFDLLNTYLTKNTDFDCLATPTIFRIMPNTAIEVMSSMTFVSARNASKEQTDLIIHIFNE
LGNAMLVEERLMGAGTALASSGIAFALRYIRAAIEGGVELGFYPKQAQEIVVHTVKGAVDLLLENKSNPEMEIDKVTTPG
GITIKGLNEMELSGFTSSVIRGLKASK
>Mature_267_residues
MRISIIGSGNIGGAIARGLAKGTMFKASDITCTAQSDETLEKMRKIDPDFILTHDNVEAARNADIIIIAVKPWRVEMIID
EIKSVLDFEKQIIVSVAAGVTFDLLNTYLTKNTDFDCLATPTIFRIMPNTAIEVMSSMTFVSARNASKEQTDLIIHIFNE
LGNAMLVEERLMGAGTALASSGIAFALRYIRAAIEGGVELGFYPKQAQEIVVHTVKGAVDLLLENKSNPEMEIDKVTTPG
GITIKGLNEMELSGFTSSVIRGLKASK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=29.3233082706767, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=32.1033210332103, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=30.4832713754647, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=30.4832713754647, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=31.4606741573034, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=26.3940520446097, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=27.2401433691756, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=210, Percent_Identity=31.4285714285714, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24648116, Length=272, Percent_Identity=30.8823529411765, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358587, Length=261, Percent_Identity=26.8199233716475, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24647700, Length=138, Percent_Identity=31.1594202898551, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28958; Mature: 28958

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISIIGSGNIGGAIARGLAKGTMFKASDITCTAQSDETLEKMRKIDPDFILTHDNVEAA
CEEEEEECCCCCHHHHHHHHHCCEEECCCEEEECCCHHHHHHHHCCCCCEEEEECCCHHH
RNADIIIIAVKPWRVEMIIDEIKSVLDFEKQIIVSVAAGVTFDLLNTYLTKNTDFDCLAT
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEC
PTIFRIMPNTAIEVMSSMTFVSARNASKEQTDLIIHIFNELGNAMLVEERLMGAGTALAS
CEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEHHHHHHCCCHHHHH
SGIAFALRYIRAAIEGGVELGFYPKQAQEIVVHTVKGAVDLLLENKSNPEMEIDKVTTPG
HHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEECCC
GITIKGLNEMELSGFTSSVIRGLKASK
CEEEECCCCHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRISIIGSGNIGGAIARGLAKGTMFKASDITCTAQSDETLEKMRKIDPDFILTHDNVEAA
CEEEEEECCCCCHHHHHHHHHCCEEECCCEEEECCCHHHHHHHHCCCCCEEEEECCCHHH
RNADIIIIAVKPWRVEMIIDEIKSVLDFEKQIIVSVAAGVTFDLLNTYLTKNTDFDCLAT
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEC
PTIFRIMPNTAIEVMSSMTFVSARNASKEQTDLIIHIFNELGNAMLVEERLMGAGTALAS
CEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEHHHHHHCCCHHHHH
SGIAFALRYIRAAIEGGVELGFYPKQAQEIVVHTVKGAVDLLLENKSNPEMEIDKVTTPG
HHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEECCC
GITIKGLNEMELSGFTSSVIRGLKASK
CEEEECCCCHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]