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The map label for this gene is ptpA [H]

Identifier: 150008856

GI number: 150008856

Start: 2632704

End: 2634938

Strand: Direct

Name: ptpA [H]

Synonym: BDI_2246

Alternate gene names: 150008856

Gene position: 2632704-2634938 (Clockwise)

Preceding gene: 150008852

Following gene: 150008857

Centisome position: 54.72

GC content: 47.38

Gene sequence:

>2235_bases
ATGAAACTAAATAAATTAATAGCGATCGCCACGATCAGCCTTCTGTCGGGAGGTATAAGCATGGCACAAAAAGCGTTGAA
TCTTGAGGATATCGTTGCCGGTAACGTCATACAAACAAAAGGCATCGGAAGCATGACTTGGCTAAAAGACGGTGAACGTT
ATAGCCGCTTGGAAAATAATAAGCAAACCGGAGGCACGGATATCGTCGCCTATCAAGCAAAAGATAACTCCCGTGAAGTC
ATTATCCCCTCATCCCTATTGACAGACAAATCTACAGGAAAGCCTATTCCCGCACGTAGTATCTCTTGGAGTGCGGATAA
TGAGAAAGTCTTGATTTATAACAATACCCAACGGGTATGGCGTTATGATACCCGGGGTGACTATTGGGTATTAAACCTAA
AGGACGGCGCTTTACGTCAATTGGGAAAAGGAATGCCGGAATCCTCCATGATGTTCGCTAAATTCTCTCCGGATGGCACA
CGTGTGGCCTATGTTTCCAACAATAATATATATGTAGAAGATATAGACTCCGGGAAAATCACGCAGCTAACAAAAGACGG
AAGCGATACGATTGTCAACGGAACTTTCGATTGGGTATATGAGGAGGAGTTCAGTTGCCGGGATGGTTTCCGCTGGAGCC
CGGACGGAAAGCATATCGCCTATTGGCAAAGCGATACGAAAGGAACGGGAGTGTTCGACATTATTAATAATGTAGACTCC
ATCTACGCAAAGGTAATCCATTTCCCATACCCCAAGGCAGGAACCACCAATTCAGCCGTAAAAGTAGGCTACGTTTCCTC
TACCGGCGGGAACACCACTTGGATCGCCATACCCGGAGATCCCCGGAACAACTACCTGCCCCGTATGGAATTCATCCCCG
AAAGCGACGAGTTGTTCATACAGCAACTAAACCGCCCGCAGAATACAAATAAGGTATGGATCGCCAAGATATCCGATAAC
TCGCTGAATAATATCTTCACTGATACGGATGCCGCATGGCTGGACACGAATGATAACATACAATGGTTAAAGGACAACCG
CTATTTCACATGGGAAAGCGAGCGTAGTGGCTGGCGACACTTATACCGGATAAGCCGGGACGGAAAAGAGATACAACCCA
TCACCAAAGGTGATTTTGATTATATCTCGCCGGTCGGGACCGATCTACAAAAGGGCTGGGTCTATTTCATCGCCTCCCCG
GACAATTTCACCCAACGTTACTTGTACCGGGCTAAAGCATTCGGCAATGGGGAAGTGGAGCGTGTAAGCCCCATGGAACA
ATCCGGACAGCACCGCTACAATATGTCACCCACCGGCAAATGGGCCATACATACGTATAGTAACGCCTCTACCCCATCCG
TTATCGACATGGTTTCTTTCCCGAAACATCAATCCGTACGCATGCTTGAGGATAATGCCCAAGCCAAGGACCAATACGCC
GCCTTAGGATTAAACCCGAAAGAATTTATCAAGGTCAAGTCCGGCAATCTAACCTTGGACGCATGGATGATAAAACCTGT
CGATTTCGACGCATCCAAGAAATACCCGGTTATCATAGAGGTATACGGCGAGCCGGCGAGCGCCACCGTACAAGATGTAT
GGGGTAACGGAGATTTATGGCAACAATATATGGCGAACCAAGGTTATATCGTGGTAAGTATCGAGAACCGGGGTGCGAAT
ACTCCCCGTGGACGTGAATGGCGGAAATGTATTTACGGGGAAGTGGGTACTTTCGCTTCCGAAGACCAGAGCAGGGGTAT
TCTGGATATGACCCGTCAATATCCGTTTATCGATGCCAACAGGATCGGTATTACCGGATGGAGCGGTGGTGGTAGCCAGA
CCTTAAACTGCATGTTCCGTTATCCGAAAATATTCCATACTGGTATAGCGATCGCTTTTGTAGCCGACCAACGTTTATAC
GACACGATCTACCAAGAACGTTACATGAATACTCCGCAGAACAATCCGGAAGGCTACCACAAAGGTTCCCCGATTACCTA
TGCCGAGGGACTGGAAGGTAATCTGCTGCTTATTCATGGTACGGGAGATGATAACGTGCATTACCAAAATTGCGAGATGC
TGGTGAACAAGTTGATCAAGAACGGAAAGATGTTTACGCAAATCAGTTACCCGATGCGTAGCCATAGCATCAACGAAAGG
GAAGGAACAACTCTTCACCTACGTAAGACAATGGCTAAATACTGGCTGGAACATCTTCCGGCCGGTGGTAAATAG

Upstream 100 bases:

>100_bases
TTATTCTTGATTTCCGAGGCGCGAATATACAAATCCATTTTGTTATATCAACTAACTTTCCGTTCTTTGCATAAATATAG
TAGTAACCAACTAATACAAC

Downstream 100 bases:

>100_bases
TTAATCCACGATTCGATGAAACAATTTTTATTGCGATTAGTGATCTTGGCAGGAATCAGTTTCCTGCCAACGGTGTCCAA
CGCCCAATTAAGGGAAAAGG

Product: dipeptidyl aminopeptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MKLNKLIAIATISLLSGGISMAQKALNLEDIVAGNVIQTKGIGSMTWLKDGERYSRLENNKQTGGTDIVAYQAKDNSREV
IIPSSLLTDKSTGKPIPARSISWSADNEKVLIYNNTQRVWRYDTRGDYWVLNLKDGALRQLGKGMPESSMMFAKFSPDGT
RVAYVSNNNIYVEDIDSGKITQLTKDGSDTIVNGTFDWVYEEEFSCRDGFRWSPDGKHIAYWQSDTKGTGVFDIINNVDS
IYAKVIHFPYPKAGTTNSAVKVGYVSSTGGNTTWIAIPGDPRNNYLPRMEFIPESDELFIQQLNRPQNTNKVWIAKISDN
SLNNIFTDTDAAWLDTNDNIQWLKDNRYFTWESERSGWRHLYRISRDGKEIQPITKGDFDYISPVGTDLQKGWVYFIASP
DNFTQRYLYRAKAFGNGEVERVSPMEQSGQHRYNMSPTGKWAIHTYSNASTPSVIDMVSFPKHQSVRMLEDNAQAKDQYA
ALGLNPKEFIKVKSGNLTLDAWMIKPVDFDASKKYPVIIEVYGEPASATVQDVWGNGDLWQQYMANQGYIVVSIENRGAN
TPRGREWRKCIYGEVGTFASEDQSRGILDMTRQYPFIDANRIGITGWSGGGSQTLNCMFRYPKIFHTGIAIAFVADQRLY
DTIYQERYMNTPQNNPEGYHKGSPITYAEGLEGNLLLIHGTGDDNVHYQNCEMLVNKLIKNGKMFTQISYPMRSHSINER
EGTTLHLRKTMAKYWLEHLPAGGK

Sequences:

>Translated_744_residues
MKLNKLIAIATISLLSGGISMAQKALNLEDIVAGNVIQTKGIGSMTWLKDGERYSRLENNKQTGGTDIVAYQAKDNSREV
IIPSSLLTDKSTGKPIPARSISWSADNEKVLIYNNTQRVWRYDTRGDYWVLNLKDGALRQLGKGMPESSMMFAKFSPDGT
RVAYVSNNNIYVEDIDSGKITQLTKDGSDTIVNGTFDWVYEEEFSCRDGFRWSPDGKHIAYWQSDTKGTGVFDIINNVDS
IYAKVIHFPYPKAGTTNSAVKVGYVSSTGGNTTWIAIPGDPRNNYLPRMEFIPESDELFIQQLNRPQNTNKVWIAKISDN
SLNNIFTDTDAAWLDTNDNIQWLKDNRYFTWESERSGWRHLYRISRDGKEIQPITKGDFDYISPVGTDLQKGWVYFIASP
DNFTQRYLYRAKAFGNGEVERVSPMEQSGQHRYNMSPTGKWAIHTYSNASTPSVIDMVSFPKHQSVRMLEDNAQAKDQYA
ALGLNPKEFIKVKSGNLTLDAWMIKPVDFDASKKYPVIIEVYGEPASATVQDVWGNGDLWQQYMANQGYIVVSIENRGAN
TPRGREWRKCIYGEVGTFASEDQSRGILDMTRQYPFIDANRIGITGWSGGGSQTLNCMFRYPKIFHTGIAIAFVADQRLY
DTIYQERYMNTPQNNPEGYHKGSPITYAEGLEGNLLLIHGTGDDNVHYQNCEMLVNKLIKNGKMFTQISYPMRSHSINER
EGTTLHLRKTMAKYWLEHLPAGGK
>Mature_744_residues
MKLNKLIAIATISLLSGGISMAQKALNLEDIVAGNVIQTKGIGSMTWLKDGERYSRLENNKQTGGTDIVAYQAKDNSREV
IIPSSLLTDKSTGKPIPARSISWSADNEKVLIYNNTQRVWRYDTRGDYWVLNLKDGALRQLGKGMPESSMMFAKFSPDGT
RVAYVSNNNIYVEDIDSGKITQLTKDGSDTIVNGTFDWVYEEEFSCRDGFRWSPDGKHIAYWQSDTKGTGVFDIINNVDS
IYAKVIHFPYPKAGTTNSAVKVGYVSSTGGNTTWIAIPGDPRNNYLPRMEFIPESDELFIQQLNRPQNTNKVWIAKISDN
SLNNIFTDTDAAWLDTNDNIQWLKDNRYFTWESERSGWRHLYRISRDGKEIQPITKGDFDYISPVGTDLQKGWVYFIASP
DNFTQRYLYRAKAFGNGEVERVSPMEQSGQHRYNMSPTGKWAIHTYSNASTPSVIDMVSFPKHQSVRMLEDNAQAKDQYA
ALGLNPKEFIKVKSGNLTLDAWMIKPVDFDASKKYPVIIEVYGEPASATVQDVWGNGDLWQQYMANQGYIVVSIENRGAN
TPRGREWRKCIYGEVGTFASEDQSRGILDMTRQYPFIDANRIGITGWSGGGSQTLNCMFRYPKIFHTGIAIAFVADQRLY
DTIYQERYMNTPQNNPEGYHKGSPITYAEGLEGNLLLIHGTGDDNVHYQNCEMLVNKLIKNGKMFTQISYPMRSHSINER
EGTTLHLRKTMAKYWLEHLPAGGK

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=747, Percent_Identity=26.2382864792503, Blast_Score=208, Evalue=2e-53,
Organism=Homo sapiens, GI18765694, Length=711, Percent_Identity=28.9732770745429, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI85787627, Length=678, Percent_Identity=24.6312684365782, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI295842403, Length=678, Percent_Identity=24.6312684365782, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI295849272, Length=674, Percent_Identity=24.6290801186944, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI295842359, Length=678, Percent_Identity=24.6312684365782, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI52426756, Length=678, Percent_Identity=24.6312684365782, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI37577089, Length=683, Percent_Identity=25.7686676427526, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI18450280, Length=683, Percent_Identity=25.7686676427526, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI86792778, Length=678, Percent_Identity=24.188790560472, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI86792774, Length=678, Percent_Identity=24.188790560472, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI86792863, Length=678, Percent_Identity=24.188790560472, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI194394146, Length=696, Percent_Identity=24.8563218390805, Blast_Score=167, Evalue=5e-41,
Organism=Homo sapiens, GI37577091, Length=683, Percent_Identity=23.4260614934114, Blast_Score=119, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17508019, Length=243, Percent_Identity=37.4485596707819, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17508017, Length=243, Percent_Identity=37.4485596707819, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17550672, Length=670, Percent_Identity=24.6268656716418, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17564632, Length=627, Percent_Identity=25.0398724082935, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17564634, Length=627, Percent_Identity=25.0398724082935, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321817, Length=685, Percent_Identity=27.2992700729927, Blast_Score=223, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6324793, Length=734, Percent_Identity=24.9318801089918, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45551969, Length=689, Percent_Identity=25.8345428156749, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45550825, Length=689, Percent_Identity=25.8345428156749, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45553511, Length=689, Percent_Identity=25.8345428156749, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17933704, Length=760, Percent_Identity=25.5263157894737, Blast_Score=182, Evalue=9e-46,
Organism=Drosophila melanogaster, GI161083744, Length=760, Percent_Identity=25.5263157894737, Blast_Score=182, Evalue=9e-46,
Organism=Drosophila melanogaster, GI221331178, Length=760, Percent_Identity=25.5263157894737, Blast_Score=182, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24582032, Length=660, Percent_Identity=26.0606060606061, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24582257, Length=285, Percent_Identity=30.8771929824561, Blast_Score=126, Evalue=7e-29,
Organism=Drosophila melanogaster, GI45551475, Length=227, Percent_Identity=28.6343612334802, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221372263, Length=227, Percent_Identity=28.6343612334802, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221372266, Length=227, Percent_Identity=28.6343612334802, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 84194; Mature: 84194

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNKLIAIATISLLSGGISMAQKALNLEDIVAGNVIQTKGIGSMTWLKDGERYSRLENN
CCCHHEEHHHHHHHHHCCHHHHHHHCCHHHHHCCCEEEECCCCCEEEECCCHHHHHHCCC
KQTGGTDIVAYQAKDNSREVIIPSSLLTDKSTGKPIPARSISWSADNEKVLIYNNTQRVW
CCCCCCEEEEEEECCCCCEEEECHHHCCCCCCCCCCCCCCEEECCCCCEEEEEECCCEEE
RYDTRGDYWVLNLKDGALRQLGKGMPESSMMFAKFSPDGTRVAYVSNNNIYVEDIDSGKI
EECCCCCEEEEEECCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCE
TQLTKDGSDTIVNGTFDWVYEEEFSCRDGFRWSPDGKHIAYWQSDTKGTGVFDIINNVDS
EEEECCCCCEEEECEEEEEECCCCCCCCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHH
IYAKVIHFPYPKAGTTNSAVKVGYVSSTGGNTTWIAIPGDPRNNYLPRMEFIPESDELFI
HHHHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCHHHHH
QQLNRPQNTNKVWIAKISDNSLNNIFTDTDAAWLDTNDNIQWLKDNRYFTWESERSGWRH
HHHCCCCCCCEEEEEEECCCCCCCEECCCCCEEEECCCCEEEEECCEEEEECCCCCCCHH
LYRISRDGKEIQPITKGDFDYISPVGTDLQKGWVYFIASPDNFTQRYLYRAKAFGNGEVE
HHEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCE
RVSPMEQSGQHRYNMSPTGKWAIHTYSNASTPSVIDMVSFPKHQSVRMLEDNAQAKDQYA
ECCCHHHCCCEEECCCCCCCEEEEEECCCCCCCEEEHHCCCCCCCEEEECCCCCCCCCEE
ALGLNPKEFIKVKSGNLTLDAWMIKPVDFDASKKYPVIIEVYGEPASATVQDVWGNGDLW
EECCCHHHEEEEECCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCCHHH
QQYMANQGYIVVSIENRGANTPRGREWRKCIYGEVGTFASEDQSRGILDMTRQYPFIDAN
HHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCC
RIGITGWSGGGSQTLNCMFRYPKIFHTGIAIAFVADQRLYDTIYQERYMNTPQNNPEGYH
CEEEEEECCCCCCEEEEEEECCHHHHCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCC
KGSPITYAEGLEGNLLLIHGTGDDNVHYQNCEMLVNKLIKNGKMFTQISYPMRSHSINER
CCCCEEEECCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCHHHCCCCCC
EGTTLHLRKTMAKYWLEHLPAGGK
CCCEEEHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLNKLIAIATISLLSGGISMAQKALNLEDIVAGNVIQTKGIGSMTWLKDGERYSRLENN
CCCHHEEHHHHHHHHHCCHHHHHHHCCHHHHHCCCEEEECCCCCEEEECCCHHHHHHCCC
KQTGGTDIVAYQAKDNSREVIIPSSLLTDKSTGKPIPARSISWSADNEKVLIYNNTQRVW
CCCCCCEEEEEEECCCCCEEEECHHHCCCCCCCCCCCCCCEEECCCCCEEEEEECCCEEE
RYDTRGDYWVLNLKDGALRQLGKGMPESSMMFAKFSPDGTRVAYVSNNNIYVEDIDSGKI
EECCCCCEEEEEECCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCE
TQLTKDGSDTIVNGTFDWVYEEEFSCRDGFRWSPDGKHIAYWQSDTKGTGVFDIINNVDS
EEEECCCCCEEEECEEEEEECCCCCCCCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHH
IYAKVIHFPYPKAGTTNSAVKVGYVSSTGGNTTWIAIPGDPRNNYLPRMEFIPESDELFI
HHHHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCHHHHH
QQLNRPQNTNKVWIAKISDNSLNNIFTDTDAAWLDTNDNIQWLKDNRYFTWESERSGWRH
HHHCCCCCCCEEEEEEECCCCCCCEECCCCCEEEECCCCEEEEECCEEEEECCCCCCCHH
LYRISRDGKEIQPITKGDFDYISPVGTDLQKGWVYFIASPDNFTQRYLYRAKAFGNGEVE
HHEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCE
RVSPMEQSGQHRYNMSPTGKWAIHTYSNASTPSVIDMVSFPKHQSVRMLEDNAQAKDQYA
ECCCHHHCCCEEECCCCCCCEEEEEECCCCCCCEEEHHCCCCCCCEEEECCCCCCCCCEE
ALGLNPKEFIKVKSGNLTLDAWMIKPVDFDASKKYPVIIEVYGEPASATVQDVWGNGDLW
EECCCHHHEEEEECCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCCHHH
QQYMANQGYIVVSIENRGANTPRGREWRKCIYGEVGTFASEDQSRGILDMTRQYPFIDAN
HHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCC
RIGITGWSGGGSQTLNCMFRYPKIFHTGIAIAFVADQRLYDTIYQERYMNTPQNNPEGYH
CEEEEEECCCCCCEEEEEEECCHHHHCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCC
KGSPITYAEGLEGNLLLIHGTGDDNVHYQNCEMLVNKLIKNGKMFTQISYPMRSHSINER
CCCCEEEECCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCHHHCCCCCC
EGTTLHLRKTMAKYWLEHLPAGGK
CCCEEEHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA