Click here to switch to the map view.

The map label for this gene is ptpA [H]

Identifier: 150008803

GI number: 150008803

Start: 2580333

End: 2582507

Strand: Reverse

Name: ptpA [H]

Synonym: BDI_2193

Alternate gene names: 150008803

Gene position: 2582507-2580333 (Counterclockwise)

Preceding gene: 150008805

Following gene: 150008802

Centisome position: 53.67

GC content: 45.01

Gene sequence:

>2175_bases
ATGAAACGATTAGGTTTTAGTTTATTGCTTTCGTTGGCCGTATTCGGAAGTGTGGCCGCACAAACCGGAAGCAAGCATGT
TGACTTAAAAGAAATAACCGATGGGAAATTTCGTCAAGTGACGGCTATCGGAGAGATGCGATCCCTGCCGGATGGAGAAC
ACTACACAGCCATGAACGCCGATAAGAGTATGATCATTAAATATTCCTATCGTACGGGAAATCCTGTGGATACATTGTTT
AATGCCCGTAAAGCTCGTGAATGTACCTTTACGGATTTTGATGGATATACAATCAGCAGCACCGGGCATCATATCTTGGT
TTGGAGGGATACGGAGTCTATTTATCGTCGCTCTACCAAGGCTGTGGTTTATGATTATGACGTACGTCGTAATTATGTGA
AGCCTATTTCCGATGCCAAGGGTAAGCAAATGATCCCGACATTCTCGCCGGATGGTCGTATGTGCGCTTATGTACGGGAT
AATAATATTTGGATACGTAAGTTTGATTTTGATACCGAGGTACAAGTTACCAAGGACGGTGAGTTGAATAAGATATTGAA
TGGTATCACGGATTGGGTGTATGAGGAAGAATTCGCGGTGACAAATCTAATGGCGTGGTCTCCCGATAGCGAGTATCTGG
CCTTTGTCCGTTTTGACGAGTCCGAGGTGCCCGAATATTCTATGCAGATGTATGGTGAGGGACTTTATCCGGGGTATTAC
GAATATAAATATCCGAAGGCCGGGCAGAAGAATTCAAAGGTCTCCGTACATTCTTATAGCGTAGTCACCAAAGACACGAA
AGAGATGAAGGTCCCGGTAGAAGGCGACTTCTATATTCCCCGCATTACTTTCACGCAGAATCCGGATCAGTTGGCTATCA
TGACATTGAACCGCCAGCAGAATGTATTCAATATGTATTATGCAAATCCGAAGAGCGGTGTGTTCCGTTTGATCTTGCGT
GAGGAAAATAAATGCTACGTGGATTCTGATTGGTTGACTTCCATCCAGTTCTTGAACAATGGGTTTACCTATGTGAGCGA
ACAAGATGGCTATTCCCATATTTATTTGTATTCCCCGACAGGTGTTATGCAACGTCAGGTAACTCAAGGGAACTGGGATG
TCACGAAGTTCTTGGGCGTGGATGAGAATACGAAGACTTTCTATTACGAGTCTGCCGAGGAAAGCCCGATCCGCCGCTCT
ATCTATAAGATCGACGCGAAAGGCGTGAAGACAAAACTCTCCACGGAAGAGGGTATGAACAAGGCGGTCTTTAGTGACAA
TTTCGCTTATTTCGTGAATACCTATTCCAACGCGAATACCCCGGCGAAGATTACAGTGAATGAGACGAAGACCAAAAAGG
AACTACGTGTCCTGCAAGATAACGCTGCGTTGAAGAGTAAACTGAAGGAATATGCTTTTGCCAAGAAGGAGTTCATGAAG
GTACATACGGCCTCGGACTATGAGTTCAACGCTTGGATCGTAAAACCCGCTGATTTTGACCCGTCGAAGAAATATCCGGT
GATGATGACGCAATATAGTGGCCCTAACTCCCAGCAAGTATTGGATCAATACGGTTTCGATTGGGAGCAATATCTGGCCT
CAAATGGTATTATCGTGGTATGTGTGGATGGTCGTGGAACCGGTGCCCGTGGTGAGGCATTCCGTAAATGTACTTATTTG
AGAATGGGCGAGCTGGAATCCAGAGACCAAGTGGAGGCTGCGCAAGCGTTAGGCAAGTTACCTTATATCGATAAGGATCG
TATCGCGATCTGGGGTTGGAGTTTCGGAGGTTATAACACGTTGATGGCCTTGAGTACCGGAAACGGAACGTTTAAGGTGG
GTATCGCTGTAGCTCCTCCGACGGACTGGAAATATTATGACTCCGTTTATACGGAGCGTTTCATGCGTACCCCGCAAGAG
AATTTCGAGGGCTATGCGGCTACCTCTCCGTTACGCCGGGTGAAAGACTTACAAGGCAAGTTATTGCTGGTTCATGGAAC
CGCCGATGATAATGTTCATTTTATGCAAACAATGGAATATGCCGAGGCTTTGGTTCAAGCCAATAAGCAGTTCGATATGC
ATGTTTATAAAGATCGGAATCATAGCATATATGGTGGTAATACCCGTTACCATTTGTATACGAAGATGGCTAATTATTTA
TTCAATAATTTGTAA

Upstream 100 bases:

>100_bases
TATCGTTTAGTTTTTTTCATAAGACAAAGATACGATTTCTCGCAATTTGAATCACTTTTTTATGCTAACTTCGCGTTTCA
ATCTGAAATAAAGAGTATAA

Downstream 100 bases:

>100_bases
GACATGGCGCAGCATTTAAGAAAGCCGGATTGGTTGAAGATCCGGCTTGGCGGAAATGAGCAATTCACGAAGACAAAAAG
TATTGTTGAATCTCATTGCC

Product: dipeptidyl aminopeptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 724; Mature: 724

Protein sequence:

>724_residues
MKRLGFSLLLSLAVFGSVAAQTGSKHVDLKEITDGKFRQVTAIGEMRSLPDGEHYTAMNADKSMIIKYSYRTGNPVDTLF
NARKARECTFTDFDGYTISSTGHHILVWRDTESIYRRSTKAVVYDYDVRRNYVKPISDAKGKQMIPTFSPDGRMCAYVRD
NNIWIRKFDFDTEVQVTKDGELNKILNGITDWVYEEEFAVTNLMAWSPDSEYLAFVRFDESEVPEYSMQMYGEGLYPGYY
EYKYPKAGQKNSKVSVHSYSVVTKDTKEMKVPVEGDFYIPRITFTQNPDQLAIMTLNRQQNVFNMYYANPKSGVFRLILR
EENKCYVDSDWLTSIQFLNNGFTYVSEQDGYSHIYLYSPTGVMQRQVTQGNWDVTKFLGVDENTKTFYYESAEESPIRRS
IYKIDAKGVKTKLSTEEGMNKAVFSDNFAYFVNTYSNANTPAKITVNETKTKKELRVLQDNAALKSKLKEYAFAKKEFMK
VHTASDYEFNAWIVKPADFDPSKKYPVMMTQYSGPNSQQVLDQYGFDWEQYLASNGIIVVCVDGRGTGARGEAFRKCTYL
RMGELESRDQVEAAQALGKLPYIDKDRIAIWGWSFGGYNTLMALSTGNGTFKVGIAVAPPTDWKYYDSVYTERFMRTPQE
NFEGYAATSPLRRVKDLQGKLLLVHGTADDNVHFMQTMEYAEALVQANKQFDMHVYKDRNHSIYGGNTRYHLYTKMANYL
FNNL

Sequences:

>Translated_724_residues
MKRLGFSLLLSLAVFGSVAAQTGSKHVDLKEITDGKFRQVTAIGEMRSLPDGEHYTAMNADKSMIIKYSYRTGNPVDTLF
NARKARECTFTDFDGYTISSTGHHILVWRDTESIYRRSTKAVVYDYDVRRNYVKPISDAKGKQMIPTFSPDGRMCAYVRD
NNIWIRKFDFDTEVQVTKDGELNKILNGITDWVYEEEFAVTNLMAWSPDSEYLAFVRFDESEVPEYSMQMYGEGLYPGYY
EYKYPKAGQKNSKVSVHSYSVVTKDTKEMKVPVEGDFYIPRITFTQNPDQLAIMTLNRQQNVFNMYYANPKSGVFRLILR
EENKCYVDSDWLTSIQFLNNGFTYVSEQDGYSHIYLYSPTGVMQRQVTQGNWDVTKFLGVDENTKTFYYESAEESPIRRS
IYKIDAKGVKTKLSTEEGMNKAVFSDNFAYFVNTYSNANTPAKITVNETKTKKELRVLQDNAALKSKLKEYAFAKKEFMK
VHTASDYEFNAWIVKPADFDPSKKYPVMMTQYSGPNSQQVLDQYGFDWEQYLASNGIIVVCVDGRGTGARGEAFRKCTYL
RMGELESRDQVEAAQALGKLPYIDKDRIAIWGWSFGGYNTLMALSTGNGTFKVGIAVAPPTDWKYYDSVYTERFMRTPQE
NFEGYAATSPLRRVKDLQGKLLLVHGTADDNVHFMQTMEYAEALVQANKQFDMHVYKDRNHSIYGGNTRYHLYTKMANYL
FNNL
>Mature_724_residues
MKRLGFSLLLSLAVFGSVAAQTGSKHVDLKEITDGKFRQVTAIGEMRSLPDGEHYTAMNADKSMIIKYSYRTGNPVDTLF
NARKARECTFTDFDGYTISSTGHHILVWRDTESIYRRSTKAVVYDYDVRRNYVKPISDAKGKQMIPTFSPDGRMCAYVRD
NNIWIRKFDFDTEVQVTKDGELNKILNGITDWVYEEEFAVTNLMAWSPDSEYLAFVRFDESEVPEYSMQMYGEGLYPGYY
EYKYPKAGQKNSKVSVHSYSVVTKDTKEMKVPVEGDFYIPRITFTQNPDQLAIMTLNRQQNVFNMYYANPKSGVFRLILR
EENKCYVDSDWLTSIQFLNNGFTYVSEQDGYSHIYLYSPTGVMQRQVTQGNWDVTKFLGVDENTKTFYYESAEESPIRRS
IYKIDAKGVKTKLSTEEGMNKAVFSDNFAYFVNTYSNANTPAKITVNETKTKKELRVLQDNAALKSKLKEYAFAKKEFMK
VHTASDYEFNAWIVKPADFDPSKKYPVMMTQYSGPNSQQVLDQYGFDWEQYLASNGIIVVCVDGRGTGARGEAFRKCTYL
RMGELESRDQVEAAQALGKLPYIDKDRIAIWGWSFGGYNTLMALSTGNGTFKVGIAVAPPTDWKYYDSVYTERFMRTPQE
NFEGYAATSPLRRVKDLQGKLLLVHGTADDNVHFMQTMEYAEALVQANKQFDMHVYKDRNHSIYGGNTRYHLYTKMANYL
FNNL

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=731, Percent_Identity=32.421340629275, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI18765694, Length=700, Percent_Identity=32.1428571428571, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI52426756, Length=680, Percent_Identity=28.9705882352941, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI85787627, Length=680, Percent_Identity=28.9705882352941, Blast_Score=276, Evalue=5e-74,
Organism=Homo sapiens, GI295842359, Length=680, Percent_Identity=28.9705882352941, Blast_Score=276, Evalue=6e-74,
Organism=Homo sapiens, GI295842403, Length=680, Percent_Identity=28.9705882352941, Blast_Score=276, Evalue=6e-74,
Organism=Homo sapiens, GI295849272, Length=680, Percent_Identity=28.9705882352941, Blast_Score=276, Evalue=6e-74,
Organism=Homo sapiens, GI86792863, Length=601, Percent_Identity=29.1181364392679, Blast_Score=263, Evalue=5e-70,
Organism=Homo sapiens, GI86792778, Length=601, Percent_Identity=29.1181364392679, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI86792774, Length=616, Percent_Identity=28.7337662337662, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI194394146, Length=700, Percent_Identity=26.7142857142857, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI18450280, Length=701, Percent_Identity=26.8188302425107, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI37577089, Length=701, Percent_Identity=26.8188302425107, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI37577091, Length=703, Percent_Identity=23.6130867709815, Blast_Score=133, Evalue=7e-31,
Organism=Homo sapiens, GI18450278, Length=119, Percent_Identity=37.8151260504202, Blast_Score=80, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17550672, Length=595, Percent_Identity=27.3949579831933, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17564632, Length=660, Percent_Identity=25.1515151515152, Blast_Score=168, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17564634, Length=591, Percent_Identity=25.8883248730964, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508017, Length=232, Percent_Identity=32.7586206896552, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17508019, Length=232, Percent_Identity=32.7586206896552, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321817, Length=665, Percent_Identity=31.8796992481203, Blast_Score=304, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6324793, Length=671, Percent_Identity=28.6140089418778, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17933704, Length=695, Percent_Identity=30.7913669064748, Blast_Score=263, Evalue=4e-70,
Organism=Drosophila melanogaster, GI161083744, Length=695, Percent_Identity=30.7913669064748, Blast_Score=262, Evalue=6e-70,
Organism=Drosophila melanogaster, GI221331178, Length=695, Percent_Identity=30.7913669064748, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24582032, Length=662, Percent_Identity=29.607250755287, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45551969, Length=693, Percent_Identity=25.974025974026, Blast_Score=207, Evalue=3e-53,
Organism=Drosophila melanogaster, GI45550825, Length=693, Percent_Identity=25.974025974026, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI45553511, Length=693, Percent_Identity=25.974025974026, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24582257, Length=273, Percent_Identity=36.6300366300366, Blast_Score=182, Evalue=8e-46,
Organism=Drosophila melanogaster, GI221372263, Length=690, Percent_Identity=23.1884057971014, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45551475, Length=690, Percent_Identity=23.4782608695652, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI221372266, Length=433, Percent_Identity=24.0184757505774, Blast_Score=136, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 83236; Mature: 83236

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLGFSLLLSLAVFGSVAAQTGSKHVDLKEITDGKFRQVTAIGEMRSLPDGEHYTAMNA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEEHHHHHCCCCCCCEEEECC
DKSMIIKYSYRTGNPVDTLFNARKARECTFTDFDGYTISSTGHHILVWRDTESIYRRSTK
CCEEEEEEECCCCCHHHHHHCCHHCCCCEEECCCCEEECCCCCEEEEEECCHHHHHCCCC
AVVYDYDVRRNYVKPISDAKGKQMIPTFSPDGRMCAYVRDNNIWIRKFDFDTEVQVTKDG
EEEEEEHHHHCCCCCCCCCCCCEECCCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCC
ELNKILNGITDWVYEEEFAVTNLMAWSPDSEYLAFVRFDESEVPEYSMQMYGEGLYPGYY
CHHHHHHHHHHHHCCCCHHEEEEEEECCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCE
EYKYPKAGQKNSKVSVHSYSVVTKDTKEMKVPVEGDFYIPRITFTQNPDQLAIMTLNRQQ
EEECCCCCCCCCEEEEEEEEEEECCCHHEECCCCCCEEEEEEEECCCCCEEEEEEECCCC
NVFNMYYANPKSGVFRLILREENKCYVDSDWLTSIQFLNNGFTYVSEQDGYSHIYLYSPT
CEEEEEEECCCCCEEEEEEECCCCEEECCHHHHHHHHHCCCEEEEECCCCCCEEEEECCC
GVMQRQVTQGNWDVTKFLGVDENTKTFYYESAEESPIRRSIYKIDAKGVKTKLSTEEGMN
CHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHEEECCCCCEEEECHHHCCC
KAVFSDNFAYFVNTYSNANTPAKITVNETKTKKELRVLQDNAALKSKLKEYAFAKKEFMK
CEEECCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHE
VHTASDYEFNAWIVKPADFDPSKKYPVMMTQYSGPNSQQVLDQYGFDWEQYLASNGIIVV
EECCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCEEEE
CVDGRGTGARGEAFRKCTYLRMGELESRDQVEAAQALGKLPYIDKDRIAIWGWSFGGYNT
EECCCCCCCCCHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEE
LMALSTGNGTFKVGIAVAPPTDWKYYDSVYTERFMRTPQENFEGYAATSPLRRVKDLQGK
EEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCEECCCHHHHHHHCCCC
LLLVHGTADDNVHFMQTMEYAEALVQANKQFDMHVYKDRNHSIYGGNTRYHLYTKMANYL
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCEEEEEHHHHHHHH
FNNL
HHCC
>Mature Secondary Structure
MKRLGFSLLLSLAVFGSVAAQTGSKHVDLKEITDGKFRQVTAIGEMRSLPDGEHYTAMNA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEEHHHHHCCCCCCCEEEECC
DKSMIIKYSYRTGNPVDTLFNARKARECTFTDFDGYTISSTGHHILVWRDTESIYRRSTK
CCEEEEEEECCCCCHHHHHHCCHHCCCCEEECCCCEEECCCCCEEEEEECCHHHHHCCCC
AVVYDYDVRRNYVKPISDAKGKQMIPTFSPDGRMCAYVRDNNIWIRKFDFDTEVQVTKDG
EEEEEEHHHHCCCCCCCCCCCCEECCCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCC
ELNKILNGITDWVYEEEFAVTNLMAWSPDSEYLAFVRFDESEVPEYSMQMYGEGLYPGYY
CHHHHHHHHHHHHCCCCHHEEEEEEECCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCE
EYKYPKAGQKNSKVSVHSYSVVTKDTKEMKVPVEGDFYIPRITFTQNPDQLAIMTLNRQQ
EEECCCCCCCCCEEEEEEEEEEECCCHHEECCCCCCEEEEEEEECCCCCEEEEEEECCCC
NVFNMYYANPKSGVFRLILREENKCYVDSDWLTSIQFLNNGFTYVSEQDGYSHIYLYSPT
CEEEEEEECCCCCEEEEEEECCCCEEECCHHHHHHHHHCCCEEEEECCCCCCEEEEECCC
GVMQRQVTQGNWDVTKFLGVDENTKTFYYESAEESPIRRSIYKIDAKGVKTKLSTEEGMN
CHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHEEECCCCCEEEECHHHCCC
KAVFSDNFAYFVNTYSNANTPAKITVNETKTKKELRVLQDNAALKSKLKEYAFAKKEFMK
CEEECCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHE
VHTASDYEFNAWIVKPADFDPSKKYPVMMTQYSGPNSQQVLDQYGFDWEQYLASNGIIVV
EECCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCEEEE
CVDGRGTGARGEAFRKCTYLRMGELESRDQVEAAQALGKLPYIDKDRIAIWGWSFGGYNT
EECCCCCCCCCHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEE
LMALSTGNGTFKVGIAVAPPTDWKYYDSVYTERFMRTPQENFEGYAATSPLRRVKDLQGK
EEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCEECCCHHHHHHHCCCC
LLLVHGTADDNVHFMQTMEYAEALVQANKQFDMHVYKDRNHSIYGGNTRYHLYTKMANYL
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCEEEEEHHHHHHHH
FNNL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA